Roles of ceramides in development of insulin resistance

No Pathway Network information available for Roles of ceramides in development of insulin resistance

Pathways in the Roles of ceramides in development of insulin resistance SuperPath

#	Name	Source	Genes
1	Roles of ceramides in development of insulin resistance	WikiPathways	ACSL1 AKT1 CD36 CPT1B EIF2AK2 ERN1 INS INSR IRS1 IRS2 MAFA MAPK8 PIK3R1 PPP2CA PRKAG3 PRKCZ RPS6KB1 SLC2A4 SMPD3 TNF TNFRSF1A TRAF1 (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SMPD3	Sphingomyelin Phosphodiesterase 3	Protein Coding	1
2	ERN1	Endoplasmic Reticulum To Nucleus Signaling 1	Protein Coding	1
3	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
4	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	1
5	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
6	CPT1B	Carnitine Palmitoyltransferase 1B	Protein Coding	1
7	ACSL1	Acyl-CoA Synthetase Long Chain Family Member 1	Protein Coding	1
8	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
9	TNF	Tumor Necrosis Factor	Protein Coding	1
10	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	1
11	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
12	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	1
13	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	1
14	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
15	MAFA	MAF BZIP Transcription Factor A	Protein Coding	1
16	INS	Insulin	Protein Coding	1
17	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
18	INSR	Insulin Receptor	Protein Coding	1
19	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
20	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	1
21	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
22	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1

Disorders associated with Roles of ceramides in development of insulin resistance SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Type 2 diabetes mellitus	Enrichment	INSR, IRS1, IRS2, SLC2A4	6.25
2	Cerebral malaria	Enrichment	CD36, TNF	4.82
3	Malaria	Enrichment	CD36, TNF	3.21
4	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.79
5	Proteus syndrome	Enrichment	AKT1	2.79
6	Insulinomatosis and diabetes mellitus	Enrichment	MAFA	2.79
7	Donohue syndrome	Enrichment	INSR	2.79
8	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.79
9	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.79
10	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.79
11	Coronary heart disease 7	Enrichment	CD36	2.79
12	Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome	Enrichment	EIF2AK2	2.79
13	Short syndrome	Enrichment	PIK3R1	2.79
14	Platelet glycoprotein iv deficiency	Enrichment	CD36	2.79
15	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.79
16	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.79
17	Cowden syndrome 6	Enrichment	AKT1	2.79
18	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.79
19	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	2.79
20	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.79
21	Dystonia 33	Enrichment	EIF2AK2	2.79
22	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.49
23	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.49
24	Hyperproinsulinemia	Enrichment	INS	2.49
25	Immunodeficiency 127	Enrichment	TNF	2.49
26	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.49
27	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.49
28	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.49
29	Type 1 diabetes mellitus 2	Enrichment	INS	2.31
30	Psoriatic arthritis	Enrichment	TNF	2.31
31	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	2.31
32	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.31
33	Torsion dystonia 1	Enrichment	EIF2AK2	2.31
34	Immunodeficiency 14	Enrichment	PIK3R1	2.31
35	Migraine without aura	Enrichment	TNF	2.31
36	Neonatal diabetes mellitus	Enrichment	INS	2.19
37	Blood platelet disease	Enrichment	CD36	2.19
38	Vascular dementia	Enrichment	TNF	2.09
39	Colorectal cancer	Enrichment	AKT1, PIK3R1	2.06
40	Type 1 diabetes mellitus	Enrichment	INS	2.01
41	Breast adenocarcinoma	Enrichment	AKT1	2.01
42	46,xy disorder of sex development	Enrichment	INSR	2.01
43	Overgrowth syndrome	Enrichment	PIK3R1	1.95
44	Permanent neonatal diabetes mellitus	Enrichment	INS	1.89
45	Charge syndrome	Enrichment	TNFRSF1A	1.84
46	Cowden syndrome	Enrichment	AKT1	1.84
47	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.79
48	Asthma	Enrichment	TNF	1.75
49	Diabetes mellitus	Enrichment	INS	1.75
50	Meningioma	Enrichment	AKT1	1.71
51	Alzheimer's disease	Enrichment	TNF	1.68
52	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.68
53	Multiple sclerosis	Enrichment	TNFRSF1A	1.65
54	Behcet syndrome	Enrichment	TNFRSF1A	1.52
55	Maturity-onset diabetes of the young	Enrichment	INS	1.50
56	Autoinflammatory disease	Enrichment	TNFRSF1A	1.42
57	Systemic lupus erythematosus	Enrichment	TNF	1.21
58	Hereditary breast carcinoma	Enrichment	AKT1	1.16
59	Breast cancer	Enrichment	AKT1	0.94
60	Ovarian cancer	Enrichment	AKT1	0.82
61	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.74

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Roles of ceramides in development of insulin resistance

Pathway Network for Roles of ceramides in development of insulin resistance

Member Pathways for Roles of ceramides in development of insulin resistance

Pathways in the Roles of ceramides in development of insulin resistance SuperPath

Associated Genes for Roles of ceramides in development of insulin resistance

Associated Disorders for Roles of ceramides in development of insulin resistance

Disorders associated with Roles of ceramides in development of insulin resistance SuperPath

STRING Interaction Network for Roles of ceramides in development of insulin resistance

Sources for Roles of ceramides in development of insulin resistance