RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

No Pathway Network information available for RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

Pathways in the RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) SuperPath

#	Name	Source	Genes
1	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Reactome	CBFB CR1 CTLA4 FOXP3 IFNG IL2 IL2RA NFATC2 RUNX1 TNFRSF18 (see all 10) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	1
2	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	1
3	IFNG	Interferon Gamma	Protein Coding	1
4	IL2	Interleukin 2	Protein Coding	1
5	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
6	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
7	FOXP3	Forkhead Box P3~Name Same As:- HGNC:13781	Protein Coding	1
8	RUNX1	RUNX Family Transcription Factor 1	Protein Coding	1
9	CBFB	Core-Binding Factor Subunit Beta	Protein Coding	1
10	TNFRSF18	TNF Receptor Superfamily Member 18	Protein Coding	1

Disorders associated with RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Type 1 diabetes mellitus 10	Enrichment	IL2RA	3.13
2	Immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	Enrichment	FOXP3	3.13
3	Celiac disease 3	Enrichment	CTLA4	3.13
4	Immunodeficiency 69	Enrichment	IFNG	3.13
5	Type 1 diabetes mellitus 12	Enrichment	CTLA4	3.13
6	Hashimoto thyroiditis	Enrichment	CTLA4	2.83
7	Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	Enrichment	FOXP3	2.83
8	Storage pool platelet disease	Enrichment	RUNX1	2.83
9	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.83
10	Cleidocranial dysplasia 2	Enrichment	CBFB	2.83
11	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.83
12	Tafro syndrome	Enrichment	RUNX1	2.83
13	Mycosis fungoides	Enrichment	CTLA4	2.66
14	Tuberous sclerosis 1	Enrichment	IFNG	2.66
15	Platelet disorder, familial, with associated myeloid malignancy	Enrichment	RUNX1	2.66
16	Hepatitis c virus	Enrichment	IFNG	2.66
17	Tuberous sclerosis 2	Enrichment	IFNG	2.66
18	Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation	Enrichment	CTLA4	2.66
19	Asparagine synthetase deficiency	Enrichment	CTLA4	2.66
20	Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome	Enrichment	CTLA4	2.66
21	Adult-onset myasthenia gravis	Enrichment	CTLA4	2.66
22	Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with runx1	Enrichment	RUNX1	2.66
23	Saczary syndrome	Enrichment	CTLA4	2.66
24	Immunodeficiency, common variable, 1	Enrichment	CTLA4	2.53
25	Blood platelet disease	Enrichment	RUNX1	2.53
26	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	CBFB	2.53
27	Aggressive systemic mastocytosis	Enrichment	RUNX1	2.43
28	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	RUNX1	2.43
29	Idiopathic aplastic anemia	Enrichment	IFNG	2.43
30	Type 1 diabetes mellitus	Enrichment	FOXP3	2.35
31	Granulomatosis with polyangiitis	Enrichment	CTLA4	2.35
32	Pancytopenia	Enrichment	RUNX1	2.35
33	Leukemia, chronic myeloid	Enrichment	RUNX1	2.29
34	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA	2.29
35	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA	2.29
36	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	RUNX1	2.18
37	Hydrops fetalis	Enrichment	FOXP3	2.18
38	Aplastic anemia	Enrichment	IFNG	2.13
39	Human immunodeficiency virus type 1	Enrichment	IFNG	1.88
40	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.81
41	Centronuclear myopathy	Enrichment	FOXP3	1.81
42	Malaria	Enrichment	CR1	1.77
43	Systemic lupus erythematosus	Enrichment	CTLA4	1.55
44	Leukemia, acute myeloid	Enrichment	RUNX1	1.54
45	Thrombocytopenia	Enrichment	RUNX1	1.46
46	Breast cancer	Enrichment	IL2	1.27
47	Inherited cancer-predisposing syndrome	Enrichment	RUNX1	1.03

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

Pathway Network for RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

Member Pathways for RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

Pathways in the RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) SuperPath

Associated Genes for RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

Associated Disorders for RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

Disorders associated with RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) SuperPath

STRING Interaction Network for RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

Sources for RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)