RUNX2 regulates bone development

Pathway network for the RUNX2 regulates bone development SuperPath

Sources:

Reactome

Pathways in the RUNX2 regulates bone development SuperPath

#	Name	Source	Genes
1	RUNX2 regulates bone development	Reactome	ABL1 AR BGLAP CBFB COL1A1 GLI2 GLI3 HDAC3 HDAC4 HDAC6 HES1 HEY1 HEY2 IHH MAF MAPK1 MAPK3 RB1 RBM14 RBM14-RBM4 RUNX2 SATB2 SMAD1 SMAD4 SMAD6 SP7 SRC UCMA WWTR1 YAP1 YES1 ZNF521 (see all 32) (see less)
2	RUNX2 regulates osteoblast differentiation	Reactome	ABL1 AR BGLAP CBFB COL1A1 GLI3 HDAC3 HDAC6 HES1 HEY1 HEY2 MAF MAPK1 MAPK3 RB1 RUNX2 SATB2 SP7 SRC UCMA WWTR1 YAP1 YES1 ZNF521 (see all 24) (see less)
3	RUNX2 regulates chondrocyte maturation	Reactome	CBFB GLI2 HDAC4 IHH RUNX2

Gene overlap in member pathways for RUNX2 regulates bone development SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	3
2	CBFB	Core-Binding Factor Subunit Beta	Protein Coding	3
3	HDAC6	Histone Deacetylase 6	Protein Coding	2
4	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	2
5	SP7	Sp7 Transcription Factor	Protein Coding	2
6	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	2
7	UCMA	Upper Zone Of Growth Plate And Cartilage Matrix Associated	Protein Coding	2
8	SATB2	SATB Homeobox 2	Protein Coding	2
9	HEY1	Hes Related Family BHLH Transcription Factor With YRPW Motif 1	Protein Coding	2
10	HEY2	Hes Related Family BHLH Transcription Factor With YRPW Motif 2	Protein Coding	2
11	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	2
12	ZNF521	Zinc Finger Protein 521	Protein Coding	2
13	WWTR1	WW Domain Containing Transcription Regulator 1	Protein Coding	2
14	GLI2	GLI Family Zinc Finger 2	Protein Coding	2
15	GLI3	GLI Family Zinc Finger 3	Protein Coding	2
16	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	2
17	IHH	Indian Hedgehog Signaling Molecule	Protein Coding	2
18	AR	Androgen Receptor	Protein Coding	2
19	MAF	MAF BZIP Transcription Factor	Protein Coding	2
20	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
21	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
22	RB1	RB Transcriptional Corepressor 1	Protein Coding	2
23	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	2
24	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
25	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	2
26	HDAC3	Histone Deacetylase 3	Protein Coding	2
27	HDAC4	Histone Deacetylase 4	Protein Coding	2
28	RBM14-RBM4	RBM14-RBM4 Readthrough	Protein Coding	1
29	RBM14	RNA Binding Motif Protein 14	Protein Coding	1
30	SMAD1	SMAD Family Member 1	Protein Coding	1
31	SMAD4	SMAD Family Member 4	Protein Coding	1
32	SMAD6	SMAD Family Member 6	Protein Coding	1

Disorders associated with RUNX2 regulates bone development SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Craniosynostosis	Enrichment	GLI2, GLI3, SMAD6	4.88
2	Malignant epithelioid hemangioendothelioma	Enrichment	WWTR1, YAP1	4.75
3	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1, HEY2, SMAD4	3.83
4	Lip and oral cavity carcinoma	Enrichment	ABL1, RB1	3.71
5	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, SP7	3.64
6	Osteoporosis	Enrichment	COL1A1, SRC	3.57
7	Culler-jones syndrome	Enrichment	GLI2	3.43
8	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	3.43
9	Acrocapitofemoral dysplasia	Enrichment	IHH	3.43
10	Holoprosencephaly 9	Enrichment	GLI2	3.43
11	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	3.43
12	Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome	Enrichment	GLI2	3.43
13	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	3.13
14	White-sutton syndrome	Enrichment	GLI2	3.13
15	Cleidocranial dysplasia 2	Enrichment	CBFB	3.13
16	Heart, malformation of	Enrichment	MAPK1, SMAD6	3.09
17	Brachydactyly, type a1	Enrichment	IHH	2.96
18	Cleidocranial dysplasia 1	Enrichment	RUNX2	2.96
19	Cleidocranial dysplasia	Enrichment	RUNX2	2.96
20	Microcephaly	Enrichment	ABL1, MAPK1, SATB2	2.89
21	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	CBFB	2.83
22	Pallister-hall syndrome	Enrichment	GLI3	2.75
23	Greig cephalopolysyndactyly syndrome	Enrichment	GLI3	2.75
24	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.75
25	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	2.75
26	Androgen insensitivity, partial	Enrichment	AR	2.75
27	Cataract 21, multiple types	Enrichment	MAF	2.75
28	Polydactyly, preaxial iv	Enrichment	GLI3	2.75
29	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	2.75
30	Noonan syndrome 13	Enrichment	MAPK1	2.75
31	Ayme-gripp syndrome	Enrichment	MAF	2.75
32	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	2.75
33	Thrombocytopenia 6	Enrichment	SRC	2.75
34	Asphyxia neonatorum	Enrichment	COL1A1	2.75
35	Trilateral retinoblastoma	Enrichment	RB1	2.75
36	Complete androgen insensitivity syndrome	Enrichment	AR	2.75
37	Lung oat cell carcinoma	Enrichment	RB1	2.75
38	Hirschsprung disease 1	Enrichment	GLI3, IHH	2.68
39	Radioulnar synostosis, nonsyndromic	Enrichment	SMAD6	2.63
40	Heritable thoracic aortic disease	Enrichment	SMAD4	2.63
41	Combined pituitary hormone deficiency	Enrichment	GLI2	2.53
42	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.45
43	Craniodiaphyseal dysplasia	Enrichment	SP7	2.45
44	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	2.45
45	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.45
46	Osteogenesis imperfecta, type xii	Enrichment	SP7	2.45
47	Developmental and epileptic encephalopathy 28	Enrichment	MAF	2.45
48	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.45
49	Spinocerebellar ataxia, autosomal recessive 12	Enrichment	MAF	2.45
50	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.45
51	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.45
52	46,xy sex reversal 1	Enrichment	AR	2.45
53	Androgen insensitivity syndrome	Enrichment	AR	2.45
54	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1	2.45
55	Tibial hemimelia	Enrichment	GLI3	2.45
56	Hypospadias 1, x-linked	Enrichment	AR	2.45
57	Synpolydactyly	Enrichment	GLI3	2.45
58	Stickler syndrome, type ii	Enrichment	COL1A1	2.45
59	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1	2.45
60	Postaxial polydactyly type b	Enrichment	GLI3	2.45
61	Posterior hypospadias	Enrichment	AR	2.45
62	Familial retinoblastoma	Enrichment	RB1	2.45
63	Myhre syndrome	Enrichment	SMAD4	2.33
64	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.33
65	Aortic valve disease 2	Enrichment	SMAD6	2.33
66	Craniosynostosis 7	Enrichment	SMAD6	2.33
67	Radioulnar synostosis	Enrichment	SMAD6	2.33
68	Retinoblastoma	Enrichment	RB1	2.28
69	Acrocallosal syndrome	Enrichment	GLI3	2.28
70	Aarskog-scott syndrome	Enrichment	GLI3	2.28
71	Osteogenic sarcoma	Enrichment	RB1	2.28
72	Glass syndrome	Enrichment	SATB2	2.28
73	Caffey disease	Enrichment	COL1A1	2.28
74	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.28
75	Hypotrichosis 8	Enrichment	RB1	2.28
76	Umbilical hernia	Enrichment	GLI3	2.28
77	Squamous cell carcinoma	Enrichment	RB1	2.28
78	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	2.28
79	Bone osteosarcoma	Enrichment	RB1	2.28
80	High bone mass osteogenesis imperfecta	Enrichment	COL1A1	2.28
81	Septopreoptic holoprosencephaly	Enrichment	GLI2	2.26
82	Midline interhemispheric variant of holoprosencephaly	Enrichment	GLI2	2.26
83	Thrombocytopenia	Enrichment	SMAD4, SRC	2.25
84	Microform holoprosencephaly	Enrichment	GLI2	2.23
85	Lobar holoprosencephaly	Enrichment	GLI2	2.23
86	Alobar holoprosencephaly	Enrichment	GLI2	2.20
87	Semilobar holoprosencephaly	Enrichment	GLI2	2.18
88	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1	2.15
89	Small cell cancer of the lung	Enrichment	RB1	2.15
90	Phenylketonuria	Enrichment	COL1A1	2.15
91	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.15
92	Lynch syndrome 4	Enrichment	RB1	2.15
93	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	2.15
94	Congenital blue dot cataract	Enrichment	MAF	2.15
95	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1	2.15
96	Pseudomyogenic hemangioendothelioma	Enrichment	WWTR1	2.15
97	Juvenile polyposis syndrome	Enrichment	SMAD4	2.15
98	Myeloma, multiple	Enrichment	HDAC4, YAP1	2.12
99	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR, GLI2	2.12
100	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1	1.98
101	Osteogenesis imperfecta, type i	Enrichment	COL1A1	1.98
102	Keratoconus	Enrichment	COL1A1	1.98
103	Classic ehlers-danlos syndrome	Enrichment	COL1A1	1.98
104	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.93
105	Osteogenesis imperfecta, type ii	Enrichment	COL1A1	1.91
106	Myelofibrosis	Enrichment	SRC	1.91
107	Leukemia, chronic myeloid	Enrichment	ABL1	1.91
108	Moyamoya angiopathy	Enrichment	ABL1	1.91
109	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.91
110	Ovarian cancer	Enrichment	AR, RB1	1.87
111	Cataract - microcornea syndrome	Enrichment	MAF	1.85
112	Difference of sex development	Enrichment	AR	1.85
113	Nephrotic syndrome	Enrichment	RUNX2	1.80
114	Gallbladder cancer	Enrichment	SMAD4	1.79
115	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.79
116	Cataract 30, multiple types	Enrichment	MAF	1.76
117	Primary bone dysplasia	Enrichment	COL1A1	1.76
118	Colorectal cancer	Enrichment	SMAD4, SRC	1.75
119	46,xy complete gonadal dysgenesis	Enrichment	AR	1.71
120	Osteochondrodysplasia	Enrichment	COL1A1	1.71
121	Specific learning disability	Enrichment	MAPK1	1.71
122	Polydactyly	Enrichment	SMAD6	1.68
123	Microphthalmia/coloboma 12	Enrichment	YAP1	1.64
124	Diaphragmatic hernia, congenital	Enrichment	GLI3	1.64
125	Lung cancer susceptibility 3	Enrichment	RB1	1.61
126	Heart disease	Enrichment	ABL1	1.61
127	Coloboma of macula	Enrichment	YAP1	1.58
128	Polydactyly, postaxial, type a1	Enrichment	GLI3	1.58
129	Osteogenesis imperfecta, type iii	Enrichment	COL1A1	1.58
130	Cleft palate, isolated	Enrichment	SATB2	1.53
131	Aortic valve disease 1	Enrichment	SMAD6	1.52
132	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD6	1.49
133	Ehlers-danlos syndrome	Enrichment	COL1A1	1.48
134	Inherited cancer-predisposing syndrome	Enrichment	RB1, SMAD4	1.41
135	Brittle bone disorder	Enrichment	COL1A1	1.40
136	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.40
137	Developmental and epileptic encephalopathy 1	Enrichment	MAF	1.36
138	Tetralogy of fallot	Enrichment	HEY2	1.35
139	Bladder cancer	Enrichment	RB1	1.30
140	Prostate cancer	Enrichment	AR	1.30
141	Pancreatic cancer	Enrichment	SMAD4	1.24
142	Male infertility	Enrichment	AR	1.23
143	Dystonia	Enrichment	SATB2	1.22
144	Benign epilepsy with centrotemporal spikes	Enrichment	MAF	1.15
145	Centralopathic epilepsy	Enrichment	MAF	1.13
146	West syndrome	Enrichment	MAF	1.12
147	Hypertelorism	Enrichment	COL1A1	1.05
148	Gastric cancer	Enrichment	SMAD4	1.01
149	Autism spectrum disorder	Enrichment	SATB2	0.75

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RUNX2 regulates bone development

Pathway Network for RUNX2 regulates bone development

Pathway network for the RUNX2 regulates bone development SuperPath

Member Pathways for RUNX2 regulates bone development

Pathways in the RUNX2 regulates bone development SuperPath

Gene overlap in member pathways for RUNX2 regulates bone development SuperPath

Associated Genes for RUNX2 regulates bone development

Associated Disorders for RUNX2 regulates bone development

Disorders associated with RUNX2 regulates bone development SuperPath

STRING Interaction Network for RUNX2 regulates bone development

Sources for RUNX2 regulates bone development