S-1P Stimulated Signaling

No Pathway Network information available for S-1P Stimulated Signaling

Pathways in the S-1P Stimulated Signaling SuperPath

#	Name	Source	Genes
1	S-1P Stimulated Signaling	QIAGEN	ADCY1 ADCY2 ADCY3 AKT1 ASAH1 ASAH2 CASP1 CASP10 CASP2 CASP3 CASP4 CASP5 CASP6 CASP7 CASP8 CASP9 CDH1 CDH10 CDH11 CDH12 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 CDH2 CDH20 CDH22 CDH23 CDH24 CDH26 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 DCHS1 DIRAS3 GNA12 GNA13 GNAI1 GNAI2 GNAI3 MAPK1 MAPK12 MAPK3 MAPK6 MAPK7 PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PTK2 PTK2B RAC1 RAC2 RAC3 RHOA RHOB RHOC RHOD RHOG RHOH RND2 RND3 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SMPD1 SMPD2 SMPD3 SPHK1 (see all 95) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADCY1	Adenylate Cyclase 1	Protein Coding	1
2	ADCY2	Adenylate Cyclase 2	Protein Coding	1
3	ADCY3	Adenylate Cyclase 3	Protein Coding	1
4	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
5	RHOA	Ras Homolog Family Member A	Protein Coding	1
6	RHOB	Ras Homolog Family Member B	Protein Coding	1
7	RHOC	Ras Homolog Family Member C	Protein Coding	1
8	RHOD	Ras Homolog Family Member D	Protein Coding	1
9	RND3	Rho Family GTPase 3	Protein Coding	1
10	RHOG	Ras Homolog Family Member G	Protein Coding	1
11	RHOH	Ras Homolog Family Member H	Protein Coding	1
12	DIRAS3	DIRAS Family GTPase 3	Protein Coding	1
13	RND2	Rho Family GTPase 2	Protein Coding	1
14	ASAH1	N-Acylsphingosine Amidohydrolase 1	Protein Coding	1
15	ASAH2	N-Acylsphingosine Amidohydrolase 2	Protein Coding	1
16	CASP1	Caspase 1	Protein Coding	1
17	CASP10	Caspase 10	Protein Coding	1
18	CASP2	Caspase 2	Protein Coding	1
19	CASP3	Caspase 3	Protein Coding	1
20	CASP4	Caspase 4	Protein Coding	1
21	CASP5	Caspase 5	Protein Coding	1
22	CASP6	Caspase 6	Protein Coding	1
23	CASP7	Caspase 7	Protein Coding	1
24	CASP8	Caspase 8	Protein Coding	1
25	CASP9	Caspase 9	Protein Coding	1
26	CDH1	Cadherin 1	Protein Coding	1
27	CDH10	Cadherin 10	Protein Coding	1
28	CDH11	Cadherin 11	Protein Coding	1
29	CDH12	Cadherin 12	Protein Coding	1
30	CDH13	Cadherin 13	Protein Coding	1
31	CDH15	Cadherin 15	Protein Coding	1
32	CDH16	Cadherin 16	Protein Coding	1
33	CDH17	Cadherin 17	Protein Coding	1
34	CDH18	Cadherin 18	Protein Coding	1
35	CDH19	Cadherin 19	Protein Coding	1
36	CDH2	Cadherin 2	Protein Coding	1
37	CDH20	Cadherin 20	Protein Coding	1
38	CDH22	Cadherin 22	Protein Coding	1
39	CDH23	Cadherin Related 23	Protein Coding	1
40	CDH24	Cadherin 24	Protein Coding	1
41	CDH26	Cadherin 26	Protein Coding	1
42	CDH3	Cadherin 3	Protein Coding	1
43	CDH4	Cadherin 4	Protein Coding	1
44	CDH5	Cadherin 5	Protein Coding	1
45	CDH6	Cadherin 6	Protein Coding	1
46	CDH7	Cadherin 7	Protein Coding	1
47	CDH8	Cadherin 8	Protein Coding	1
48	CDH9	Cadherin 9	Protein Coding	1
49	S1PR1	Sphingosine-1-Phosphate Receptor 1	Protein Coding	1
50	S1PR3	Sphingosine-1-Phosphate Receptor 3	Protein Coding	1
51	S1PR2	Sphingosine-1-Phosphate Receptor 2	Protein Coding	1
52	S1PR4	Sphingosine-1-Phosphate Receptor 4	Protein Coding	1
53	S1PR5	Sphingosine-1-Phosphate Receptor 5	Protein Coding	1
54	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
55	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
56	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
57	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
58	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
59	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
60	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
61	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
62	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
63	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
64	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
65	DCHS1	Dachsous Cadherin-Related 1	Protein Coding	1
66	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	1
67	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
68	PDGFC	Platelet Derived Growth Factor C	Protein Coding	1
69	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	1
70	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
71	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
72	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
73	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
74	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
75	PLCB1	Phospholipase C Beta 1	Protein Coding	1
76	PLCB2	Phospholipase C Beta 2	Protein Coding	1
77	PLCB3	Phospholipase C Beta 3	Protein Coding	1
78	PLCB4	Phospholipase C Beta 4	Protein Coding	1
79	PLCD1	Phospholipase C Delta 1	Protein Coding	1
80	PLCD3	Phospholipase C Delta 3	Protein Coding	1
81	PLCD4	Phospholipase C Delta 4	Protein Coding	1
82	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
83	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
84	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
85	PLCZ1	Phospholipase C Zeta 1	Protein Coding	1
86	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
87	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
88	RAC1	Rac Family Small GTPase 1	Protein Coding	1
89	RAC2	Rac Family Small GTPase 2	Protein Coding	1
90	RAC3	Rac Family Small GTPase 3	Protein Coding	1
91	PDGFD	Platelet Derived Growth Factor D	Protein Coding	1
92	SMPD1	Sphingomyelin Phosphodiesterase 1	Protein Coding	1
93	SMPD2	Sphingomyelin Phosphodiesterase 2	Protein Coding	1
94	SMPD3	Sphingomyelin Phosphodiesterase 3	Protein Coding	1
95	SPHK1	Sphingosine Kinase 1	Protein Coding	1

Disorders associated with S-1P Stimulated Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Auriculocondylar syndrome 1	Enrichment	GNAI3, PLCB4	3.54
2	Primary hypereosinophilic syndrome	Enrichment	PDGFRA, PDGFRB	3.32
3	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	2.88
4	Meningioma	Enrichment	AKT1, PDGFB	2.51
5	Cleft lip/palate	Enrichment	CDH1, PDGFRA	2.38
6	Proteus syndrome	Enrichment	AKT1	2.15
7	Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome	Enrichment	CDH3	2.15
8	Elsahy-waters syndrome	Enrichment	CDH11	2.15
9	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.15
10	Caspase 8 deficiency	Enrichment	CASP8	2.15
11	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	2.15
12	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.15
13	Intellectual developmental disorder, autosomal dominant 3	Enrichment	CDH15	2.15
14	Mitral valve prolapse 2	Enrichment	DCHS1	2.15
15	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.15
16	Keloid formation	Enrichment	ASAH1	2.15
17	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	2.15
18	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.15
19	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.15
20	Gist-plus syndrome	Enrichment	PDGFRA	2.15
21	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.15
22	Ventricular tachycardia, familial	Enrichment	GNAI2	2.15
23	Teebi hypertelorism syndrome 2	Enrichment	CDH11	2.15
24	Noonan syndrome 13	Enrichment	MAPK1	2.15
25	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.15
26	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.15
27	Short syndrome	Enrichment	PIK3R1	2.15
28	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.15
29	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.15
30	Deafness, autosomal recessive 68	Enrichment	S1PR2	2.15
31	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	2.15
32	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	2.15
33	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.15
34	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.15
35	Hypotrichosis	Enrichment	CDH3	2.15
36	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.15
37	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	2.15
38	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.15
39	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.15
40	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.15
41	Cowden syndrome 6	Enrichment	AKT1	2.15
42	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.15
43	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.15
44	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.15
45	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.15
46	Acid sphingomyelinase deficiency	Enrichment	SMPD1	2.15
47	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.15
48	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.15
49	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.15
50	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.15
51	Immunodeficiency 129	Enrichment	RHOH	2.15
52	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.15
53	Tsh producing pituitary tumor	Enrichment	CDH23	2.15
54	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	2.15
55	Asah1-related disorders	Enrichment	ASAH1	2.15
56	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	2.15
57	T-cell immunodeficiency with epidermodysplasia verruciformis	Enrichment	RHOH	2.15
58	Breast lobular carcinoma	Enrichment	CDH1	2.15
59	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.15
60	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.15
61	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.15
62	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.15
63	Blepharocheilodontic syndrome 1	Enrichment	CDH1	1.86
64	Mitral valve prolapse 1	Enrichment	DCHS1	1.86
65	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	1.86
66	Scoliosis, isolated 1	Enrichment	MAPK7	1.86
67	Spinal muscular atrophy with progressive myoclonic epilepsy	Enrichment	ASAH1	1.86
68	Farber lipogranulomatosis	Enrichment	ASAH1	1.86
69	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.86
70	Van maldergem syndrome 1	Enrichment	DCHS1	1.86
71	Hypotrichosis, congenital, with juvenile macular dystrophy	Enrichment	CDH3	1.86
72	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	1.86
73	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.86
74	Deafness, autosomal recessive 84a	Enrichment	CDH23	1.86
75	Spermatogenic failure 17	Enrichment	PLCZ1	1.86
76	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.86
77	Infantile myofibromatosis	Enrichment	PDGFRB	1.86
78	Combined saposin deficiency	Enrichment	CDH23	1.86
79	Body mass index quantitative trait locus 19	Enrichment	ADCY3	1.86
80	Ocular melanoma	Enrichment	PLCB4	1.86
81	Hypopituitarism	Enrichment	GNAI2	1.86
82	Combined psap deficiency	Enrichment	CDH23	1.86
83	Chronic eosinophilic leukemia	Enrichment	PDGFRA	1.86
84	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	1.86
85	Familial isolated pituitary adenoma	Enrichment	CDH23	1.86
86	Breast cancer	Enrichment	AKT1, CASP8, CDH1	1.81
87	Niemann-pick disease, type a	Enrichment	SMPD1	1.68
88	Niemann-pick disease, type b	Enrichment	SMPD1	1.68
89	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.68
90	Nephrotic syndrome, type 3	Enrichment	PLCE1	1.68
91	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.68
92	Ceroid lipofuscinosis, neuronal, 6a	Enrichment	SMPD1	1.68
93	Immunodeficiency 14	Enrichment	PIK3R1	1.68
94	Colorectal cancer	Enrichment	AKT1, CDH1, PIK3R1	1.64
95	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1, CDH23, S1PR2	1.61
96	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1	1.56
97	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10	1.56
98	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.56
99	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.56
100	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.56
101	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.56
102	Pituitary adenoma 5, multiple types	Enrichment	CDH23	1.56
103	Achromatopsia 4	Enrichment	GNAI3	1.56
104	Prolactinoma	Enrichment	CDH23	1.56
105	Vacterl association	Enrichment	CDH13	1.56
106	Benign epilepsy with centrotemporal spikes	Enrichment	ASAH1, PLCB1	1.48
107	Ovarian cancer	Enrichment	AKT1, CDH1, PDGFRA	1.47
108	Niemann-pick disease, type c1	Enrichment	SMPD1	1.46
109	Vater/vacterl association	Enrichment	CDH13	1.46
110	Niemann-pick disease	Enrichment	SMPD1	1.46
111	Centralopathic epilepsy	Enrichment	ASAH1, PLCB1	1.44
112	Gastric cancer	Enrichment	CASP10, CDH1	1.44
113	Hereditary breast carcinoma	Enrichment	AKT1, CDH1	1.42
114	Melanoma, uveal	Enrichment	PLCB4	1.38
115	Hemihyperplasia, isolated	Enrichment	RHOA	1.38
116	Usher syndrome, type id	Enrichment	CDH23	1.38
117	Deafness, autosomal recessive 12	Enrichment	CDH23	1.38
118	Breast adenocarcinoma	Enrichment	AKT1	1.38
119	Syndromic rod-cone dystrophy	Enrichment	CDH23	1.38
120	Cleft lip with or without cleft palate	Enrichment	CDH1	1.38
121	Meniere disease	Enrichment	CDH23	1.32
122	Usher syndrome, type iia	Enrichment	CDH23	1.32
123	Gastrointestinal stromal tumor	Enrichment	PDGFRA	1.32
124	Overgrowth syndrome	Enrichment	PIK3R1	1.32
125	Lymphoma, non-hodgkin, familial	Enrichment	CASP10	1.26
126	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.21
127	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.21
128	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.21
129	Adult hepatocellular carcinoma	Enrichment	CASP8	1.21
130	Primary hyperaldosteronism	Enrichment	CDH23	1.21
131	Cowden syndrome	Enrichment	AKT1	1.21
132	Hypotrichosis simplex	Enrichment	CDH3	1.21
133	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.17
134	Meningioma, familial	Enrichment	PDGFB	1.13
135	Usher syndrome type 2	Enrichment	CDH23	1.13
136	Specific learning disability	Enrichment	MAPK1	1.13
137	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2	1.03
138	Corpus callosum, agenesis of	Enrichment	CDH2	1.00
139	Usher syndrome, type i	Enrichment	CDH23	1.00
140	Hydrocephalus	Enrichment	PDGFRB	1.00
141	Isolated corpus callosum agenesis	Enrichment	CDH2	1.00
142	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2	1.00
143	Dandy-walker syndrome	Enrichment	PDGFRB	0.95
144	Heart, malformation of	Enrichment	MAPK1	0.92
145	Arteriovenous malformations of the brain	Enrichment	CDH2	0.90
146	Focal segmental glomerulosclerosis	Enrichment	PLCE1	0.88
147	Endometrial cancer	Enrichment	CDH1	0.86
148	Hepatocellular carcinoma	Enrichment	CASP8	0.84
149	Ear malformation	Enrichment	CDH23	0.81
150	Auditory neuropathy	Enrichment	CDH2	0.78
151	Prostate cancer	Enrichment	CDH1	0.73
152	Severe covid-19	Enrichment	CASP10	0.73
153	Lung cancer	Enrichment	CASP8	0.70
154	Usher syndrome	Enrichment	CDH23	0.68
155	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	0.67
156	Non-syndromic genetic deafness	Enrichment	CDH23	0.65
157	Fetal akinesia deformation sequence 1	Enrichment	ASAH1	0.64
158	Inherited cancer-predisposing syndrome	Enrichment	CDH1, PDGFRA	0.63
159	Cerebral palsy	Enrichment	PDGFRB	0.62
160	Distal arthrogryposis	Enrichment	ASAH1	0.59
161	Nonsyndromic hearing loss	Enrichment	CDH23	0.59
162	Nephrotic syndrome	Enrichment	PLCE1	0.58
163	West syndrome	Enrichment	PLCB1	0.57
164	Sensorineural hearing loss	Enrichment	CDH23	0.54
165	Body mass index quantitative trait locus 11	Enrichment	ADCY3	0.53
166	Autosomal dominant non-syndromic intellectual disability	Enrichment	CDH15	0.53
167	Myeloma, multiple	Enrichment	PIK3R2	0.49
168	Deafness, autosomal recessive	Enrichment	CDH23	0.45
169	Autosomal recessive nonsyndromic deafness	Enrichment	CDH23	0.44
170	Rare genetic deafness	Enrichment	CDH23	0.37
171	Retinitis pigmentosa	Enrichment	CDH23, CDH3	0.36
172	Congenital nervous system abnormality	Enrichment	ASAH1	0.28
173	Nervous system disease	Enrichment	ASAH1	0.28
174	Microcephaly	Enrichment	MAPK1	0.24
175	Complex neurodevelopmental disorder	Enrichment	RAC3	0.23
176	Hereditary retinal dystrophy	Enrichment	CDH23, CDH3	0.22
177	Fundus dystrophy	Enrichment	CDH23, CDH3	0.22

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

S-1P Stimulated Signaling

Pathway Network for S-1P Stimulated Signaling

Member Pathways for S-1P Stimulated Signaling

Pathways in the S-1P Stimulated Signaling SuperPath

Associated Genes for S-1P Stimulated Signaling

Associated Disorders for S-1P Stimulated Signaling

Disorders associated with S-1P Stimulated Signaling SuperPath

STRING Interaction Network for S-1P Stimulated Signaling

Sources for S-1P Stimulated Signaling