S1P1 pathway

No Pathway Network information available for S1P1 pathway

Pathways in the S1P1 pathway SuperPath

#	Name	Source	Genes
1	S1P1 pathway	PubChem	ABCC1 KDR MAPK3 PDGFB PDGFRB PLCB2 PLCG1 PRRT2 PTGS2 RAC1 RHOA S1PR1 SPHK1 VEGFA (see all 14) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PRRT2	Proline Rich Transmembrane Protein 2	Protein Coding	1
2	S1PR1	Sphingosine-1-Phosphate Receptor 1	Protein Coding	1
3	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
4	SPHK1	Sphingosine Kinase 1	Protein Coding	1
5	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	1
6	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
7	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
8	RHOA	Ras Homolog Family Member A	Protein Coding	1
9	RAC1	Rac Family Small GTPase 1	Protein Coding	1
10	KDR	Kinase Insert Domain Receptor	Protein Coding	1
11	PLCB2	Phospholipase C Beta 2	Protein Coding	1
12	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
13	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
14	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1

Disorders associated with S1P1 pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	4.56
2	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.99
3	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.99
4	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.99
5	Deafness, autosomal dominant 77	Enrichment	ABCC1	2.99
6	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.99
7	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.99
8	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.99
9	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.99
10	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.99
11	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.99
12	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.99
13	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.99
14	Tufted angioma of skin	Enrichment	KDR	2.99
15	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.99
16	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.69
17	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.69
18	Seizures, benign familial infantile, 2	Enrichment	PRRT2	2.69
19	Angioma, tufted	Enrichment	KDR	2.69
20	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.69
21	Infantile myofibromatosis	Enrichment	PDGFRB	2.69
22	Prrt2-related disorder	Enrichment	PRRT2	2.69
23	Glut1 deficiency syndrome 2	Enrichment	PRRT2	2.51
24	Paroxysmal nonkinesigenic dyskinesia 1	Enrichment	PRRT2	2.38
25	Episodic kinesigenic dyskinesia 1	Enrichment	PRRT2	2.38
26	Familial paroxysmal nonkinesigenic dyskinesia	Enrichment	PRRT2	2.38
27	Familial or sporadic hemiplegic migraine	Enrichment	PRRT2	2.38
28	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PRRT2	2.29
29	Self-limited infantile epilepsy	Enrichment	PRRT2	2.29
30	Primary hypereosinophilic syndrome	Enrichment	PDGFRB	2.29
31	Hemihyperplasia, isolated	Enrichment	RHOA	2.21
32	Hemangioma, capillary infantile	Enrichment	KDR	2.21
33	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.03
34	Meningioma, familial	Enrichment	PDGFB	1.95
35	Meningioma	Enrichment	PDGFB	1.91
36	Generalized epilepsy with febrile seizures plus	Enrichment	PRRT2	1.84
37	Hydrocephalus	Enrichment	PDGFRB	1.81
38	Dandy-walker syndrome	Enrichment	PDGFRB	1.76
39	Tetralogy of fallot	Enrichment	KDR	1.58
40	Cerebral palsy	Enrichment	PDGFRB	1.40
41	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	1.28
42	Primary ovarian insufficiency	Enrichment	KDR	1.23

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for S1P1 pathway

Member Pathways for S1P1 pathway

Pathways in the S1P1 pathway SuperPath

Associated Genes for S1P1 pathway

Associated Disorders for S1P1 pathway

Disorders associated with S1P1 pathway SuperPath

STRING Interaction Network for S1P1 pathway

Sources for S1P1 pathway