S1P2 pathway

No Pathway Network information available for S1P2 pathway

Pathways in the S1P2 pathway SuperPath

#	Name	Source	Genes
1	S1P2 pathway	PubChem	CDH5 ELK1 FOS GNA12 GNA13 IRS1 JUN MAPK14 MAPK3 MAPK8 PAK1 PIK3CA PIK3R1 RAC1 RHOA S1PR2 (see all 16) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	S1PR2	Sphingosine-1-Phosphate Receptor 2	Protein Coding	1
2	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
3	CDH5	Cadherin 5	Protein Coding	1
4	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
5	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
6	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
7	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
8	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
9	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
10	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
11	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
12	RHOA	Ras Homolog Family Member A	Protein Coding	1
13	RAC1	Rac Family Small GTPase 1	Protein Coding	1
14	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
15	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
16	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with S1P2 pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.41
2	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	4.71
3	Macrodactyly	Enrichment	PIK3CA	2.93
4	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.93
5	Cowden syndrome 5	Enrichment	PIK3CA	2.93
6	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.93
7	Short syndrome	Enrichment	PIK3R1	2.93
8	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.93
9	Deafness, autosomal recessive 68	Enrichment	S1PR2	2.93
10	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.93
11	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.93
12	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.93
13	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.93
14	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.93
15	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.93
16	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.93
17	Hypospadias	Enrichment	PIK3CA	2.93
18	Rare venous malformation	Enrichment	PIK3CA	2.93
19	Diaphragmatic eventration	Enrichment	PIK3CA	2.93
20	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.93
21	Rare combined vascular malformation	Enrichment	PIK3CA	2.93
22	Cavernous lymphangioma	Enrichment	PIK3CA	2.93
23	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.93
24	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.93
25	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.93
26	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.93
27	Macrodactyly of toe	Enrichment	PIK3CA	2.93
28	Keratosis, seborrheic	Enrichment	PIK3CA	2.63
29	Noonan syndrome 8	Enrichment	PIK3CA	2.63
30	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.63
31	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.63
32	Breast cancer	Enrichment	JUN, PIK3CA	2.46
33	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.45
34	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.45
35	Immunodeficiency 14	Enrichment	PIK3R1	2.45
36	Keratoacanthoma	Enrichment	PIK3CA	2.45
37	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	2.34
38	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.33
39	Congenital generalized lipodystrophy	Enrichment	FOS	2.33
40	Cerebrovascular disease	Enrichment	PIK3CA	2.33
41	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.33
42	Capillary malformations, congenital	Enrichment	PIK3CA	2.23
43	Histiocytoid hemangioma	Enrichment	FOS	2.23
44	Hemimegalencephaly	Enrichment	PIK3CA	2.23
45	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.15
46	Cowden syndrome 1	Enrichment	PIK3CA	2.15
47	Breast adenocarcinoma	Enrichment	PIK3CA	2.15
48	Lung squamous cell carcinoma	Enrichment	PIK3CA	2.15
49	Nevus, epidermal	Enrichment	PIK3CA	2.08
50	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	2.08
51	Gallbladder cancer	Enrichment	PIK3CA	2.08
52	Overgrowth syndrome	Enrichment	PIK3R1	2.08
53	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.98
54	Arteriovenous malformation	Enrichment	PIK3CA	1.98
55	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.98
56	Cowden syndrome	Enrichment	PIK3CA	1.98
57	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.93
58	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.93
59	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.89
60	Meningioma	Enrichment	PIK3CA	1.85
61	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.85
62	Lynch syndrome	Enrichment	PIK3CA	1.76
63	Endometrial cancer	Enrichment	PIK3CA	1.61
64	Hepatocellular carcinoma	Enrichment	PIK3CA	1.59
65	Bladder cancer	Enrichment	PIK3CA	1.47
66	Prostate cancer	Enrichment	PIK3CA	1.47
67	Lung cancer	Enrichment	PIK3CA	1.43
68	Type 2 diabetes mellitus	Enrichment	IRS1	1.31
69	Gastric cancer	Enrichment	PIK3CA	1.30
70	Hereditary breast carcinoma	Enrichment	PIK3CA	1.30
71	Hypertelorism	Enrichment	PIK3CA	1.22
72	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	S1PR2	1.00
73	Ovarian cancer	Enrichment	PIK3CA	0.95

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for S1P2 pathway

Member Pathways for S1P2 pathway

Pathways in the S1P2 pathway SuperPath

Associated Genes for S1P2 pathway

Associated Disorders for S1P2 pathway

Disorders associated with S1P2 pathway SuperPath

STRING Interaction Network for S1P2 pathway

Sources for S1P2 pathway