S1P3 pathway

No Pathway Network information available for S1P3 pathway

Pathways in the S1P3 pathway SuperPath

#	Name	Source	Genes
1	S1P3 pathway	PubChem	AKT1 AKT3 CXCR4 FLT1 GNA12 GNA13 JAK2 MAPK3 PDGFB PDGFRB RAC1 RHOA S1PR3 SRC VEGFA (see all 15) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	S1PR3	Sphingosine-1-Phosphate Receptor 3	Protein Coding	1
2	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	1
3	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
4	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
5	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
6	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
7	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
8	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
9	RHOA	Ras Homolog Family Member A	Protein Coding	1
10	RAC1	Rac Family Small GTPase 1	Protein Coding	1
11	JAK2	Janus Kinase 2	Protein Coding	1
12	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
13	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
14	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
15	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1

Disorders associated with S1P3 pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Myelofibrosis	Enrichment	JAK2, SRC	4.62
2	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	4.50
3	Meningioma	Enrichment	AKT1, PDGFB	4.13
4	Proteus syndrome	Enrichment	AKT1	2.96
5	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.96
6	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.96
7	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.96
8	Whim syndrome 1	Enrichment	CXCR4	2.96
9	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.96
10	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.96
11	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.96
12	Cowden syndrome 6	Enrichment	AKT1	2.96
13	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.96
14	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.96
15	Thrombocytopenia 6	Enrichment	SRC	2.96
16	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.96
17	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.96
18	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.96
19	Capillary hemangioma	Enrichment	AKT3	2.96
20	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.96
21	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.66
22	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.66
23	Thrombocythemia 3	Enrichment	JAK2	2.66
24	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.66
25	Infantile myofibromatosis	Enrichment	PDGFRB	2.66
26	Senior-loken syndrome 7	Enrichment	AKT3	2.66
27	Bardet-biedl syndrome 16	Enrichment	AKT3	2.66
28	Polycythemia	Enrichment	JAK2	2.66
29	Hypereosinophilic syndrome	Enrichment	JAK2	2.66
30	Polycythemia vera	Enrichment	JAK2	2.48
31	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	2.48
32	Colorectal cancer	Enrichment	AKT1, SRC	2.39
33	Erythrocytosis, familial, 1	Enrichment	JAK2	2.35
34	Budd-chiari syndrome	Enrichment	JAK2	2.35
35	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.35
36	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.35
37	Pre-eclampsia	Enrichment	FLT1	2.26
38	Myeloproliferative neoplasm	Enrichment	JAK2	2.26
39	Hemimegalencephaly	Enrichment	AKT3	2.26
40	Primary hypereosinophilic syndrome	Enrichment	PDGFRB	2.26
41	Hemihyperplasia, isolated	Enrichment	RHOA	2.18
42	Breast adenocarcinoma	Enrichment	AKT1	2.18
43	Essential thrombocythemia	Enrichment	JAK2	2.11
44	Megacolon	Enrichment	AKT3	2.11
45	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	2.00
46	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.00
47	Cowden syndrome	Enrichment	AKT1	2.00
48	Polymicrogyria	Enrichment	AKT3	1.96
49	Meningioma, familial	Enrichment	PDGFB	1.92
50	Osteoporosis	Enrichment	SRC	1.81
51	Hydrocephalus	Enrichment	PDGFRB	1.78
52	Dandy-walker syndrome	Enrichment	PDGFRB	1.73
53	Cerebral palsy	Enrichment	PDGFRB	1.37
54	Leukemia, acute myeloid	Enrichment	JAK2	1.36
55	Hereditary breast carcinoma	Enrichment	AKT1	1.32
56	Thrombocytopenia	Enrichment	SRC	1.29
57	Primary ovarian insufficiency	Enrichment	JAK2	1.20
58	Breast cancer	Enrichment	AKT1	1.10
59	Ovarian cancer	Enrichment	AKT1	0.97

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for S1P3 pathway

Member Pathways for S1P3 pathway

Pathways in the S1P3 pathway SuperPath

Associated Genes for S1P3 pathway

Associated Disorders for S1P3 pathway

Disorders associated with S1P3 pathway SuperPath

STRING Interaction Network for S1P3 pathway

Sources for S1P3 pathway