S1P receptor signal transduction

No Pathway Network information available for S1P receptor signal transduction

Pathways in the S1P receptor signal transduction SuperPath

#	Name	Source	Genes
1	S1P receptor signal transduction	WikiPathways	AKT1 AKT2 AKT3 ASAH1 GNAI1 GNAI2 GNAI3 MAPK1 MAPK12 MAPK3 MAPK4 MAPK6 MAPK7 PIK3C2B PLCB1 PLCB2 PLCB3 RACGAP1 S1PR1 S1PR2 S1PR3 S1PR5 SMPD2 SPHK1 SPHK2 (see all 25) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SMPD2	Sphingomyelin Phosphodiesterase 2	Protein Coding	1
2	PLCB3	Phospholipase C Beta 3	Protein Coding	1
3	PLCB2	Phospholipase C Beta 2	Protein Coding	1
4	S1PR2	Sphingosine-1-Phosphate Receptor 2	Protein Coding	1
5	SPHK1	Sphingosine Kinase 1	Protein Coding	1
6	SPHK2	Sphingosine Kinase 2	Protein Coding	1
7	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
8	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
9	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
10	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
11	S1PR5	Sphingosine-1-Phosphate Receptor 5	Protein Coding	1
12	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	1
13	ASAH1	N-Acylsphingosine Amidohydrolase 1	Protein Coding	1
14	RACGAP1	Rac GTPase Activating Protein 1	Protein Coding	1
15	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
16	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
17	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
18	PLCB1	Phospholipase C Beta 1	Protein Coding	1
19	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
20	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
21	S1PR1	Sphingosine-1-Phosphate Receptor 1	Protein Coding	1
22	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
23	S1PR3	Sphingosine-1-Phosphate Receptor 3	Protein Coding	1
24	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
25	MAPK4	Mitogen-Activated Protein Kinase 4	Protein Coding	1

Disorders associated with S1P receptor signal transduction SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Proteus syndrome	Enrichment	AKT1	2.73
2	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.73
3	Keloid formation	Enrichment	ASAH1	2.73
4	Ventricular tachycardia, familial	Enrichment	GNAI2	2.73
5	Noonan syndrome 13	Enrichment	MAPK1	2.73
6	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.73
7	Deafness, autosomal recessive 68	Enrichment	S1PR2	2.73
8	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.73
9	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.73
10	Cowden syndrome 6	Enrichment	AKT1	2.73
11	Asah1-related disorders	Enrichment	ASAH1	2.73
12	Capillary hemangioma	Enrichment	AKT3	2.73
13	Congenital dyserythropoietic anemia type iiib	Enrichment	RACGAP1	2.73
14	Anemia, congenital dyserythropoietic, type iiib, autosomal recessive	Enrichment	RACGAP1	2.73
15	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.73
16	Benign epilepsy with centrotemporal spikes	Enrichment	ASAH1, PLCB1	2.59
17	Centralopathic epilepsy	Enrichment	ASAH1, PLCB1	2.55
18	Anemia, congenital dyserythropoietic, type iiia	Enrichment	RACGAP1	2.43
19	Scoliosis, isolated 1	Enrichment	MAPK7	2.43
20	Spinal muscular atrophy with progressive myoclonic epilepsy	Enrichment	ASAH1	2.43
21	Farber lipogranulomatosis	Enrichment	ASAH1	2.43
22	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.43
23	Senior-loken syndrome 7	Enrichment	AKT3	2.43
24	Bardet-biedl syndrome 16	Enrichment	AKT3	2.43
25	Hypopituitarism	Enrichment	GNAI2	2.43
26	Auriculocondylar syndrome 1	Enrichment	GNAI3	2.13
27	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.13
28	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.13
29	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.13
30	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	2.13
31	Achromatopsia 4	Enrichment	GNAI3	2.13
32	Hemimegalencephaly	Enrichment	AKT3	2.04
33	Breast adenocarcinoma	Enrichment	AKT1	1.96
34	Megacolon	Enrichment	AKT3	1.89
35	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.78
36	Cowden syndrome	Enrichment	AKT1	1.78
37	Polymicrogyria	Enrichment	AKT3	1.74
38	Specific learning disability	Enrichment	MAPK1	1.70
39	Meningioma	Enrichment	AKT1	1.66
40	Heart, malformation of	Enrichment	MAPK1	1.49
41	Fetal akinesia deformation sequence 1	Enrichment	ASAH1	1.18
42	Type 2 diabetes mellitus	Enrichment	AKT2	1.13
43	Distal arthrogryposis	Enrichment	ASAH1	1.13
44	West syndrome	Enrichment	PLCB1	1.11
45	Hereditary breast carcinoma	Enrichment	AKT1	1.11
46	Breast cancer	Enrichment	AKT1	0.89
47	Colorectal cancer	Enrichment	AKT1	0.83
48	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	S1PR2	0.82
49	Ovarian cancer	Enrichment	AKT1	0.77
50	Congenital nervous system abnormality	Enrichment	ASAH1	0.75
51	Nervous system disease	Enrichment	ASAH1	0.75
52	Microcephaly	Enrichment	MAPK1	0.69

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

S1P receptor signal transduction

Pathway Network for S1P receptor signal transduction

Member Pathways for S1P receptor signal transduction

Pathways in the S1P receptor signal transduction SuperPath

Associated Genes for S1P receptor signal transduction

Associated Disorders for S1P receptor signal transduction

Disorders associated with S1P receptor signal transduction SuperPath

STRING Interaction Network for S1P receptor signal transduction

Sources for S1P receptor signal transduction