SARS-CoV-1-host interactions

Pathway network for the SARS-CoV-1-host interactions SuperPath

Sources:

Reactome

Pathways in the SARS-CoV-1-host interactions SuperPath

#	Name	Source	Genes
1	SARS-CoV-1-host interactions	Reactome	BCL2L1 BST2 CASP1 CAV1 EEF1A1 EP300 FAU FKBP1A HNRNPA1 IFIH1 IKBKE IRAK2 IRF3 ITCH KPNA2 KPNB1 MAVS NFKB1 NFKBIA NLRP3 NMI NPM1 PALS1 PCBP2 PDPK1 PKLR PPIA PPIB PPIG PPIH PSMC6 PYCARD RCAN3 RELA RIGI RIPK1 RIPK3 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS27L RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS4Y2 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA RUNX1 SFN SFTPD SIKE1 SMAD3 SMAD4 SP1 STING1 TBK1 TKFC TLR7 TOMM70 TRAF3 TRAF6 TRIM25 UBA52 UBB UBC UBE2I YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 96) (see less)
2	SARS-CoV-1 Infection	Reactome	ACE2 BCL2L1 BECN1 BST2 CANX CASP1 CAV1 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 CTSL DDX5 EEF1A1 EP300 FAU FKBP1A GALNT1 GANAB GSK3A GSK3B HNRNPA1 IFIH1 IKBKE IRAK2 IRF3 ITCH KPNA2 KPNB1 MAP1LC3B MAVS MGAT1 MOGS NFKB1 NFKBIA NLRP3 NMI NPM1 PALS1 PARP10 PARP14 PARP16 PARP4 PARP6 PARP8 PARP9 PCBP2 PDPK1 PIK3C3 PIK3R4 PKLR PPIA PPIB PPIG PPIH PRKCSH PSMC6 PYCARD RB1 RCAN3 RELA RIGI RIPK1 RIPK3 RNF103-CHMP3 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS27L RPS28 RPS29 RPS3 RPS3A RPS4X RPS4Y1 RPS4Y2 RPS5 RPS6 RPS7 RPS8 RPS9 RPSA RUNX1 SFN SFTPD SIKE1 SMAD3 SMAD4 SP1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST6GAL1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 STING1 SUMO1 TBK1 TKFC TLR7 TMPRSS2 TOMM70 TRAF3 TRAF6 TRIM25 UBA52 UBB UBC UBE2I UVRAG VCP VHL YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZCRB1 (see all 142) (see less)
3	SARS-CoV-1 activates/modulates innate immune responses	Reactome	BST2 CASP1 FKBP1A IFIH1 IKBKE IRAK2 IRF3 ITCH KPNA2 KPNB1 MAVS NFKB1 NFKBIA NLRP3 NMI PCBP2 PPIA PPIB PPIG PPIH PYCARD RCAN3 RELA RIGI RIPK3 RPS27A RUNX1 SFTPD SIKE1 STING1 TBK1 TKFC TLR7 TOMM70 TRAF3 TRAF6 TRIM25 UBA52 UBB UBC (see all 40) (see less)
4	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	Reactome	CAV1 EP300 PDPK1 PSMC6 SFN SMAD3 SMAD4 SP1 UBE2I YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 15) (see less)

Gene overlap in member pathways for SARS-CoV-1-host interactions SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PPIH	Peptidylprolyl Isomerase H	Protein Coding	3
2	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	3
3	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	3
4	RCAN3	RCAN Family Member 3	Protein Coding	3
5	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	3
6	EP300	EP300 Lysine Acetyltransferase	Protein Coding	3
7	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	3
8	RIGI	RNA Sensor RIG-I	Protein Coding	3
9	TKFC	Triokinase And FMN Cyclase	Protein Coding	3
10	SFN	Stratifin	Protein Coding	3
11	PYCARD	PYD And CARD Domain Containing	Protein Coding	3
12	TBK1	TANK Binding Kinase 1	Protein Coding	3
13	STING1	Stimulator Of Interferon Response CGAMP Interactor 1	Protein Coding	3
14	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	3
15	IRF3	Interferon Regulatory Factor 3	Protein Coding	3
16	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	3
17	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	3
18	SMAD3	SMAD Family Member 3	Protein Coding	3
19	SMAD4	SMAD Family Member 4	Protein Coding	3
20	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	3
21	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	3
22	PCBP2	Poly(RC) Binding Protein 2	Protein Coding	3
23	TLR7	Toll Like Receptor 7	Protein Coding	3
24	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	3
25	PPIA	Peptidylprolyl Isomerase A	Protein Coding	3
26	PPIB	Peptidylprolyl Isomerase B	Protein Coding	3
27	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	3
28	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	3
29	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	3
30	RPS27A	Ribosomal Protein S27a	Protein Coding	3
31	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	3
32	SFTPD	Surfactant Protein D	Protein Coding	3
33	SP1	Sp1 Transcription Factor	Protein Coding	3
34	BST2	Bone Marrow Stromal Cell Antigen 2	Protein Coding	3
35	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	3
36	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	3
37	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
38	UBB	Ubiquitin B	Protein Coding	3
39	UBC	Ubiquitin C	Protein Coding	3
40	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	3
41	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	3
42	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	3
43	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	3
44	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	3
45	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	3
46	TRIM25	Tripartite Motif Containing 25	Protein Coding	3
47	SIKE1	Suppressor Of IKBKE 1	Protein Coding	3
48	CASP1	Caspase 1	Protein Coding	3
49	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	3
50	CAV1	Caveolin 1	Protein Coding	3
51	RUNX1	RUNX Family Transcription Factor 1	Protein Coding	3
52	NMI	N-Myc And STAT Interactor	Protein Coding	3
53	PPIG	Peptidylprolyl Isomerase G	Protein Coding	3
54	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	3
55	TOMM70	Translocase Of Outer Mitochondrial Membrane 70	Protein Coding	3
56	RPS4Y2	Ribosomal Protein S4 Y-Linked 2	Protein Coding	2
57	EEF1A1	Eukaryotic Translation Elongation Factor 1 Alpha 1	Protein Coding	2
58	FAU	FAU Ubiquitin Like And Ribosomal Protein S30 Fusion	Protein Coding	2
59	HNRNPA1	Heterogeneous Nuclear Ribonucleoprotein A1	Protein Coding	2
60	RPSA	Ribosomal Protein SA	Protein Coding	2
61	NPM1	Nucleophosmin 1	Protein Coding	2
62	RPS27L	Ribosomal Protein S27 Like	Protein Coding	2
63	PKLR	Pyruvate Kinase L/R	Protein Coding	2
64	BCL2L1	BCL2 Like 1	Protein Coding	2
65	RPS2	Ribosomal Protein S2	Protein Coding	2
66	RPS3	Ribosomal Protein S3	Protein Coding	2
67	RPS3A	Ribosomal Protein S3A	Protein Coding	2
68	RPS4X	Ribosomal Protein S4 X-Linked	Protein Coding	2
69	RPS4Y1	Ribosomal Protein S4 Y-Linked 1	Protein Coding	2
70	RPS5	Ribosomal Protein S5	Protein Coding	2
71	RPS6	Ribosomal Protein S6	Protein Coding	2
72	RPS7	Ribosomal Protein S7	Protein Coding	2
73	RPS8	Ribosomal Protein S8	Protein Coding	2
74	RPS9	Ribosomal Protein S9	Protein Coding	2
75	RPS10	Ribosomal Protein S10	Protein Coding	2
76	RPS11	Ribosomal Protein S11	Protein Coding	2
77	RPS12	Ribosomal Protein S12	Protein Coding	2
78	RPS13	Ribosomal Protein S13	Protein Coding	2
79	RPS14	Ribosomal Protein S14	Protein Coding	2
80	RPS15	Ribosomal Protein S15	Protein Coding	2
81	RPS15A	Ribosomal Protein S15a	Protein Coding	2
82	RPS16	Ribosomal Protein S16	Protein Coding	2
83	RPS17	Ribosomal Protein S17	Protein Coding	2
84	RPS18	Ribosomal Protein S18	Protein Coding	2
85	RPS19	Ribosomal Protein S19	Protein Coding	2
86	RPS20	Ribosomal Protein S20	Protein Coding	2
87	RPS21	Ribosomal Protein S21	Protein Coding	2
88	RPS23	Ribosomal Protein S23	Protein Coding	2
89	RPS24	Ribosomal Protein S24	Protein Coding	2
90	RPS25	Ribosomal Protein S25	Protein Coding	2
91	RPS26	Ribosomal Protein S26	Protein Coding	2
92	RPS27	Ribosomal Protein S27	Protein Coding	2
93	RPS28	Ribosomal Protein S28	Protein Coding	2
94	RPS29	Ribosomal Protein S29	Protein Coding	2
95	PALS1	Protein Associated With LIN7 1, MAGUK P55 Family Member	Protein Coding	2
96	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	2
97	RNF103-CHMP3	RNF103-CHMP3 Readthrough	Protein Coding	1
98	ST6GALNAC2	ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2	Protein Coding	1
99	CHMP4B	Charged Multivesicular Body Protein 4B	Protein Coding	1
100	PARP4	Poly(ADP-Ribose) Polymerase Family Member 4	Protein Coding	1
101	CTSL	Cathepsin L	Protein Coding	1
102	DDX5	DEAD-Box Helicase 5	Protein Coding	1
103	GANAB	Glucosidase II Alpha Subunit	Protein Coding	1
104	ST6GALNAC3	ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3	Protein Coding	1
105	GALNT1	Polypeptide N-Acetylgalactosaminyltransferase 1	Protein Coding	1
106	CHMP2B	Charged Multivesicular Body Protein 2B	Protein Coding	1
107	ST6GALNAC4	ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4	Protein Coding	1
108	CHMP2A	Charged Multivesicular Body Protein 2A	Protein Coding	1
109	CHMP4A	Charged Multivesicular Body Protein 4A	Protein Coding	1
110	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
111	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
112	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
113	MGAT1	Alpha-1,3-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
114	CHMP3	Charged Multivesicular Body Protein 3	Protein Coding	1
115	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	1
116	PARP14	Poly(ADP-Ribose) Polymerase Family Member 14	Protein Coding	1
117	PARP16	Poly(ADP-Ribose) Polymerase Family Member 16	Protein Coding	1
118	PRKCSH	PRKCSH Beta Subunit Of Glucosidase II	Protein Coding	1
119	PARP6	Poly(ADP-Ribose) Polymerase Family Member 6	Protein Coding	1
120	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
121	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	1
122	ST6GAL1	ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1	Protein Coding	1
123	ST3GAL1	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1	Protein Coding	1
124	ST3GAL2	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2	Protein Coding	1
125	ST3GAL4	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4	Protein Coding	1
126	ST3GAL3	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3	Protein Coding	1
127	TMPRSS2	Transmembrane Serine Protease 2	Protein Coding	1
128	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	1
129	UVRAG	UV Radiation Resistance Associated	Protein Coding	1
130	VCP	Valosin Containing Protein	Protein Coding	1
131	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	1
132	MOGS	Mannosyl-Oligosaccharide Glucosidase	Protein Coding	1
133	CHMP6	Charged Multivesicular Body Protein 6	Protein Coding	1
134	PARP8	Poly(ADP-Ribose) Polymerase Family Member 8	Protein Coding	1
135	MAP1LC3B	Microtubule Associated Protein 1 Light Chain 3 Beta	Protein Coding	1
136	CANX	Calnexin	Protein Coding	1
137	PARP9	Poly(ADP-Ribose) Polymerase Family Member 9	Protein Coding	1
138	PARP10	Poly(ADP-Ribose) Polymerase Family Member 10	Protein Coding	1
139	ZCRB1	Zinc Finger CCHC-Type And RNA Binding Motif Containing 1	Protein Coding	1
140	BECN1	Beclin 1	Protein Coding	1
141	CHMP7	Charged Multivesicular Body Protein 7	Protein Coding	1
142	CHMP4C	Charged Multivesicular Body Protein 4C	Protein Coding	1

Disorders associated with SARS-CoV-1-host interactions SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe acute respiratory syndrome	Direct

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

SARS-CoV-1-host interactions

Pathway Network for SARS-CoV-1-host interactions

Pathway network for the SARS-CoV-1-host interactions SuperPath

Member Pathways for SARS-CoV-1-host interactions

Pathways in the SARS-CoV-1-host interactions SuperPath

Gene overlap in member pathways for SARS-CoV-1-host interactions SuperPath

Associated Genes for SARS-CoV-1-host interactions

Associated Disorders for SARS-CoV-1-host interactions

Disorders associated with SARS-CoV-1-host interactions SuperPath

STRING Interaction Network for SARS-CoV-1-host interactions

Sources for SARS-CoV-1-host interactions