SARS-CoV-2 and COVID-19 pathway

No Pathway Network information available for SARS-CoV-2 and COVID-19 pathway

#	Name	Source	Genes
1	SARS-CoV-2 and COVID-19 pathway	WikiPathways	ACAT1 ACE2 CTSL FURIN NRP1 SCARB1 SLC6A19 TLR7 TMPRSS2 TMPRSS4 (see all 10) (see less)
2	Defective regulation of TLR7 by endogenous ligand	Reactome	TLR7

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TLR7	Toll Like Receptor 7	Protein Coding	2
2	TMPRSS4	Transmembrane Serine Protease 4	Protein Coding	1
3	TMPRSS2	Transmembrane Serine Protease 2	Protein Coding	1
4	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	1
5	CTSL	Cathepsin L	Protein Coding	1
6	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
7	NRP1	Neuropilin 1	Protein Coding	1
8	SCARB1	Scavenger Receptor Class B Member 1	Protein Coding	1
9	ACAT1	Acetyl-CoA Acetyltransferase 1	Protein Coding	1
10	SLC6A19	Solute Carrier Family 6 Member 19	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autoimmune disease	Direct
2	Systemic lupus erythematosus	Direct
3	High density lipoprotein cholesterol level quantitative trait locus 6	Enrichment	SCARB1	3.13
4	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	3.13
5	X-linked immunodeficiency 74	Enrichment	TLR7	3.13
6	Systemic lupus erythematosus 17	Enrichment	TLR7	3.13
7	Autosomal recessive cerebral atrophy	Enrichment	TMPRSS4	3.13
8	Hyperglycinuria	Enrichment	SLC6A19	2.83
9	Alpha-methylacetoacetic aciduria	Enrichment	ACAT1	2.83
10	Hartnup disorder	Enrichment	SLC6A19	2.83
11	Hyperalphalipoproteinemia 1	Enrichment	SCARB1	2.66
12	Iminoglycinuria	Enrichment	SLC6A19	2.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for SARS-CoV-2 and COVID-19 pathway