SARS-CoV-2 innate immunity evasion and cell-specific immune response

No Pathway Network information available for SARS-CoV-2 innate immunity evasion and cell-specific immune response

Pathways in the SARS-CoV-2 innate immunity evasion and cell-specific immune response SuperPath

#	Name	Source	Genes
1	SARS-CoV-2 innate immunity evasion and cell-specific immune response	WikiPathways	ACE2 BSG CASP8 CCL2 CCL3 CCL4 CCL5 CD160 CSF2 CXCL1 CXCL17 CXCL2 CXCL8 CXCR2 DHX58 EP300 FADD HAVCR2 HDAC2 IFIT2 IFITM1 IFN1@ IFNB1 IL10 IRF3 IRF7 LAG3 LARP1 MAVS MX1 NFKB1 NUP98 RAE1 RIGI RIPK1 SMAD3 STAT2 TANK TBK1 TFAP2A TGFB1 TLR7 TNF TP53I3 TRADD TRAF2 TRAF3 TRAF5 TRAF6 TRIM25 (see all 50) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IL10	Interleukin 10	Protein Coding	1
2	CSF2	Colony Stimulating Factor 2	Protein Coding	1
3	CASP8	Caspase 8	Protein Coding	1
4	TNF	Tumor Necrosis Factor	Protein Coding	1
5	BSG	Basigin (Ok Blood Group)	Protein Coding	1
6	TP53I3	Tumor Protein P53 Inducible Protein 3	Protein Coding	1
7	FADD	Fas Associated Via Death Domain	Protein Coding	1
8	IFITM1	Interferon Induced Transmembrane Protein 1	Protein Coding	1
9	HAVCR2	Hepatitis A Virus Cellular Receptor 2	Protein Coding	1
10	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
11	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
12	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
13	TFAP2A	Transcription Factor AP-2 Alpha	Protein Coding	1
14	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	1
15	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	1
16	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	1
17	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	1
18	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
19	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	1
20	TLR7	Toll Like Receptor 7	Protein Coding	1
21	NUP98	Nucleoporin 98 And 96 Precursor	Protein Coding	1
22	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
23	MX1	MX Dynamin Like GTPase 1	Protein Coding	1
24	SMAD3	SMAD Family Member 3	Protein Coding	1
25	IRF7	Interferon Regulatory Factor 7	Protein Coding	1
26	IRF3	Interferon Regulatory Factor 3	Protein Coding	1
27	CXCR2	C-X-C Motif Chemokine Receptor 2	Protein Coding	1
28	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
29	IFNB1	Interferon Beta 1	Protein Coding	1
30	IFIT2	Interferon Induced Protein With Tetratricopeptide Repeats 2	Protein Coding	1
31	HDAC2	Histone Deacetylase 2	Protein Coding	1
32	CXCL2	C-X-C Motif Chemokine Ligand 2	Protein Coding	1
33	CXCL1	C-X-C Motif Chemokine Ligand 1	Protein Coding	1
34	TBK1	TANK Binding Kinase 1	Protein Coding	1
35	RIGI	RNA Sensor RIG-I	Protein Coding	1
36	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
37	TANK	TRAF Family Member Associated NFKB Activator	Protein Coding	1
38	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
39	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
40	RAE1	Ribonucleic Acid Export 1	Protein Coding	1
41	CD160	CD160 Molecule	Protein Coding	1
42	DHX58	DExH-Box Helicase 58	Protein Coding	1
43	TRIM25	Tripartite Motif Containing 25	Protein Coding	1
44	TRAF5	TNF Receptor Associated Factor 5	Protein Coding	1
45	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
46	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	1
47	LAG3	Lymphocyte Activating 3	Protein Coding	1
48	IFN1@	Interferon, Type 1, Cluster	Gene Cluster	1
49	CXCL17	C-X-C Motif Chemokine Ligand 17	Protein Coding	1
50	LARP1	La Ribonucleoprotein 1, Translational Regulator	Protein Coding	1

Disorders associated with SARS-CoV-2 innate immunity evasion and cell-specific immune response SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Human immunodeficiency virus type 1	Enrichment	CCL2, CCL3, CCL5, IL10	6.32
2	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10, RIPK1, TGFB1	6.03
3	Multisystem inflammatory syndrome in children	Enrichment	IFNB1, IRF3, TRAF3	4.16
4	Herpes simplex virus encephalitis	Enrichment	TBK1, TRAF3	3.88
5	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1, TGFB1	3.70
6	Systemic lupus erythematosus	Enrichment	IL10, TLR7, TNF	3.41
7	Caspase 8 deficiency	Enrichment	CASP8	2.43
8	Immunodeficiency 39 viral infections	Enrichment	IRF7	2.43
9	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	2.43
10	Pseudo-torch syndrome 3	Enrichment	STAT2	2.43
11	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.43
12	Graft-versus-host disease	Enrichment	IL10	2.43
13	X-linked immunodeficiency 74	Enrichment	TLR7	2.43
14	Immunodeficiency 132a	Enrichment	TRAF3	2.43
15	Immunodeficiency 132b	Enrichment	TRAF3	2.43
16	Systemic lupus erythematosus 17	Enrichment	TLR7	2.43
17	Immunodeficiency 39	Enrichment	IRF7	2.43
18	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.43
19	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.43
20	Singleton-merten syndrome 2	Enrichment	RIGI	2.43
21	T-cell lymphoma, subcutaneous panniculitis-like	Enrichment	HAVCR2	2.43
22	Corticobasal syndrome	Enrichment	TBK1	2.43
23	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.43
24	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.43
25	Whim syndrome 2	Enrichment	CXCR2	2.43
26	Autosomal recessive severe congenital neutropenia due to cxcr2 deficiency	Enrichment	CXCR2	2.43
27	Camurati-engelmann disease 1	Enrichment	TGFB1	2.13
28	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.13
29	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.13
30	Menke-hennekam syndrome 2	Enrichment	EP300	2.13
31	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.13
32	Immunodeficiency 127	Enrichment	TNF	2.13
33	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.13
34	Camurati-engelmann disease	Enrichment	TGFB1	2.13
35	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.13
36	Esotropia	Enrichment	TFAP2A	2.13
37	Singleton-merten syndrome	Enrichment	RIGI	2.13
38	Common variable immunodeficiency 12	Enrichment	NFKB1	2.13
39	Lens subluxation	Enrichment	TFAP2A	2.13
40	Oculootodental syndrome	Enrichment	FADD	2.13
41	Psoriatic arthritis	Enrichment	TNF	1.96
42	Migraine without aura	Enrichment	TNF	1.96
43	Immunodeficiency 44	Enrichment	STAT2	1.96
44	Branchiooculofacial syndrome	Enrichment	TFAP2A	1.83
45	Aortic aneurysm	Enrichment	SMAD3	1.83
46	Cerebral malaria	Enrichment	TNF	1.83
47	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.74
48	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.74
49	Amblyopia	Enrichment	TFAP2A	1.74
50	Vascular dementia	Enrichment	TNF	1.74
51	Branchiootorenal syndrome 1	Enrichment	TFAP2A	1.66
52	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.66
53	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.66
54	Branchiootorenal syndrome	Enrichment	TFAP2A	1.59
55	Motor neuron disease	Enrichment	TBK1	1.59
56	Common variable immunodeficiency	Enrichment	NFKB1	1.59
57	Rheumatoid arthritis	Enrichment	IL10	1.49
58	Charge syndrome	Enrichment	EP300	1.49
59	Loeys-dietz syndrome	Enrichment	SMAD3	1.49
60	Adult hepatocellular carcinoma	Enrichment	CASP8	1.49
61	Progressive non-fluent aphasia	Enrichment	TBK1	1.49
62	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.49
63	Cat eye syndrome	Enrichment	TFAP2A	1.44
64	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	1.44
65	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.44
66	Immune deficiency disease	Enrichment	RIPK1	1.40
67	Asthma	Enrichment	TNF	1.40
68	Epicanthus	Enrichment	TFAP2A	1.36
69	Alzheimer's disease	Enrichment	TNF	1.33
70	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.30
71	Polydactyly, postaxial, type a1	Enrichment	EP300	1.27
72	Rare genetic intellectual disability	Enrichment	EP300	1.27
73	Behcet syndrome	Enrichment	IL10	1.17
74	Ehlers-danlos syndrome	Enrichment	SMAD3	1.17
75	Hepatocellular carcinoma	Enrichment	CASP8	1.11
76	Microphthalmia	Enrichment	TFAP2A	1.11
77	Malaria	Enrichment	TNF	1.09
78	Hirschsprung disease 1	Enrichment	NUP98	0.99
79	Lung cancer	Enrichment	CASP8	0.95
80	Cystic fibrosis	Enrichment	TGFB1	0.95
81	Connective tissue disease	Enrichment	SMAD3	0.95
82	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3	0.82
83	Hypertelorism	Enrichment	TFAP2A	0.76
84	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.73
85	Myeloma, multiple	Enrichment	TRAF5	0.73
86	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	0.71
87	Breast cancer	Enrichment	CASP8	0.62
88	Colorectal cancer	Enrichment	EP300	0.56
89	Microcephaly	Enrichment	EP300	0.44

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

SARS-CoV-2 innate immunity evasion and cell-specific immune response

Pathway Network for SARS-CoV-2 innate immunity evasion and cell-specific immune response

Member Pathways for SARS-CoV-2 innate immunity evasion and cell-specific immune response

Pathways in the SARS-CoV-2 innate immunity evasion and cell-specific immune response SuperPath

Associated Genes for SARS-CoV-2 innate immunity evasion and cell-specific immune response

Associated Disorders for SARS-CoV-2 innate immunity evasion and cell-specific immune response

Disorders associated with SARS-CoV-2 innate immunity evasion and cell-specific immune response SuperPath

STRING Interaction Network for SARS-CoV-2 innate immunity evasion and cell-specific immune response

Sources for SARS-CoV-2 innate immunity evasion and cell-specific immune response