SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction

No Pathway Network information available for SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction

Pathways in the SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction SuperPath

#	Name	Source	Genes
1	SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction	WikiPathways	ACAD9 BCS1L ECSIT IL18 IL6 LOC105371348 MAVS NDUFAF1 NDUFAF2 NFKB1 NLRP3 NLRX1 SIRT6 TERF2 TOMM70 TRAF3 TRAF6 (see all 17) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IL18	Interleukin 18	Protein Coding	1
2	IL6	Interleukin 6	Protein Coding	1
3	NDUFAF2	NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 2	Protein Coding	1
4	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
5	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
6	TERF2	Telomeric Repeat Binding Factor 2	Protein Coding	1
7	BCS1L	BCS1 Ubiquinol-Cytochrome C Reductase Complex Chaperone	Protein Coding	1
8	SIRT6	Sirtuin 6	Protein Coding	1
9	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
10	ACAD9	Acyl-CoA Dehydrogenase Family Member 9	Protein Coding	1
11	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	1
12	TOMM70	Translocase Of Outer Mitochondrial Membrane 70	Protein Coding	1
13	LOC105371348	Uncharacterized LOC105371348	RNA Gene	1
14	NLRX1	NLR Family Member X1	Protein Coding	1
15	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	1
16	ECSIT	ECSIT Signaling Integrator	Protein Coding	1
17	NDUFAF1	NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 1	Protein Coding	1

Disorders associated with SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mitochondrial complex i deficiency, nuclear type 1	Enrichment	ACAD9, NDUFAF1, NDUFAF2	4.87
2	Arteriovenous malformations of the brain	Enrichment	IL6, NLRP3	3.60
3	Cinca syndrome	Enrichment	NLRP3	2.90
4	Keratoendotheliitis fugax hereditaria	Enrichment	NLRP3	2.90
5	Familial cold autoinflammatory syndrome 1	Enrichment	NLRP3	2.90
6	Muckle-wells syndrome	Enrichment	NLRP3	2.90
7	Bjornstad syndrome	Enrichment	BCS1L	2.90
8	Deafness, autosomal dominant 34, with or without inflammation	Enrichment	NLRP3	2.90
9	Mitochondrial complex i deficiency, nuclear type 11	Enrichment	NDUFAF1	2.90
10	Immunodeficiency 132a	Enrichment	TRAF3	2.90
11	Immunodeficiency 132b	Enrichment	TRAF3	2.90
12	Gracile syndrome	Enrichment	BCS1L	2.90
13	Renal tubulopathy-encephalopathy-liver failure syndrome	Enrichment	BCS1L	2.90
14	Cryopyrin associated periodic syndrome	Enrichment	NLRP3	2.90
15	Familial amyloid nephropathy with urticaria and deafness	Enrichment	NLRP3	2.90
16	Lethal brain and heart developmental defects	Enrichment	SIRT6	2.90
17	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.60
18	Mitochondrial complex i deficiency, nuclear type 10	Enrichment	NDUFAF2	2.60
19	Pericardial effusion	Enrichment	NLRP3	2.60
20	Common variable immunodeficiency 12	Enrichment	NFKB1	2.60
21	Leigh syndrome, nuclear	Enrichment	BCS1L, NDUFAF2	2.48
22	Mitochondrial complex iii deficiency, nuclear type 1	Enrichment	BCS1L	2.43
23	Mitochondrial complex i deficiency, nuclear type 20	Enrichment	ACAD9	2.43
24	Uv-sensitive syndrome 2	Enrichment	NDUFAF2	2.43
25	Leigh disease	Enrichment	BCS1L, NDUFAF2	2.40
26	Kaposi sarcoma	Enrichment	IL6	2.30
27	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.30
28	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.20
29	Cockayne syndrome a	Enrichment	NDUFAF2	2.20
30	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	2.20
31	Herpes simplex virus encephalitis	Enrichment	TRAF3	2.20
32	Type 1 diabetes mellitus	Enrichment	IL6	2.13
33	Cockayne syndrome	Enrichment	NDUFAF2	2.06
34	Common variable immunodeficiency	Enrichment	NFKB1	2.06
35	Inflammatory bowel disease 1	Enrichment	IL6	1.95
36	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.90
37	Movement disease	Enrichment	BCS1L	1.86
38	Isolated complex iii deficiency	Enrichment	BCS1L	1.86
39	Multisystem inflammatory syndrome in children	Enrichment	TRAF3	1.56
40	Autoinflammatory disease	Enrichment	NLRP3	1.53
41	Type 2 diabetes mellitus	Enrichment	IL6	1.29
42	Primary ovarian insufficiency	Enrichment	SIRT6	1.15
43	Microcephaly	Enrichment	BCS1L	0.84

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction

Pathway Network for SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction

Member Pathways for SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction

Pathways in the SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction SuperPath

Associated Genes for SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction

Associated Disorders for SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction

Disorders associated with SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction SuperPath

STRING Interaction Network for SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction

Sources for SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction