Selective autophagy

Pathway network for the Selective autophagy SuperPath

Sources:

Reactome

Pathways in the Selective autophagy SuperPath

#	Name	Source	Genes
1	Selective autophagy	Reactome	ARL13B ATG12 ATG5 ATG9A ATM CETN1 CFTR CSNK2A1 CSNK2A2 CSNK2B DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 EPAS1 FUNDC1 HDAC6 HSF1 HSP90AA1 HSPA8 IFT88 MAP1LC3A MAP1LC3B MFN1 MFN2 MTERF3 NBR1 OPTN PARK7 PCNT PEX5 PGAM5 PINK1 PLIN2 PLIN3 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRKN RPS27A SQSTM1 SRC TBK1 TOMM20 TOMM22 TOMM40 TOMM5 TOMM6 TOMM7 TOMM70 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B UBA52 UBB UBC UBE2D2 UBE2D3 UBE2L3 UBE2N UBE2V1 ULK1 USP30 VCP VDAC1 VDAC2 VDAC3 VIM (see all 90) (see less)
2	Autophagy	Reactome	AMBRA1 ARL13B ATG10 ATG101 ATG12 ATG13 ATG14 ATG16L1 ATG16L2 ATG3 ATG4A ATG4B ATG4C ATG4D ATG5 ATG7 ATG9A ATG9B ATM BECN1 CETN1 CFTR CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 CSNK2A1 CSNK2A2 CSNK2B DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 EEF1A1 EPAS1 FUNDC1 GABARAP GABARAPL1 GABARAPL2 GFAP HBB HDAC6 HSF1 HSP90AA1 HSP90AB1 HSPA8 IFT88 LAMP2 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 MAP1LC3A MAP1LC3B MAP1LC3C MFN1 MFN2 MLST8 MTERF3 MTMR14 MTMR3 MTOR MVB12A MVB12B NBR1 OPTN PARK7 PCNT PEX5 PGAM5 PIK3C3 PIK3R4 PINK1 PLIN2 PLIN3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRKN RB1CC1 RHEB RNASE1 RNF103-CHMP3 RPS27A RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 SQSTM1 SRC TBK1 TOMM20 TOMM22 TOMM40 TOMM5 TOMM6 TOMM7 TOMM70 TSC1 TSC2 TSG101 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B UBA52 UBAP1 UBB UBC UBE2D2 UBE2D3 UBE2L3 UBE2N UBE2V1 ULK1 USP30 UVRAG VCP VDAC1 VDAC2 VDAC3 VIM VPS28 VPS37A VPS37B VPS37C VPS37D WDR45 WDR45B WIPI1 WIPI2 (see all 160) (see less)
3	Macroautophagy	Reactome	AMBRA1 ARL13B ATG10 ATG101 ATG12 ATG13 ATG14 ATG16L1 ATG16L2 ATG3 ATG4A ATG4B ATG4C ATG4D ATG5 ATG7 ATG9A ATG9B ATM BECN1 CETN1 CFTR CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 CSNK2A1 CSNK2A2 CSNK2B DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 EPAS1 FUNDC1 GABARAP GABARAPL1 GABARAPL2 HDAC6 HSF1 HSP90AA1 HSPA8 IFT88 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 MAP1LC3A MAP1LC3B MAP1LC3C MFN1 MFN2 MLST8 MTERF3 MTMR14 MTMR3 MTOR NBR1 OPTN PARK7 PCNT PEX5 PGAM5 PIK3C3 PIK3R4 PINK1 PLIN2 PLIN3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRKN RB1CC1 RHEB RNF103-CHMP3 RPS27A RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 SQSTM1 SRC TBK1 TOMM20 TOMM22 TOMM40 TOMM5 TOMM6 TOMM7 TOMM70 TSC1 TSC2 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B UBA52 UBB UBC UBE2D2 UBE2D3 UBE2L3 UBE2N UBE2V1 ULK1 USP30 UVRAG VCP VDAC1 VDAC2 VDAC3 VIM WDR45 WDR45B WIPI1 WIPI2 (see all 145) (see less)
4	Aggrephagy	Reactome	ARL13B CETN1 CFTR DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 HDAC6 HSF1 HSP90AA1 IFT88 PARK7 PCNT PRKN RPS27A TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B UBA52 UBB UBC UBE2N UBE2V1 VCP VIM (see all 44) (see less)
5	Pexophagy	Reactome	ATM EPAS1 MAP1LC3B NBR1 PEX5 RPS27A SQSTM1 UBA52 UBB UBC USP30 (see all 11) (see less)
6	Lipophagy	Reactome	HSPA8 PLIN2 PLIN3 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 (see all 9) (see less)

Gene overlap in member pathways for Selective autophagy SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RPS27A	Ribosomal Protein S27a	Protein Coding	5
2	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	5
3	UBB	Ubiquitin B	Protein Coding	5
4	UBC	Ubiquitin C	Protein Coding	5
5	HDAC6	Histone Deacetylase 6	Protein Coding	4
6	PLIN3	Perilipin 3	Protein Coding	4
7	TUBA1B	Tubulin Alpha 1b	Protein Coding	4
8	TUBB3	Tubulin Beta 3 Class III	Protein Coding	4
9	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	4
10	TUBB4B	Tubulin Beta 4B Class IVb	Protein Coding	4
11	CETN1	Centrin 1	Protein Coding	4
12	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	4
13	TUBA3E	Tubulin Alpha 3e	Protein Coding	4
14	PARK7	Parkinsonism Associated Deglycase	Protein Coding	4
15	TUBA3D	Tubulin Alpha 3d	Protein Coding	4
16	PLIN2	Perilipin 2	Protein Coding	4
17	DYNLL2	Dynein Light Chain LC8-Type 2	Protein Coding	4
18	DYNC1H1	Dynein Cytoplasmic 1 Heavy Chain 1	Protein Coding	4
19	DYNC1I1	Dynein Cytoplasmic 1 Intermediate Chain 1	Protein Coding	4
20	DYNC1I2	Dynein Cytoplasmic 1 Intermediate Chain 2	Protein Coding	4
21	DYNC1LI2	Dynein Cytoplasmic 1 Light Intermediate Chain 2	Protein Coding	4
22	ARL13B	ARF Like GTPase 13B	Protein Coding	4
23	EPAS1	Endothelial PAS Domain Protein 1	Protein Coding	4
24	TUBB8B	Tubulin Beta 8B	Protein Coding	4
25	HSF1	Heat Shock Transcription Factor 1	Protein Coding	4
26	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	4
27	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	4
28	TUBB8	Tubulin Beta 8 Class VIII	Protein Coding	4
29	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	4
30	NBR1	NBR1 Autophagy Cargo Receptor	Protein Coding	4
31	ATM	ATM Serine/Threonine Kinase	Protein Coding	4
32	PRKN	Parkin RBR E3 Ubiquitin Protein Ligase	Protein Coding	4
33	DYNC1LI1	Dynein Cytoplasmic 1 Light Intermediate Chain 1	Protein Coding	4
34	PCNT	Pericentrin	Protein Coding	4
35	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	4
36	TUBA8	Tubulin Alpha 8	Protein Coding	4
37	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	4
38	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	4
39	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	4
40	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	4
41	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	4
42	PEX5	Peroxisomal Biogenesis Factor 5	Protein Coding	4
43	TUBA4A	Tubulin Alpha 4a	Protein Coding	4
44	TUBA3C	Tubulin Alpha 3c	Protein Coding	4
45	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	4
46	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	4
47	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	4
48	VCP	Valosin Containing Protein	Protein Coding	4
49	VIM	Vimentin	Protein Coding	4
50	TUBA1A	Tubulin Alpha 1a	Protein Coding	4
51	TUBAL3	Tubulin Alpha Like 3	Protein Coding	4
52	TUBA4B	Tubulin Alpha 4b	Protein Coding	4
53	IFT88	Intraflagellar Transport 88	Protein Coding	4
54	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	4
55	MAP1LC3B	Microtubule Associated Protein 1 Light Chain 3 Beta	Protein Coding	4
56	TUBB6	Tubulin Beta 6 Class V	Protein Coding	4
57	USP30	Ubiquitin Specific Peptidase 30	Protein Coding	4
58	TUBA1C	Tubulin Alpha 1c	Protein Coding	4
59	DYNLL1	Dynein Light Chain LC8-Type 1	Protein Coding	4
60	SQSTM1	Sequestosome 1	Protein Coding	4
61	TOMM6	Translocase Of Outer Mitochondrial Membrane 6	Protein Coding	3
62	OPTN	Optineurin	Protein Coding	3
63	TOMM40	Translocase Of Outer Mitochondrial Membrane 40	Protein Coding	3
64	FUNDC1	FUN14 Domain Containing 1	Protein Coding	3
65	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	3
66	CSNK2A2	Casein Kinase 2 Alpha 2	Protein Coding	3
67	CSNK2B	Casein Kinase 2 Beta	Protein Coding	3
68	PGAM5	PGAM Family Member 5, Mitochondrial Serine/Threonine Protein Phosphatase	Protein Coding	3
69	TBK1	TANK Binding Kinase 1	Protein Coding	3
70	TOMM5	Translocase Of Outer Mitochondrial Membrane 5	Protein Coding	3
71	MTERF3	Mitochondrial Transcription Termination Factor 3	Protein Coding	3
72	TOMM7	Translocase Of Outer Mitochondrial Membrane 7	Protein Coding	3
73	MFN1	Mitofusin 1	Protein Coding	3
74	TOMM22	Translocase Of Outer Mitochondrial Membrane 22	Protein Coding	3
75	PINK1	PTEN Induced Kinase 1	Protein Coding	3
76	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	3
77	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	3
78	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	3
79	UBE2L3	Ubiquitin Conjugating Enzyme E2 L3	Protein Coding	3
80	VDAC1	Voltage Dependent Anion Channel 1	Protein Coding	3
81	VDAC2	Voltage Dependent Anion Channel 2	Protein Coding	3
82	VDAC3	Voltage Dependent Anion Channel 3	Protein Coding	3
83	ATG9A	Autophagy Related 9A	Protein Coding	3
84	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	3
85	MAP1LC3A	Microtubule Associated Protein 1 Light Chain 3 Alpha	Protein Coding	3
86	ATG12	Autophagy Related 12	Protein Coding	3
87	ATG5	Autophagy Related 5	Protein Coding	3
88	TOMM20	Translocase Of Outer Mitochondrial Membrane 20	Protein Coding	3
89	TOMM70	Translocase Of Outer Mitochondrial Membrane 70	Protein Coding	3
90	MFN2	Mitofusin 2	Protein Coding	3
91	RNF103-CHMP3	RNF103-CHMP3 Readthrough	Protein Coding	2
92	RRAGB	Ras Related GTP Binding B	Protein Coding	2
93	ATG7	Autophagy Related 7	Protein Coding	2
94	LAMTOR5	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5	Protein Coding	2
95	RRAGA	Ras Related GTP Binding A	Protein Coding	2
96	WDR45	WD Repeat Domain 45	Protein Coding	2
97	GABARAP	GABA Type A Receptor-Associated Protein	Protein Coding	2
98	GABARAPL2	GABA Type A Receptor Associated Protein Like 2	Protein Coding	2
99	ATG4A	Autophagy Related 4A Cysteine Peptidase	Protein Coding	2
100	CHMP4B	Charged Multivesicular Body Protein 4B	Protein Coding	2
101	SLC38A9	Solute Carrier Family 38 Member 9	Protein Coding	2
102	ATG14	Autophagy Related 14	Protein Coding	2
103	ATG4B	Autophagy Related 4B Cysteine Peptidase	Protein Coding	2
104	GABARAPL1	GABA Type A Receptor Associated Protein Like 1	Protein Coding	2
105	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	2
106	CHMP2B	Charged Multivesicular Body Protein 2B	Protein Coding	2
107	WIPI2	WD Repeat Domain, Phosphoinositide Interacting 2	Protein Coding	2
108	CHMP2A	Charged Multivesicular Body Protein 2A	Protein Coding	2
109	ATG9B	Autophagy Related 9B	Protein Coding	2
110	LAMTOR2	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 2	Protein Coding	2
111	CHMP4A	Charged Multivesicular Body Protein 4A	Protein Coding	2
112	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	2
113	LAMTOR4	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4	Protein Coding	2
114	MAP1LC3C	Microtubule Associated Protein 1 Light Chain 3 Gamma	Protein Coding	2
115	CHMP3	Charged Multivesicular Body Protein 3	Protein Coding	2
116	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	2
117	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	2
118	ATG16L1	Autophagy Related 16 Like 1	Protein Coding	2
119	WIPI1	WD Repeat Domain, Phosphoinositide Interacting 1	Protein Coding	2
120	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	2
121	AMBRA1	Autophagy And Beclin 1 Regulator 1	Protein Coding	2
122	WDR45B	WD Repeat Domain 45B	Protein Coding	2
123	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	2
124	RRAGD	Ras Related GTP Binding D	Protein Coding	2
125	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	2
126	ATG101	Autophagy Related 101	Protein Coding	2
127	RRAGC	Ras Related GTP Binding C	Protein Coding	2
128	MLST8	MTOR Associated Protein MLST8	Protein Coding	2
129	MTMR14	Myotubularin Related Protein 14	Protein Coding	2
130	ATG3	Autophagy Related 3	Protein Coding	2
131	TSC1	TSC Complex Subunit 1	Protein Coding	2
132	TSC2	TSC Complex Subunit 2	Protein Coding	2
133	UVRAG	UV Radiation Resistance Associated	Protein Coding	2
134	CHMP6	Charged Multivesicular Body Protein 6	Protein Coding	2
135	ATG10	Autophagy Related 10	Protein Coding	2
136	ATG4C	Autophagy Related 4C Cysteine Peptidase	Protein Coding	2
137	ATG4D	Autophagy Related 4D Cysteine Peptidase	Protein Coding	2
138	LAMTOR3	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 3	Protein Coding	2
139	BECN1	Beclin 1	Protein Coding	2
140	MTMR3	Myotubularin Related Protein 3	Protein Coding	2
141	ATG16L2	Autophagy Related 16 Like 2	Protein Coding	2
142	CHMP7	Charged Multivesicular Body Protein 7	Protein Coding	2
143	CHMP4C	Charged Multivesicular Body Protein 4C	Protein Coding	2
144	ATG13	Autophagy Related 13	Protein Coding	2
145	RB1CC1	RB1 Inducible Coiled-Coil 1	Protein Coding	2
146	VPS37A	VPS37A Subunit Of ESCRT-I	Protein Coding	1
147	VPS37D	VPS37D Subunit Of ESCRT-I	Protein Coding	1
148	EEF1A1	Eukaryotic Translation Elongation Factor 1 Alpha 1	Protein Coding	1
149	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	1
150	HBB	Hemoglobin Subunit Beta	Protein Coding	1
151	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	1
152	LAMP2	Lysosomal Associated Membrane Protein 2	Protein Coding	1
153	VPS28	VPS28 Subunit Of ESCRT-I	Protein Coding	1
154	UBAP1	Ubiquitin Associated Protein 1	Protein Coding	1
155	VPS37C	VPS37C Subunit Of ESCRT-I	Protein Coding	1
156	RNASE1	Ribonuclease A Family Member 1, Pancreatic	Protein Coding	1
157	TSG101	Tumor Susceptibility 101	Protein Coding	1
158	VPS37B	VPS37B Subunit Of ESCRT-I	Protein Coding	1
159	MVB12B	Multivesicular Body Subunit 12B	Protein Coding	1
160	MVB12A	Multivesicular Body Subunit 12A	Protein Coding	1

Disorders associated with Selective autophagy SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lissencephaly	Enrichment	DYNC1H1, TUBA1A, TUBA3E, TUBB2B, TUBB3	8.26
2	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	7.90
3	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	7.90
4	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB2B, TUBB3	7.50
5	Tubulinopathy	Enrichment	TUBA1A, TUBB2A, TUBB2B	6.90
6	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB2B, TUBB3	6.20
7	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1, TBK1, VCP	4.48
8	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1, VCP	4.36
9	Early-onset parkinson's disease	Enrichment	PARK7, PINK1, PRKN	4.23
10	Progressive non-fluent aphasia	Enrichment	CHMP2B, TBK1, VCP	4.02
11	Behavioral variant of frontotemporal dementia	Enrichment	CHMP2B, SQSTM1, VCP	4.02
12	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	3.95
13	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A, TUBB2B	3.67
14	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	3.47
15	Hamartoma	Enrichment	TSC1, TSC2	3.47
16	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A, TUBB2B	3.44
17	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CHMP2B, OPTN, SQSTM1, TBK1, VCP	3.42
18	Autosomal dominant macrothrombocytopenia	Enrichment	TUBA8, TUBB1	3.34
19	Parkinson disease 6, autosomal recessive early-onset	Enrichment	PARK7, PINK1	3.19
20	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	3.18
21	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	3.18
22	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	3.18
23	Tuberous sclerosis	Enrichment	TSC1, TSC2	3.17
24	Paget disease of bone 3	Enrichment	SQSTM1	3.09
25	Peroxisome biogenesis disorder 2a	Enrichment	PEX5	3.09
26	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	3.09
27	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	3.09
28	Erythrocytosis, familial, 4	Enrichment	EPAS1	3.09
29	Endometrial serous adenocarcinoma	Enrichment	ATM	3.09
30	Rhizomelic chondrodysplasia punctata, type 5	Enrichment	PEX5	3.09
31	Multiple paragangliomas associated with polycythemia	Enrichment	EPAS1	3.09
32	B-cell non-hodgkin lymphoma	Enrichment	ATM	3.09
33	Motor neuron disease	Enrichment	OPTN, TBK1	3.05
34	Hemimegalencephaly	Enrichment	MTOR, RHEB	2.95
35	Welander distal myopathy	Enrichment	SQSTM1	2.79
36	Peroxisome biogenesis disorder 2b	Enrichment	PEX5	2.79
37	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	2.79
38	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.79
39	Erythrocytosis, familial, 3	Enrichment	EPAS1	2.79
40	High grade glioma	Enrichment	ATM	2.79
41	T-cell prolymphocytic leukemia	Enrichment	ATM	2.79
42	Paget's disease of bone	Enrichment	SQSTM1	2.79
43	Submucosal cleft palate	Enrichment	UBB	2.79
44	Cleft hard palate	Enrichment	UBB	2.79
45	Autosomal dominant secondary polycythemia	Enrichment	EPAS1, HBB	2.70
46	Cerebral palsy	Enrichment	MFN2, TUBA1A, TUBB4A	2.66
47	Renal cell carcinoma, papillary, 1	Enrichment	ATM, MTOR	2.64
48	Ataxia-telangiectasia	Enrichment	ATM	2.61
49	Polycythemia vera	Enrichment	ATM	2.61
50	Uvula, bifid	Enrichment	UBB	2.61
51	Cleft soft palate	Enrichment	UBB	2.61
52	Koolen-de vries syndrome	Enrichment	ATM	2.61
53	Adenocarcinoma	Enrichment	ATM	2.61
54	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	2.49
55	Mantle cell lymphoma	Enrichment	ATM	2.49
56	Rhizomelic chondrodysplasia punctata	Enrichment	PEX5	2.49
57	Paget's disease of bone 2	Enrichment	SQSTM1	2.49
58	Oculomotor apraxia	Enrichment	ATM	2.49
59	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.49
60	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	2.49
61	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1	Enrichment	VCP	2.49
62	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	2.49
63	Leprosy 2	Enrichment	PRKN	2.49
64	Joubert syndrome 8	Enrichment	ARL13B	2.49
65	Microcephalic osteodysplastic primordial dwarfism, type ii	Enrichment	PCNT	2.49
66	Leber congenital amaurosis with early-onset deafness	Enrichment	TUBB4B	2.49
67	Oocyte/zygote/embryo maturation arrest 24	Enrichment	TUBA1C	2.49
68	Parkinson disease 7, autosomal recessive early-onset	Enrichment	PARK7	2.49
69	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	2.49
70	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	2.49
71	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	2.49
72	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Enrichment	VCP	2.49
73	Dync1h1-related disorders	Enrichment	DYNC1H1	2.49
74	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	2.49
75	Neurodevelopmental disorder with microcephaly and structural brain anomalies	Enrichment	DYNC1I2	2.49
76	Multisystem proteinopathy	Enrichment	VCP	2.49
77	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	2.49
78	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	2.49
79	Congenital myopathy 26	Enrichment	TUBA4A	2.49
80	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	2.49
81	Adult-onset distal myopathy due to vcp mutation	Enrichment	VCP	2.49
82	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	2.49
83	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	2.49
84	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	2.49
85	Premature aging	Enrichment	VIM	2.49
86	Adult hepatocellular carcinoma	Enrichment	TSC1, TSC2	2.41
87	Glioblastoma	Enrichment	ATM	2.39
88	Peroxisome biogenesis disorder 1a	Enrichment	PEX5	2.31
89	Clear cell renal cell carcinoma	Enrichment	ATM	2.31
90	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	EPAS1	2.31
91	Congenital nervous system abnormality	Enrichment	DYNC1H1, TUBA1A, TUBB4A	2.31
92	Nervous system disease	Enrichment	DYNC1H1, TUBA1A, TUBB4A	2.31
93	Autism spectrum disorder	Enrichment	CSNK2A1, CSNK2B, DYNC1H1, PRKN	2.23
94	Zellweger spectrum disorder	Enrichment	PEX5	2.19
95	Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1	Enrichment	PARK7	2.19
96	Spinal muscular atrophy, lower extremity-predominant, 1, autosomal dominant	Enrichment	DYNC1H1	2.19
97	Dystonia 4, torsion, autosomal dominant	Enrichment	TUBB4A	2.19
98	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	2.19
99	Parkinson disease 12	Enrichment	PRKN	2.19
100	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	VCP	2.19
101	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	2.19
102	Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies	Enrichment	DYNC1I2	2.19
103	Cortical dysplasia, complex, with other brain malformations 13	Enrichment	DYNC1H1	2.19
104	Keratoconus 9	Enrichment	TUBA3D	2.19
105	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	2.19
106	Lissencephaly 3	Enrichment	TUBA1A	2.19
107	Spinal muscular atrophy with lower extremity predominant	Enrichment	DYNC1H1	2.19
108	Cataract 30	Enrichment	VIM	2.19
109	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	2.19
110	Charcot-marie-tooth disease, axonal, type 2o	Enrichment	DYNC1H1	2.19
111	Torsion dystonia 4	Enrichment	TUBB4A	2.19
112	Continuous spikes and waves during sleep	Enrichment	TUBA1A	2.19
113	Spinocerebellar ataxia, autosomal recessive 25	Enrichment	ATG5	2.18
114	Multiple symmetric lipomatosis	Enrichment	MFN2	2.18
115	Charcot-marie-tooth disease, axonal, autosomal dominant, type 2a2a	Enrichment	MFN2	2.18
116	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.18
117	Thrombocytopenia 6	Enrichment	SRC	2.18
118	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.18
119	Charcot-marie-tooth disease, axonal, autosomal recessive, type 2a2b	Enrichment	MFN2	2.18
120	Corticobasal syndrome	Enrichment	TBK1	2.18
121	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.18
122	Garg-mishra progeroid syndrome	Enrichment	TOMM7	2.18
123	Charcot-marie-tooth disease type 5	Enrichment	MFN2	2.18
124	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	2.18
125	Charcot-marie-tooth disease type 2a2b	Enrichment	MFN2	2.18
126	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	MFN2, VCP	2.16
127	Colonic benign neoplasm	Enrichment	ATM	2.14
128	Lynch syndrome 1	Enrichment	ATM	2.09
129	Leukemia, chronic lymphocytic	Enrichment	ATM	2.09
130	Immune deficiency disease	Enrichment	ATM	2.05
131	Uterine corpus cancer	Enrichment	ATM	2.05
132	Familial colorectal cancer type x	Enrichment	ATM	2.05
133	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	2.01
134	Nuchal bleb, familial	Enrichment	CFTR	2.01
135	Leukodystrophy, hypomyelinating, 6	Enrichment	TUBB4A	2.01
136	Oocyte/zygote/embryo maturation arrest 2	Enrichment	TUBB8	2.01
137	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	2.01
138	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	VCP	2.01
139	Breast-ovarian cancer, familial 1	Enrichment	ATM	1.98
140	Neonatal adrenoleukodystrophy	Enrichment	PEX5	1.98
141	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	1.98
142	Immunodeficiency due to defect in mapbp-interacting protein	Enrichment	LAMTOR2	1.97
143	Cataract 31, multiple types	Enrichment	CHMP4B	1.97
144	Intellectual developmental disorder with short stature and variable skeletal anomalies	Enrichment	WIPI2	1.97
145	Inflammatory bowel disease 10	Enrichment	ATG16L1	1.97
146	Spermatogenic failure 101	Enrichment	ATG4D	1.97
147	Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures	Enrichment	WDR45B	1.97
148	Primary immunodeficiency syndrome due to p14 deficiency	Enrichment	LAMTOR2	1.97
149	Tubular renal disease-cardiomyopathy syndrome	Enrichment	RRAGD	1.97
150	Renal cell carcinoma, nonpapillary	Enrichment	ATM, MTOR	1.96
151	West syndrome	Enrichment	TSC2, TUBA1A, WDR45	1.94
152	Danon disease	Enrichment	LAMP2	1.93
153	Spastic paraplegia 53, autosomal recessive	Enrichment	VPS37A	1.93
154	Spastic paraplegia 80, autosomal dominant	Enrichment	UBAP1	1.93
155	Sickle cell-beta-thalassemia disease syndrome	Enrichment	HBB	1.93
156	Hemoglobin c-beta-thalassemia syndrome	Enrichment	HBB	1.93
157	Sickle cell s-o arab disease	Enrichment	HBB	1.93
158	Sickle cell-beta zero-thalassemia	Enrichment	HBB	1.93
159	Sickle cell s-d punjab disease	Enrichment	HBB	1.93
160	Sickle cell s-c disease	Enrichment	HBB	1.93
161	Sickle cell s-e disease	Enrichment	HBB	1.93
162	Homozygous hemoglobin o arab disease	Enrichment	HBB	1.93
163	Sickle cell s-other specified hemoglobin variant	Enrichment	HBB	1.93
164	Peroxisome biogenesis disorder 1b	Enrichment	PEX5	1.92
165	Zellweger syndrome	Enrichment	PEX5	1.92
166	Auditory neuropathy	Enrichment	MFN2, TUBB4A	1.89
167	Gliosarcoma	Enrichment	ATM	1.89
168	Idiopathic bronchiectasis	Enrichment	CFTR	1.89
169	Complex hereditary spastic paraplegia	Enrichment	PRKN	1.89
170	Lipomatosis, multiple symmetric, with or without axonal peripheral neuropathy	Enrichment	MFN2	1.88
171	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	1.88
172	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	1.88
173	Amyotrophic lateral sclerosis 12 with or without frontotemporal dementia	Enrichment	OPTN	1.88
174	Axonal neuropathy	Enrichment	MFN2	1.88
175	Amyotrophic lateral sclerosis type 12	Enrichment	OPTN	1.88
176	Multiple system atrophy, cerebellar type	Enrichment	MFN2	1.88
177	Giant cell glioblastoma	Enrichment	ATM	1.86
178	Dementia, lewy body	Enrichment	VCP	1.79
179	Parkinson disease 2, autosomal recessive juvenile	Enrichment	PRKN	1.79
180	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	VCP	1.79
181	Spinal muscular atrophy	Enrichment	DYNC1H1	1.79
182	Histiocytoid hemangioma	Enrichment	VIM	1.79
183	Parkin type of early-onset parkinson disease	Enrichment	PRKN	1.79
184	Female infertility due to oocyte meiotic arrest	Enrichment	TUBB8	1.79
185	Endometrial cancer	Enrichment	ATM	1.77
186	Peripheral nervous system disease	Enrichment	DYNC1H1, MFN2	1.72
187	Neuropathy	Enrichment	DYNC1H1, MFN2	1.72
188	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	1.71
189	Early myoclonic encephalopathy	Enrichment	TUBA1A	1.71
190	Prognathism, mandibular	Enrichment	CSNK2B	1.70
191	Neuropathy, hereditary motor and sensory, type via, with optic atrophy	Enrichment	MFN2	1.70
192	Glaucoma, normal tension	Enrichment	OPTN	1.70
193	Hyperpigmentation of the skin	Enrichment	MFN2	1.70
194	Pancreatic cancer	Enrichment	ATM	1.70
195	Fatty liver disease 1	Enrichment	ATG7	1.67
196	Hypomagnesemia 7, renal, with or without dilated cardiomyopathy	Enrichment	RRAGD	1.67
197	Cebalid syndrome	Enrichment	MTOR	1.67
198	Spinocerebellar ataxia, autosomal recessive 31	Enrichment	ATG7	1.67
199	Smith-kingsmore syndrome	Enrichment	MTOR	1.67
200	Long-olsen-distelmaier syndrome	Enrichment	RRAGC	1.67
201	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.66
202	Bladder cancer	Enrichment	ATM	1.63
203	Prostate cancer	Enrichment	ATM	1.63
204	Alexander disease	Enrichment	GFAP	1.63
205	Spastic paraplegia 12, autosomal dominant	Enrichment	UBAP1	1.63
206	Spastic paraplegia, intellectual disability, nystagmus, and obesity	Enrichment	GFAP	1.63
207	Hemoglobin lepore-beta-thalassemia syndrome	Enrichment	HBB	1.63
208	Sickle cell s-lepore disease	Enrichment	HBB	1.63
209	Cryptorchidism	Enrichment	TUBA1A	1.59
210	Enophthalmos	Enrichment	CSNK2B	1.58
211	Syndactyly	Enrichment	CSNK2B	1.58
212	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.55
213	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	1.54
214	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	1.54
215	Cryptorchidism, unilateral or bilateral	Enrichment	TUBA1A	1.54
216	Charcot-marie-tooth disease	Enrichment	DYNC1H1, MFN2	1.52
217	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.50
218	Neurodegeneration with brain iron accumulation 5	Enrichment	WDR45	1.50
219	Optic atrophy 2	Enrichment	WDR45	1.50
220	Cerebral-cerebellar-coloboma syndrome, x-linked	Enrichment	WDR45	1.50
221	Tuberous sclerosis 2	Enrichment	TSC2	1.50
222	Xanthinuria, type ii	Enrichment	TSC2	1.50
223	Cataract 30, multiple types	Enrichment	VIM	1.50
224	Polymicrogyria	Enrichment	DYNC1H1	1.50
225	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	OPTN	1.48
226	Herpes simplex virus encephalitis	Enrichment	TBK1	1.48
227	Genetic motor neuron disease	Enrichment	MFN2	1.48
228	Gastric cancer	Enrichment	ATM	1.46
229	Hemoglobin e disease	Enrichment	HBB	1.46
230	Sickle cell-hemoglobin c disease	Enrichment	HBB	1.46
231	Hemoglobin d disease	Enrichment	HBB	1.46
232	Delta beta-thalassemia	Enrichment	HBB	1.46
233	Unstable hemoglobin disease	Enrichment	HBB	1.46
234	Hemoglobin e/beta thalassemia disease	Enrichment	HBB	1.46
235	Hereditary breast carcinoma	Enrichment	ATM	1.45
236	Short-rib thoracic dysplasia 3 with or without polydactyly	Enrichment	DYNC1H1	1.42
237	Congenital hypothyroidism	Enrichment	TUBB1	1.42
238	Glaucoma, primary open angle	Enrichment	OPTN	1.41
239	Thrombocytopenia	Enrichment	SRC, TUBB1	1.39
240	Alzheimer's disease	Enrichment	VCP	1.38
241	Albinism, oculocutaneous, type vii	Enrichment	WDR45	1.38
242	Basal ganglia calcification	Enrichment	WDR45	1.38
243	Autosomal dominant non-syndromic intellectual disability	Enrichment	CSNK2B, DYNC1H1	1.36
244	Hereditary breast ovarian cancer syndrome	Enrichment	ATM	1.36
245	Lung cancer susceptibility 3	Enrichment	PRKN	1.35
246	Seckel syndrome	Enrichment	PCNT	1.35
247	Hereditary chronic pancreatitis	Enrichment	CFTR	1.35
248	Myeloma, multiple	Enrichment	ATM	1.35
249	Myelofibrosis	Enrichment	SRC	1.34
250	Early-onset autosomal dominant alzheimer disease	Enrichment	TOMM40	1.34
251	Sickle cell disease	Enrichment	HBB	1.33
252	Beta-thalassemia, dominant inclusion body type	Enrichment	HBB	1.33
253	Erythrocytosis, familial, 6	Enrichment	HBB	1.33
254	Beta-thalassemia intermedia	Enrichment	HBB	1.33
255	Hemoglobinopathy	Enrichment	HBB	1.33
256	Hemoglobin c disease	Enrichment	HBB	1.33
257	Hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome	Enrichment	HBB	1.33
258	Methemoglobinemia, beta-globin type	Enrichment	HBB	1.33
259	Corpus callosum, agenesis of	Enrichment	TUBA1A	1.32
260	Lynch syndrome	Enrichment	CFTR	1.32
261	Isolated corpus callosum agenesis	Enrichment	TUBA1A	1.32
262	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	TUBA1A	1.32
263	Microcephaly	Enrichment	DYNC1H1, MFN2, TUBB4A	1.32
264	Isolated congenital microcephaly	Enrichment	TUBA3E	1.30
265	Cataract 6, multiple types	Enrichment	CHMP4B	1.28
266	Alzheimer disease, familial, 1	Enrichment	VCP	1.27
267	Pancreatitis, hereditary	Enrichment	CFTR	1.27
268	Dandy-walker syndrome	Enrichment	TUBA1A	1.27
269	Charcot-marie-tooth disease type 4	Enrichment	DYNC1H1	1.25
270	Thalassemia	Enrichment	HBB	1.24
271	Hereditary persistence of fetal hemoglobin-sickle cell disease syndrome	Enrichment	HBB	1.24
272	Breast cancer	Enrichment	ATM	1.23
273	Parkinson's disease	Enrichment	PRKN	1.22
274	Myopathy, centronuclear, 1	Enrichment	MTMR14	1.20
275	Keratoconus	Enrichment	TSC1	1.20
276	Breast adenocarcinoma	Enrichment	RB1CC1	1.20
277	Colorectal cancer	Enrichment	ATM	1.17
278	Metachromatic leukodystrophy	Enrichment	GFAP	1.16
279	Methemoglobinemia, beta type	Enrichment	HBB	1.16
280	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.14
281	Semantic dementia	Enrichment	CHMP2B	1.14
282	Polycystic kidney disease 1	Enrichment	TSC2	1.14
283	Overgrowth syndrome	Enrichment	MTOR	1.14
284	Parkinson disease, late-onset	Enrichment	PRKN	1.12
285	Ovarian cancer	Enrichment	ATM	1.10
286	Beta-thalassemia	Enrichment	HBB	1.10
287	Beta-thalassemia major	Enrichment	HBB	1.10
288	Hemolytic anemia	Enrichment	HBB	1.10
289	Early-onset posterior polar cataract	Enrichment	CHMP4B	1.08
290	Osteoporosis	Enrichment	SRC	1.05
291	Heinz body anemias	Enrichment	HBB	1.04
292	Fetal hemoglobin quantitative trait locus 1	Enrichment	HBB	1.04
293	Heinz body anemia	Enrichment	HBB	1.04
294	Isolated joubert syndrome	Enrichment	ARL13B	1.03
295	Lung cancer	Enrichment	PRKN	1.01
296	Cystic fibrosis	Enrichment	CFTR	1.01
297	Alpha-thalassemia	Enrichment	HBB	0.99
298	Inherited cancer-predisposing syndrome	Enrichment	ATM	0.99
299	Male infertility	Enrichment	CFTR	0.98
300	Beckwith-wiedemann syndrome	Enrichment	MFN2	0.95
301	Fetal akinesia deformation sequence 1	Enrichment	TUBA1A	0.95
302	Myopathy	Enrichment	DYNC1H1	0.91
303	Optic atrophy plus syndrome	Enrichment	TUBB6	0.87
304	Protein-deficiency anemia	Enrichment	HBB	0.84
305	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	0.83
306	Kidney disease	Enrichment	TSC1	0.83
307	Rare genetic intellectual disability	Enrichment	MTOR	0.83
308	Joubert syndrome 1	Enrichment	ARL13B	0.82
309	Spastic ataxia	Enrichment	TUBB3	0.80
310	Atypical hemolytic-uremic syndrome	Enrichment	HBB	0.79
311	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	0.78
312	Schizophrenia	Enrichment	PRKN	0.76
313	Autism	Enrichment	PRKN, WDR45	0.75
314	Williams-beuren syndrome	Enrichment	VPS37D	0.67
315	Systemic lupus erythematosus	Enrichment	UBE2L3	0.64
316	Malaria	Enrichment	HBB	0.62
317	Scoliosis	Enrichment	GFAP	0.61
318	Leber plus disease	Enrichment	TUBB4B	0.57
319	Dystonia	Enrichment	WDR45	0.50
320	Left ventricular noncompaction	Enrichment	LAMP2	0.47
321	Primary ovarian insufficiency	Enrichment	ATG9B	0.33
322	Retinitis pigmentosa	Enrichment	IFT88	0.30
323	Complex neurodevelopmental disorder	Enrichment	CSNK2A1	0.25
324	Dilated cardiomyopathy	Enrichment	LAMP2	0.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Selective autophagy

Pathway Network for Selective autophagy

Pathway network for the Selective autophagy SuperPath

Member Pathways for Selective autophagy

Pathways in the Selective autophagy SuperPath

Gene overlap in member pathways for Selective autophagy SuperPath

Associated Genes for Selective autophagy

Associated Disorders for Selective autophagy

Disorders associated with Selective autophagy SuperPath

STRING Interaction Network for Selective autophagy

Sources for Selective autophagy