Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

No Pathway Network information available for Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

Pathways in the Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics	PharmGKB	ADCY1 ADCY2 DDC GNAI1 GNAI2 GNAI3 GNAQ GNAS HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2C HTR3A HTR4 HTR6 HTR7 MAOA PLCB1 PLCB2 PLCB3 PLCB4 SLC18A2 SLC6A4 TPH1 TPH2 (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TPH1	Tryptophan Hydroxylase 1	Protein Coding	1
2	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	1
3	SLC18A2	Solute Carrier Family 18 Member A2	Protein Coding	1
4	MAOA	Monoamine Oxidase A	Protein Coding	1
5	PLCB1	Phospholipase C Beta 1	Protein Coding	1
6	DDC	Dopa Decarboxylase	Protein Coding	1
7	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	1
8	HTR1B	5-Hydroxytryptamine Receptor 1B	Protein Coding	1
9	HTR1D	5-Hydroxytryptamine Receptor 1D	Protein Coding	1
10	HTR1E	5-Hydroxytryptamine Receptor 1E	Protein Coding	1
11	HTR1F	5-Hydroxytryptamine Receptor 1F	Protein Coding	1
12	HTR2A	5-Hydroxytryptamine Receptor 2A	Protein Coding	1
13	HTR2C	5-Hydroxytryptamine Receptor 2C	Protein Coding	1
14	HTR3A	5-Hydroxytryptamine Receptor 3A	Protein Coding	1
15	HTR4	5-Hydroxytryptamine Receptor 4	Protein Coding	1
16	HTR6	5-Hydroxytryptamine Receptor 6	Protein Coding	1
17	HTR7	5-Hydroxytryptamine Receptor 7	Protein Coding	1
18	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
19	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
20	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
21	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
22	GNAS	GNAS Complex Locus	Protein Coding	1
23	PLCB2	Phospholipase C Beta 2	Protein Coding	1
24	PLCB3	Phospholipase C Beta 3	Protein Coding	1
25	PLCB4	Phospholipase C Beta 4	Protein Coding	1
26	ADCY1	Adenylate Cyclase 1	Protein Coding	1
27	ADCY2	Adenylate Cyclase 2	Protein Coding	1
28	TPH2	Tryptophan Hydroxylase 2	Protein Coding	1

Disorders associated with Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Obsessive-compulsive disorder	Enrichment	HTR2A, SLC6A4	5.39
2	Auriculocondylar syndrome 1	Enrichment	GNAI3, PLCB4	4.61
3	Major depressive disorder	Enrichment	HTR2A, TPH2	4.39
4	Melanoma, uveal	Enrichment	GNAQ, PLCB4	4.21
5	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.69
6	Osseous heteroplasia, progressive	Enrichment	GNAS	2.69
7	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.69
8	Sturge-weber syndrome	Enrichment	GNAQ	2.69
9	Ventricular tachycardia, familial	Enrichment	GNAI2	2.69
10	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.69
11	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.69
12	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.69
13	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.69
14	Brunner syndrome	Enrichment	MAOA	2.69
15	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.69
16	Periodic fever, menstrual cycle-dependent	Enrichment	HTR1A	2.69
17	Disorders of gnas inactivation	Enrichment	GNAS	2.69
18	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.69
19	Monostotic fibrous dysplasia	Enrichment	GNAS	2.69
20	Mazabraud syndrome	Enrichment	GNAS	2.69
21	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.38
22	Major affective disorder 1	Enrichment	TPH2	2.38
23	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.38
24	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.38
25	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.38
26	Aromatic l-amino acid decarboxylase deficiency	Enrichment	DDC	2.38
27	Parkinsonism-dystonia 2, infantile-onset	Enrichment	SLC18A2	2.38
28	Pseudohypoparathyroidism	Enrichment	GNAS	2.38
29	Ocular melanoma	Enrichment	PLCB4	2.38
30	Hypopituitarism	Enrichment	GNAI2	2.38
31	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.38
32	Phakomatosis cesioflammea	Enrichment	GNAQ	2.38
33	Mccune-albright syndrome	Enrichment	GNAS	2.21
34	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.21
35	Anastomosing haemangioma	Enrichment	GNAQ	2.21
36	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	2.08
37	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	2.08
38	Achromatopsia 4	Enrichment	GNAI3	2.08
39	Capillary malformations, congenital	Enrichment	GNAQ	1.99
40	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.91
41	Anxiety	Enrichment	SLC6A4	1.91
42	Brachydactyly	Enrichment	GNAS	1.84
43	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.79
44	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.73
45	Primary hyperaldosteronism	Enrichment	GNAS	1.73
46	Rasopathy	Enrichment	DDC	1.28
47	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	1.09
48	Centralopathic epilepsy	Enrichment	PLCB1	1.07
49	West syndrome	Enrichment	PLCB1	1.06
50	Body mass index quantitative trait locus 11	Enrichment	GNAS	1.01
51	Schizophrenia	Enrichment	HTR2A	0.94
52	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.77

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

Pathway Network for Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

Member Pathways for Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

Pathways in the Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics SuperPath

Associated Genes for Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

Associated Disorders for Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

Disorders associated with Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics SuperPath

STRING Interaction Network for Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

Sources for Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics