Selenium Metabolism and Selenoproteins

No Pathway Network information available for Selenium Metabolism and Selenoproteins

Pathways in the Selenium Metabolism and Selenoproteins SuperPath

#	Name	Source	Genes
1	Selenium Metabolism and Selenoproteins	WikiPathways	DIO1 DIO2 DIO3 EEFSEC FABP1 FOS GPX1 GPX2 GPX3 GPX4 GPX6 JUN MSRB1 NFKB1 RELA RPL30 SARS2 SCLY SELENBP1 SELENOH SELENOI SELENOK SELENOM SELENON SELENOO SELENOP SELENOS SELENOT SELENOV SELENOW SEPHS2 SEPSECS SP3 TRNAU1AP TXNRD1 TXNRD2 TXNRD3 (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SELENOI	Selenoprotein I	Protein Coding	1
2	SELENBP1	Selenium Binding Protein 1	Protein Coding	1
3	TXNRD1	Thioredoxin Reductase 1	Protein Coding	1
4	SELENOW	Selenoprotein W	Protein Coding	1
5	SELENOP	Selenoprotein P	Protein Coding	1
6	EEFSEC	Eukaryotic Elongation Factor, Selenocysteine-TRNA Specific	Protein Coding	1
7	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
8	SELENON	Selenoprotein N	Protein Coding	1
9	SELENOS	Selenoprotein S	Protein Coding	1
10	SARS2	Seryl-TRNA Synthetase 2, Mitochondrial	Protein Coding	1
11	SEPSECS	Sep (O-Phosphoserine) TRNA:Sec (Selenocysteine) TRNA Synthase	Protein Coding	1
12	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
13	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
14	GPX4	Glutathione Peroxidase 4	Protein Coding	1
15	GPX3	Glutathione Peroxidase 3	Protein Coding	1
16	GPX2	Glutathione Peroxidase 2	Protein Coding	1
17	GPX1	Glutathione Peroxidase 1	Protein Coding	1
18	GPX6	Glutathione Peroxidase 6	Protein Coding	1
19	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
20	FABP1	Fatty Acid Binding Protein 1	Protein Coding	1
21	DIO3	Iodothyronine Deiodinase 3	Protein Coding	1
22	DIO2	Iodothyronine Deiodinase 2	Protein Coding	1
23	DIO1	Iodothyronine Deiodinase 1	Protein Coding	1
24	SELENOM	Selenoprotein M	Protein Coding	1
25	TXNRD3	Thioredoxin Reductase 3	Protein Coding	1
26	TXNRD2	Thioredoxin Reductase 2	Protein Coding	1
27	SELENOO	Selenoprotein O	Protein Coding	1
28	SP3	Sp3 Transcription Factor	Protein Coding	1
29	RPL30	Ribosomal Protein L30	Protein Coding	1
30	SELENOK	Selenoprotein K	Protein Coding	1
31	TRNAU1AP	TRNA Selenocysteine 1 Associated Protein 1	Protein Coding	1
32	MSRB1	Methionine Sulfoxide Reductase B1	Protein Coding	1
33	SELENOT	Selenoprotein T	Protein Coding	1
34	SCLY	Selenocysteine Lyase	Protein Coding	1
35	SELENOV	Selenoprotein V	Protein Coding	1
36	SELENOH	Selenoprotein H	Protein Coding	1
37	SEPHS2	Selenophosphate Synthetase 2	Protein Coding	1

Disorders associated with Selenium Metabolism and Selenoproteins SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Spondylometaphyseal dysplasia, sedaghatian type	Enrichment	GPX4	2.56
2	Glucocorticoid deficiency 5	Enrichment	TXNRD2	2.56
3	Glutathione peroxidase deficiency	Enrichment	GPX1	2.56
4	Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome	Enrichment	SARS2	2.56
5	Spastic paraplegia 81, autosomal recessive	Enrichment	SELENOI	2.56
6	Thyroid hormone metabolism, abnormal, 2	Enrichment	DIO1	2.56
7	Extraoral halitosis due to methanethiol oxidase deficiency	Enrichment	SELENBP1	2.56
8	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.26
9	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.26
10	Rela fusion-positive ependymoma	Enrichment	RELA	2.26
11	Common variable immunodeficiency 12	Enrichment	NFKB1	2.26
12	Microcephaly, postnatal progressive, with seizures and brain atrophy	Enrichment	EEFSEC	2.09
13	Neurodevelopmental disorder with progressive spasticity and brain abnormalities	Enrichment	EEFSEC	2.09
14	Kyphosis	Enrichment	SEPSECS	2.09
15	Congenital generalized lipodystrophy	Enrichment	FOS	1.96
16	Congenital myopathy 3 with rigid spine	Enrichment	SELENON	1.87
17	Pontocerebellar hypoplasia, type 2d	Enrichment	SEPSECS	1.87
18	Spastic diplegia	Enrichment	SEPSECS	1.87
19	Histiocytoid hemangioma	Enrichment	FOS	1.87
20	Familial glucocorticoid deficiency	Enrichment	TXNRD2	1.87
21	Autosomal recessive intellectual developmental disorder	Enrichment	EEFSEC	1.79
22	Pontocerebellar hypoplasia, type 2e	Enrichment	SEPSECS	1.72
23	Common variable immunodeficiency	Enrichment	NFKB1	1.72
24	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.57
25	Congenital myopathy 4a, autosomal dominant	Enrichment	SELENON	1.40
26	Pontocerebellar hypoplasia	Enrichment	SEPSECS	1.32
27	Muscular dystrophy	Enrichment	SELENON	1.20
28	Distal arthrogryposis	Enrichment	SEPSECS	0.96
29	Spastic ataxia	Enrichment	SEPSECS	0.87
30	Familial isolated dilated cardiomyopathy	Enrichment	TXNRD2	0.87
31	Autosomal recessive non-syndromic intellectual disability	Enrichment	EEFSEC	0.83
32	Breast cancer	Enrichment	JUN	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Selenium Metabolism and Selenoproteins

Pathway Network for Selenium Metabolism and Selenoproteins

Member Pathways for Selenium Metabolism and Selenoproteins

Pathways in the Selenium Metabolism and Selenoproteins SuperPath

Associated Genes for Selenium Metabolism and Selenoproteins

Associated Disorders for Selenium Metabolism and Selenoproteins

Disorders associated with Selenium Metabolism and Selenoproteins SuperPath

STRING Interaction Network for Selenium Metabolism and Selenoproteins

Sources for Selenium Metabolism and Selenoproteins