Semaphorin interactions

Pathway network for the Semaphorin interactions SuperPath

Sources:

Reactome
QIAGEN

Pathways in the Semaphorin interactions SuperPath

#	Name	Source	Genes
1	Semaphorin interactions	Reactome	ARHGAP35 ARHGEF11 ARHGEF12 CD72 CDK5 CDK5R1 CFL1 CRMP1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 ERBB2 FARP2 FES FYN GSK3B HSP90AA1 HSP90AB1 ITGA1 ITGB1 LIMK1 LIMK2 MET MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 NRP1 PAK1 PAK2 PAK3 PIP5K1C PLXNA1 PLXNA2 PLXNA3 PLXNA4 PLXNB1 PLXNB3 PLXNC1 PLXND1 PTPRC RAC1 RHOA RHOB RHOC RND1 ROCK1 ROCK2 RRAS SEMA3A SEMA3E SEMA4A SEMA4D SEMA5A SEMA6A SEMA6D SEMA7A TLN1 TREM2 TYROBP (see all 64) (see less)
2	Semaphorin Signaling	QIAGEN	ARHGEF12 CDK5 CFL1 CFL2 CRMP1 DIRAS3 DPYSL5 FES FYN ITGB1 LIMK1 LIMK2 MAPK1 MAPK12 MAPK3 MAPK6 MAPK7 MET NRP1 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PLXNB1 PTK2 PTK2B RAC1 RAC2 RAC3 RHOA RHOB RHOC RHOD RHOG RHOH RND1 RND2 RND3 ROCK1 ROCK2 SEMA3A SEMA4D SEMA7A (see all 45) (see less)
3	Sema4D in semaphorin signaling	Reactome	ARHGAP35 ARHGEF11 ARHGEF12 ERBB2 LIMK1 LIMK2 MET MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 PLXNB1 RAC1 RHOA RHOB RHOC RND1 ROCK1 ROCK2 RRAS SEMA4D (see all 24) (see less)
4	RHO GTPases activate PAKs	Reactome	CALM1 CALM2 CALM3 CDC42 CTTN FLNA LIMK1 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLK NF2 PAK1 PAK2 PAK3 PPP1CB PPP1R12A PPP1R12B RAC1 (see all 23) (see less)
5	Sema4D induced cell migration and growth-cone collapse	Reactome	ARHGEF11 ARHGEF12 ERBB2 LIMK1 LIMK2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 PLXNB1 RHOA RHOB RHOC RND1 ROCK1 ROCK2 SEMA4D (see all 20) (see less)
6	RHO GTPases activate CIT	Reactome	CDKN1B CIT DLG4 KIF14 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 PPP1CB PPP1R12A PPP1R12B PRC1 RAC1 RHOA RHOB RHOC (see all 19) (see less)
7	Other semaphorin interactions	Reactome	CD72 ITGA1 ITGB1 PLXNA1 PLXNA2 PLXNA4 PLXNB3 PLXNC1 PLXND1 PTPRC SEMA3E SEMA4A SEMA4D SEMA5A SEMA6A SEMA6D SEMA7A TREM2 TYROBP (see all 19) (see less)
8	RHO GTPases Activate ROCKs	Reactome	CFL1 LIMK1 LIMK2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 PAK1 PPP1CB PPP1R12A PPP1R12B RHOA RHOB RHOC ROCK1 ROCK2 (see all 19) (see less)
9	Sema3A PAK dependent Axon repulsion	Reactome	CFL1 FES FYN HSP90AA1 HSP90AB1 LIMK1 NRP1 PAK1 PAK2 PAK3 PLXNA1 PLXNA2 PLXNA3 PLXNA4 RAC1 SEMA3A (see all 16) (see less)
10	CRMPs in Sema3A signaling	Reactome	CDK5 CDK5R1 CRMP1 DPYSL2 DPYSL3 DPYSL4 DPYSL5 FES FYN GSK3B NRP1 PLXNA1 PLXNA2 PLXNA3 PLXNA4 SEMA3A (see all 16) (see less)
11	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	Reactome	FARP2 FES FYN NRP1 PIP5K1C PLXNA1 PLXNA2 PLXNA3 PLXNA4 RAC1 RND1 RRAS SEMA3A TLN1 (see all 14) (see less)
12	Sema4D mediated inhibition of cell attachment and migration	Reactome	ARHGAP35 MET PLXNB1 RAC1 RHOA RND1 RRAS SEMA4D (see all 8) (see less)

Gene overlap in member pathways for Semaphorin interactions SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RAC1	Rac Family Small GTPase 1	Protein Coding	8
2	RHOA	Ras Homolog Family Member A	Protein Coding	7
3	LIMK1	LIM Domain Kinase 1	Protein Coding	7
4	MYL12B	Myosin Light Chain 12B	Protein Coding	6
5	MYL9	Myosin Light Chain 9	Protein Coding	6
6	SEMA4D	Semaphorin 4D	Protein Coding	6
7	RND1	Rho Family GTPase 1	Protein Coding	6
8	RHOB	Ras Homolog Family Member B	Protein Coding	6
9	RHOC	Ras Homolog Family Member C	Protein Coding	6
10	MYH9	Myosin Heavy Chain 9	Protein Coding	6
11	MYH10	Myosin Heavy Chain 10	Protein Coding	6
12	MYH11	Myosin Heavy Chain 11	Protein Coding	6
13	MYL6	Myosin Light Chain 6	Protein Coding	6
14	MYH14	Myosin Heavy Chain 14	Protein Coding	6
15	SEMA3A	Semaphorin 3A	Protein Coding	5
16	FES	FES Proto-Oncogene, Tyrosine Kinase	Protein Coding	5
17	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	5
18	LIMK2	LIM Domain Kinase 2	Protein Coding	5
19	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	5
20	PLXNA1	Plexin A1	Protein Coding	5
21	PLXNA2	Plexin A2	Protein Coding	5
22	PLXNB1	Plexin B1	Protein Coding	5
23	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	5
24	NRP1	Neuropilin 1	Protein Coding	5
25	PLXNA4	Plexin A4	Protein Coding	5
26	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	5
27	CFL1	Cofilin 1	Protein Coding	4
28	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	4
29	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	4
30	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	4
31	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	4
32	PLXNA3	Plexin A3	Protein Coding	4
33	RRAS	RAS Related	Protein Coding	4
34	CDK5	Cyclin Dependent Kinase 5	Protein Coding	3
35	CRMP1	Collapsin Response Mediator Protein 1	Protein Coding	3
36	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	3
37	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	3
38	ITGB1	Integrin Subunit Beta 1	Protein Coding	3
39	DPYSL5	Dihydropyrimidinase Like 5	Protein Coding	3
40	SEMA7A	Semaphorin 7A (JohnMiltonHagen Blood Group)	Protein Coding	3
41	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	3
42	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	3
43	PPP1R12B	Protein Phosphatase 1 Regulatory Subunit 12B	Protein Coding	3
44	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	3
45	PLXNC1	Plexin C1	Protein Coding	2
46	DPYSL4	Dihydropyrimidinase Like 4	Protein Coding	2
47	DPYSL2	Dihydropyrimidinase Like 2	Protein Coding	2
48	DPYSL3	Dihydropyrimidinase Like 3	Protein Coding	2
49	PLXND1	Plexin D1	Protein Coding	2
50	PIP5K1C	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Gamma	Protein Coding	2
51	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	2
52	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	2
53	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	2
54	ITGA1	Integrin Subunit Alpha 1	Protein Coding	2
55	PLXNB3	Plexin B3	Protein Coding	2
56	TREM2	Triggering Receptor Expressed On Myeloid Cells 2	Protein Coding	2
57	SEMA6A	Semaphorin 6A	Protein Coding	2
58	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	2
59	SEMA4A	Semaphorin 4A	Protein Coding	2
60	TLN1	Talin 1	Protein Coding	2
61	TYROBP	Transmembrane Immune Signaling Adaptor TYROBP	Protein Coding	2
62	SEMA6D	Semaphorin 6D	Protein Coding	2
63	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	2
64	SEMA5A	Semaphorin 5A	Protein Coding	2
65	CD72	CD72 Molecule	Protein Coding	2
66	SEMA3E	Semaphorin 3E	Protein Coding	2
67	FARP2	FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2	Protein Coding	2
68	RHOD	Ras Homolog Family Member D	Protein Coding	1
69	RND3	Rho Family GTPase 3	Protein Coding	1
70	RHOG	Ras Homolog Family Member G	Protein Coding	1
71	RHOH	Ras Homolog Family Member H	Protein Coding	1
72	DIRAS3	DIRAS Family GTPase 3	Protein Coding	1
73	RND2	Rho Family GTPase 2	Protein Coding	1
74	CFL2	Cofilin 2	Protein Coding	1
75	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
76	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
77	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
78	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
79	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
80	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	1
81	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	1
82	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	1
83	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
84	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
85	RAC2	Rac Family Small GTPase 2	Protein Coding	1
86	RAC3	Rac Family Small GTPase 3	Protein Coding	1
87	CTTN	Cortactin	Protein Coding	1
88	FLNA	Filamin A	Protein Coding	1
89	MYLK	Myosin Light Chain Kinase	Protein Coding	1
90	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	1
91	CALM1	Calmodulin 1	Protein Coding	1
92	CALM2	Calmodulin 2	Protein Coding	1
93	CALM3	Calmodulin 3	Protein Coding	1
94	CDC42	Cell Division Cycle 42	Protein Coding	1
95	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
96	CIT	Citron Rho-Interacting Serine/Threonine Kinase	Protein Coding	1
97	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	1
98	PRC1	Protein Regulator Of Cytokinesis 1	Protein Coding	1
99	KIF14	Kinesin Family Member 14	Protein Coding	1

Disorders associated with Semaphorin interactions SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	6.62
2	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1	Enrichment	TREM2, TYROBP	5.73
3	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYH11, MYLK	4.78
4	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	4.78
5	Visceral myopathy 1	Enrichment	MYH11, MYLK	4.56
6	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	FLNA, MYH11, MYLK	4.27
7	Familial thoracic aortic aneurysm and dissection	Enrichment	MYH11, MYLK	4.01
8	Aortic aneurysm, familial thoracic 1	Enrichment	MYH11, MYLK	3.61
9	Osteofibrous dysplasia	Enrichment	MET	3.23
10	Deafness, autosomal recessive 97	Enrichment	MET	3.23
11	Autism 9	Enrichment	MET	3.23
12	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	3.23
13	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	3.23
14	Arthrogryposis, distal, type 11	Enrichment	MET	3.23
15	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	3.23
16	Primary autosomal recessive microcephaly	Enrichment	CIT, KIF14	3.05
17	Hypogonadotropic hypogonadism 16 with or without anosmia	Enrichment	SEMA3A	2.99
18	Dworschak-punetha neurodevelopmental syndrome	Enrichment	PLXNA1	2.99
19	Capillary leak syndrome	Enrichment	TLN1	2.99
20	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.93
21	Childhood hepatocellular carcinoma	Enrichment	MET	2.93
22	Papillary renal cell carcinoma	Enrichment	MET	2.93
23	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.93
24	Knobloch syndrome 2	Enrichment	PAK2	2.93
25	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.93
26	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.93
27	Ritscher-schinzel syndrome 4	Enrichment	DPYSL5	2.93
28	Long qt syndrome	Enrichment	CALM1, CALM2	2.91
29	Deafness, autosomal dominant 17	Enrichment	MYH9	2.85
30	Deafness, autosomal dominant 4a	Enrichment	MYH14	2.85
31	Neuroendocrine tumor	Enrichment	CDKN1B	2.85
32	Peripheral neuropathy, myopathy, hoarseness, and hearing loss	Enrichment	MYH14	2.85
33	Microcephaly 20, primary, autosomal recessive	Enrichment	KIF14	2.85
34	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.85
35	Meckel syndrome 12	Enrichment	KIF14	2.85
36	Autosomal dominant nonsyndromic hearing loss 17	Enrichment	MYH9	2.85
37	Cone-rod dystrophy 10	Enrichment	SEMA4A	2.85
38	Cholestasis, progressive familial intrahepatic, 11	Enrichment	SEMA7A	2.85
39	Retinitis pigmentosa 35	Enrichment	SEMA4A	2.85
40	Blood group, john milton hagen system	Enrichment	SEMA7A	2.85
41	Alzheimer disease 17	Enrichment	TREM2	2.85
42	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.85
43	Cd45 deficiency	Enrichment	PTPRC	2.85
44	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2	Enrichment	TREM2	2.85
45	Lung cancer	Enrichment	ERBB2, MET	2.84
46	Paget disease, extramammary	Enrichment	ERBB2	2.83
47	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.83
48	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.83
49	Otopalatodigital syndrome, type i	Enrichment	FLNA	2.77
50	Intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked	Enrichment	FLNA	2.77
51	Schwannomatosis, vestibular	Enrichment	NF2	2.77
52	Terminal osseous dysplasia	Enrichment	FLNA	2.77
53	Fg syndrome 2	Enrichment	FLNA	2.77
54	Otopalatodigital syndrome spectrum disorder	Enrichment	FLNA	2.77
55	Long qt syndrome 16	Enrichment	CALM3	2.77
56	X-linked ehlers-danlos syndrome	Enrichment	FLNA	2.77
57	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.77
58	Long qt syndrome 15	Enrichment	CALM2	2.77
59	Acoustic neuroma	Enrichment	NF2	2.77
60	Nocarh syndrome	Enrichment	CDC42	2.77
61	X-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome	Enrichment	FLNA	2.77
62	Renal cell carcinoma	Enrichment	MET	2.75
63	Lethal congenital contracture syndrome 3	Enrichment	PIP5K1C	2.69
64	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MYH14, MYH9	2.63
65	Complex neurodevelopmental disorder	Enrichment	DPYSL5, MYH10, PAK3, PLXNA1	2.56
66	Aortic aneurysm, familial thoracic 4	Enrichment	MYH11	2.55
67	Cataract 35	Enrichment	MYH9	2.55
68	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.55
69	Megacystis-microcolon-intestinal hypoperistalsis syndrome 2	Enrichment	MYH11	2.55
70	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	2.55
71	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	2.55
72	Vulto-van silfhout-de vries syndrome	Enrichment	DLG4	2.55
73	Pseudosarcomatous fibromatosis	Enrichment	MYH9	2.55
74	Visceral myopathy 2	Enrichment	MYH11	2.55
75	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	2.55
76	Cri-du-chat syndrome	Enrichment	SEMA5A	2.55
77	Sveinsson chorioretinal atrophy	Enrichment	SEMA4A	2.55
78	Congenital heart defects, multiple types, 9	Enrichment	PLXND1	2.55
79	Delayed puberty, self-limited	Enrichment	SEMA6A	2.55
80	Immunodeficiency 104, severe combined	Enrichment	PTPRC	2.55
81	Martsolf syndrome 1	Enrichment	ARHGAP35	2.53
82	Cholangitis, primary sclerosing	Enrichment	SEMA4D	2.53
83	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.48
84	Noonan syndrome 13	Enrichment	MAPK1	2.48
85	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.48
86	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.48
87	Nemaline myopathy 7	Enrichment	CFL2	2.48
88	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.48
89	Immunodeficiency 129	Enrichment	RHOH	2.48
90	T-cell immunodeficiency with epidermodysplasia verruciformis	Enrichment	RHOH	2.48
91	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.48
92	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.48
93	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.48
94	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	FLNA	2.47
95	Otopalatodigital syndrome, type ii	Enrichment	FLNA	2.47
96	Melnick-needles syndrome	Enrichment	FLNA	2.47
97	Frontometaphyseal dysplasia 1	Enrichment	FLNA	2.47
98	Schwannomatosis 1	Enrichment	NF2	2.47
99	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.47
100	Long qt syndrome 14	Enrichment	CALM1	2.47
101	Cardiac valvular dysplasia, x-linked	Enrichment	FLNA	2.47
102	Immune system disease	Enrichment	CDC42	2.47
103	Hemihyperplasia, isolated	Enrichment	RHOA	2.45
104	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	2.45
105	Renal cell carcinoma, papillary, 1	Enrichment	MET	2.38
106	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	MYH9	2.38
107	Heart defects, congenital, and other congenital anomalies	Enrichment	DLG4	2.38
108	Intellectual developmental disorder, autosomal dominant 62	Enrichment	DLG4	2.38
109	Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizures	Enrichment	DLG4	2.38
110	Microcephaly 17, primary, autosomal recessive	Enrichment	CIT	2.38
111	Dlg4-related synaptopathy	Enrichment	DLG4	2.38
112	Tricuspid valve insufficiency	Enrichment	MYH11	2.38
113	Hypogonadotropic hypogonadism 5 with or without anosmia	Enrichment	SEMA3E	2.38
114	Arthrogryposis, distal, type 1a	Enrichment	MET	2.33
115	Knobloch syndrome	Enrichment	PAK2	2.33
116	Prune belly syndrome	Enrichment	FLNA	2.29
117	Arterial tortuosity syndrome	Enrichment	FLNA	2.29
118	Periventricular nodular heterotopia 1	Enrichment	FLNA	2.29
119	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	2.29
120	Congenital short bowel syndrome	Enrichment	FLNA	2.29
121	Frontometaphyseal dysplasia	Enrichment	FLNA	2.29
122	Cellular ependymoma	Enrichment	NF2	2.29
123	Tanycytic ependymoma	Enrichment	NF2	2.29
124	Papillary ependymoma	Enrichment	NF2	2.29
125	Spindle cell sarcoma	Enrichment	NF2	2.29
126	Clear cell ependymoma	Enrichment	NF2	2.29
127	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.28
128	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DLG4	2.25
129	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	MYH11	2.25
130	Mitral valve insufficiency	Enrichment	MYH11	2.25
131	Primary hyperparathyroidism	Enrichment	CDKN1B	2.25
132	Peters-plus syndrome	Enrichment	ARHGAP35	2.23
133	Knobloch syndrome 1	Enrichment	PAK2	2.23
134	Barrett esophagus	Enrichment	ERBB2	2.23
135	Scoliosis, isolated 1	Enrichment	MAPK7	2.18
136	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.17
137	Full schwannomatosis	Enrichment	NF2	2.17
138	Benign ependymoma	Enrichment	NF2	2.17
139	Deafness, autosomal recessive 63	Enrichment	MYH9	2.16
140	Congenital ptosis	Enrichment	MYH10	2.16
141	Moebius syndrome	Enrichment	PLXND1	2.16
142	Persistent truncus arteriosus	Enrichment	PLXND1	2.16
143	Juvenile myelomonocytic leukemia	Enrichment	RRAS	2.15
144	Ritscher-schinzel syndrome 1	Enrichment	DPYSL5	2.15
145	Hemangioma, capillary infantile	Enrichment	MYH9	2.08
146	Intestinal pseudo-obstruction	Enrichment	MYH11	2.08
147	Renal cell carcinoma, nonpapillary	Enrichment	MET	2.05
148	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	2.01
149	Semantic dementia	Enrichment	TREM2	2.01
150	Early-onset autosomal dominant alzheimer disease	Enrichment	TREM2	2.01
151	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.99
152	Patent ductus arteriosus	Enrichment	FLNA	1.99
153	Colorectal cancer	Enrichment	ERBB2, MET	1.99
154	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MET, MYH9	1.97
155	Glioma susceptibility 1	Enrichment	ERBB2	1.93
156	Charge syndrome	Enrichment	SEMA3E	1.90
157	Progressive non-fluent aphasia	Enrichment	TREM2	1.90
158	Behavioral variant of frontotemporal dementia	Enrichment	TREM2	1.90
159	Hepatocellular carcinoma	Enrichment	MET	1.89
160	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.88
161	Fanconi anemia, complementation group c	Enrichment	FLNA	1.87
162	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.87
163	Noonan syndrome 1	Enrichment	RRAS	1.87
164	Ovarian cancer	Enrichment	ERBB2, MET	1.87
165	Frontotemporal dementia 1	Enrichment	TREM2	1.82
166	Familial colorectal cancer type x	Enrichment	SEMA4A	1.82
167	Lung non-small cell carcinoma	Enrichment	ERBB2	1.79
168	Mosaic variegated aneuploidy syndrome 1	Enrichment	PAK6	1.78
169	Microphthalmia/coloboma 12	Enrichment	MYH10	1.74
170	Neural tube defects	Enrichment	ITGB1	1.74
171	Meningioma, familial	Enrichment	NF2	1.73
172	Typical nemaline myopathy	Enrichment	CFL2	1.70
173	Meningioma	Enrichment	NF2	1.70
174	Lung cancer susceptibility 3	Enrichment	ERBB2	1.69
175	Coloboma of macula	Enrichment	MYH10	1.68
176	Myopia	Enrichment	MYH11	1.68
177	Hypertension	Enrichment	MYH9	1.65
178	Williams-beuren syndrome	Enrichment	LIMK1	1.63
179	Periventricular nodular heterotopia	Enrichment	FLNA	1.63
180	Kallmann syndrome	Enrichment	SEMA3A	1.63
181	Dandy-walker syndrome	Enrichment	PPP1CB	1.63
182	Mosaic variegated aneuploidy syndrome	Enrichment	PAK6	1.58
183	Brugada syndrome	Enrichment	SEMA3A	1.58
184	Cleft palate, isolated	Enrichment	FLNA	1.55
185	Sudden infant death syndrome	Enrichment	CALM2	1.55
186	Cardiomyopathy, dilated, 1a	Enrichment	SEMA3E	1.54
187	Patent foramen ovale	Enrichment	FLNA	1.52
188	Rasopathy	Enrichment	PPP1CB	1.45
189	Specific learning disability	Enrichment	MAPK1	1.44
190	Bladder cancer	Enrichment	ERBB2	1.38
191	Hirschsprung disease 1	Enrichment	ERBB2	1.38
192	Severe combined immunodeficiency	Enrichment	PTPRC	1.34
193	Non-syndromic genetic deafness	Enrichment	MYH14	1.31
194	Nonsyndromic hearing loss	Enrichment	MYH14	1.24
195	Autosomal dominant non-syndromic intellectual disability	Enrichment	DPYSL2	1.24
196	Heart, malformation of	Enrichment	MAPK1	1.24
197	Gastric cancer	Enrichment	ERBB2	1.21
198	Microcephaly	Enrichment	MAPK1, PAK3	1.20
199	Undetermined early-onset epileptic encephalopathy	Enrichment	LIMK1	1.19
200	Thrombocytopenia	Enrichment	MYH9	1.19
201	Centronuclear myopathy	Enrichment	CFL2	1.17
202	Joubert syndrome 1	Enrichment	KIF14	1.17
203	Body mass index quantitative trait locus 11	Enrichment	MYH9	1.17
204	Hypertelorism	Enrichment	MYH10	1.15
205	Inherited cancer-predisposing syndrome	Enrichment	MET	1.12
206	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TREM2	1.11
207	Deafness, autosomal recessive	Enrichment	MYH9	1.07
208	Autosomal recessive nonsyndromic deafness	Enrichment	MYH9	1.07
209	Cone-rod dystrophy 2	Enrichment	SEMA4A	1.04
210	Rare genetic deafness	Enrichment	MYH9	0.98
211	Retinitis pigmentosa	Enrichment	SEMA4A	0.59
212	Hereditary retinal dystrophy	Enrichment	SEMA4A	0.47
213	Fundus dystrophy	Enrichment	SEMA4A	0.47

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Semaphorin interactions

Pathway Network for Semaphorin interactions

Pathway network for the Semaphorin interactions SuperPath

Member Pathways for Semaphorin interactions

Pathways in the Semaphorin interactions SuperPath

Gene overlap in member pathways for Semaphorin interactions SuperPath

Associated Genes for Semaphorin interactions

Associated Disorders for Semaphorin interactions

Disorders associated with Semaphorin interactions SuperPath

STRING Interaction Network for Semaphorin interactions

Sources for Semaphorin interactions