Senescence and autophagy in cancer

No Pathway Network information available for Senescence and autophagy in cancer

Pathways in the Senescence and autophagy in cancer SuperPath

#	Name	Source	Genes
1	Senescence and autophagy in cancer	WikiPathways	AKT1S1 AMBRA1 ATG10 ATG12 ATG13 ATG14 ATG16L1 ATG3 ATG5 ATG7 BCL2 BECN1 BMI1 BMP2 BRAF CCL3 CD44 CDC25B CDKN1A CDKN1B CDKN2A CEBPB COL10A1 COL1A1 COL3A1 CREG1 CXCL1 CXCL14 CXCL8 E2F1 FKBP8 FN1 GABARAP GABARAPL1 GABARAPL2 GSK3B GSN HMGA1 HRAS IFI16 IFNB1 IFNG IGF1 IGF1R IGFBP3 IGFBP5 IGFBP7 IL1A IL1B IL24 IL3 IL6 IL6R IL6ST ING1 ING2 INHBA INS IRF1 IRF5 IRF7 JUN KMT2A LAMP1 LAMP2 MAP1LC3A MAP1LC3B MAP1LC3C MAP2K1 MAP2K3 MAPK1 MAPK14 MDM2 MLST8 MMP14 MTOR PCNA PIK3C3 PLAT PLAU PTEN RAF1 RB1 RB1CC1 RNASEL RSL1D1 SERPINB2 SERPINE1 SH3GLB1 SLC39A1 SLC39A2 SLC39A3 SLC39A4 SMAD3 SMAD4 SPARC SQSTM1 SRC TGFB1 THBS1 TNFSF15 TP53 ULK1 UVRAG VTN (see all 105) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	1
2	TNFSF15	TNF Superfamily Member 15	Protein Coding	1
3	CDC25B	Cell Division Cycle 25B	Protein Coding	1
4	RB1CC1	RB1 Inducible Coiled-Coil 1	Protein Coding	1
5	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	1
6	CXCL14	C-X-C Motif Chemokine Ligand 14	Protein Coding	1
7	ATG5	Autophagy Related 5	Protein Coding	1
8	SQSTM1	Sequestosome 1	Protein Coding	1
9	CREG1	Cellular Repressor Of E1A Stimulated Genes 1	Protein Coding	1
10	BECN1	Beclin 1	Protein Coding	1
11	MAP1LC3A	Microtubule Associated Protein 1 Light Chain 3 Alpha	Protein Coding	1
12	AKT1S1	AKT1 Substrate 1	Protein Coding	1
13	ATG10	Autophagy Related 10	Protein Coding	1
14	MAP1LC3B	Microtubule Associated Protein 1 Light Chain 3 Beta	Protein Coding	1
15	VTN	Vitronectin	Protein Coding	1
16	TP53	Tumor Protein P53	Protein Coding	1
17	THBS1	Thrombospondin 1	Protein Coding	1
18	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
19	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
20	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
21	SPARC	Secreted Protein Acidic And Cysteine Rich	Protein Coding	1
22	BMP2	Bone Morphogenetic Protein 2	Protein Coding	1
23	BMI1	BMI1 Proto-Oncogene, Polycomb Ring Finger	Protein Coding	1
24	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	1
25	RNASEL	Ribonuclease L	Protein Coding	1
26	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
27	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
28	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
29	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
30	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
31	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
32	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
33	SLC39A4	Solute Carrier Family 39 Member 4	Protein Coding	1
34	AMBRA1	Autophagy And Beclin 1 Regulator 1	Protein Coding	1
35	ATG16L1	Autophagy Related 16 Like 1	Protein Coding	1
36	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
37	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	1
38	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
39	SERPINB2	Serpin Family B Member 2	Protein Coding	1
40	SERPINE1	Serpin Family E Member 1	Protein Coding	1
41	MMP14	Matrix Metallopeptidase 14	Protein Coding	1
42	KMT2A	Lysine Methyltransferase 2A	Protein Coding	1
43	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
44	SMAD4	SMAD Family Member 4	Protein Coding	1
45	SMAD3	SMAD Family Member 3	Protein Coding	1
46	LAMP2	Lysosomal Associated Membrane Protein 2	Protein Coding	1
47	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
48	IRF7	Interferon Regulatory Factor 7	Protein Coding	1
49	IRF5	Interferon Regulatory Factor 5	Protein Coding	1
50	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
51	INS	Insulin	Protein Coding	1
52	INHBA	Inhibin Subunit Beta A	Protein Coding	1
53	ING1	Inhibitor Of Growth Family Member 1	Protein Coding	1
54	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
55	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
56	IL6R	Interleukin 6 Receptor	Protein Coding	1
57	IL6	Interleukin 6	Protein Coding	1
58	IL3	Interleukin 3	Protein Coding	1
59	IL1B	Interleukin 1 Beta	Protein Coding	1
60	IL1A	Interleukin 1 Alpha	Protein Coding	1
61	IGFBP7	Insulin Like Growth Factor Binding Protein 7	Protein Coding	1
62	IGFBP5	Insulin Like Growth Factor Binding Protein 5	Protein Coding	1
63	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	1
64	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
65	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
66	IFNG	Interferon Gamma	Protein Coding	1
67	IFNB1	Interferon Beta 1	Protein Coding	1
68	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
69	HMGA1	High Mobility Group AT-Hook 1	Protein Coding	1
70	GSN	Gelsolin	Protein Coding	1
71	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
72	CXCL1	C-X-C Motif Chemokine Ligand 1	Protein Coding	1
73	SLC39A1	Solute Carrier Family 39 Member 1	Protein Coding	1
74	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
75	FN1	Fibronectin 1	Protein Coding	1
76	E2F1	E2F Transcription Factor 1	Protein Coding	1
77	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
78	COL10A1	Collagen Type X Alpha 1 Chain	Protein Coding	1
79	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	1
80	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
81	IL24	Interleukin 24	Protein Coding	1
82	ATG7	Autophagy Related 7	Protein Coding	1
83	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
84	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
85	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
86	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
87	ATG13	Autophagy Related 13	Protein Coding	1
88	ATG12	Autophagy Related 12	Protein Coding	1
89	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	1
90	GABARAPL2	GABA Type A Receptor Associated Protein Like 2	Protein Coding	1
91	GABARAP	GABA Type A Receptor-Associated Protein	Protein Coding	1
92	UVRAG	UV Radiation Resistance Associated	Protein Coding	1
93	ATG3	Autophagy Related 3	Protein Coding	1
94	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
95	SH3GLB1	SH3 Domain Containing GRB2 Like, Endophilin B1	Protein Coding	1
96	MAP1LC3C	Microtubule Associated Protein 1 Light Chain 3 Gamma	Protein Coding	1
97	LAMP1	Lysosomal Associated Membrane Protein 1	Protein Coding	1
98	ING2	Inhibitor Of Growth Family Member 2	Protein Coding	1
99	IFI16	Interferon Gamma Inducible Protein 16	Protein Coding	1
100	SLC39A2	Solute Carrier Family 39 Member 2	Protein Coding	1
101	SLC39A3	Solute Carrier Family 39 Member 3	Protein Coding	1
102	RSL1D1	Ribosomal L1 Domain Containing 1	Protein Coding	1
103	FKBP8	FKBP Prolyl Isomerase 8	Protein Coding	1
104	GABARAPL1	GABA Type A Receptor Associated Protein Like 1	Protein Coding	1
105	ATG14	Autophagy Related 14	Protein Coding	1

Disorders associated with Senescence and autophagy in cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lip and oral cavity carcinoma	Enrichment	BRAF, CDKN2A, HRAS, RB1, TP53	7.72
2	Bladder cancer	Enrichment	CDKN1A, CDKN2A, HRAS, PTEN, RB1, TP53	7.12
3	Gastric cancer	Enrichment	CDKN2A, IL1B, IRF1, PTEN, SMAD4, TP53	6.05
4	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, IRF1, MAP2K1	5.97
5	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, MAP2K1, RAF1	5.36
6	Acute megakaryocytic leukemia	Enrichment	KMT2A, PTEN, TP53	5.35
7	Li-fraumeni syndrome	Enrichment	CDKN2A, MDM2, TP53	5.05
8	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, PTEN	4.81
9	Squamous cell carcinoma, head and neck	Enrichment	ING1, PTEN, TP53	4.81
10	Gallbladder cancer	Enrichment	BRAF, SMAD4, TP53	4.81
11	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, PTEN	4.81
12	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, RAF1	4.61
13	Noonan syndrome 1	Enrichment	BRAF, HRAS, MAP2K1, RAF1	4.57
14	Rasopathy	Enrichment	BRAF, HRAS, MAP2K1, RAF1	4.35
15	Melanoma	Enrichment	BRAF, CDKN2A, PTEN	4.28
16	Ovarian cancer	Enrichment	CDKN1B, CDKN2A, PTEN, RB1, RNASEL, TP53	3.89
17	Lung cancer susceptibility 3	Enrichment	BRAF, RB1, TP53	3.81
18	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	3.75
19	Osteogenic sarcoma	Enrichment	RB1, TP53	3.75
20	Squamous cell carcinoma	Enrichment	RB1, TP53	3.75
21	Laryngeal squamous cell carcinoma	Enrichment	ING1, PTEN	3.75
22	Bone osteosarcoma	Enrichment	RB1, TP53	3.75
23	Rhabdomyosarcoma	Enrichment	HRAS, PTEN, TP53	3.63
24	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1	3.45
25	Small cell cancer of the lung	Enrichment	RB1, TP53	3.45
26	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF, TP53	3.45
27	Cardiofaciocutaneous syndrome	Enrichment	BRAF, MAP2K1	3.45
28	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.45
29	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1, COL3A1, SMAD3, SMAD4	3.44
30	Diffuse large b-cell lymphoma	Enrichment	BRAF, PTEN, TP53	3.40
31	Ehlers-danlos syndrome	Enrichment	COL1A1, COL3A1, SMAD3	3.40
32	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, CDKN2A, PTEN, RB1, SMAD4, TP53	3.26
33	Insulin-like growth factor i	Enrichment	IGF1, IGF1R	3.23
34	Hemimegalencephaly	Enrichment	MTOR, PTEN	3.23
35	Type 1 diabetes mellitus	Enrichment	IL6, INS	3.06
36	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	3.06
37	Breast adenocarcinoma	Enrichment	RB1CC1, TP53	3.06
38	Pancreatic cancer	Enrichment	CDKN2A, SMAD4, TP53	3.04
39	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	2.92
40	Noonan syndrome 3	Enrichment	HRAS, RAF1	2.92
41	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	2.92
42	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	2.92
43	Prostate cancer	Enrichment	PTEN, RNASEL, TP53	2.85
44	Lymphoma, non-hodgkin, familial	Enrichment	BRAF, TP53	2.79
45	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	2.69
46	Primary hyperaldosteronism	Enrichment	BRAF, TP53	2.69
47	Primary biliary cholangitis	Enrichment	IRF5, TNFSF15	2.69
48	Familial thoracic aortic aneurysm and dissection	Enrichment	COL3A1, SMAD3	2.69
49	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	2.59
50	Breast cancer	Enrichment	JUN, PTEN, RB1CC1, TP53	2.57
51	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, SPARC	2.36
52	Colorectal cancer	Enrichment	BRAF, SMAD4, SRC, TP53	2.34
53	Hereditary breast carcinoma	Enrichment	PTEN, RB1CC1, TP53	2.32
54	Osteoporosis	Enrichment	COL1A1, SRC	2.29
55	Aortic aneurysm, familial thoracic 1	Enrichment	COL3A1, SMAD3	2.29
56	Rare genetic intellectual disability	Enrichment	KMT2A, MTOR	2.23
57	Melanoma, cutaneous malignant 1	Enrichment	BRAF, CDKN2A	2.13
58	Paget disease of bone 3	Enrichment	SQSTM1	2.11
59	Acrodermatitis enteropathica, zinc-deficiency type	Enrichment	SLC39A4	2.11
60	Vacterl association with hydrocephalus	Enrichment	PTEN	2.11
61	Noonan syndrome 5	Enrichment	RAF1	2.11
62	Prostate cancer, hereditary, 1	Enrichment	RNASEL	2.11
63	Melorheostosis, isolated	Enrichment	MAP2K1	2.11
64	Noonan syndrome 7	Enrichment	BRAF	2.11
65	Leopard syndrome 3	Enrichment	BRAF	2.11
66	Amyloidosis, finnish type	Enrichment	GSN	2.11
67	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.11
68	Immunodeficiency 39 viral infections	Enrichment	IRF7	2.11
69	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.11
70	Accelerated tumor formation	Enrichment	MDM2	2.11
71	Acrogeria, gottron type	Enrichment	COL3A1	2.11
72	Immunodeficiency 69	Enrichment	IFNG	2.11
73	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	2.11
74	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.11
75	Noonan syndrome 13	Enrichment	MAPK1	2.11
76	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.11
77	Spinocerebellar ataxia, autosomal recessive 25	Enrichment	ATG5	2.11
78	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	2.11
79	Lessel-kubisch syndrome	Enrichment	MDM2	2.11
80	Bone marrow failure syndrome 5	Enrichment	TP53	2.11
81	Winchester syndrome	Enrichment	MMP14	2.11
82	Acrodermatitis enteropathica	Enrichment	SLC39A4	2.11
83	Papilloma of choroid plexus	Enrichment	TP53	2.11
84	Basal cell carcinoma 7	Enrichment	TP53	2.11
85	Danon disease	Enrichment	LAMP2	2.11
86	Anaplastic thyroid carcinoma	Enrichment	TP53	2.11
87	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.11
88	Immunodeficiency 39	Enrichment	IRF7	2.11
89	Papillary tumor of the pineal region	Enrichment	PTEN	2.11
90	Ovary adenocarcinoma	Enrichment	INHBA	2.11
91	Lymphangioma	Enrichment	BRAF	2.11
92	Systemic lupus erythematosus 10	Enrichment	IRF5	2.11
93	Phace association	Enrichment	BRAF	2.11
94	Melorheostosis	Enrichment	MAP2K1	2.11
95	Neuroendocrine tumor	Enrichment	CDKN1B	2.11
96	Inflammatory bowel disease 10	Enrichment	ATG16L1	2.11
97	Leopard syndrome 2	Enrichment	RAF1	2.11
98	Retinal arterial macroaneurysm with supravalvular pulmonic stenosis	Enrichment	IGFBP7	2.11
99	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.11
100	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.11
101	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.11
102	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.11
103	Inflammatory bowel disease 14	Enrichment	IRF5	2.11
104	Glioma susceptibility 2	Enrichment	PTEN	2.11
105	Ductal carcinoma in situ	Enrichment	TP53	2.11
106	20p12.3 microdeletion syndrome	Enrichment	BMP2	2.11
107	Thrombocytopenia 6	Enrichment	SRC	2.11
108	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.11
109	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.11
110	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	2.11
111	Trigonitis	Enrichment	RAF1	2.11
112	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.11
113	Asphyxia neonatorum	Enrichment	COL1A1	2.11
114	Trilateral retinoblastoma	Enrichment	RB1	2.11
115	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.11
116	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.11
117	Heritable thoracic aortic disease	Enrichment	SMAD4	2.11
118	Acute myeloid leukemia with mll rearrangement	Enrichment	KMT2A	2.11
119	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.11
120	Choroid plexus cancer	Enrichment	TP53	2.11
121	Syringocystadenoma papilliferum	Enrichment	BRAF	2.11
122	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.11
123	Ganglioglioma	Enrichment	BRAF	2.11
124	Abdominal aortic aneurysm	Enrichment	COL3A1	2.11
125	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.11
126	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.11
127	Phace syndrome	Enrichment	BRAF	2.11
128	Lethal hydranencephaly-diaphragmatic hernia syndrome	Enrichment	PLAT	2.11
129	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.11
130	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.11
131	Classic hairy cell leukemia	Enrichment	BRAF	2.11
132	Lung oat cell carcinoma	Enrichment	RB1	2.11
133	Human immunodeficiency virus type 1	Enrichment	CCL3, IFNG	2.08
134	Arteriovenous malformations of the brain	Enrichment	BRAF, IL6	2.03
135	Ehlers-danlos syndrome, vascular type	Enrichment	COL3A1	1.81
136	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	1.81
137	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.81
138	Ehlers-danlos syndrome, hypermobility type	Enrichment	COL3A1	1.81
139	Metaphyseal chondrodysplasia, schmid type	Enrichment	COL10A1	1.81
140	Myhre syndrome	Enrichment	SMAD4	1.81
141	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.81
142	Camurati-engelmann disease 1	Enrichment	TGFB1	1.81
143	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	1.81
144	Costello syndrome	Enrichment	HRAS	1.81
145	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	1.81
146	Quebec platelet disorder	Enrichment	PLAU	1.81
147	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	1.81
148	Cervical cancer	Enrichment	TP53	1.81
149	Pulmonic stenosis	Enrichment	BRAF	1.81
150	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.81
151	Welander distal myopathy	Enrichment	SQSTM1	1.81
152	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.81
153	Chromosome 13q14 deletion syndrome	Enrichment	RB1	1.81
154	Fatty liver disease 1	Enrichment	ATG7	1.81
155	Maturity-onset diabetes of the young, type 10	Enrichment	INS	1.81
156	Lymphoma, hodgkin, classic	Enrichment	TP53	1.81
157	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.81
158	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.81
159	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	1.81
160	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	1.81
161	Hyperproinsulinemia	Enrichment	INS	1.81
162	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1	1.81
163	Cebalid syndrome	Enrichment	MTOR	1.81
164	Polymicrogyria with or without vascular-type ehlers-danlos syndrome	Enrichment	COL3A1	1.81
165	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.81
166	Intravascular large b-cell lymphoma	Enrichment	BCL2	1.81
167	Aortic dissection	Enrichment	COL3A1	1.81
168	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.81
169	Spinocerebellar ataxia, autosomal recessive 31	Enrichment	ATG7	1.81
170	Osteogenesis imperfecta, type xvii	Enrichment	SPARC	1.81
171	Camurati-engelmann disease	Enrichment	TGFB1	1.81
172	Congenital fibrosarcoma	Enrichment	TP53	1.81
173	Stickler syndrome, type ii	Enrichment	COL1A1	1.81
174	Li-fraumeni syndrome 1	Enrichment	TP53	1.81
175	Sarcoma	Enrichment	TP53	1.81
176	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	1.81
177	Cervix carcinoma	Enrichment	TP53	1.81
178	Hodgkin's lymphoma	Enrichment	TP53	1.81
179	Paget's disease of bone	Enrichment	SQSTM1	1.81
180	Smith-kingsmore syndrome	Enrichment	MTOR	1.81
181	Craniosynostosis 7	Enrichment	BMP2	1.81
182	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1	1.81
183	Vacterl with hydrocephalus	Enrichment	PTEN	1.81
184	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	1.81
185	Immunodeficiency 117	Enrichment	IRF1	1.81
186	Acute myeloid leukemia with t(9;11)(p22;q23)	Enrichment	KMT2A	1.81
187	Familial retinoblastoma	Enrichment	RB1	1.81
188	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	KMT2A	1.81
189	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KMT2A	1.81
190	Juvenile polyposis of infancy	Enrichment	PTEN	1.81
191	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.81
192	Wooly hair nevus	Enrichment	HRAS	1.81
193	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	1.81
194	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS	1.68
195	Type 1 diabetes mellitus 2	Enrichment	INS	1.64
196	Retinoblastoma	Enrichment	RB1	1.64
197	Ataxia-telangiectasia	Enrichment	BRAF	1.64
198	Juvenile polyposis syndrome	Enrichment	SMAD4	1.64
199	Tuberous sclerosis 1	Enrichment	IFNG	1.64
200	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	1.64
201	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.64
202	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP14	1.64
203	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	1.64
204	Hepatitis c virus	Enrichment	IFNG	1.64
205	Nasopharyngeal carcinoma	Enrichment	TP53	1.64
206	Caffey disease	Enrichment	COL1A1	1.64
207	Tuberous sclerosis 2	Enrichment	IFNG	1.64
208	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.64
209	Hypotrichosis 8	Enrichment	RB1	1.64
210	Tethered spinal cord syndrome	Enrichment	BRAF	1.64
211	Large congenital melanocytic nevus	Enrichment	HRAS	1.64
212	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	1.64
213	Dedifferentiated liposarcoma	Enrichment	MDM2	1.64
214	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.64
215	Anaplastic astrocytoma	Enrichment	TP53	1.64
216	Adenocarcinoma	Enrichment	TP53	1.64
217	Spermatocytoma	Enrichment	HRAS	1.64
218	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.64
219	High bone mass osteogenesis imperfecta	Enrichment	COL1A1	1.64
220	Well-differentiated liposarcoma	Enrichment	MDM2	1.64
221	Mixed phenotype acute leukemia with t	Enrichment	KMT2A	1.64
222	Stüve-wiedemann syndrome	Enrichment	IL6ST	1.64
223	Dilated cardiomyopathy	Enrichment	BRAF, LAMP2, RAF1	1.62
224	Lung cancer	Enrichment	BRAF, IRF1	1.60
225	Familial hypertrophic cardiomyopathy	Enrichment	LAMP2, RAF1	1.57
226	Left ventricular noncompaction	Enrichment	LAMP2, RAF1	1.52
227	Kaposi sarcoma	Enrichment	IL6	1.51
228	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1	1.51
229	Brachydactyly, type a2	Enrichment	BMP2	1.51
230	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.51
231	Phenylketonuria	Enrichment	COL1A1	1.51
232	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	1.51
233	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.51
234	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.51
235	Lynch syndrome 4	Enrichment	RB1	1.51
236	Neonatal diabetes mellitus	Enrichment	INS	1.51
237	Lung sarcomatoid carcinoma	Enrichment	TP53	1.51
238	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.51
239	Aortic aneurysm	Enrichment	SMAD3	1.51
240	Craniopharyngioma	Enrichment	BRAF	1.51
241	Newborn respiratory distress syndrome	Enrichment	BRAF	1.51
242	Epidermolytic nevus	Enrichment	HRAS	1.51
243	Paget's disease of bone 2	Enrichment	SQSTM1	1.51
244	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1	1.51
245	Primary hyperparathyroidism	Enrichment	CDKN1B	1.51
246	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.51
247	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.51
248	Glioma	Enrichment	PTEN	1.51
249	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	1.51
250	Alzheimer disease 2	Enrichment	PLAU	1.42
251	Rhabdomyosarcoma 2	Enrichment	TP53	1.42
252	Macrocephaly/autism syndrome	Enrichment	PTEN	1.42
253	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.42
254	Ventricular septal defect 1	Enrichment	BMP2	1.42
255	Follicular lymphoma	Enrichment	BCL2	1.42
256	Lymphoma	Enrichment	TP53	1.42
257	Hemangioma	Enrichment	PTEN	1.42
258	Diffuse cutaneous systemic sclerosis	Enrichment	IRF5	1.42
259	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.42
260	Idiopathic aplastic anemia	Enrichment	IFNG	1.42
261	Familial cerebral saccular aneurysm	Enrichment	COL3A1	1.42
262	Leukemia, acute myeloid	Enrichment	KMT2A, TP53	1.42
263	Type 2 diabetes mellitus	Enrichment	HMGA1, IL6	1.38
264	Atrial septal defect 1	Enrichment	BMP2	1.34
265	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1	1.34
266	Osteogenesis imperfecta, type i	Enrichment	COL1A1	1.34
267	Kabuki syndrome 1	Enrichment	KMT2A	1.34
268	Cowden syndrome 1	Enrichment	PTEN	1.34
269	Wilms tumor 5	Enrichment	BRAF	1.34
270	Wiedemann-steiner syndrome	Enrichment	KMT2A	1.34
271	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.34
272	Keratoconus	Enrichment	COL1A1	1.34
273	Limited scleroderma	Enrichment	IRF5	1.34
274	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.34
275	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.34
276	Classic ehlers-danlos syndrome	Enrichment	COL1A1	1.34
277	Autism spectrum disorder	Enrichment	KMT2A, MAP2K1, PTEN	1.28
278	Esophageal cancer	Enrichment	TP53	1.28
279	Nevus, epidermal	Enrichment	HRAS	1.28
280	Osteogenesis imperfecta, type ii	Enrichment	COL1A1	1.28
281	Myelofibrosis	Enrichment	SRC	1.28
282	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.28
283	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.28
284	Essential thrombocythemia	Enrichment	TP53	1.28
285	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.28
286	Overgrowth syndrome	Enrichment	MTOR	1.28
287	Thrombocytopenia	Enrichment	SMAD4, SRC	1.27
288	Glioma susceptibility 1	Enrichment	TP53	1.22
289	Spastic paraplegia 4, autosomal dominant	Enrichment	COL3A1	1.22
290	Hemochromatosis, type 1	Enrichment	BMP2	1.22
291	Permanent neonatal diabetes mellitus	Enrichment	INS	1.22
292	Cornelia de lange syndrome 1	Enrichment	KMT2A	1.17
293	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.17
294	Rheumatoid arthritis	Enrichment	IRF5	1.17
295	Inflammatory bowel disease 1	Enrichment	IL6	1.17
296	Loeys-dietz syndrome	Enrichment	SMAD3	1.17
297	Adult hepatocellular carcinoma	Enrichment	TP53	1.17
298	Ventricular septal defect	Enrichment	BRAF	1.17
299	Cornelia de lange syndrome	Enrichment	KMT2A	1.17
300	Cowden syndrome	Enrichment	PTEN	1.17
301	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.17
302	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN, TP53	1.17
303	Myeloma, multiple	Enrichment	BRAF, TP53	1.16
304	Microcephaly	Enrichment	IGF1R, KMT2A, MAPK1	1.15
305	Leukemia, chronic lymphocytic	Enrichment	TP53	1.13
306	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1	1.13
307	Aplastic anemia	Enrichment	IFNG	1.13
308	Familial colorectal cancer	Enrichment	TP53	1.13
309	Primary bone dysplasia	Enrichment	COL1A1	1.13
310	Meningioma, familial	Enrichment	PTEN	1.09
311	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.09
312	Myelodysplastic syndrome	Enrichment	TP53	1.09
313	Osteochondrodysplasia	Enrichment	COL1A1	1.09
314	Diabetes mellitus	Enrichment	INS	1.09
315	Uterine corpus cancer	Enrichment	PTEN	1.09
316	Specific learning disability	Enrichment	MAPK1	1.09
317	Meningioma	Enrichment	PTEN	1.05
318	Nk-cell enteropathy	Enrichment	IGF1R	1.02
319	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	0.96
320	Wilms tumor 1	Enrichment	BRAF	0.96
321	Osteogenesis imperfecta, type iii	Enrichment	COL1A1	0.96
322	Gliosarcoma	Enrichment	TP53	0.93
323	Alzheimer disease, familial, 1	Enrichment	PLAU	0.91
324	Dandy-walker syndrome	Enrichment	BRAF	0.91
325	Giant cell glioblastoma	Enrichment	TP53	0.91
326	Heart, malformation of	Enrichment	MAPK1	0.88
327	Maturity-onset diabetes of the young	Enrichment	INS	0.84
328	Endometrial cancer	Enrichment	PTEN	0.82
329	Hepatoblastoma	Enrichment	TP53	0.82
330	Hepatocellular carcinoma	Enrichment	TP53	0.80
331	Multisystem inflammatory syndrome in children	Enrichment	IFNB1	0.80
332	Diamond-blackfan anemia 1	Enrichment	TP53	0.79
333	Brittle bone disorder	Enrichment	COL1A1	0.79
334	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	0.79
335	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.77
336	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.74
337	Non-immune hydrops fetalis	Enrichment	HRAS	0.67
338	Cystic fibrosis	Enrichment	TGFB1	0.66
339	Connective tissue disease	Enrichment	SMAD3	0.66
340	Diamond-blackfan anemia	Enrichment	TP53	0.61
341	Systemic lupus erythematosus	Enrichment	IRF5	0.58
342	Nephrotic syndrome	Enrichment	FN1	0.55
343	Hypertrophic cardiomyopathy	Enrichment	LAMP2	0.55
344	Hypertelorism	Enrichment	COL1A1	0.48
345	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.47
346	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SQSTM1	0.44
347	Primary ovarian insufficiency	Enrichment	THBS1	0.43
348	Congenital nervous system abnormality	Enrichment	PTEN	0.25
349	Nervous system disease	Enrichment	PTEN	0.25

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Senescence and autophagy in cancer

Pathway Network for Senescence and autophagy in cancer

Member Pathways for Senescence and autophagy in cancer

Pathways in the Senescence and autophagy in cancer SuperPath

Associated Genes for Senescence and autophagy in cancer

Associated Disorders for Senescence and autophagy in cancer

Disorders associated with Senescence and autophagy in cancer SuperPath

STRING Interaction Network for Senescence and autophagy in cancer

Sources for Senescence and autophagy in cancer