Sensory perception of taste

Pathway network for the Sensory perception of taste SuperPath

Sources:

Reactome

Pathways in the Sensory perception of taste SuperPath

#	Name	Source	Genes
1	Sensory perception of taste	Reactome	CALHM1 CALHM3 GNAT3 GNB1 GNB3 GNG13 GRM1 GRM4 ITPR3 KCNJ2 OTOP1 PLCB2 SCN1B SCN2A SCN2B SCN3A SCN4B SCN9A SCNN1A SCNN1B SCNN1D SCNN1G TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R43 TAS2R46 TAS2R5 TAS2R50 TAS2R7 TAS2R8 TRPM4 TRPM5 (see all 47) (see less)
2	Sensory perception of sweet, bitter, and umami (glutamate) taste	Reactome	CALHM1 CALHM3 GNAT3 GNB1 GNB3 GNG13 GRM1 GRM4 ITPR3 PLCB2 SCN1B SCN2A SCN2B SCN3A SCN4B SCN9A TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R43 TAS2R46 TAS2R5 TAS2R50 TAS2R7 TAS2R8 TRPM4 TRPM5 (see all 41) (see less)
3	Class C/3 (Metabotropic glutamate/pheromone receptors)	Reactome	CASR GABBR1 GABBR2 GPRC6A GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 (see all 39) (see less)
4	Sensory perception of salty taste	Reactome	CALHM1 CALHM3 SCNN1A SCNN1B SCNN1D SCNN1G (see all 6) (see less)
5	Sensory perception of sour taste	Reactome	KCNJ2 OTOP1

Gene overlap in member pathways for Sensory perception of taste SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CALHM3	Calcium Homeostasis Modulator 3	Protein Coding	3
2	CALHM1	Calcium Homeostasis Modulator 1	Protein Coding	3
3	TAS2R39	Taste 2 Receptor Member 39	Protein Coding	3
4	TAS2R40	Taste 2 Receptor Member 40	Protein Coding	3
5	TAS2R41	Taste 2 Receptor Member 41	Protein Coding	3
6	TAS2R43	Taste 2 Receptor Member 43	Protein Coding	3
7	TAS2R31	Taste 2 Receptor Member 31	Protein Coding	3
8	TAS2R46	Taste 2 Receptor Member 46	Protein Coding	3
9	TAS2R30	Taste 2 Receptor Member 30	Protein Coding	3
10	TAS2R20	Taste 2 Receptor Member 20	Protein Coding	3
11	TAS2R50	Taste 2 Receptor Member 50	Protein Coding	3
12	GRM1	Glutamate Metabotropic Receptor 1	Protein Coding	3
13	GRM4	Glutamate Metabotropic Receptor 4	Protein Coding	3
14	TAS2R3	Taste 2 Receptor Member 3	Protein Coding	3
15	TAS2R4	Taste 2 Receptor Member 4	Protein Coding	3
16	TAS2R16	Taste 2 Receptor Member 16	Protein Coding	3
17	TAS2R1	Taste 2 Receptor Member 1	Protein Coding	3
18	TAS2R8	Taste 2 Receptor Member 8	Protein Coding	3
19	TAS2R7	Taste 2 Receptor Member 7	Protein Coding	3
20	TAS2R13	Taste 2 Receptor Member 13	Protein Coding	3
21	TAS2R10	Taste 2 Receptor Member 10	Protein Coding	3
22	TAS2R14	Taste 2 Receptor Member 14	Protein Coding	3
23	TAS2R5	Taste 2 Receptor Member 5	Protein Coding	3
24	TAS2R38	Taste 2 Receptor Member 38	Protein Coding	3
25	TAS1R2	Taste 1 Receptor Member 2	Protein Coding	3
26	TAS1R1	Taste 1 Receptor Member 1	Protein Coding	3
27	TAS1R3	Taste 1 Receptor Member 3	Protein Coding	3
28	OTOP1	Otopetrin 1	Protein Coding	2
29	GNB1	G Protein Subunit Beta 1	Protein Coding	2
30	GNB3	G Protein Subunit Beta 3	Protein Coding	2
31	TRPM5	Transient Receptor Potential Cation Channel Subfamily M Member 5	Protein Coding	2
32	GNAT3	G Protein Subunit Alpha Transducin 3	Protein Coding	2
33	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	2
34	KCNJ2	Potassium Inwardly Rectifying Channel Subfamily J Member 2	Protein Coding	2
35	GNG13	G Protein Subunit Gamma 13	Protein Coding	2
36	PLCB2	Phospholipase C Beta 2	Protein Coding	2
37	TRPM4	Transient Receptor Potential Cation Channel Subfamily M Member 4	Protein Coding	2
38	SCN1B	Sodium Voltage-Gated Channel Beta Subunit 1	Protein Coding	2
39	SCN2A	Sodium Voltage-Gated Channel Alpha Subunit 2	Protein Coding	2
40	SCN2B	Sodium Voltage-Gated Channel Beta Subunit 2	Protein Coding	2
41	SCN3A	Sodium Voltage-Gated Channel Alpha Subunit 3	Protein Coding	2
42	SCN4B	Sodium Voltage-Gated Channel Beta Subunit 4	Protein Coding	2
43	SCN9A	Sodium Voltage-Gated Channel Alpha Subunit 9	Protein Coding	2
44	SCNN1A	Sodium Channel Epithelial 1 Subunit Alpha	Protein Coding	2
45	SCNN1B	Sodium Channel Epithelial 1 Subunit Beta	Protein Coding	2
46	SCNN1D	Sodium Channel Epithelial 1 Subunit Delta	Protein Coding	2
47	SCNN1G	Sodium Channel Epithelial 1 Subunit Gamma	Protein Coding	2
48	GPRC6A	G Protein-Coupled Receptor Class C Group 6 Member A	Protein Coding	1
49	GABBR1	Gamma-Aminobutyric Acid Type B Receptor Subunit 1	Protein Coding	1
50	TAS2R19	Taste 2 Receptor Member 19	Protein Coding	1
51	GRM2	Glutamate Metabotropic Receptor 2	Protein Coding	1
52	GRM3	Glutamate Metabotropic Receptor 3	Protein Coding	1
53	GRM5	Glutamate Metabotropic Receptor 5	Protein Coding	1
54	GRM6	Glutamate Metabotropic Receptor 6	Protein Coding	1
55	GRM7	Glutamate Metabotropic Receptor 7	Protein Coding	1
56	GRM8	Glutamate Metabotropic Receptor 8	Protein Coding	1
57	TAS2R60	Taste 2 Receptor Member 60	Protein Coding	1
58	TAS2R42	Taste 2 Receptor Member 42	Protein Coding	1
59	TAS2R9	Taste 2 Receptor Member 9	Protein Coding	1
60	CASR	Calcium Sensing Receptor	Protein Coding	1
61	GABBR2	Gamma-Aminobutyric Acid Type B Receptor Subunit 2	Protein Coding	1

Disorders associated with Sensory perception of taste SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Liddle syndrome 1	Enrichment	SCNN1A, SCNN1B, SCNN1G	10.25
2	Pseudohypoaldosteronism, type ib1, autosomal recessive	Enrichment	SCNN1A, SCNN1B, SCNN1G	10.25
3	Idiopathic bronchiectasis	Enrichment	SCNN1A, SCNN1B, SCNN1G	9.62
4	Familial atrial fibrillation	Enrichment	KCNJ2, SCN1B, SCN2B, SCN4B	5.89
5	Brugada syndrome	Enrichment	SCN1B, SCN2B, SCNN1A, TRPM4	5.75
6	Dravet syndrome	Enrichment	SCN1B, SCN2A, SCN9A	5.52
7	Generalized epilepsy with febrile seizures plus	Enrichment	SCN1B, SCN2A, SCN9A	5.04
8	Hereditary progressive cardiac conduction defect	Enrichment	SCN1B, TRPM4	4.27
9	Short qt syndrome 3	Enrichment	KCNJ2	3.83
10	Atrial fibrillation, familial, 9	Enrichment	KCNJ2	3.83
11	Benign epilepsy with centrotemporal spikes	Enrichment	SCN1B, SCN2A, SCN9A	3.60
12	Centralopathic epilepsy	Enrichment	SCN1B, SCN2A, SCN9A	3.54
13	Andersen cardiodysrhythmic periodic paralysis	Enrichment	KCNJ2	3.53
14	Bronchiectasis with or without elevated sweat chloride 2	Enrichment	SCNN1A	3.35
15	Bronchiectasis with or without elevated sweat chloride 3	Enrichment	SCNN1G	3.35
16	Pseudohypoaldosteronism, type ib2, autosomal recessive	Enrichment	SCNN1B	3.35
17	Liddle syndrome 2	Enrichment	SCNN1G	3.35
18	Liddle syndrome 3	Enrichment	SCNN1A	3.35
19	Pseudohypoaldosteronism, type ib3, autosomal recessive	Enrichment	SCNN1G	3.35
20	Congenital short qt syndrome	Enrichment	KCNJ2	3.13
21	Polymyoclonus, infantile	Enrichment	SCNN1B	3.05
22	Pseudohypoaldosteronism	Enrichment	SCNN1A	3.05
23	Early infantile developmental and epileptic encephalopathy	Enrichment	SCN1B, SCN2A	2.88
24	Thiourea tasting	Enrichment	TAS2R38	2.54
25	Hypocalcemia, autosomal dominant 1	Enrichment	CASR	2.54
26	Hypocalciuric hypercalcemia, familial, type i	Enrichment	CASR	2.54
27	Spinocerebellar ataxia, autosomal recessive 13	Enrichment	GRM1	2.54
28	Neurodevelopmental disorder with poor language and loss of hand skills	Enrichment	GABBR2	2.54
29	Developmental and epileptic encephalopathy 59	Enrichment	GABBR2	2.54
30	Epilepsy, idiopathic generalized 8	Enrichment	CASR	2.54
31	Spinocerebellar ataxia 44	Enrichment	GRM1	2.54
32	Neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities	Enrichment	GRM7	2.54
33	Beta-glucopyranoside tasting	Enrichment	TAS2R16	2.54
34	Neurodevelopmental disorder with language delay and variable cognitive abnormalities	Enrichment	GABBR1	2.54
35	Hypercalcemia	Enrichment	CASR	2.54
36	Familial hypocalciuric hypercalcemia	Enrichment	CASR	2.54
37	Chondromyxoid fibroma	Enrichment	GRM1	2.54
38	Brugada syndrome 5	Enrichment	SCN1B	2.52
39	Long qt syndrome 10	Enrichment	SCN4B	2.52
40	Developmental and epileptic encephalopathy 11	Enrichment	SCN2A	2.52
41	Atrial fibrillation, familial, 14	Enrichment	SCN2B	2.52
42	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.52
43	Progressive familial heart block, type ib	Enrichment	TRPM4	2.52
44	Developmental and epileptic encephalopathy 62	Enrichment	SCN3A	2.52
45	Erythrokeratodermia variabilis et progressiva 6	Enrichment	TRPM4	2.52
46	Atrial fibrillation, familial, 13	Enrichment	SCN1B	2.52
47	Episodic ataxia, type 9	Enrichment	SCN2A	2.52
48	Benign familial infantile epilepsy	Enrichment	SCN2A	2.52
49	Epilepsy, familial focal, with variable foci 4	Enrichment	SCN3A	2.52
50	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.52
51	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.52
52	Long qt syndrome 1	Enrichment	ITPR3, SCN4B	2.43
53	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	SCNN1B	2.40
54	Developmental and epileptic encephalopathy	Enrichment	SCN2A, SCN3A	2.28
55	Hyperparathyroidism, neonatal severe	Enrichment	CASR	2.24
56	Autosomal dominant hypocalcemia	Enrichment	CASR	2.24
57	Indifference to pain, congenital, autosomal recessive	Enrichment	SCN9A	2.22
58	Seizures, benign familial infantile, 3	Enrichment	SCN2A	2.22
59	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.22
60	Benign familial neonatal epilepsy	Enrichment	SCN2A	2.22
61	Developmental and epileptic encephalopathy 30	Enrichment	SCN2A	2.22
62	Malignant migrating partial seizures of infancy	Enrichment	SCN2A	2.22
63	Small fiber neuropathy	Enrichment	SCN9A	2.22
64	Benign neonatal seizures	Enrichment	SCN2A	2.22
65	Cerebral visual impairment	Enrichment	GNB1	2.22
66	Epilepsy	Enrichment	SCN2A, SCN3A	2.19
67	Night blindness, congenital stationary, type 1b	Enrichment	GRM6	2.07
68	Familial isolated hypoparathyroidism	Enrichment	CASR	2.07
69	Parathyroid adenoma	Enrichment	CASR	2.07
70	Dystonia 12	Enrichment	SCN2A	2.04
71	Generalized epilepsy with febrile seizures plus, type 1	Enrichment	SCN1B	2.04
72	Generalized epilepsy with febrile seizures plus, type 7	Enrichment	SCN9A	2.04
73	Hereditary episodic ataxia	Enrichment	SCN2A	2.04
74	Hereditary sodium channelopathy-related small fibers neuropathy	Enrichment	SCN9A	2.04
75	Tobacco addiction	Enrichment	GABBR2	1.94
76	Primary hyperparathyroidism	Enrichment	CASR	1.94
77	Erythermalgia, primary	Enrichment	SCN9A	1.92
78	Neuropathy, hereditary sensory and autonomic, type iia	Enrichment	SCN9A	1.92
79	Developmental and epileptic encephalopathy 12	Enrichment	SCN2A	1.92
80	Hereditary sensory and autonomic neuropathy type 2	Enrichment	SCN9A	1.92
81	Developmental and epileptic encephalopathy 52	Enrichment	SCN1B	1.92
82	Episodic ataxia	Enrichment	SCN2A	1.92
83	Undetermined early-onset epileptic encephalopathy	Enrichment	SCN1B, SCN3A	1.91
84	Night blindness, congenital stationary, type 1c	Enrichment	GRM6	1.84
85	Paroxysmal extreme pain disorder	Enrichment	SCN9A	1.82
86	Self-limited infantile epilepsy	Enrichment	SCN2A	1.82
87	Alcohol dependence	Enrichment	TAS2R16	1.77
88	Rett syndrome	Enrichment	GABBR2	1.70
89	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	SCN3A	1.68
90	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	SCN9A	1.68
91	Focal epilepsy	Enrichment	SCN2A	1.68
92	Rett syndrome, congenital variant	Enrichment	GABBR2	1.64
93	Erythrokeratodermia variabilis et progressiva 1	Enrichment	TRPM4	1.62
94	Alternating hemiplegia of childhood	Enrichment	SCN2A	1.62
95	Hypothyroidism	Enrichment	GNB1	1.62
96	Neurofibromatosis, type i	Enrichment	GABBR1	1.59
97	Developmental and epileptic encephalopathy 14	Enrichment	SCN2A	1.57
98	Bilateral perisylvian polymicrogyria	Enrichment	SCN3A	1.57
99	Polymicrogyria	Enrichment	SCN3A	1.53
100	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.48
101	Myelodysplastic syndrome	Enrichment	GNB1	1.48
102	Movement disease	Enrichment	SCN2A	1.48
103	Cardiac conduction defect	Enrichment	SCN1B	1.45
104	Congenital long qt syndrome	Enrichment	ITPR3	1.45
105	Autism spectrum disorder	Enrichment	GNB1, SCN2A	1.37
106	Pancreatitis, hereditary	Enrichment	CASR	1.32
107	Hypertension, essential	Enrichment	GNB3	1.30
108	Cleft palate, isolated	Enrichment	GNB1	1.30
109	Congenital stationary night blindness	Enrichment	GRM6	1.19
110	Strabismus	Enrichment	GNB1	1.10
111	Dystonia	Enrichment	GNB1	1.00
112	Cerebral palsy	Enrichment	GNB1	0.95
113	Hypertrophic cardiomyopathy	Enrichment	CASR	0.93
114	West syndrome	Enrichment	SCN2A	0.90
115	Autosomal dominant non-syndromic intellectual disability	Enrichment	GABBR1	0.87
116	Spastic ataxia	Enrichment	SCN2A	0.83
117	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRM7	0.81
118	Autism	Enrichment	SCN2A	0.71
119	Leber plus disease	Enrichment	GRM6	0.62
120	Microcephaly	Enrichment	GRM7	0.52
121	Complex neurodevelopmental disorder	Enrichment	SCN2A	0.50
122	Hereditary retinal dystrophy	Enrichment	GRM6	0.24
123	Fundus dystrophy	Enrichment	GRM6	0.24

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² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Sensory perception of taste

Pathway Network for Sensory perception of taste

Pathway network for the Sensory perception of taste SuperPath

Member Pathways for Sensory perception of taste

Pathways in the Sensory perception of taste SuperPath

Gene overlap in member pathways for Sensory perception of taste SuperPath

Associated Genes for Sensory perception of taste

Associated Disorders for Sensory perception of taste

Disorders associated with Sensory perception of taste SuperPath

STRING Interaction Network for Sensory perception of taste

Sources for Sensory perception of taste