Sensory processing of sound

Pathway network for the Sensory processing of sound SuperPath

Sources:
  • Reactome

Pathways in the Sensory processing of sound SuperPath

#NameSourceGenes
1Sensory processing of soundReactome
2Sensory processing of sound by inner hair cells of the cochleaReactome
3Sensory processing of sound by outer hair cells of the cochleaReactome
4Acetylcholine inhibits contraction of outer hair cellsReactome

Gene overlap in member pathways for Sensory processing of sound SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Sensory processing of sound SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Non-syndromic genetic deafnessEnrichmentACTG1, CDH23, KCNQ4, MYO15A, MYO3A, MYO7A, OTOF, RDX, STRC, TMC1, TRIOBP16.00
2Deafness, autosomal recessiveEnrichmentCABP2, CDH23, CIB2, CLIC5, EPS8, ESPN, GRXCR1, GRXCR2, LHFPL5, MYH9, MYO15A, MYO7A, OTOF, PCDH15, PJVK, TMC1, TMIE, TPRN, TRIOBP, USH1C, USH1G, WHRN12.52
3Rare genetic deafnessEnrichmentACTG1, CDH23, CIB2, ESPN, GRXCR1, KCNQ4, MYH9, MYO15A, MYO7A, OTOF, PCDH15, PJVK, RDX, STRC, TMC1, TPRN, TRIOBP, USH1C, WHRN11.85
4Nonsyndromic hearing lossEnrichmentACTG1, CDH23, KCNQ4, MYO15A, MYO3A, MYO7A, OTOF, PCDH15, RDX, STRC, TMC1, TRIOBP11.24
5Ear malformationEnrichmentCDH23, LHFPL5, MYO15A, MYO7A, OTOF, PCDH15, PJVK, TMC111.11
6Autosomal recessive nonsyndromic deafnessEnrichmentCABP2, CDH23, CIB2, CLIC5, EPS8, ESPN, GRXCR1, GRXCR2, LHFPL5, MYH9, MYO15A, MYO7A, OTOF, PCDH15, PJVK, TMC1, TMIE, TPRN, TRIOBP, USH1C, USH1G, WHRN10.98
7Rare autosomal recessive non-syndromic sensorineural deafness type dfnbEnrichmentATP2B2, CABP2, CDH23, CIB2, CLIC5, EPS8, EPS8L2, ESPN, GRXCR1, GRXCR2, LHFPL5, MYH9, MYO15A, MYO3A, MYO7A, OTOF, PCDH15, PJVK, RDX, RIPOR2, STRC, TMC1, TMIE, TPRN, TRIOBP, USH1C, USH1G, WHRN10.91
8Rare autosomal dominant non-syndromic sensorineural deafness type dfnaEnrichmentACTG1, ATP2B2, KCNQ4, MYH9, MYO1C, MYO7A, PLS1, SLC17A8, TMC110.77
9Usher syndrome, type iEnrichmentCDH23, CIB2, ESPN, MYO7A, PCDH15, USH1C, USH1G10.76
10Usher syndromeEnrichmentCDH23, MYO7A, PCDH15, USH1C, USH1G, WHRN8.51
11Sensorineural hearing lossEnrichmentCDH23, MYO15A, MYO3A, MYO7A, TMC1, TMIE7.49
12Usher syndrome type 2EnrichmentCDH23, MYO7A, USH1C, WHRN7.14
13Baraitser-winter cerebrofrontofacial syndromeEnrichmentACTB, ACTG14.81
14Deafness, autosomal recessive 3EnrichmentMYO15A, OTOF4.12
15Hereditary retinal dystrophyEnrichmentCDH23, CIB2, ESPN, FSCN2, MYO7A, PCDH15, USH1C3.85
16Fundus dystrophyEnrichmentCDH23, CIB2, ESPN, FSCN2, MYO7A, PCDH15, USH1C3.85
17Usher syndrome, type idEnrichmentCDH23, PCDH153.64
18Deafness, autosomal recessive 12EnrichmentATP2B2, CDH233.64
19Deafness, autosomal recessive 9EnrichmentMYO15A, OTOF3.60
20Otof-related hearing lossEnrichmentMYO15A, OTOF3.60
21Auditory neuropathyEnrichmentMYO7A, OTOF, SLC17A83.52
22Meniere diseaseEnrichmentCDH23, MYO7A3.49
23Epilepsy, idiopathic generalized 16EnrichmentKCNMA13.43
24Cerebellar atrophy, developmental delay, and seizuresEnrichmentKCNMA13.43
25Focal epilepsyEnrichmentSNAP25, SPTAN13.28
26Hypertension, diastolicEnrichmentKCNMB13.13
27Neurodevelopmental disorder with or without variable movement or behavioral abnormalitiesEnrichmentKCNN23.13
28Dystonia 34, myoclonicEnrichmentKCNN23.13
29Liang-wang syndromeEnrichmentKCNMA13.13
30Developmental and epileptic encephalopathyEnrichmentCACNA2D2, SNAP25, SPTAN13.10
31Paroxysmal nonkinesigenic dyskinesia 3 with or without generalized epilepsyEnrichmentKCNMA12.96
32Retinitis pigmentosaEnrichmentCDH23, FSCN2, MYO7A, PCDH15, USH1C2.82
33MicrocephalyEnrichmentACTB, ACTG1, CASK, SNAP252.45
34Baraitser-winter syndrome 1EnrichmentACTB2.40
35Usher syndrome, type icEnrichmentUSH1C2.40
36Deafness, autosomal recessive 18aEnrichmentUSH1C2.40
37Retinitis pigmentosa 30EnrichmentFSCN22.40
38Immunodeficiency 50EnrichmentMSN2.40
39Deafness, autosomal recessive 2EnrichmentMYO7A2.40
40Deafness, autosomal recessive 67EnrichmentLHFPL52.40
41Deafness, autosomal recessive 25EnrichmentGRXCR12.40
42Deafness, autosomal recessive 24EnrichmentRDX2.40
43Deafness, autosomal dominant 17EnrichmentMYH92.40
44Deafness, autosomal recessive 36, with or without vestibular involvementEnrichmentESPN2.40
45Deafness, autosomal recessive 31EnrichmentWHRN2.40
46Deafness, autosomal recessive 59EnrichmentPJVK2.40
47Developmental and epileptic encephalopathy 5EnrichmentSPTAN12.40
48Chromosome 20q11-q12 deletion syndromeEnrichmentEPB41L12.40
49Deafness, autosomal recessive 84bEnrichmentOTOGL2.40
50Deafness, autosomal recessive 101EnrichmentGRXCR22.40
51Deafness, autosomal recessive 6EnrichmentTMIE2.40
52Deafness, autosomal recessive 103EnrichmentCLIC52.40
53Deafness, autosomal dominant 82EnrichmentATP2B22.40
54Deafness, autosomal recessive 61EnrichmentSLC26A52.40
55Congenital smooth muscle hamartoma, with or without hemihypertrophyEnrichmentACTB2.40
56Deafness, autosomal dominant 76EnrichmentPLS12.40
57Developmental delay, impaired speech, and behavioral abnormalitiesEnrichmentSPTBN12.40
58Deafness, autosomal dominant 11EnrichmentMYO7A2.40
59Deafness, autosomal dominant 21EnrichmentRIPOR22.40
60Deafness, autosomal recessive 30EnrichmentMYO3A2.40
61Becker nevus syndromeEnrichmentACTB2.40
62Dystonia-deafness syndrome 1EnrichmentACTB2.40
63Usher syndrome, type ijEnrichmentCIB22.40
64Deafness, autosomal recessive 18bEnrichmentOTOG2.40
65Deafness, autosomal recessive 102EnrichmentEPS82.40
66Usher syndrome, type iidEnrichmentWHRN2.40
67Deafness, autosomal recessive 106EnrichmentEPS8L22.40
68Thrombocytopenia 8, with dysmorphic features and developmental delayEnrichmentACTB2.40
69Deafness, autosomal dominant 90EnrichmentMYO3A2.40
70Usher syndrome, type 1mEnrichmentESPN2.40
71Autosomal recessive nonsyndromic deafness 36EnrichmentESPN2.40
72Tsh producing pituitary tumorEnrichmentCDH232.40
73Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxiaEnrichmentSPTAN12.40
74Developmental delay with or without epilepsyEnrichmentSPTAN12.40
75Baraitser-winter syndromeEnrichmentACTB2.40
76Neuronopathy, distal hereditary motor, autosomal dominant 11EnrichmentSPTAN12.40
77Usher syndrome type 1bEnrichmentMYO7A2.40
78Cask-related intellectual disabilityEnrichmentCASK2.40
79Autosomal dominant nonsyndromic hearing loss 17EnrichmentMYH92.40
80Congenital smooth muscle hamartomaEnrichmentACTB2.40
81Developmental malformations-deafness-dystonia syndromeEnrichmentACTB2.40
82Ceroid lipofuscinosis, neuronal, 4EnrichmentDNAJC52.29
83Brugada syndrome 4EnrichmentCACNB22.29
84Deafness, autosomal recessive 93EnrichmentCABP22.29
85Intellectual developmental disorder, autosomal dominant 66EnrichmentATP2B12.29
86Intellectual developmental disorder, x-linked 50EnrichmentSYN12.29
87Developmental and epileptic encephalopathy 117EnrichmentSNAP252.29
88Epilepsy, x-linked 1, with variable learning disabilities and behavior disordersEnrichmentSYN12.29
89Primary aldosteronism, seizures, and neurologic abnormalitiesEnrichmentCACNA1D2.29
90Arthrogryposis and ectodermal dysplasiaEnrichmentOTOF2.29
91Deafness, autosomal dominant 25EnrichmentSLC17A82.29
92X-linked epilepsy with variable learning disabilities and behavior disordersEnrichmentSYN12.29
93Pontocerebellar hypoplasia, type 3EnrichmentPCLO2.29
94Sinoatrial node dysfunction and deafnessEnrichmentCACNA1D2.29
95Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movementsEnrichmentVAMP22.29
96Epilepsy with generalized tonic-clonic seizuresEnrichmentSNAP252.29
97Aldosterone-producing adenoma with seizures and neurological abnormalitiesEnrichmentCACNA1D2.29
98AutismEnrichmentATP2B1, PCDH15, STX1A2.23
99Intellectual developmental disorder, x-linked, syndromic, raymond typeEnrichmentSPTAN12.10
100Deafness, autosomal dominant 2aEnrichmentKCNQ42.10
101Cataract 35EnrichmentMYH92.10
102Deafness, autosomal dominant 16EnrichmentSTRC2.10
103Fg syndrome 4EnrichmentCASK2.10
104Usher syndrome, type ifEnrichmentPCDH152.10
105Deafness, autosomal dominant 30EnrichmentMYO3A2.10
106Deafness, autosomal dominant 36EnrichmentTMC12.10
107Deafness, autosomal recessive 48EnrichmentCIB22.10
108Deafness, autosomal recessive 23EnrichmentPCDH152.10
109Deafness, autosomal recessive 28EnrichmentTRIOBP2.10
110Deafness, autosomal dominant 20EnrichmentACTG12.10
111Baraitser-winter syndrome 2EnrichmentACTG12.10
112Deafness, autosomal recessive 84aEnrichmentCDH232.10
113Deafness, autosomal recessive 104EnrichmentRIPOR22.10
114Deafness, autosomal recessive 7EnrichmentTMC12.10
115Combined saposin deficiencyEnrichmentCDH232.10
116Spermatogenic failure 7EnrichmentSTRC2.10
117Syndromic x-linked intellectual disabilityEnrichmentCASK2.10
118Deafness, autosomal recessive 16EnrichmentSTRC2.10
119Usher syndrome, type igEnrichmentUSH1G2.10
120Pseudosarcomatous fibromatosisEnrichmentMYH92.10
121Combined psap deficiencyEnrichmentCDH232.10
122Dfna2 nonsyndromic hearing lossEnrichmentKCNQ42.10
123Familial isolated pituitary adenomaEnrichmentCDH232.10
124Congenital disorder of glycosylation, type iw, autosomal dominantEnrichmentCACNA1D1.99
125Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing lossEnrichmentMYH91.92
126Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasiaEnrichmentCASK1.92
127Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophyEnrichmentSPTBN11.92
128Short-rib thoracic dysplasia 11 with or without polydactylyEnrichmentSPTAN11.92
129Syndromic x-linked intellectual disability najm typeEnrichmentCASK1.92
130Cerebellar diseaseEnrichmentCASK1.92
131Non-syndromic x-linked intellectual disabilityEnrichmentCASK, SYP1.84
132Intellectual developmental disorder, x-linked 96EnrichmentSYP1.82
133Intellectual developmental disorder, autosomal dominant 30, with speech delay and behavioral abnormalitiesEnrichmentATP2B11.82
134Aland island eye diseaseEnrichmentWHRN1.80
135Deafness-infertility syndromeEnrichmentSTRC1.80
136Deafness, autosomal recessive 79EnrichmentTPRN1.80
137Aminoacylase 1 deficiencyEnrichmentACTB1.80
138Pituitary adenoma 5, multiple typesEnrichmentCDH231.80
139ProlactinomaEnrichmentCDH231.80
140Charcot-marie-tooth hereditary neuropathyEnrichmentSPTAN11.80
141Pseudomyogenic hemangioendotheliomaEnrichmentACTB1.80
142EpilepsyEnrichmentBSN, SYN11.76
143Anemia, congenital, nonspherocytic hemolytic, 1EnrichmentCASK1.70
144Deafness, autosomal recessive 63EnrichmentMYH91.70
145Pervasive developmental disorderEnrichmentSPTBN11.70
146Macular degenerationEnrichmentFSCN21.70
147Coloboma of choroid and retinaEnrichmentACTG11.70
148Rare pervasive developmental disorderEnrichmentSPTBN11.70
149Developmental and epileptic encephalopathy 2EnrichmentSNAP251.69
150Cerebellar atrophy with seizures and variable developmental delayEnrichmentCACNA2D21.69
151Autosomal recessive non-syndromic intellectual disabilityEnrichmentEZR, LHFPL51.65
152Hemangioma, capillary infantileEnrichmentMYH91.63
153Autosomal recessive intellectual developmental disorderEnrichmentLHFPL51.63
154Syndromic rod-cone dystrophyEnrichmentCDH231.63
155Usher syndrome, type iiaEnrichmentCDH231.56
156Pierre robin syndromeEnrichmentATP2B11.52
157Primary hyperaldosteronismEnrichmentCDH231.45
158Cat eye syndromeEnrichmentACTG11.41
159Autism spectrum disorderEnrichmentKCNMA11.40
160Cone-rod dystrophy 6EnrichmentPCDH151.26
161Presynaptic congenital myasthenic syndromesEnrichmentSNAP251.26
162Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delayEnrichmentCASK1.21
163HypertensionEnrichmentMYH91.21
164Isolated congenital microcephalyEnrichmentCASK1.21
165Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactylyEnrichmentATP2B11.19
166ClubfootEnrichmentATP2B11.19
167Stereotypic movement disorderEnrichmentSNAP251.19
168Periventricular nodular heterotopiaEnrichmentATP2B11.16
169Neuromuscular diseaseEnrichmentSPTAN11.16
170Early infantile developmental and epileptic encephalopathyEnrichmentCASK1.16
171Neuronal ceroid lipofuscinosisEnrichmentDNAJC51.13
172LissencephalyEnrichmentACTG11.09
173Jeune thoracic dystrophyEnrichmentSPTAN11.02
174Williams-beuren syndromeEnrichmentSTX1A1.01
175Asphyxiating thoracic dystrophyEnrichmentSPTAN10.98
176Short-rib thoracic dysplasia 1 with or without polydactylyEnrichmentSPTAN10.91
177Brugada syndromeEnrichmentCACNB20.91
178CakutEnrichmentACTG10.90
179DystoniaEnrichmentCASK0.88
180Complex neurodevelopmental disorderEnrichmentATP2B1, SPTBN10.88
181Cystic fibrosisEnrichmentSTX1A0.82
182Benign epilepsy with centrotemporal spikesEnrichmentSPTAN10.82
183Hereditary spastic paraplegiaEnrichmentSPTAN10.81
184Centralopathic epilepsyEnrichmentSPTAN10.80
185West syndromeEnrichmentSPTAN10.79
186ThrombocytopeniaEnrichmentMYH90.76
187Body mass index quantitative trait locus 11EnrichmentMYH90.74
188Autosomal dominant non-syndromic intellectual disabilityEnrichmentEPB41L10.74
189Spastic ataxiaEnrichmentSPTAN10.72
190Hereditary breast ovarian cancer syndromeEnrichmentMYO7A0.70
191Optic atrophy plus syndromeEnrichmentSNAP250.70
192SchizophreniaEnrichmentPCDH150.68
193Congenital nervous system abnormalityEnrichmentCASK0.46
194Nervous system diseaseEnrichmentCASK0.46

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