serine and glycine biosynthesis

Pathway network for the serine and glycine biosynthesis SuperPath

Sources:

PubChem
WikiPathways

Pathways in the serine and glycine biosynthesis SuperPath

#	Name	Source	Genes
1	serine and glycine biosynthesis	PubChem	PHGDH PSAT1 PSPH SHMT1 SHMT2 VPS29 (see all 6) (see less)
2	Serine metabolism	WikiPathways	DHFR PHGDH PSAT1 PSPH SHMT1 SHMT2 SRR TYMS (see all 8) (see less)
3	Amino acid metabolism in triple-negative breast cancer cells	WikiPathways	GLS PHGDH PSAT1 PSPH SLC1A5 SLC2A1 SLC7A11 (see all 7) (see less)
4	superpathway of L-serine and glycine biosynthesis I	PubChem	PHGDH PSAT1 PSPH SHMT1 SHMT2
5	serine biosynthesis (phosphorylated route)	PubChem	PHGDH PSAT1 PSPH VPS29
6	L-serine biosynthesis I	PubChem	PHGDH PSAT1 PSPH

Gene overlap in member pathways for serine and glycine biosynthesis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PSAT1	Phosphoserine Aminotransferase 1	Protein Coding	6
2	PSPH	Phosphoserine Phosphatase	Protein Coding	6
3	PHGDH	Phosphoglycerate Dehydrogenase	Protein Coding	6
4	SHMT2	Serine Hydroxymethyltransferase 2	Protein Coding	3
5	SHMT1	Serine Hydroxymethyltransferase 1	Protein Coding	3
6	VPS29	VPS29 Retromer Complex Component	Protein Coding	2
7	SRR	Serine Racemase	Protein Coding	1
8	DHFR	Dihydrofolate Reductase	Protein Coding	1
9	TYMS	Thymidylate Synthetase	Protein Coding	1
10	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
11	SLC1A5	Solute Carrier Family 1 Member 5	Protein Coding	1
12	GLS	Glutaminase	Protein Coding	1
13	SLC7A11	Solute Carrier Family 7 Member 11	Protein Coding	1

Disorders associated with serine and glycine biosynthesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neu-laxova syndrome 1	Enrichment	PHGDH	3.66
2	Phosphoglycerate dehydrogenase deficiency	Enrichment	PHGDH	3.66
3	Phosphoserine aminotransferase deficiency	Enrichment	PSAT1	3.66
4	Phosphoserine phosphatase deficiency	Enrichment	PSPH	3.66
5	Neu-laxova syndrome 2	Enrichment	PSAT1	3.66
6	Neurometabolic disorder due to serine deficiency	Enrichment	PSAT1	3.66
7	Neu-laxova syndrome due to 3-phosphoserine phosphatase deficiency	Enrichment	PSPH	3.66
8	Neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities	Enrichment	SHMT2	3.43
9	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	3.29
10	Casgid syndrome	Enrichment	GLS	3.29
11	Developmental and epileptic encephalopathy 71	Enrichment	GLS	3.29
12	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	3.29
13	Spastic ataxia-dysarthria due to glutaminase deficiency	Enrichment	GLS	3.29
14	Epilepsy with myoclonic absences	Enrichment	SLC2A1	3.29
15	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	3.29
16	Megaloblastic anemia due to dihydrofolate reductase deficiency	Enrichment	DHFR	3.23
17	Dystonia 9	Enrichment	SLC2A1	2.99
18	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	2.99
19	Global developmental delay, progressive ataxia, and elevated glutamine	Enrichment	GLS	2.99
20	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	2.99
21	Dyskeratosis congenita, digenic	Enrichment	TYMS	2.93
22	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	2.81
23	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	2.81
24	Familial adenomatous polyposis 4	Enrichment	DHFR	2.75
25	Paroxysmal dystonia	Enrichment	SLC2A1	2.44
26	Alternating hemiplegia of childhood	Enrichment	SLC2A1	2.38
27	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	2.33
28	Esophageal atresia/tracheoesophageal fistula	Enrichment	GLS	2.01
29	Dyskeratosis congenita	Enrichment	TYMS	1.95
30	Endometrial cancer	Enrichment	DHFR	1.91
31	Developmental and epileptic encephalopathy 1	Enrichment	SLC2A1	1.89
32	Strabismus	Enrichment	SLC2A1	1.86
33	Epilepsy	Enrichment	SLC2A1	1.69
34	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1	1.68
35	Centralopathic epilepsy	Enrichment	SLC2A1	1.66
36	West syndrome	Enrichment	SLC2A1	1.65
37	Microcephaly	Enrichment	SLC2A1	1.21
38	Inherited cancer-predisposing syndrome	Enrichment	DHFR	1.12

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

serine and glycine biosynthesis

Pathway Network for serine and glycine biosynthesis

Pathway network for the serine and glycine biosynthesis SuperPath

Member Pathways for serine and glycine biosynthesis

Pathways in the serine and glycine biosynthesis SuperPath

Gene overlap in member pathways for serine and glycine biosynthesis SuperPath

Associated Genes for serine and glycine biosynthesis

Associated Disorders for serine and glycine biosynthesis

Disorders associated with serine and glycine biosynthesis SuperPath

STRING Interaction Network for serine and glycine biosynthesis

Sources for serine and glycine biosynthesis