Serotonin HTR1 group and FOS pathway

Pathway network for the Serotonin HTR1 group and FOS pathway SuperPath

Sources:
  • WikiPathways

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Serotonin HTR1 group and FOS pathway SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1RasopathyEnrichmentHRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF111.19
2Noonan syndrome 1EnrichmentHRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF110.60
3Noonan syndrome and noonan-related syndromeEnrichmentHRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF110.56
4Lung non-small cell carcinomaEnrichmentHRAS, KRAS, MAP2K1, NRAS9.04
5Cardiofaciocutaneous syndrome 1EnrichmentBRAF, MAP2K1, MAP2K28.11
6Cardiofaciocutaneous syndromeEnrichmentBRAF, MAP2K1, MAP2K28.11
7Schimmelpenning-feuerstein-mims syndromeEnrichmentHRAS, KRAS, NRAS8.03
8Nevus, epidermalEnrichmentHRAS, KRAS, NRAS7.09
9Noonan syndrome 3EnrichmentHRAS, KRAS, RAF17.09
10Melanocytic nevus syndrome, congenitalEnrichmentHRAS, NRAS, RAF16.89
11Primary hyperaldosteronismEnrichmentBRAF, GNAS, NR3C16.79
12Breast implant-associated anaplastic large cell lymphomaEnrichmentJAK2, STAT36.71
13Ras-associated autoimmune leukoproliferative disorderEnrichmentKRAS, NRAS5.73
14Langerhans cell histiocytosisEnrichmentBRAF, MAP2K15.30
15Melanoma of soft tissueEnrichmentATF1, CREB15.30
16Large congenital melanocytic nevusEnrichmentHRAS, NRAS5.25
17Differentiated thyroid carcinomaEnrichmentHRAS, KRAS, NRAS5.08
18Chronic myelogenous leukemia, bcr-abl1 positiveEnrichmentKRAS, NRAS4.95
19Capillary malformations, congenitalEnrichmentGNAQ, PIK3CA4.42
20Thyroid cancer, nonmedullary, 2EnrichmentHRAS, NRAS4.41
21Capillary malformation-arteriovenous malformation 1EnrichmentKRAS, MAP2K14.41
22Leukemia, chronic myeloidEnrichmentKRAS, NRAS4.41
23Pilomyxoid astrocytomaEnrichmentKRAS, RAF14.41
24Follicular thyroid carcinomaEnrichmentHRAS, NRAS4.41
25Klippel-trenaunay-weber syndromeEnrichmentGNAQ, PIK3CA4.24
26Hemihyperplasia, isolatedEnrichmentPIK3CA, RHOA4.24
27Arteriovenous malformationEnrichmentHRAS, MAP2K14.18
28Gallbladder cancerEnrichmentBRAF, PIK3CA4.10
29Myopathy, x-linked, with excessive autophagyEnrichmentHRAS, MAP2K14.08
30Juvenile myelomonocytic leukemiaEnrichmentKRAS, NRAS3.91
31Thrombocythemia 3EnrichmentJAK23.83
32PolycythemiaEnrichmentJAK23.83
33Hypereosinophilic syndromeEnrichmentJAK23.83
34Polycythemia veraEnrichmentJAK23.66
35Lip and oral cavity carcinomaEnrichmentBRAF, PIK3CA3.60
36Sturge-weber syndromeEnrichmentGNAQ3.53
37T-cell large granular lymphocyte leukemiaEnrichmentSTAT33.53
38Autoimmune disease, multisystem, infantile-onset, 1EnrichmentSTAT33.53
39Stat3-related early-onset multisystem autoimmune diseaseEnrichmentSTAT33.53
40Chronic lymphoproliferative disorder of natural killer cellsEnrichmentSTAT33.53
41Erythrocytosis, familial, 1EnrichmentJAK23.53
42Budd-chiari syndromeEnrichmentJAK23.53
43Myeloproliferative neoplasmEnrichmentJAK23.43
44MyelofibrosisEnrichmentJAK23.29
45Essential thrombocythemiaEnrichmentJAK23.29
46Obsessive-compulsive disorderEnrichmentHTR2A3.23
47Phakomatosis cesioflammeaEnrichmentGNAQ3.23
48Diffuse large b-cell lymphomaEnrichmentBRAF, STAT33.19
49Leukemia, acute lymphoblastic 3EnrichmentJAK23.18
50Bladder cancerEnrichmentHRAS, KRAS3.13
51Non-immune hydrops fetalisEnrichmentHRAS, KRAS3.07
52Hyper-ige syndrome 1, autosomal dominant, with recurrent infectionsEnrichmentSTAT33.05
53Hyper ige syndromeEnrichmentSTAT33.05
54Anastomosing haemangiomaEnrichmentGNAQ3.05
55Pseudohypoparathyroidism, type icEnrichmentGNAS2.88
56Melorheostosis, isolatedEnrichmentMAP2K12.88
57Osseous heteroplasia, progressiveEnrichmentGNAS2.88
58Noonan syndrome 7EnrichmentBRAF2.88
59Leopard syndrome 3EnrichmentBRAF2.88
60Cardiofaciocutaneous syndrome 3EnrichmentMAP2K12.88
61Glucocorticoid resistance, generalizedEnrichmentNR3C12.88
62Acth-independent macronodular adrenal hyperplasia 1EnrichmentGNAS2.88
63Pituitary adenoma 3, multiple typesEnrichmentGNAS2.88
64LymphangiomaEnrichmentBRAF2.88
65Phace associationEnrichmentBRAF2.88
66MelorheostosisEnrichmentMAP2K12.88
67Cardiofaciocutaneous syndrome 4EnrichmentMAP2K22.88
68Disorders of gnas inactivationEnrichmentGNAS2.88
69Syringocystadenoma papilliferumEnrichmentBRAF2.88
70GangliogliomaEnrichmentBRAF2.88
71Nongerminomatous germ cell tumorEnrichmentBRAF2.88
72Monostotic fibrous dysplasiaEnrichmentGNAS2.88
73Phace syndromeEnrichmentBRAF2.88
74Classic hairy cell leukemiaEnrichmentBRAF2.88
75Mazabraud syndromeEnrichmentGNAS2.88
76Oculoectodermal syndromeEnrichmentKRAS2.85
77Noonan syndrome 5EnrichmentRAF12.85
78Cardiomyopathy, dilated, 1nnEnrichmentRAF12.85
79Melanosis, neurocutaneousEnrichmentNRAS2.85
80Noonan syndrome 6EnrichmentNRAS2.85
81Atrioventricular septal defect 4EnrichmentGATA42.85
82Immunodeficiency 64 with lymphoproliferationEnrichmentRASGRP12.85
83Cardiofaciocutaneous syndrome 2EnrichmentKRAS2.85
84Atrial septal defect 2EnrichmentGATA42.85
85Leopard syndrome 2EnrichmentRAF12.85
86Testicular anomalies with or without congenital heart diseaseEnrichmentGATA42.85
878p23.1 microdeletion syndromeEnrichmentGATA42.85
88TrigonitisEnrichmentRAF12.85
89Congenital pulmonary airway malformationEnrichmentKRAS2.85
90Immunodeficiency 64EnrichmentRASGRP12.85
91Ebv-induced lymphoproliferative disease due to rasgrp1 deficiencyEnrichmentRASGRP12.85
92Partial atrioventricular septal defect with ventricular hypoplasiaEnrichmentGATA42.85
93Phakomatosis pigmentokeratoticaEnrichmentHRAS2.85
94Neurocutaneous melanocytosisEnrichmentNRAS2.85
95Leukemia, acute myeloidEnrichmentKRAS, NRAS2.85
96Major depressive disorderEnrichmentHTR2A2.83
97Melanoma, uvealEnrichmentGNAQ2.75
98Lung cancerEnrichmentBRAF, PIK3CA2.74
99MacrodactylyEnrichmentPIK3CA2.70
100Megalencephaly, autosomal dominantEnrichmentPIK3CA2.70
101Cowden syndrome 5EnrichmentPIK3CA2.70
10246,xy sex reversal 6EnrichmentMAP3K12.70
103Cerebral cavernous malformations 4EnrichmentPIK3CA2.70
104Hemifacial myohyperplasiaEnrichmentPIK3CA2.70
105Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowthEnrichmentPIK3CA2.70
106Macular dystrophy, patterned, 3EnrichmentMAPKAPK32.70
107Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomaliesEnrichmentRHOA2.70
108Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomaliesEnrichmentRHOA2.70
109Segmental progressive overgrowth syndrome with fibroadipose hyperplasiaEnrichmentPIK3CA2.70
110HypospadiasEnrichmentPIK3CA2.70
111Rare venous malformationEnrichmentPIK3CA2.70
112Diaphragmatic eventrationEnrichmentPIK3CA2.70
113Pik3ca-related overgrowth spectrumEnrichmentPIK3CA2.70
114Rare combined vascular malformationEnrichmentPIK3CA2.70
115Cavernous lymphangiomaEnrichmentPIK3CA2.70
116Pik3ca-related overgrowth syndromeEnrichmentPIK3CA2.70
117Hemihyperplasia-multiple lipomatosis syndromeEnrichmentPIK3CA2.70
118Eccrine angiomatous hamartomaEnrichmentPIK3CA2.70
119Macrodactyly of toeEnrichmentPIK3CA2.70
120Permanent neonatal diabetes mellitusEnrichmentSTAT32.63
121Pseudohypoparathyroidism, type iaEnrichmentGNAS2.58
122Galactosemia iiEnrichmentNR3C12.58
123Pulmonic stenosisEnrichmentBRAF2.58
124Histiocytoma, angiomatoid fibrousEnrichmentCREB12.58
125Pigmented nodular adrenocortical disease, primary, 1EnrichmentGNAS2.58
126PseudopseudohypoparathyroidismEnrichmentGNAS2.58
127PseudohypoparathyroidismEnrichmentGNAS2.58
128Acth-independent macronodular adrenal hyperplasiaEnrichmentGNAS2.58
129Tafro syndromeEnrichmentMAP2K22.58
130Spinocerebellar ataxia 29EnrichmentITPR12.55
131Costello syndromeEnrichmentHRAS2.55
132Encephalocraniocutaneous lipomatosisEnrichmentKRAS2.55
13346,xy sex reversal 3EnrichmentGATA42.55
134Wooly hair nevusEnrichmentHRAS2.55
135Acute promyelocytic leukemiaEnrichmentSTAT32.42
136Mccune-albright syndromeEnrichmentGNAS2.40
137Ataxia-telangiectasiaEnrichmentBRAF2.40
138Tethered spinal cord syndromeEnrichmentBRAF2.40
139Cushing syndrome due to bilateral macronodular adrenocortical diseaseEnrichmentGNAS2.40
140Keratosis, seborrheicEnrichmentPIK3CA2.40
141Noonan syndrome 8EnrichmentPIK3CA2.40
142Rosette-forming glioneuronal tumorEnrichmentPIK3CA2.40
143Gillespie syndromeEnrichmentITPR12.38
144SpermatocytomaEnrichmentHRAS2.38
145Primary ovarian insufficiencyEnrichmentJAK22.36
146Thyroid cancer, nonmedullary, 1EnrichmentBRAF2.28
147Pseudohypoparathyroidism, type ibEnrichmentGNAS2.28
148Neurofibromatosis-noonan syndromeEnrichmentMAP2K22.28
149CraniopharyngiomaEnrichmentBRAF2.28
150Noonan syndrome with multiple lentiginesEnrichmentBRAF2.28
151Newborn respiratory distress syndromeEnrichmentBRAF2.28
152Diffuse gastric and lobular breast cancer syndromeEnrichmentKRAS2.25
153Spinocerebellar ataxia 15EnrichmentITPR12.25
154Lung sarcomatoid carcinomaEnrichmentKRAS2.25
155Pilocytic astrocytomaEnrichmentKRAS2.25
156Epidermolytic nevusEnrichmentHRAS2.25
157Transposition of the great arteriesEnrichmentGATA42.25
158Pompe disease, infantile-onsetEnrichmentPIK3CA2.22
159Congenital lipomatous overgrowth, vascular malformations, and epidermal neviEnrichmentPIK3CA2.22
160Bacteremia 2EnrichmentMAPKAPK32.22
161KeratoacanthomaEnrichmentPIK3CA2.22
162Ventricular septal defect 1EnrichmentGATA42.16
163Congenital heart defects, multiple types, 4EnrichmentGATA42.16
164Wilms tumor 5EnrichmentBRAF2.10
165Megalencephaly-capillary malformation-polymicrogyria syndromeEnrichmentPIK3CA2.10
166Congenital generalized lipodystrophyEnrichmentFOS2.10
167Cerebrovascular diseaseEnrichmentPIK3CA2.10
168TuberculosisEnrichmentMAPKAPK32.10
169Familial cerebral cavernous malformationsEnrichmentPIK3CA2.10
170Spinocerebellar ataxia, autosomal recessive 16EnrichmentITPR12.08
171Breast adenocarcinomaEnrichmentKRAS2.08
172Lung squamous cell carcinomaEnrichmentKRAS2.08
173BrachydactylyEnrichmentGNAS2.03
174Histiocytoid hemangiomaEnrichmentFOS2.00
175HemimegalencephalyEnrichmentPIK3CA2.00
176Spastic paraplegia 4, autosomal dominantEnrichmentGNAS1.98
177Lymphoma, non-hodgkin, familialEnrichmentBRAF1.98
178Cardiomyopathy, familial hypertrophic, 4EnrichmentBRAF1.93
179Ventricular septal defectEnrichmentBRAF1.93
180Cowden syndrome 1EnrichmentPIK3CA1.92
181Colorectal cancerEnrichmentBRAF, PIK3CA1.89
182MelanomaEnrichmentBRAF1.88
183Ovarian cancerEnrichmentMAP3K1, PIK3CA1.77
184SchizophreniaEnrichmentHTR2A1.76
185Adult hepatocellular carcinomaEnrichmentPIK3CA1.75
186Cowden syndromeEnrichmentPIK3CA1.75
187Protein-deficiency anemiaEnrichmentNRAS1.74
188Lung cancer susceptibility 3EnrichmentBRAF1.73
189Multiple sclerosisEnrichmentITPR11.71
190Aortic aneurysm, familial thoracic 1EnrichmentGATA41.71
191Heart diseaseEnrichmentGATA41.71
19246,xy partial gonadal dysgenesisEnrichmentGATA41.71
193Wilms tumor 1EnrichmentBRAF1.70
194Anterior segment dysgenesisEnrichmentITPR11.68
195Lynch syndromeEnrichmentKRAS1.68
19646,xy complete gonadal dysgenesisEnrichmentMAP3K11.66
197RhabdomyosarcomaEnrichmentHRAS1.65
198Melanoma, cutaneous malignant 1EnrichmentBRAF1.65
199Dandy-walker syndromeEnrichmentBRAF1.65
200MeningiomaEnrichmentPIK3CA1.63
201Heart, malformation ofEnrichmentGATA41.60
202Patent foramen ovaleEnrichmentGATA41.60
203Arteriovenous malformations of the brainEnrichmentBRAF1.60
204Cardiomyopathy, familial hypertrophic, 1EnrichmentRAF11.48
205Familial atrial fibrillationEnrichmentGATA41.48
206Pancreatic cancerEnrichmentKRAS1.46
207Tetralogy of fallotEnrichmentGATA41.45
208Hydrops fetalis, nonimmuneEnrichmentHRAS1.45
209Endometrial cancerEnrichmentPIK3CA1.39
210Hepatocellular carcinomaEnrichmentPIK3CA1.37
211MalariaEnrichmentMAPKAPK31.35
212Familial hypertrophic cardiomyopathyEnrichmentRAF11.34
213Left ventricular noncompactionEnrichmentRAF11.32
214Prostate cancerEnrichmentPIK3CA1.25
215Gastric cancerEnrichmentKRAS1.23
216Hereditary breast carcinomaEnrichmentKRAS1.22
217Body mass index quantitative trait locus 11EnrichmentGNAS1.19
218Spastic ataxiaEnrichmentITPR11.14
219Familial isolated dilated cardiomyopathyEnrichmentRAF11.14
220Myeloma, multipleEnrichmentBRAF1.14
221Hereditary breast ovarian cancer syndromeEnrichmentKRAS1.13
222Male infertility with azoospermia or oligozoospermia due to single gene mutationEnrichmentGATA41.12
223HypertelorismEnrichmentPIK3CA1.01
224Breast cancerEnrichmentKRAS1.00
225Dilated cardiomyopathyEnrichmentBRAF1.00
226Autism spectrum disorderEnrichmentMAP2K10.87

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