SHP2 signaling

No Pathway Network information available for SHP2 signaling

Pathways in the SHP2 signaling SuperPath

#	Name	Source	Genes
1	SHP2 signaling	PubChem	AFDN ANGPT1 ARHGAP35 BDNF EGF EGFR FGFR2 FGFR3 FRS2 GAB1 GAB2 GNAI1 GNAI3 GRB2 IFNG IFNGR1 IGF1R IL2 IL2RA IL2RB IL2RG IL6 IL6R IL6ST IRS1 JAK1 JAK2 JAK3 KDR LCK LMO4 MAP2K1 NGF NOS3 NTF3 NTF4 NTRK1 NTRK2 NTRK3 PAG1 PDGFB PDGFRB PIK3CA PIK3R1 PRKACA PTPN11 RAF1 RHOA SDC2 SHC1 SOS1 STAT1 TEK VEGFA (see all 54) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AFDN	Afadin, Adherens Junction Formation Factor	Protein Coding	1
2	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
3	LMO4	LIM Domain Only 4	Protein Coding	1
4	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
5	IL6R	Interleukin 6 Receptor	Protein Coding	1
6	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
7	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
8	JAK3	Janus Kinase 3	Protein Coding	1
9	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	1
10	IFNG	Interferon Gamma	Protein Coding	1
11	IL2	Interleukin 2	Protein Coding	1
12	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
13	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
14	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
15	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
16	IL6	Interleukin 6	Protein Coding	1
17	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
18	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
19	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	1
20	NTF4	Neurotrophin 4	Protein Coding	1
21	NTF3	Neurotrophin 3	Protein Coding	1
22	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	1
23	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
24	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	1
25	NGF	Nerve Growth Factor	Protein Coding	1
26	PAG1	Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1	Protein Coding	1
27	EGF	Epidermal Growth Factor	Protein Coding	1
28	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
29	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
30	ANGPT1	Angiopoietin 1	Protein Coding	1
31	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	1
32	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	1
33	SDC2	Syndecan 2	Protein Coding	1
34	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
35	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
36	RHOA	Ras Homolog Family Member A	Protein Coding	1
37	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	1
38	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
39	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
40	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
41	JAK2	Janus Kinase 2	Protein Coding	1
42	KDR	Kinase Insert Domain Receptor	Protein Coding	1
43	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
44	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
45	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
46	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
47	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
48	SHC1	SHC Adaptor Protein 1	Protein Coding	1
49	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
50	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
51	JAK1	Janus Kinase 1	Protein Coding	1
52	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
53	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
54	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1

Disorders associated with SHP2 signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, PTPN11, RAF1, SOS1	6.53
2	Lung squamous cell carcinoma	Enrichment	EGFR, FGFR3, PIK3CA	5.93
3	Noonan syndrome 1	Enrichment	MAP2K1, PTPN11, RAF1, SOS1	5.73
4	Noonan syndrome 3	Enrichment	PTPN11, RAF1, SOS1	5.69
5	Rasopathy	Enrichment	MAP2K1, PTPN11, RAF1, SOS1	5.50
6	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA, TEK	5.31
7	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA, TEK	5.15
8	Lung non-small cell carcinoma	Enrichment	EGFR, MAP2K1, PIK3CA	5.02
9	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	4.81
10	Crouzon syndrome	Enrichment	FGFR2, FGFR3	4.33
11	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	4.33
12	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.33
13	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2	4.33
14	Primary ovarian insufficiency	Enrichment	JAK2, KDR, NOS3, NTRK1	4.06
15	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	4.03
16	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.03
17	Glioma	Enrichment	FGFR2, NTRK3	4.03
18	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	3.81
19	Bladder cancer	Enrichment	EGFR, FGFR3, PIK3CA	3.69
20	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	3.64
21	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.64
22	Nevus, epidermal	Enrichment	FGFR3, PIK3CA	3.49
23	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.49
24	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF, NTRK1	3.49
25	Pilomyxoid astrocytoma	Enrichment	NTRK2, RAF1	3.49
26	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	3.49
27	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	3.49
28	Colorectal cancer	Enrichment	FGFR2, FGFR3, PIK3CA, PIK3R1	3.41
29	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	3.37
30	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	3.26
31	Meningioma	Enrichment	PDGFB, PIK3CA	3.00
32	Lip and oral cavity carcinoma	Enrichment	EGFR, PIK3CA	3.00
33	Nk-cell enteropathy	Enrichment	IGF1R, JAK3	2.93
34	Hydrocephalus	Enrichment	FGFR2, PDGFRB	2.80
35	Gliosarcoma	Enrichment	EGFR, FGFR3	2.74
36	Giant cell glioblastoma	Enrichment	EGFR, FGFR3	2.69
37	Arteriovenous malformations of the brain	Enrichment	EGFR, IL6	2.59
38	Craniosynostosis	Enrichment	FGFR2, FGFR3	2.55
39	Endometrial cancer	Enrichment	FGFR2, PIK3CA	2.51
40	Breast cancer	Enrichment	IL2, PIK3CA, SHC1	2.48
41	Hypochondroplasia	Enrichment	FGFR3	2.40
42	Macrodactyly	Enrichment	PIK3CA	2.40
43	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.40
44	Metachondromatosis	Enrichment	PTPN11	2.40
45	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.40
46	Muenke syndrome	Enrichment	FGFR3	2.40
47	Helicobacter pylori infection	Enrichment	IFNGR1	2.40
48	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.40
49	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.40
50	Deafness, autosomal recessive 26	Enrichment	GAB1	2.40
51	Noonan syndrome 5	Enrichment	RAF1	2.40
52	Hypomagnesemia 4, renal	Enrichment	EGF	2.40
53	Noonan syndrome 4	Enrichment	SOS1	2.40
54	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.40
55	Melorheostosis, isolated	Enrichment	MAP2K1	2.40
56	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.40
57	Apert syndrome	Enrichment	FGFR2	2.40
58	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.40
59	Leopard syndrome 1	Enrichment	PTPN11	2.40
60	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.40
61	Cowden syndrome 5	Enrichment	PIK3CA	2.40
62	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.40
63	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.40
64	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.40
65	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.40
66	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.40
67	Immunodeficiency 27a	Enrichment	IFNGR1	2.40
68	Angioedema, hereditary, 5	Enrichment	ANGPT1	2.40
69	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.40
70	Immunodeficiency 69	Enrichment	IFNG	2.40
71	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.40
72	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.40
73	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	2.40
74	Venous malformations, multiple cutaneous and mucosal	Enrichment	TEK	2.40
75	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.40
76	Short syndrome	Enrichment	PIK3R1	2.40
77	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.40
78	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.40
79	Immunodeficiency 27b	Enrichment	IFNGR1	2.40
80	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.40
81	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.40
82	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.40
83	Melorheostosis	Enrichment	MAP2K1	2.40
84	Leopard syndrome 2	Enrichment	RAF1	2.40
85	Glaucoma 1, open angle, o	Enrichment	NTF4	2.40
86	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.40
87	Immunodeficiency 31a	Enrichment	STAT1	2.40
88	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.40
89	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.40
90	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.40
91	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.40
92	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.40
93	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.40
94	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.40
95	Immunodeficiency 31b	Enrichment	STAT1	2.40
96	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	2.40
97	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.40
98	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.40
99	Immunodeficiency 22	Enrichment	LCK	2.40
100	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.40
101	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.40
102	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.40
103	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.40
104	Glaucoma 3, primary congenital, e	Enrichment	TEK	2.40
105	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.40
106	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.40
107	Trigonitis	Enrichment	RAF1	2.40
108	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.40
109	Tufted angioma of skin	Enrichment	KDR	2.40
110	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.40
111	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.40
112	Hypospadias	Enrichment	PIK3CA	2.40
113	Bockenheimer syndrome	Enrichment	TEK	2.40
114	Rare venous malformation	Enrichment	PIK3CA	2.40
115	Diaphragmatic eventration	Enrichment	PIK3CA	2.40
116	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.40
117	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.40
118	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.40
119	Rare combined vascular malformation	Enrichment	PIK3CA	2.40
120	Cavernous lymphangioma	Enrichment	PIK3CA	2.40
121	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.40
122	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.40
123	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.40
124	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.40
125	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.40
126	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.40
127	Macrodactyly of toe	Enrichment	PIK3CA	2.40
128	Malignant astrocytoma	Enrichment	PTPN11	2.40
129	Differentiated thyroid carcinoma	Enrichment	NTRK1, NTRK3	2.23
130	Lung cancer	Enrichment	EGFR, PIK3CA	2.15
131	Ovarian cancer	Enrichment	EGFR, NTRK1, PIK3CA	2.12
132	Severe combined immunodeficiency	Enrichment	JAK3, LCK	2.12
133	Blue rubber bleb nevus	Enrichment	TEK	2.10
134	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.10
135	Fibromatosis, gingival, 1	Enrichment	SOS1	2.10
136	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	2.10
137	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.10
138	Cervical cancer	Enrichment	FGFR3	2.10
139	Pulmonic stenosis	Enrichment	SOS1	2.10
140	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.10
141	Aural atresia, congenital	Enrichment	FGFR2	2.10
142	Pfeiffer syndrome	Enrichment	FGFR2	2.10
143	Jackson-weiss syndrome	Enrichment	FGFR2	2.10
144	Angioma, tufted	Enrichment	KDR	2.10
145	Noonan syndrome 8	Enrichment	PIK3CA	2.10
146	Thrombocythemia 3	Enrichment	JAK2	2.10
147	Immunodeficiency 31c	Enrichment	STAT1	2.10
148	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	2.10
149	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.10
150	Werner syndrome	Enrichment	PTPN11	2.10
151	Infantile myofibromatosis	Enrichment	PDGFRB	2.10
152	Split hand-foot malformation	Enrichment	FGFR2	2.10
153	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.10
154	Congenital mesoblastic nephroma	Enrichment	NTRK3	2.10
155	Fibrolamellar carcinoma	Enrichment	PRKACA	2.10
156	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.10
157	Cervix carcinoma	Enrichment	FGFR3	2.10
158	Fibrosarcoma	Enrichment	NTRK3	2.10
159	Polycythemia	Enrichment	JAK2	2.10
160	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.10
161	Hypereosinophilic syndrome	Enrichment	JAK2	2.10
162	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.92
163	Achondroplasia	Enrichment	FGFR3	1.92
164	Larsen syndrome	Enrichment	FGFR3	1.92
165	Thyroid carcinoma, familial medullary	Enrichment	NTRK1	1.92
166	Polycythemia vera	Enrichment	JAK2	1.92
167	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.92
168	Tuberous sclerosis 1	Enrichment	IFNG	1.92
169	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	1.92
170	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	1.92
171	Nuchal bleb, familial	Enrichment	SOS1	1.92
172	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.92
173	Combined immunodeficiency, x-linked	Enrichment	IL2RG	1.92
174	Hepatitis c virus	Enrichment	IFNG	1.92
175	Tuberous sclerosis 2	Enrichment	IFNG	1.92
176	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.92
177	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.92
178	Hamartoma	Enrichment	FGFR3	1.92
179	Testicular germ cell cancer	Enrichment	FGFR3	1.92
180	Immunodeficiency 14	Enrichment	PIK3R1	1.92
181	Spermatocytoma	Enrichment	FGFR3	1.92
182	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.92
183	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.92
184	Tricuspid valve insufficiency	Enrichment	PTPN11	1.92
185	Stüve-wiedemann syndrome	Enrichment	IL6ST	1.92
186	Testicular cancer	Enrichment	FGFR3	1.92
187	Keratoacanthoma	Enrichment	PIK3CA	1.92
188	Type 2 diabetes mellitus	Enrichment	IL6, IRS1	1.92
189	Gastric cancer	Enrichment	FGFR2, PIK3CA	1.90
190	Kaposi sarcoma	Enrichment	IL6	1.80
191	Erythrocytosis, familial, 1	Enrichment	JAK2	1.80
192	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	1.80
193	Budd-chiari syndrome	Enrichment	JAK2	1.80
194	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.80
195	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.80
196	Glaucoma 3, primary infantile, b	Enrichment	TEK	1.80
197	Achromatopsia 4	Enrichment	GNAI3	1.80
198	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	1.80
199	Hepatitis b	Enrichment	IFNGR1	1.80
200	Cerebrovascular disease	Enrichment	PIK3CA	1.80
201	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.80
202	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.80
203	Adenosine deaminase deficiency	Enrichment	JAK3	1.80
204	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.80
205	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.80
206	Gingival fibromatosis	Enrichment	SOS1	1.80
207	Hereditary angioedema with normal c1inh not related to f12 or plg variant	Enrichment	ANGPT1	1.80
208	Hypertelorism	Enrichment	FGFR2, PIK3CA	1.74
209	Capillary malformations, congenital	Enrichment	PIK3CA	1.70
210	Alzheimer disease 2	Enrichment	NOS3	1.70
211	Martsolf syndrome 1	Enrichment	ARHGAP35	1.70
212	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.70
213	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.70
214	Insulin-like growth factor i	Enrichment	IGF1R	1.70
215	Pre-eclampsia	Enrichment	NOS3	1.70
216	Lymphoma	Enrichment	PTPN11	1.70
217	Myeloproliferative neoplasm	Enrichment	JAK2	1.70
218	Hemimegalencephaly	Enrichment	PIK3CA	1.70
219	Primary hypereosinophilic syndrome	Enrichment	PDGFRB	1.70
220	Idiopathic aplastic anemia	Enrichment	IFNG	1.70
221	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.63
222	Split-hand/foot malformation 1	Enrichment	FGFR2	1.63
223	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	1.63
224	Type 1 diabetes mellitus	Enrichment	IL6	1.63
225	Testicular germ cell tumor	Enrichment	FGFR3	1.63
226	Hemangioma, capillary infantile	Enrichment	KDR	1.63
227	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	1.63
228	Patent ductus arteriosus	Enrichment	PTPN11	1.63
229	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.63
230	Breast adenocarcinoma	Enrichment	PIK3CA	1.63
231	46,xy disorder of sex development	Enrichment	FGFR3	1.63
232	Glaucoma 3, primary congenital, a	Enrichment	TEK	1.56
233	Myelofibrosis	Enrichment	JAK2	1.56
234	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.56
235	Essential thrombocythemia	Enrichment	JAK2	1.56
236	Gallbladder cancer	Enrichment	PIK3CA	1.56
237	Overgrowth syndrome	Enrichment	PIK3R1	1.56
238	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.50
239	Ellis-van creveld syndrome	Enrichment	PRKACA	1.45
240	Inflammatory bowel disease 1	Enrichment	IL6	1.45
241	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.45
242	Congenital central hypoventilation syndrome	Enrichment	BDNF	1.45
243	Ventricular septal defect	Enrichment	TEK	1.45
244	Cowden syndrome	Enrichment	PIK3CA	1.45
245	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.41
246	Peters-plus syndrome	Enrichment	ARHGAP35	1.41
247	Omenn syndrome	Enrichment	IL2RG	1.41
248	Stroke, ischemic	Enrichment	NOS3	1.41
249	Aplastic anemia	Enrichment	IFNG	1.41
250	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.41
251	Primary bone dysplasia	Enrichment	FGFR3	1.41
252	Pectus excavatum	Enrichment	PTPN11	1.37
253	Meningioma, familial	Enrichment	PDGFB	1.37
254	Combined immunodeficiency	Enrichment	IL2RG	1.37
255	Osteochondrodysplasia	Enrichment	FGFR3	1.37
256	Ichthyosis	Enrichment	IL2RB	1.37
257	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	1.37
258	Specific learning disability	Enrichment	PTPN11	1.37
259	Combined t and b cell immunodeficiency	Enrichment	IL2RG	1.37
260	Epicanthus	Enrichment	PTPN11	1.33
261	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.33
262	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.33
263	Congenital long qt syndrome	Enrichment	PTPN11	1.33
264	Aortic valve disease 1	Enrichment	SOS1	1.30
265	Lung cancer susceptibility 3	Enrichment	EGFR	1.26
266	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.26
267	Lynch syndrome	Enrichment	PIK3CA	1.24
268	Alzheimer disease, familial, 1	Enrichment	NOS3	1.18
269	Hypertension, essential	Enrichment	NOS3	1.18
270	Dandy-walker syndrome	Enrichment	PDGFRB	1.18
271	Human immunodeficiency virus type 1	Enrichment	IFNG	1.16
272	Patent foramen ovale	Enrichment	PTPN11	1.16
273	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.16
274	Behcet syndrome	Enrichment	IFNGR1	1.14
275	Hepatoblastoma	Enrichment	FGFR3	1.09
276	Hepatocellular carcinoma	Enrichment	PIK3CA	1.08
277	Microcephaly	Enrichment	IGF1R, PTPN11	1.07
278	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.04
279	Scoliosis	Enrichment	PTPN11	1.04
280	Inherited cancer-predisposing syndrome	Enrichment	EGFR, PTPN11	1.01
281	Tetralogy of fallot	Enrichment	KDR	1.01
282	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.01
283	Strabismus	Enrichment	PTPN11	0.99
284	Prostate cancer	Enrichment	PIK3CA	0.96
285	Severe covid-19	Enrichment	JAK3	0.96
286	Long qt syndrome 1	Enrichment	PTPN11	0.95
287	Non-immune hydrops fetalis	Enrichment	PTPN11	0.93
288	Connective tissue disease	Enrichment	FGFR3	0.92
289	Peripheral nervous system disease	Enrichment	NGF	0.92
290	Neuropathy	Enrichment	NGF	0.92
291	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.91
292	Left ventricular noncompaction	Enrichment	RAF1	0.88
293	Cerebral palsy	Enrichment	PDGFRB	0.84
294	Leukemia, acute myeloid	Enrichment	JAK2	0.83
295	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.80
296	West syndrome	Enrichment	NTRK2	0.79
297	Hereditary breast carcinoma	Enrichment	PIK3CA	0.79
298	Thrombocytopenia	Enrichment	PTPN11	0.76
299	Body mass index quantitative trait locus 11	Enrichment	BDNF	0.74
300	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.72
301	Myeloma, multiple	Enrichment	FGFR3	0.70
302	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.70
303	Undetermined early-onset epileptic encephalopathy	Enrichment	NTRK2	0.70
304	Dilated cardiomyopathy	Enrichment	RAF1	0.56
305	Congenital nervous system abnormality	Enrichment	FGFR3	0.46
306	Nervous system disease	Enrichment	FGFR3	0.46

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

SHP2 signaling

Pathway Network for SHP2 signaling

Member Pathways for SHP2 signaling

Pathways in the SHP2 signaling SuperPath

Associated Genes for SHP2 signaling

Associated Disorders for SHP2 signaling

Disorders associated with SHP2 signaling SuperPath

STRING Interaction Network for SHP2 signaling

Sources for SHP2 signaling