Signal regulatory protein family interactions

No Pathway Network information available for Signal regulatory protein family interactions

Pathways in the Signal regulatory protein family interactions SuperPath

#	Name	Source	Genes
1	Signal regulatory protein family interactions	Reactome	CD47 FYB1 GRB2 PTK2 PTK2B PTPN11 PTPN6 SFTPA1 SFTPA2 SFTPD SIRPA SIRPB1 SIRPG SKAP2 SRC TYROBP (see all 16) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SIRPB1	Signal Regulatory Protein Beta 1	Protein Coding	1
2	SIRPA	Signal Regulatory Protein Alpha	Protein Coding	1
3	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
4	FYB1	FYN Binding Protein 1	Protein Coding	1
5	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
6	SIRPG	Signal Regulatory Protein Gamma	Protein Coding	1
7	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
8	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
9	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
10	SFTPD	Surfactant Protein D	Protein Coding	1
11	SFTPA1	Surfactant Protein A1	Protein Coding	1
12	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
13	SFTPA2	Surfactant Protein A2	Protein Coding	1
14	TYROBP	Transmembrane Immune Signaling Adaptor TYROBP	Protein Coding	1
15	SKAP2	Src Kinase Associated Phosphoprotein 2	Protein Coding	1
16	CD47	CD47 Molecule	Protein Coding	1

Disorders associated with Signal regulatory protein family interactions SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Interstitial lung disease 2	Enrichment	SFTPA1, SFTPA2	3.76
2	Metachondromatosis	Enrichment	PTPN11	2.93
3	Leopard syndrome 1	Enrichment	PTPN11	2.93
4	Interstitial lung disease 1	Enrichment	SFTPA1	2.93
5	Thrombocytopenia 3	Enrichment	FYB1	2.93
6	Thrombocytopenia 6	Enrichment	SRC	2.93
7	Congenital autosomal recessive small-platelet thrombocytopenia	Enrichment	FYB1	2.93
8	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.93
9	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.93
10	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.93
11	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.93
12	Malignant astrocytoma	Enrichment	PTPN11	2.93
13	Thrombocytopenia	Enrichment	PTPN11, SRC	2.85
14	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1	Enrichment	TYROBP	2.63
15	Werner syndrome	Enrichment	PTPN11	2.63
16	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.45
17	Tricuspid valve insufficiency	Enrichment	PTPN11	2.45
18	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.33
19	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.33
20	Lymphoma	Enrichment	PTPN11	2.23
21	Patent ductus arteriosus	Enrichment	PTPN11	2.15
22	Myelofibrosis	Enrichment	SRC	2.08
23	Noonan syndrome 3	Enrichment	PTPN11	2.08
24	Pectus excavatum	Enrichment	PTPN11	1.89
25	Specific learning disability	Enrichment	PTPN11	1.89
26	Epicanthus	Enrichment	PTPN11	1.85
27	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.85
28	Congenital long qt syndrome	Enrichment	PTPN11	1.85
29	Osteoporosis	Enrichment	SRC	1.79
30	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.76
31	Patent foramen ovale	Enrichment	PTPN11	1.68
32	Noonan syndrome 1	Enrichment	PTPN11	1.57
33	Scoliosis	Enrichment	PTPN11	1.55
34	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.52
35	Rasopathy	Enrichment	PTPN11	1.52
36	Strabismus	Enrichment	PTPN11	1.50
37	Long qt syndrome 1	Enrichment	PTPN11	1.46
38	Non-immune hydrops fetalis	Enrichment	PTPN11	1.44
39	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.30
40	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.19
41	Colorectal cancer	Enrichment	SRC	1.01
42	Autism spectrum disorder	Enrichment	PTPN11	0.92
43	Microcephaly	Enrichment	PTPN11	0.87
44	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.84

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signal regulatory protein family interactions

Pathway Network for Signal regulatory protein family interactions

Member Pathways for Signal regulatory protein family interactions

Pathways in the Signal regulatory protein family interactions SuperPath

Associated Genes for Signal regulatory protein family interactions

Associated Disorders for Signal regulatory protein family interactions

Disorders associated with Signal regulatory protein family interactions SuperPath

STRING Interaction Network for Signal regulatory protein family interactions

Sources for Signal regulatory protein family interactions