Signal transduction by L1

No Pathway Network information available for Signal transduction by L1

Pathways in the Signal transduction by L1 SuperPath

#	Name	Source	Genes
1	Signal transduction by L1	Reactome	CSNK2A1 CSNK2A2 CSNK2B EGFR FGFR1 ITGA2B ITGA5 ITGA9 ITGAV ITGB1 ITGB3 L1CAM MAP2K1 MAP2K2 MAPK1 MAPK3 NCAM1 NRP1 PAK1 RAC1 VAV2 (see all 21) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	1
2	CSNK2A2	Casein Kinase 2 Alpha 2	Protein Coding	1
3	CSNK2B	Casein Kinase 2 Beta	Protein Coding	1
4	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
5	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
6	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	1
7	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
8	ITGA9	Integrin Subunit Alpha 9	Protein Coding	1
9	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
10	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
11	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
12	L1CAM	L1 Cell Adhesion Molecule	Protein Coding	1
13	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	1
14	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
15	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
16	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
17	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
18	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
19	RAC1	Rac Family Small GTPase 1	Protein Coding	1
20	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
21	NRP1	Neuropilin 1	Protein Coding	1

Disorders associated with Signal transduction by L1 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	5.16
2	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.86
3	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.86
4	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2B, ITGB3	4.47
5	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	4.32
6	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	3.99
7	Lung non-small cell carcinoma	Enrichment	EGFR, MAP2K1	3.90
8	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2	3.63
9	Gliosarcoma	Enrichment	EGFR, FGFR1	3.57
10	Giant cell glioblastoma	Enrichment	EGFR, FGFR1	3.51
11	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2	3.25
12	Autism spectrum disorder	Enrichment	CSNK2A1, CSNK2B, MAP2K1	3.22
13	Rasopathy	Enrichment	MAP2K1, MAP2K2	3.14
14	Osteoglophonic dysplasia	Enrichment	FGFR1	2.81
15	Trigonocephaly 1	Enrichment	FGFR1	2.81
16	Hydrocephalus due to congenital stenosis of aqueduct of sylvius	Enrichment	L1CAM	2.81
17	Melorheostosis, isolated	Enrichment	MAP2K1	2.81
18	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.81
19	Noonan syndrome 13	Enrichment	MAPK1	2.81
20	Corpus callosum, partial agenesis of, x-linked	Enrichment	L1CAM	2.81
21	Hydrocephalus, congenital, x-linked	Enrichment	L1CAM	2.81
22	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.81
23	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.81
24	Masa syndrome	Enrichment	L1CAM	2.81
25	Melorheostosis	Enrichment	MAP2K1	2.81
26	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.81
27	Hartsfield syndrome	Enrichment	FGFR1	2.81
28	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.81
29	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	2.81
30	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.81
31	X-linked complicated spastic paraplegia type 1	Enrichment	L1CAM	2.81
32	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.81
33	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.81
34	Thrombocytopenia	Enrichment	ITGA2B, ITGB3	2.61
35	Pfeiffer syndrome	Enrichment	FGFR1	2.51
36	Jackson-weiss syndrome	Enrichment	FGFR1	2.51
37	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	2.51
38	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.51
39	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	2.51
40	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	2.51
41	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.51
42	Tafro syndrome	Enrichment	MAP2K2	2.51
43	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.33
44	Prognathism, mandibular	Enrichment	CSNK2B	2.33
45	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	2.33
46	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.33
47	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	2.33
48	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.33
49	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.33
50	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.33
51	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.21
52	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.21
53	Enophthalmos	Enrichment	CSNK2B	2.21
54	Syndactyly	Enrichment	CSNK2B	2.21
55	Glanzmann thrombasthenia 2	Enrichment	ITGB3	2.11
56	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	L1CAM	2.11
57	Holoprosencephaly	Enrichment	FGFR1	2.11
58	Primary hypereosinophilic syndrome	Enrichment	FGFR1	2.11
59	Cowden syndrome 1	Enrichment	EGFR	2.03
60	Holoprosencephaly 1	Enrichment	FGFR1	2.03
61	Lung squamous cell carcinoma	Enrichment	EGFR	2.03
62	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.97
63	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.97
64	Pilomyxoid astrocytoma	Enrichment	FGFR1	1.97
65	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.86
66	Arteriovenous malformation	Enrichment	MAP2K1	1.86
67	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.86
68	Hydrops fetalis	Enrichment	L1CAM	1.86
69	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.81
70	Specific learning disability	Enrichment	MAPK1	1.77
71	Septooptic dysplasia	Enrichment	FGFR1	1.73
72	Lip and oral cavity carcinoma	Enrichment	EGFR	1.73
73	Neural tube defects	Enrichment	ITGB1	1.70
74	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.67
75	Lung cancer susceptibility 3	Enrichment	EGFR	1.67
76	Microform holoprosencephaly	Enrichment	FGFR1	1.61
77	Lobar holoprosencephaly	Enrichment	FGFR1	1.61
78	Heart, malformation of	Enrichment	MAPK1	1.56
79	Semilobar holoprosencephaly	Enrichment	FGFR1	1.56
80	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	1.56
81	Arteriovenous malformations of the brain	Enrichment	EGFR	1.54
82	Myocardial infarction	Enrichment	ITGB3	1.47
83	Tooth agenesis	Enrichment	FGFR1	1.47
84	Kallmann syndrome	Enrichment	FGFR1	1.46
85	Bladder cancer	Enrichment	EGFR	1.36
86	Severe covid-19	Enrichment	ITGAV	1.36
87	Lung cancer	Enrichment	EGFR	1.31
88	Autosomal dominant non-syndromic intellectual disability	Enrichment	CSNK2B	1.13
89	Ovarian cancer	Enrichment	EGFR	0.84
90	Microcephaly	Enrichment	MAPK1	0.76
91	Complex neurodevelopmental disorder	Enrichment	CSNK2A1	0.76
92	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signal transduction by L1

Pathway Network for Signal transduction by L1

Member Pathways for Signal transduction by L1

Pathways in the Signal transduction by L1 SuperPath

Associated Genes for Signal transduction by L1

Associated Disorders for Signal transduction by L1

Disorders associated with Signal transduction by L1 SuperPath

STRING Interaction Network for Signal transduction by L1

Sources for Signal transduction by L1