Signal transduction_Erk Interactions- Inhibition of Erk

No Pathway Network information available for Signal transduction_Erk Interactions- Inhibition of Erk

Pathways in the Signal transduction_Erk Interactions- Inhibition of Erk SuperPath

#	Name	Source	Genes
1	Signal transduction_Erk Interactions- Inhibition of Erk	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CD247 CD3D CD3E CD3G DUSP1 DUSP16 DUSP3 DUSP4 DUSP6 DUSP7 DUSP9 GMFB GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D LCK MAP2K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 PEA15 PPP2CA PPP2CB PPP3CA PPP3CB PPP3CC PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD2 PRKD3 PTPN5 PTPN7 PTPRE PTPRR TRA TRAC TRAJ18 TRAV24 TRB TRBV11-1 TRBV11-2 TRBV11-3 TRBV17 VRK3 ZAP70 (see all 74) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
3	CALM1	Calmodulin 1	Protein Coding	1
4	CALM2	Calmodulin 2	Protein Coding	1
5	CALM3	Calmodulin 3	Protein Coding	1
6	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
7	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
8	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
9	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
10	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
11	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
12	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
13	CD247	CD247 Molecule	Protein Coding	1
14	DUSP1	Dual Specificity Phosphatase 1	Protein Coding	1
15	DUSP3	Dual Specificity Phosphatase 3	Protein Coding	1
16	DUSP4	Dual Specificity Phosphatase 4	Protein Coding	1
17	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	1
18	DUSP7	Dual Specificity Phosphatase 7	Protein Coding	1
19	DUSP9	Dual Specificity Phosphatase 9	Protein Coding	1
20	GMFB	Glia Maturation Factor Beta	Protein Coding	1
21	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	1
22	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	1
23	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
24	GRIN2C	Glutamate Ionotropic Receptor NMDA Type Subunit 2C	Protein Coding	1
25	GRIN2D	Glutamate Ionotropic Receptor NMDA Type Subunit 2D	Protein Coding	1
26	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
27	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
28	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
29	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
30	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
31	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
32	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
33	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
34	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
35	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
36	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
37	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
38	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
39	PRKCA	Protein Kinase C Alpha	Protein Coding	1
40	PRKCB	Protein Kinase C Beta	Protein Coding	1
41	PRKCD	Protein Kinase C Delta	Protein Coding	1
42	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
43	PRKCG	Protein Kinase C Gamma	Protein Coding	1
44	PRKCH	Protein Kinase C Eta	Protein Coding	1
45	PRKCI	Protein Kinase C Iota	Protein Coding	1
46	PRKD1	Protein Kinase D1	Protein Coding	1
47	PRKCQ	Protein Kinase C Theta	Protein Coding	1
48	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
49	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
50	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
51	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
52	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
53	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
54	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
55	PTPN7	Protein Tyrosine Phosphatase Non-Receptor Type 7	Protein Coding	1
56	PTPRE	Protein Tyrosine Phosphatase Receptor Type E	Protein Coding	1
57	PTPRR	Protein Tyrosine Phosphatase Receptor Type R	Protein Coding	1
58	TRA	T Cell Receptor Alpha Locus	Protein Coding	1
59	TRB	T Cell Receptor Beta Locus	Protein Coding	1
60	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
61	PEA15	Proliferation And Apoptosis Adaptor Protein 15	Protein Coding	1
62	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
63	PRKD3	Protein Kinase D3	Protein Coding	1
64	PRKD2	Protein Kinase D2	Protein Coding	1
65	TRBV17	T Cell Receptor Beta Variable 17 (Non-Functional)	Protein Coding	1
66	TRBV11-3	T Cell Receptor Beta Variable 11-3	Protein Coding	1
67	TRBV11-2	T Cell Receptor Beta Variable 11-2	Protein Coding	1
68	TRBV11-1	T Cell Receptor Beta Variable 11-1	Protein Coding	1
69	TRAV24	T Cell Receptor Alpha Variable 24	Protein Coding	1
70	TRAJ18	T Cell Receptor Alpha Joining 18	Protein Coding	1
71	TRAC	T Cell Receptor Alpha Constant	Protein Coding	1
72	VRK3	VRK Serine/Threonine Kinase 3	Protein Coding	1
73	DUSP16	Dual Specificity Phosphatase 16	Protein Coding	1
74	PTPN5	Protein Tyrosine Phosphatase Non-Receptor Type 5	Protein Coding	1

Disorders associated with Signal transduction_Erk Interactions- Inhibition of Erk SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, LCK, ZAP70	7.67
2	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	6.81
3	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, GRIN1, GRIN2B, PPP3CA	5.13
4	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	5.07
5	Immunodeficiency 7	Enrichment	TRA, TRAC	4.06
6	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	3.24
7	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.99
8	Proteus syndrome	Enrichment	AKT1	2.26
9	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.26
10	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.26
11	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	2.26
12	Carney complex, type 1	Enrichment	PRKAR1A	2.26
13	Melorheostosis, isolated	Enrichment	MAP2K1	2.26
14	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.26
15	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.26
16	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.26
17	Noonan syndrome 13	Enrichment	MAPK1	2.26
18	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.26
19	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.26
20	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.26
21	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.26
22	Immunodeficiency 48	Enrichment	ZAP70	2.26
23	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.26
24	Immunodeficiency 18	Enrichment	CD3E	2.26
25	Myxoma, intracardiac	Enrichment	PRKAR1A	2.26
26	Immunodeficiency 25	Enrichment	CD247	2.26
27	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.26
28	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.26
29	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.26
30	Melorheostosis	Enrichment	MAP2K1	2.26
31	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.26
32	Long qt syndrome 16	Enrichment	CALM3	2.26
33	Cowden syndrome 6	Enrichment	AKT1	2.26
34	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	2.26
35	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.26
36	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.26
37	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.26
38	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.26
39	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.26
40	Immunodeficiency 22	Enrichment	LCK	2.26
41	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.26
42	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.26
43	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.26
44	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.26
45	Long qt syndrome 15	Enrichment	CALM2	2.26
46	Capillary hemangioma	Enrichment	AKT3	2.26
47	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.26
48	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.26
49	Landau-kleffner syndrome	Enrichment	GRIN2A	2.26
50	Immunodeficiency 19	Enrichment	CD3D	2.26
51	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.26
52	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	2.26
53	Grin2a-related disorders	Enrichment	GRIN2A	2.26
54	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.26
55	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.26
56	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.26
57	Precursor t-cell acute lymphoblastic leukemia	Enrichment	TRA, TRB	2.16
58	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.96
59	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	1.96
60	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.96
61	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.96
62	Long qt syndrome 14	Enrichment	CALM1	1.96
63	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.96
64	Usher syndrome, type iv	Enrichment	PRKAR1A	1.96
65	Bilateral generalized polymicrogyria	Enrichment	GRIN1	1.96
66	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	1.96
67	Senior-loken syndrome 7	Enrichment	AKT3	1.96
68	Developmental and epileptic encephalopathy 46	Enrichment	GRIN2D	1.96
69	Acrodysostosis	Enrichment	PRKAR1A	1.96
70	Fibrolamellar carcinoma	Enrichment	PRKACA	1.96
71	Trypsinogen deficiency	Enrichment	TRB	1.96
72	Immunodeficiency 17	Enrichment	CD3G	1.96
73	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.96
74	Bardet-biedl syndrome 16	Enrichment	AKT3	1.96
75	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.96
76	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.96
77	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	1.96
78	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	1.96
79	Long qt syndrome	Enrichment	CALM1, CALM2	1.91
80	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.79
81	Auditory neuropathy and optic atrophy	Enrichment	GRIN2C	1.79
82	Epilepsy	Enrichment	GRIN2A, GRIN2B	1.70
83	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, GRIN2A	1.68
84	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	1.66
85	Astigmatism	Enrichment	GRIN2B	1.66
86	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.66
87	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.66
88	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.66
89	Carney complex variant	Enrichment	PRKAR1A	1.66
90	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.66
91	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	1.66
92	Hereditary ataxia	Enrichment	PRKCG	1.66
93	Centralopathic epilepsy	Enrichment	GRIN1, GRIN2A	1.64
94	West syndrome	Enrichment	GRIN1, GRIN2B	1.62
95	Vitamin d-dependent rickets, type 2a	Enrichment	TRB	1.57
96	Hemimegalencephaly	Enrichment	AKT3	1.57
97	Sleep disorder	Enrichment	GRIN2B	1.57
98	Microcephaly	Enrichment	CAMK2B, GRIN2B, MAPK1	1.53
99	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.49
100	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.49
101	Breast adenocarcinoma	Enrichment	AKT1	1.49
102	Undetermined early-onset epileptic encephalopathy	Enrichment	GRIN2D, PPP3CA	1.43
103	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.43
104	Megacolon	Enrichment	AKT3	1.43
105	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.43
106	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.43
107	Lennox-gastaut syndrome	Enrichment	MAPK10	1.37
108	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.37
109	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.32
110	Arteriovenous malformation	Enrichment	MAP2K1	1.32
111	Cowden syndrome	Enrichment	AKT1	1.32
112	Stroke, ischemic	Enrichment	PRKCH	1.27
113	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.27
114	Polymicrogyria	Enrichment	AKT3	1.27
115	Combined immunodeficiency	Enrichment	ZAP70	1.23
116	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.23
117	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	1.23
118	Specific learning disability	Enrichment	MAPK1	1.23
119	Combined t and b cell immunodeficiency	Enrichment	ZAP70	1.23
120	Meningioma	Enrichment	AKT1	1.20
121	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.16
122	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.16
123	Hereditary chronic pancreatitis	Enrichment	TRB	1.13
124	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1	1.10
125	Pancreatitis, hereditary	Enrichment	TRB	1.05
126	Sudden infant death syndrome	Enrichment	CALM2	1.05
127	Heart, malformation of	Enrichment	MAPK1	1.03
128	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1	1.03
129	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	1.03
130	Craniosynostosis	Enrichment	GRIN2B	0.98
131	Noonan syndrome 1	Enrichment	MAP2K1	0.93
132	Kallmann syndrome	Enrichment	DUSP6	0.93
133	Autism spectrum disorder	Enrichment	GRIN2B, MAP2K1	0.92
134	Scoliosis	Enrichment	GRIN2B	0.91
135	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1	0.89
136	Rasopathy	Enrichment	MAP2K1	0.88
137	Complex neurodevelopmental disorder	Enrichment	GRIN2B, PPP2CA	0.83
138	Dystonia	Enrichment	CAMK2B	0.76
139	Cerebral palsy	Enrichment	GRIN2B	0.72
140	Type 2 diabetes mellitus	Enrichment	AKT2	0.69
141	Hereditary breast carcinoma	Enrichment	AKT1	0.67
142	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIN1	0.56
143	Autism	Enrichment	CAMK2G	0.49
144	Breast cancer	Enrichment	AKT1	0.47
145	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.47
146	Colorectal cancer	Enrichment	AKT1	0.42
147	Ovarian cancer	Enrichment	AKT1	0.37
148	Congenital nervous system abnormality	Enrichment	CAMK2B	0.36
149	Nervous system disease	Enrichment	CAMK2B	0.36
150	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.29

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signal transduction_Erk Interactions- Inhibition of Erk

Pathway Network for Signal transduction_Erk Interactions- Inhibition of Erk

Member Pathways for Signal transduction_Erk Interactions- Inhibition of Erk

Pathways in the Signal transduction_Erk Interactions- Inhibition of Erk SuperPath

Associated Genes for Signal transduction_Erk Interactions- Inhibition of Erk

Associated Disorders for Signal transduction_Erk Interactions- Inhibition of Erk

Disorders associated with Signal transduction_Erk Interactions- Inhibition of Erk SuperPath

STRING Interaction Network for Signal transduction_Erk Interactions- Inhibition of Erk

Sources for Signal transduction_Erk Interactions- Inhibition of Erk