Signal transduction_JNK pathway

No Pathway Network information available for Signal transduction_JNK pathway

Pathways in the Signal transduction_JNK pathway SuperPath

#	Name	Source	Genes
1	Signal transduction_JNK pathway	GeneGo (Thomson Reuters)	ATF2 CDC42 CRK DAXX ELK1 ELK4 FAS FASLG GRB2 HRAS JUN JUND MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K1 MAP4K2 MAP4K3 MAP4K4 MAP4K5 MAPK10 MAPK8 MAPK9 NFATC1 NFATC3 RAC1 RAF1 SOS1 SOS2 TNF TNFRSF1A TP53 TRADD TRAF2 (see all 44) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
2	FASLG	Fas Ligand	Protein Coding	1
3	CDC42	Cell Division Cycle 42	Protein Coding	1
4	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	1
5	ATF2	Activating Transcription Factor 2	Protein Coding	1
6	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
7	DAXX	Death Domain Associated Protein	Protein Coding	1
8	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
9	ELK4	ETS Transcription Factor ELK4	Protein Coding	1
10	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
11	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
12	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
13	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
14	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
15	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
16	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
17	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
18	MAP3K10	Mitogen-Activated Protein Kinase Kinase Kinase 10	Protein Coding	1
19	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
20	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
21	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	1
22	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
23	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
24	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
25	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
26	MAP4K2	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2	Protein Coding	1
27	RAC1	Rac Family Small GTPase 1	Protein Coding	1
28	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
29	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
30	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
31	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
32	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
33	TNF	Tumor Necrosis Factor	Protein Coding	1
34	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
35	TP53	Tumor Protein P53	Protein Coding	1
36	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
37	MAP3K12	Mitogen-Activated Protein Kinase Kinase Kinase 12	Protein Coding	1
38	MAP4K3	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3	Protein Coding	1
39	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
40	MAP3K13	Mitogen-Activated Protein Kinase Kinase Kinase 13	Protein Coding	1
41	MAP4K4	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4	Protein Coding	1
42	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
43	MAP4K5	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5	Protein Coding	1
44	MAP4K1	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1	Protein Coding	1

Disorders associated with Signal transduction_JNK pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	HRAS, RAF1, SOS1, SOS2	6.09
2	Noonan syndrome 3	Enrichment	HRAS, RAF1, SOS1	5.96
3	Rasopathy	Enrichment	HRAS, RAF1, SOS1, SOS2	5.86
4	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, RAF1, SOS1	4.85
5	Autoimmune lymphoproliferative syndrome	Enrichment	FAS, FASLG	4.21
6	Lung cancer	Enrichment	FAS, FASLG, MAP3K8	3.83
7	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.55
8	Lip and oral cavity carcinoma	Enrichment	HRAS, TP53	3.18
9	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	3.04
10	Rhabdomyosarcoma	Enrichment	HRAS, TP53	2.92
11	Behcet syndrome	Enrichment	FAS, TNFRSF1A	2.77
12	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.49
13	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.49
14	Noonan syndrome 5	Enrichment	RAF1	2.49
15	Noonan syndrome 4	Enrichment	SOS1	2.49
16	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.49
17	Noonan syndrome 9	Enrichment	SOS2	2.49
18	46,xy sex reversal 6	Enrichment	MAP3K1	2.49
19	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.49
20	Bone marrow failure syndrome 5	Enrichment	TP53	2.49
21	Papilloma of choroid plexus	Enrichment	TP53	2.49
22	Basal cell carcinoma 7	Enrichment	TP53	2.49
23	Anaplastic thyroid carcinoma	Enrichment	TP53	2.49
24	Leopard syndrome 2	Enrichment	RAF1	2.49
25	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.49
26	Ductal carcinoma in situ	Enrichment	TP53	2.49
27	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.49
28	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.49
29	Trigonitis	Enrichment	RAF1	2.49
30	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.49
31	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.49
32	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.49
33	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.49
34	Choroid plexus cancer	Enrichment	TP53	2.49
35	Nocarh syndrome	Enrichment	CDC42	2.49
36	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.49
37	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.49
38	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.49
39	Verrucous hemangioma	Enrichment	MAP3K3	2.49
40	Bladder cancer	Enrichment	HRAS, TP53	2.40
41	Fibromatosis, gingival, 1	Enrichment	SOS1	2.19
42	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.19
43	Costello syndrome	Enrichment	HRAS	2.19
44	Cervical cancer	Enrichment	TP53	2.19
45	Pulmonic stenosis	Enrichment	SOS1	2.19
46	Lymphoma, hodgkin, classic	Enrichment	TP53	2.19
47	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.19
48	Immunodeficiency 127	Enrichment	TNF	2.19
49	Congenital fibrosarcoma	Enrichment	TP53	2.19
50	Li-fraumeni syndrome 1	Enrichment	TP53	2.19
51	Sarcoma	Enrichment	TP53	2.19
52	Cervix carcinoma	Enrichment	TP53	2.19
53	Immune system disease	Enrichment	CDC42	2.19
54	Hodgkin's lymphoma	Enrichment	TP53	2.19
55	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.19
56	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.19
57	Wooly hair nevus	Enrichment	HRAS	2.19
58	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.01
59	Nuchal bleb, familial	Enrichment	SOS1	2.01
60	Osteogenic sarcoma	Enrichment	TP53	2.01
61	Psoriatic arthritis	Enrichment	TNF	2.01
62	Nasopharyngeal carcinoma	Enrichment	TP53	2.01
63	Anus, imperforate	Enrichment	MAP4K4	2.01
64	Large congenital melanocytic nevus	Enrichment	HRAS	2.01
65	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.01
66	Anaplastic astrocytoma	Enrichment	TP53	2.01
67	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.01
68	Squamous cell carcinoma	Enrichment	TP53	2.01
69	Adenocarcinoma	Enrichment	TP53	2.01
70	Migraine without aura	Enrichment	TNF	2.01
71	Bone osteosarcoma	Enrichment	TP53	2.01
72	Spermatocytoma	Enrichment	HRAS	2.01
73	Vogt-koyanagi-harada disease	Enrichment	FAS	2.01
74	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.89
75	Small cell cancer of the lung	Enrichment	TP53	1.89
76	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.89
77	Lung sarcomatoid carcinoma	Enrichment	TP53	1.89
78	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.89
79	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.89
80	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.89
81	Epidermolytic nevus	Enrichment	HRAS	1.89
82	Cerebral malaria	Enrichment	TNF	1.89
83	Gingival fibromatosis	Enrichment	SOS1	1.89
84	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.89
85	Rhabdomyosarcoma 2	Enrichment	TP53	1.79
86	Lymphoma	Enrichment	TP53	1.79
87	Vascular dementia	Enrichment	TNF	1.79
88	Acute megakaryocytic leukemia	Enrichment	TP53	1.79
89	Li-fraumeni syndrome	Enrichment	TP53	1.71
90	Adrenocortical carcinoma	Enrichment	TP53	1.71
91	Breast adenocarcinoma	Enrichment	TP53	1.71
92	Esophageal cancer	Enrichment	TP53	1.65
93	Nevus, epidermal	Enrichment	HRAS	1.65
94	Multiple endocrine neoplasia, type i	Enrichment	MAP4K2	1.65
95	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.65
96	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.65
97	Essential thrombocythemia	Enrichment	TP53	1.65
98	Gallbladder cancer	Enrichment	TP53	1.65
99	Pilomyxoid astrocytoma	Enrichment	RAF1	1.65
100	Follicular thyroid carcinoma	Enrichment	HRAS	1.65
101	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.65
102	Breast cancer	Enrichment	JUN, TP53	1.61
103	Glioma susceptibility 1	Enrichment	TP53	1.59
104	Renal hypodysplasia/aplasia 1	Enrichment	MAP4K4	1.59
105	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.59
106	Lennox-gastaut syndrome	Enrichment	MAPK10	1.59
107	Charge syndrome	Enrichment	TNFRSF1A	1.54
108	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.54
109	Arteriovenous malformation	Enrichment	HRAS	1.54
110	Adult hepatocellular carcinoma	Enrichment	TP53	1.54
111	Primary hyperaldosteronism	Enrichment	TP53	1.54
112	Leukemia, chronic lymphocytic	Enrichment	TP53	1.50
113	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.50
114	Familial colorectal cancer	Enrichment	TP53	1.50
115	Asthma	Enrichment	TNF	1.45
116	Myelodysplastic syndrome	Enrichment	TP53	1.45
117	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.45
118	Lung non-small cell carcinoma	Enrichment	HRAS	1.45
119	Aortic valve disease 1	Enrichment	SOS1	1.38
120	Alzheimer's disease	Enrichment	TNF	1.38
121	Ovarian cancer	Enrichment	MAP3K1, TP53	1.37
122	Multiple sclerosis	Enrichment	TNFRSF1A	1.35
123	Lung cancer susceptibility 3	Enrichment	TP53	1.35
124	Gliosarcoma	Enrichment	TP53	1.30
125	Giant cell glioblastoma	Enrichment	TP53	1.27
126	Arteriovenous malformations of the brain	Enrichment	MAP4K4	1.22
127	Diffuse large b-cell lymphoma	Enrichment	TP53	1.22
128	Hepatoblastoma	Enrichment	TP53	1.18
129	Inherited cancer-predisposing syndrome	Enrichment	MAP4K2, TP53	1.17
130	Hepatocellular carcinoma	Enrichment	TP53	1.16
131	Diamond-blackfan anemia 1	Enrichment	TP53	1.14
132	Malaria	Enrichment	TNF	1.14
133	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.12
134	Autoinflammatory disease	Enrichment	TNFRSF1A	1.12
135	Pancreatic cancer	Enrichment	TP53	1.11
136	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.09
137	Prostate cancer	Enrichment	TP53	1.05
138	Differentiated thyroid carcinoma	Enrichment	HRAS	1.05
139	Non-immune hydrops fetalis	Enrichment	HRAS	1.02
140	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.99
141	Left ventricular noncompaction	Enrichment	RAF1	0.97
142	Diamond-blackfan anemia	Enrichment	TP53	0.96
143	Systemic lupus erythematosus	Enrichment	TNF	0.92
144	Leukemia, acute myeloid	Enrichment	TP53	0.91
145	Gastric cancer	Enrichment	TP53	0.88
146	Hereditary breast carcinoma	Enrichment	TP53	0.87
147	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.80
148	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.79
149	Myeloma, multiple	Enrichment	TP53	0.78
150	Dilated cardiomyopathy	Enrichment	RAF1	0.64
151	Colorectal cancer	Enrichment	TP53	0.61

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signal transduction_JNK pathway

Pathway Network for Signal transduction_JNK pathway

Member Pathways for Signal transduction_JNK pathway

Pathways in the Signal transduction_JNK pathway SuperPath

Associated Genes for Signal transduction_JNK pathway

Associated Disorders for Signal transduction_JNK pathway

Disorders associated with Signal transduction_JNK pathway SuperPath

STRING Interaction Network for Signal transduction_JNK pathway

Sources for Signal transduction_JNK pathway