Signaling by ALK

Pathway network for the Signaling by ALK SuperPath

Sources:

Reactome

Pathways in the Signaling by ALK SuperPath

#	Name	Source	Genes
1	Signaling by ALK	Reactome	ALK ALKAL1 ALKAL2 CD274 DNMT1 EP300 FRS2 HDAC1 HDAC2 HDAC3 HIF1A IL2RG IRS1 JAK3 MDK MYC MYCN PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PRDM1 PTN PTPN6 PTPRZ1 SHC1 SIN3A SRC STAT3 (see all 30) (see less)
2	STAT3 nuclear events downstream of ALK signaling	Reactome	CD274 DNMT1 EP300 HDAC1 HDAC2 HDAC3 HIF1A IL2RG PRDM1 SIN3A STAT3 (see all 11) (see less)
3	MDK and PTN in ALK signaling	Reactome	ALK MDK PTN PTPRZ1

Gene overlap in member pathways for Signaling by ALK SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DNMT1	DNA Methyltransferase 1	Protein Coding	2
2	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
3	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	2
4	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	2
5	CD274	CD274 Molecule	Protein Coding	2
6	HDAC1	Histone Deacetylase 1	Protein Coding	2
7	HDAC2	Histone Deacetylase 2	Protein Coding	2
8	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	2
9	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	2
10	MDK	Midkine	Protein Coding	2
11	PTN	Pleiotrophin	Protein Coding	2
12	PTPRZ1	Protein Tyrosine Phosphatase Receptor Type Z1	Protein Coding	2
13	PRDM1	PR/SET Domain 1	Protein Coding	2
14	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
15	HDAC3	Histone Deacetylase 3	Protein Coding	2
16	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	1
17	ALKAL2	ALK And LTK Ligand 2	Protein Coding	1
18	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
19	JAK3	Janus Kinase 3	Protein Coding	1
20	ALKAL1	ALK And LTK Ligand 1	Protein Coding	1
21	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
22	MYCN	MYCN Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
23	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
24	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
25	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
26	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
27	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
28	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
29	SHC1	SHC Adaptor Protein 1	Protein Coding	1
30	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1

Disorders associated with Signaling by ALK SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.85
2	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.55
3	Colorectal cancer	Enrichment	EP300, PIK3CA, PIK3R1, SRC	4.42
4	Lung squamous cell carcinoma	Enrichment	ALK, PIK3CA	4.15
5	Neuroblastoma	Enrichment	ALK, MYCN	3.88
6	Neuroblastoma 3	Enrichment	ALK	3.53
7	Alk-positive anaplastic large cell lymphoma	Enrichment	ALK	3.53
8	Alk-positive large b-cell lymphoma	Enrichment	ALK	3.53
9	Nk-cell enteropathy	Enrichment	JAK3, PIK3CB	3.44
10	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.09
11	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.09
12	Autoimmune disease, multisystem, infantile-onset, 5	Enrichment	CD274	3.09
13	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	3.09
14	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.09
15	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.09
16	Menke-hennekam syndrome 2	Enrichment	EP300	2.79
17	Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant	Enrichment	DNMT1	2.79
18	Witteveen-kolk syndrome	Enrichment	SIN3A	2.79
19	Inflammatory myofibroblastic tumor	Enrichment	ALK	2.75
20	Macrodactyly	Enrichment	PIK3CA	2.66
21	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.66
22	Cowden syndrome 5	Enrichment	PIK3CA	2.66
23	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.66
24	Short syndrome	Enrichment	PIK3R1	2.66
25	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.66
26	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.66
27	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.66
28	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.66
29	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.66
30	Thrombocytopenia 6	Enrichment	SRC	2.66
31	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.66
32	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.66
33	Hypospadias	Enrichment	PIK3CA	2.66
34	Rare venous malformation	Enrichment	PIK3CA	2.66
35	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.66
36	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.66
37	Diaphragmatic eventration	Enrichment	PIK3CA	2.66
38	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.66
39	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.66
40	Rare combined vascular malformation	Enrichment	PIK3CA	2.66
41	Cavernous lymphangioma	Enrichment	PIK3CA	2.66
42	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.66
43	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.66
44	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.66
45	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.66
46	Macrodactyly of toe	Enrichment	PIK3CA	2.66
47	Lung cancer	Enrichment	ALK, PIK3CA	2.65
48	Melanocytic nevus syndrome, congenital	Enrichment	ALK	2.63
49	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.61
50	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	2.61
51	Combined immunodeficiency, x-linked	Enrichment	IL2RG	2.61
52	Neuropathy, hereditary sensory, type ie	Enrichment	DNMT1	2.61
53	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.61
54	Hyper ige syndrome	Enrichment	STAT3	2.61
55	Enchondromatosis	Enrichment	HIF1A	2.61
56	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	2.39
57	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.39
58	Burkitt lymphoma	Enrichment	MYC	2.35
59	Keratosis, seborrheic	Enrichment	PIK3CA	2.35
60	Noonan syndrome 8	Enrichment	PIK3CA	2.35
61	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.35
62	Megalencephaly-polydactyly syndrome	Enrichment	MYCN	2.35
63	Familial retinoblastoma	Enrichment	MYCN	2.35
64	Rhabdomyosarcoma	Enrichment	ALK	2.33
65	Rubinstein-taybi syndrome 1	Enrichment	EP300	2.31
66	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	2.31
67	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	2.25
68	Hereditary sensory and autonomic neuropathy type 1	Enrichment	DNMT1	2.25
69	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.19
70	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	2.18
71	Retinoblastoma	Enrichment	MYCN	2.18
72	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.18
73	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.18
74	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.18
75	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.18
76	Immunodeficiency 14	Enrichment	PIK3R1	2.18
77	Keratoacanthoma	Enrichment	PIK3CA	2.18
78	Charge syndrome	Enrichment	EP300	2.14
79	Omenn syndrome	Enrichment	IL2RG	2.09
80	Differentiated thyroid carcinoma	Enrichment	ALK	2.07
81	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.05
82	Cerebrovascular disease	Enrichment	PIK3CA	2.05
83	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.05
84	Adenosine deaminase deficiency	Enrichment	JAK3	2.05
85	Combined immunodeficiency	Enrichment	IL2RG	2.05
86	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	2.05
87	Combined t and b cell immunodeficiency	Enrichment	IL2RG	2.05
88	Acute promyelocytic leukemia	Enrichment	STAT3	1.98
89	Capillary malformations, congenital	Enrichment	PIK3CA	1.96
90	Feingold syndrome 1	Enrichment	MYCN	1.96
91	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.96
92	Hemimegalencephaly	Enrichment	PIK3CA	1.96
93	Pituitary stalk interruption syndrome	Enrichment	DNMT1	1.95
94	Breast cancer	Enrichment	PIK3CA, SHC1	1.93
95	Polydactyly, postaxial, type a1	Enrichment	EP300	1.92
96	Rare genetic intellectual disability	Enrichment	EP300	1.92
97	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.88
98	Cowden syndrome 1	Enrichment	PIK3CA	1.88
99	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.88
100	Breast adenocarcinoma	Enrichment	PIK3CA	1.88
101	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.82
102	Nevus, epidermal	Enrichment	PIK3CA	1.81
103	Myelofibrosis	Enrichment	SRC	1.81
104	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.81
105	Gallbladder cancer	Enrichment	PIK3CA	1.81
106	Overgrowth syndrome	Enrichment	PIK3R1	1.81
107	Arteriovenous malformation	Enrichment	PIK3CA	1.70
108	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.70
109	Cowden syndrome	Enrichment	PIK3CA	1.70
110	Ovarian cancer	Enrichment	ALK, PIK3CA	1.68
111	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.66
112	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.66
113	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.62
114	Meningioma	Enrichment	PIK3CA	1.58
115	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.58
116	Osteoporosis	Enrichment	SRC	1.52
117	Lynch syndrome	Enrichment	PIK3CA	1.49
118	Inherited cancer-predisposing syndrome	Enrichment	ALK	1.42
119	Spastic ataxia	Enrichment	DNMT1	1.38
120	Endometrial cancer	Enrichment	PIK3CA	1.34
121	Hepatocellular carcinoma	Enrichment	PIK3CA	1.32
122	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.30
123	Bladder cancer	Enrichment	PIK3CA	1.21
124	Prostate cancer	Enrichment	PIK3CA	1.21
125	Severe covid-19	Enrichment	JAK3	1.21
126	Severe combined immunodeficiency	Enrichment	JAK3	1.15
127	Type 2 diabetes mellitus	Enrichment	IRS1	1.05
128	Gastric cancer	Enrichment	PIK3CA	1.04
129	Hereditary breast carcinoma	Enrichment	PIK3CA	1.03
130	Microcephaly	Enrichment	EP300	1.02
131	Thrombocytopenia	Enrichment	SRC	1.00
132	Hypertelorism	Enrichment	PIK3CA	0.96
133	Myeloma, multiple	Enrichment	PIK3R2	0.93

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by ALK

Pathway Network for Signaling by ALK

Pathway network for the Signaling by ALK SuperPath

Member Pathways for Signaling by ALK

Pathways in the Signaling by ALK SuperPath

Gene overlap in member pathways for Signaling by ALK SuperPath

Associated Genes for Signaling by ALK

Associated Disorders for Signaling by ALK

Disorders associated with Signaling by ALK SuperPath

STRING Interaction Network for Signaling by ALK

Sources for Signaling by ALK