Signaling by ALK fusions and activated point mutants

Pathway network for the Signaling by ALK fusions and activated point mutants SuperPath

Sources:

Reactome

Pathways in the Signaling by ALK fusions and activated point mutants SuperPath

#	Name	Source	Genes
1	Signaling by ALK fusions and activated point mutants	Reactome	AGO1 AGO2 AGO3 AGO4 ALK ATIC BCL11A BCL2A1 BIRC6 CARS1 CCNB1 CDKN1A CEBPB CLTC CUL1 DCTN1 DNMT1 EEF1G EIF2AK3 EML4 FN1 FOXM1 FRS2 FRS3 GCC2 GRB2 HDAC1 HIP1 ICOS IL10 IL10RA IL22 IRF4 IRS1 JUN JUNB KIF5B KLC1 LMO7 MAPK1 MAPK3 MAPK8 MAPK9 MCL1 MDM2 MECP2 MOV10 MSN MYH9 NPM1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PPFIBP1 PPM1B PRF1 PRKAR1A PTPN6 RANBP2 RB1 RBX1 RNF213 RPS27A RPS6 RRBP1 SEC31A SHC1 SKP1 SQSTM1 STAT1 STAT3 STAT5A STRN TFG TNRC6C TP53 TPM3 TPM4 TPR TWIST1 TYK2 UBA52 UBB UBC VCL WDCP ZAP70 ZC3HC1 (see all 90) (see less)
2	Signaling by ALK in cancer	Reactome	AGO1 AGO2 AGO3 AGO4 ALK ATIC BCL11A BCL2A1 BIRC6 CARS1 CCNB1 CDKN1A CEBPB CLTC CUL1 DCTN1 DNMT1 EEF1G EIF2AK3 EML4 FN1 FOXM1 FRS2 FRS3 GCC2 GRB2 HDAC1 HIP1 ICOS IL10 IL10RA IL22 IRF4 IRS1 JUN JUNB KIF5B KLC1 LMO7 MAPK1 MAPK3 MAPK8 MAPK9 MCL1 MDM2 MECP2 MOV10 MSN MYH9 NPM1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PPFIBP1 PPM1B PRF1 PRKAR1A PTPN6 RANBP2 RB1 RBX1 RNF213 RPS27A RPS6 RRBP1 SEC31A SHC1 SKP1 SQSTM1 STAT1 STAT3 STAT5A STRN TFG TNRC6C TP53 TPM3 TPM4 TPR TWIST1 TYK2 UBA52 UBB UBC VCL WDCP ZAP70 ZC3HC1 (see all 90) (see less)
3	Nuclear events stimulated by ALK signaling in cancer	Reactome	AGO1 AGO2 AGO3 AGO4 BCL2A1 CCNB1 CEBPB CUL1 DNMT1 FOXM1 HDAC1 ICOS IL10RA IRF4 JUNB MAPK1 MAPK3 MECP2 MOV10 NPM1 PRF1 PTPN6 RB1 RBX1 RPS6 SKP1 STAT3 STAT5A TNRC6C TWIST1 ZAP70 ZC3HC1 (see all 32) (see less)
4	ALK mutants bind TKIs	Reactome	ALK BCL11A BIRC6 CLTC EIF2AK3 EML4 FN1 HIP1 NPM1 PPM1B PRKAR1A STRN (see all 12) (see less)

Gene overlap in member pathways for Signaling by ALK fusions and activated point mutants SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NPM1	Nucleophosmin 1	Protein Coding	4
2	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	3
3	CLTC	Clathrin Heavy Chain	Protein Coding	3
4	DNMT1	DNA Methyltransferase 1	Protein Coding	3
5	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	3
6	AGO4	Argonaute RISC Component 4	Protein Coding	3
7	FOXM1	Forkhead Box M1	Protein Coding	3
8	FN1	Fibronectin 1	Protein Coding	3
9	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	3
10	AGO1	Argonaute RISC Component 1	Protein Coding	3
11	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	3
12	EML4	EMAP Like 4	Protein Coding	3
13	ICOS	Inducible T Cell Costimulator	Protein Coding	3
14	HDAC1	Histone Deacetylase 1	Protein Coding	3
15	HIP1	Huntingtin Interacting Protein 1	Protein Coding	3
16	IL10RA	Interleukin 10 Receptor Subunit Alpha	Protein Coding	3
17	IRF4	Interferon Regulatory Factor 4	Protein Coding	3
18	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
19	MECP2	Methyl-CpG Binding Protein 2	Protein Coding	3
20	MOV10	Mov10 RNA Helicase	Protein Coding	3
21	ZC3HC1	Zinc Finger C3HC-Type Containing 1	Protein Coding	3
22	BCL11A	BCL11 Transcription Factor A	Protein Coding	3
23	PPM1B	Protein Phosphatase, Mg2+/Mn2+ Dependent 1B	Protein Coding	3
24	PRF1	Perforin 1	Protein Coding	3
25	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	3
26	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
27	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
28	BIRC6	Baculoviral IAP Repeat Containing 6	Protein Coding	3
29	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	3
30	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	3
31	RB1	RB Transcriptional Corepressor 1	Protein Coding	3
32	BCL2A1	BCL2 Related Protein A1	Protein Coding	3
33	RPS6	Ribosomal Protein S6	Protein Coding	3
34	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	3
35	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	3
36	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	3
37	STRN	Striatin	Protein Coding	3
38	TWIST1	Twist Family BHLH Transcription Factor 1	Protein Coding	3
39	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	3
40	CUL1	Cullin 1	Protein Coding	3
41	CCNB1	Cyclin B1	Protein Coding	3
42	EIF2AK3	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3	Protein Coding	3
43	RBX1	Ring-Box 1	Protein Coding	3
44	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	2
45	TFG	Trafficking From ER To Golgi Regulator	Protein Coding	2
46	FRS3	Fibroblast Growth Factor Receptor Substrate 3	Protein Coding	2
47	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	2
48	DCTN1	Dynactin Subunit 1	Protein Coding	2
49	EEF1G	Eukaryotic Translation Elongation Factor 1 Gamma	Protein Coding	2
50	SEC31A	SEC31 Homolog A, COPII Component	Protein Coding	2
51	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
52	IL10	Interleukin 10	Protein Coding	2
53	IRS1	Insulin Receptor Substrate 1	Protein Coding	2
54	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
55	KIF5B	Kinesin Family Member 5B	Protein Coding	2
56	KLC1	Kinesin Light Chain 1	Protein Coding	2
57	LMO7	LIM Domain 7	Protein Coding	2
58	MCL1	MCL1 Apoptosis Regulator, BCL2 Family Member	Protein Coding	2
59	MDM2	MDM2 Proto-Oncogene	Protein Coding	2
60	MSN	Moesin	Protein Coding	2
61	MYH9	Myosin Heavy Chain 9	Protein Coding	2
62	ATIC	5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase	Protein Coding	2
63	IL22	Interleukin 22	Protein Coding	2
64	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
65	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
66	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
67	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
68	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
69	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
70	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
71	RNF213	Ring Finger Protein 213	Protein Coding	2
72	RANBP2	RAN Binding Protein 2	Protein Coding	2
73	RPS27A	Ribosomal Protein S27a	Protein Coding	2
74	RRBP1	Ribosome Binding Protein 1	Protein Coding	2
75	SHC1	SHC Adaptor Protein 1	Protein Coding	2
76	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	2
77	TP53	Tumor Protein P53	Protein Coding	2
78	TPM3	Tropomyosin 3	Protein Coding	2
79	TPM4	Tropomyosin 4	Protein Coding	2
80	TPR	Translocated Promoter Region, Nuclear Basket Protein	Protein Coding	2
81	TYK2	Tyrosine Kinase 2	Protein Coding	2
82	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
83	UBB	Ubiquitin B	Protein Coding	2
84	UBC	Ubiquitin C	Protein Coding	2
85	VCL	Vinculin	Protein Coding	2
86	WDCP	WD Repeat And Coiled Coil Containing	Protein Coding	2
87	CARS1	Cysteinyl-TRNA Synthetase 1	Protein Coding	2
88	PPFIBP1	PPFIB Scaffold Protein 1	Protein Coding	2
89	SQSTM1	Sequestosome 1	Protein Coding	2
90	GCC2	GRIP And Coiled-Coil Domain Containing 2	Protein Coding	2

Disorders associated with Signaling by ALK fusions and activated point mutants SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Inflammatory myofibroblastic tumor	Enrichment	ALK, CARS1, CLTC, RANBP2, TPM3, TPM4	11.03
2	Bladder cancer	Enrichment	CDKN1A, PIK3CA, RB1, TP53	4.42
3	Lymphomatoid papulosis	Enrichment	NPM1, TYK2	4.36
4	Primary cutaneous anaplastic large cell lymphoma	Enrichment	NPM1, TYK2	4.36
5	Acute promyelocytic leukemia	Enrichment	NPM1, PRKAR1A	4.25
6	Lip and oral cavity carcinoma	Enrichment	PIK3CA, RB1, TP53	4.23
7	Glomerulopathy with fibronectin deposits 2	Enrichment	ATIC, FN1	3.89
8	Osteogenic sarcoma	Enrichment	RB1, TP53	3.89
9	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.89
10	Squamous cell carcinoma	Enrichment	RB1, TP53	3.89
11	Bone osteosarcoma	Enrichment	RB1, TP53	3.89
12	Breast cancer	Enrichment	JUN, KLC1, PIK3CA, SHC1, TP53	3.86
13	Small cell cancer of the lung	Enrichment	RB1, TP53	3.59
14	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.59
15	Cerebrovascular disease	Enrichment	PIK3CA, RNF213	3.59
16	Li-fraumeni syndrome	Enrichment	MDM2, TP53	3.19
17	Adrenocortical carcinoma	Enrichment	PRKAR1A, TP53	3.19
18	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10, IL10RA	3.19
19	Breast adenocarcinoma	Enrichment	PIK3CA, TP53	3.19
20	Lung squamous cell carcinoma	Enrichment	ALK, PIK3CA	3.19
21	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	3.05
22	Fetal hemoglobin quantitative trait locus 5	Enrichment	BCL11A	3.05
23	Carney complex, type 1	Enrichment	PRKAR1A	3.05
24	Neuroblastoma 3	Enrichment	ALK	3.05
25	Myxoma, intracardiac	Enrichment	PRKAR1A	3.05
26	Intellectual developmental disorder with persistence of fetal hemoglobin	Enrichment	BCL11A	3.05
27	Bcl11a-related intellectual disability	Enrichment	BCL11A	3.05
28	Acute myeloid leukemia with multilineage dysplasia	Enrichment	NPM1	3.05
29	Acute myeloid leukemia with npm1 somatic mutations	Enrichment	NPM1	3.05
30	Alk-positive anaplastic large cell lymphoma	Enrichment	ALK	3.05
31	Alk-positive large b-cell lymphoma	Enrichment	ALK	3.05
32	Gallbladder cancer	Enrichment	PIK3CA, TP53	3.05
33	Differentiated thyroid carcinoma	Enrichment	ALK, TFG, TPR	3.04
34	Lymphoma, non-hodgkin, familial	Enrichment	PRF1, TP53	2.93
35	Adult hepatocellular carcinoma	Enrichment	PIK3CA, TP53	2.82
36	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.75
37	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.75
38	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.75
39	Epiphyseal dysplasia, multiple, with early-onset diabetes mellitus	Enrichment	EIF2AK3	2.75
40	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	2.75
41	Usher syndrome, type iv	Enrichment	PRKAR1A	2.75
42	Acrodysostosis	Enrichment	PRKAR1A	2.75
43	Acute myeloid leukemia without maturation	Enrichment	NPM1	2.75
44	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.75
45	Hemophagocytic lymphohistiocytosis, familial, 2	Enrichment	PRF1	2.63
46	Facial hypertrichosis	Enrichment	MECP2	2.63
47	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.63
48	Noonan syndrome 13	Enrichment	MAPK1	2.63
49	Intellectual developmental disorder, x-linked, syndromic, lubs type	Enrichment	MECP2	2.63
50	Immunodeficiency 131	Enrichment	IRF4	2.63
51	Autism x-linked 3	Enrichment	MECP2	2.63
52	Immunodeficiency 48	Enrichment	ZAP70	2.63
53	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.63
54	Syndromic x-linked intellectual disability lubs type	Enrichment	MECP2	2.63
55	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.63
56	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.63
57	Trilateral retinoblastoma	Enrichment	RB1	2.63
58	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.63
59	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.63
60	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.63
61	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.63
62	Whipple disease	Enrichment	IRF4	2.63
63	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.63
64	Fatal post-viral neurodegenerative disorder	Enrichment	PRF1	2.63
65	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.63
66	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.63
67	Lung oat cell carcinoma	Enrichment	RB1	2.63
68	Menkes disease	Enrichment	EIF2AK3	2.58
69	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	2.58
70	Carney complex variant	Enrichment	PRKAR1A	2.45
71	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	2.45
72	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	2.45
73	2p21 microdeletion syndrome	Enrichment	PPM1B	2.45
74	Lung cancer susceptibility 3	Enrichment	RB1, TP53	2.42
75	Acute myeloid leukemia with maturation	Enrichment	NPM1	2.35
76	Hereditary persistence of fetal hemoglobin-sickle cell disease syndrome	Enrichment	BCL11A	2.35
77	Ovarian cancer	Enrichment	ALK, PIK3CA, RB1, TP53	2.34
78	Robinow-sorauf syndrome	Enrichment	TWIST1	2.33
79	Encephalopathy, neonatal severe, due to mecp2 mutations	Enrichment	MECP2	2.33
80	Inflammatory bowel disease 28, autosomal recessive	Enrichment	IL10RA	2.33
81	Premature ovarian failure 3	Enrichment	AGO2	2.33
82	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.33
83	Sweeney-cox syndrome	Enrichment	TWIST1	2.33
84	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	2.33
85	Intellectual developmental disorder, x-linked, syndromic 13	Enrichment	MECP2	2.33
86	Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant	Enrichment	DNMT1	2.33
87	X-linked intellectual disability-psychosis-macroorchidism syndrome	Enrichment	MECP2	2.33
88	Inflammatory bowel disease 28	Enrichment	IL10RA	2.33
89	Familial retinoblastoma	Enrichment	RB1	2.33
90	Non-syndromic sagittal craniosynostosis	Enrichment	TWIST1	2.33
91	Progressive bulbar palsy	Enrichment	MECP2	2.33
92	Bruxism	Enrichment	MECP2	2.33
93	Rhabdomyosarcoma	Enrichment	ALK, TP53	2.31
94	Inherited cancer-predisposing syndrome	Enrichment	ALK, PRKAR1A	2.24
95	Noonan syndrome 3	Enrichment	CLTC	2.21
96	Renal cell carcinoma with mit translocations	Enrichment	CLTC	2.21
97	Macrodactyly	Enrichment	PIK3CA	2.18
98	Perry syndrome	Enrichment	DCTN1	2.18
99	Paget disease of bone 3	Enrichment	SQSTM1	2.18
100	Immunodeficiency 50	Enrichment	MSN	2.18
101	Aica-ribosiduria due to atic deficiency	Enrichment	ATIC	2.18
102	Immunodeficiency 35	Enrichment	TYK2	2.18
103	Deafness, autosomal dominant 17	Enrichment	MYH9	2.18
104	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.18
105	Congenital myopathy 4b, autosomal recessive	Enrichment	TPM3	2.18
106	Cowden syndrome 5	Enrichment	PIK3CA	2.18
107	Spastic paraplegia 57, autosomal recessive	Enrichment	TFG	2.18
108	Accelerated tumor formation	Enrichment	MDM2	2.18
109	Halperin-birk syndrome	Enrichment	SEC31A	2.18
110	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.18
111	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	2.18
112	Neurodevelopmental disorder with seizures, microcephaly, and brain abnormalities	Enrichment	PPFIBP1	2.18
113	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	2.18
114	Bleeding disorder, platelet-type, 25	Enrichment	TPM4	2.18
115	Lessel-kubisch syndrome	Enrichment	MDM2	2.18
116	Short syndrome	Enrichment	PIK3R1	2.18
117	Bone marrow failure syndrome 5	Enrichment	TP53	2.18
118	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.18
119	Graft-versus-host disease	Enrichment	IL10	2.18
120	Papilloma of choroid plexus	Enrichment	TP53	2.18
121	Basal cell carcinoma 7	Enrichment	TP53	2.18
122	Anaplastic thyroid carcinoma	Enrichment	TP53	2.18
123	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.18
124	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.18
125	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.18
126	Neuronopathy, distal hereditary motor, autosomal dominant 14	Enrichment	DCTN1	2.18
127	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.18
128	Immunodeficiency 31a	Enrichment	STAT1	2.18
129	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.18
130	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.18
131	Immunodeficiency 31b	Enrichment	STAT1	2.18
132	Ductal carcinoma in situ	Enrichment	TP53	2.18
133	Intellectual developmental disorder, autosomal recessive 79	Enrichment	TPR	2.18
134	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.18
135	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.18
136	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.18
137	Hypospadias	Enrichment	PIK3CA	2.18
138	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.18
139	Autosomal dominant nonsyndromic hearing loss 17	Enrichment	MYH9	2.18
140	Choroid plexus cancer	Enrichment	TP53	2.18
141	Rare venous malformation	Enrichment	PIK3CA	2.18
142	Diaphragmatic eventration	Enrichment	PIK3CA	2.18
143	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.18
144	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.18
145	Rare combined vascular malformation	Enrichment	PIK3CA	2.18
146	Cavernous lymphangioma	Enrichment	PIK3CA	2.18
147	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.18
148	Familial acute necrotizing encephalopathy	Enrichment	RANBP2	2.18
149	Autosomal dominant charcot-marie-tooth disease type 2 due to tfg mutation	Enrichment	TFG	2.18
150	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.18
151	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.18
152	Congenital generalized hypercontractile muscle stiffness syndrome	Enrichment	TPM3	2.18
153	Macrodactyly of toe	Enrichment	PIK3CA	2.18
154	Diffuse large b-cell lymphoma	Enrichment	STAT3, TP53	2.16
155	Melanocytic nevus syndrome, congenital	Enrichment	ALK	2.15
156	Neuroblastoma	Enrichment	ALK	2.15
157	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.15
158	Craniosynostosis 1	Enrichment	TWIST1	2.15
159	Laryngomalacia	Enrichment	MECP2	2.15
160	Retinoblastoma	Enrichment	RB1	2.15
161	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.15
162	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.15
163	Neuropathy, hereditary sensory, type ie	Enrichment	DNMT1	2.15
164	Hypotrichosis 8	Enrichment	RB1	2.15
165	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.15
166	Hyper ige syndrome	Enrichment	STAT3	2.15
167	Lessel-kreienkamp syndrome	Enrichment	AGO2	2.15
168	Hepatocellular carcinoma	Enrichment	PIK3CA, TP53	2.04
169	Attention deficit-hyperactivity disorder	Enrichment	KIF5B, MECP2	2.04
170	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.03
171	Saethre-chotzen syndrome	Enrichment	TWIST1	2.03
172	Immunodeficiency, common variable, 1	Enrichment	ICOS	2.03
173	Lynch syndrome 4	Enrichment	RB1	2.03
174	Sick sinus syndrome	Enrichment	MECP2	2.03
175	Non-syndromic bicoronal craniosynostosis	Enrichment	TWIST1	2.03
176	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	PRF1	1.93
177	Idiopathic aplastic anemia	Enrichment	PRF1	1.93
178	Polydactyly, postaxial, type a1	Enrichment	BCL11A	1.88
179	Corpus callosum, agenesis of	Enrichment	BCL11A	1.88
180	Isolated corpus callosum agenesis	Enrichment	BCL11A	1.88
181	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	BCL11A	1.88
182	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.88
183	Camptodactyly-arthropathy-coxa vara-pericarditis syndrome	Enrichment	TPR	1.88
184	Cataract 35	Enrichment	MYH9	1.88
185	Cervical cancer	Enrichment	TP53	1.88
186	Welander distal myopathy	Enrichment	SQSTM1	1.88
187	Keratosis, seborrheic	Enrichment	PIK3CA	1.88
188	Melanoma, cutaneous malignant 6	Enrichment	KLC1	1.88
189	Noonan syndrome 8	Enrichment	PIK3CA	1.88
190	Lymphoma, hodgkin, classic	Enrichment	TP53	1.88
191	Immunodeficiency 31c	Enrichment	STAT1	1.88
192	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	1.88
193	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.88
194	Congenital fibrosarcoma	Enrichment	TP53	1.88
195	Li-fraumeni syndrome 1	Enrichment	TP53	1.88
196	Sarcoma	Enrichment	TP53	1.88
197	Pseudosarcomatous fibromatosis	Enrichment	MYH9	1.88
198	Cervix carcinoma	Enrichment	TP53	1.88
199	Hodgkin's lymphoma	Enrichment	TP53	1.88
200	Paget's disease of bone	Enrichment	SQSTM1	1.88
201	Distal hereditary motor neuropathy type 7	Enrichment	DCTN1	1.88
202	Skeletal muscle disease	Enrichment	KIF5B	1.88
203	Acute necrotizing encephalopathy of childhood	Enrichment	RANBP2	1.88
204	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.88
205	Submucosal cleft palate	Enrichment	UBB	1.88
206	Cleft hard palate	Enrichment	UBB	1.88
207	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	1.88
208	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	BCL11A	1.85
209	Angelman syndrome	Enrichment	MECP2	1.85
210	Prostate cancer	Enrichment	PIK3CA, TP53	1.80
211	Rett syndrome	Enrichment	MECP2	1.79
212	Hereditary sensory and autonomic neuropathy type 1	Enrichment	DNMT1	1.79
213	Focal epilepsy	Enrichment	MECP2	1.79
214	Dyskeratosis congenita	Enrichment	NPM1	1.78
215	Rett syndrome, congenital variant	Enrichment	MECP2	1.73
216	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.73
217	Lung cancer	Enrichment	ALK, PIK3CA	1.72
218	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	MYH9	1.70
219	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.70
220	Uvula, bifid	Enrichment	UBB	1.70
221	Cleft soft palate	Enrichment	UBB	1.70
222	Nasopharyngeal carcinoma	Enrichment	TP53	1.70
223	Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.70
224	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.70
225	Microcephaly, developmental delay, and brittle hair syndrome	Enrichment	CARS1	1.70
226	Dedifferentiated liposarcoma	Enrichment	MDM2	1.70
227	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.70
228	Anaplastic astrocytoma	Enrichment	TP53	1.70
229	Immunodeficiency 14	Enrichment	PIK3R1	1.70
230	Moyamoya disease 2	Enrichment	RNF213	1.70
231	Adenocarcinoma	Enrichment	TP53	1.70
232	Cap myopathy	Enrichment	TPM3	1.70
233	Well-differentiated liposarcoma	Enrichment	MDM2	1.70
234	Keratoacanthoma	Enrichment	PIK3CA	1.70
235	Colorectal cancer	Enrichment	PIK3CA, PIK3R1, TP53	1.70
236	Aplastic anemia	Enrichment	PRF1	1.63
237	Combined immunodeficiency	Enrichment	ZAP70	1.59
238	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	1.59
239	Specific learning disability	Enrichment	MAPK1	1.59
240	Combined t and b cell immunodeficiency	Enrichment	ZAP70	1.59
241	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.58
242	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.58
243	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	1.58
244	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.58
245	Lung sarcomatoid carcinoma	Enrichment	TP53	1.58
246	Ectodermal dysplasia	Enrichment	RANBP2	1.58
247	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.58
248	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.58
249	Paget's disease of bone 2	Enrichment	SQSTM1	1.58
250	Intermediate nemaline myopathy	Enrichment	TPM3	1.58
251	Middle aortic syndrome	Enrichment	RNF213	1.58
252	Systemic lupus erythematosus	Enrichment	IL10, MECP2	1.56
253	Leukemia, acute myeloid	Enrichment	NPM1, TP53	1.54
254	Charcot-marie-tooth disease	Enrichment	DCTN1, TFG	1.52
255	Stereotypic movement disorder	Enrichment	MECP2	1.52
256	Pituitary stalk interruption syndrome	Enrichment	DNMT1	1.49
257	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	RANBP2	1.48
258	Capillary malformations, congenital	Enrichment	PIK3CA	1.48
259	Kearns-sayre syndrome	Enrichment	KIF5B	1.48
260	Rhabdomyosarcoma 2	Enrichment	TP53	1.48
261	Deafness, autosomal recessive 63	Enrichment	MYH9	1.48
262	Chondrosarcoma, extraskeletal myxoid	Enrichment	TFG	1.48
263	Lymphoma	Enrichment	TP53	1.48
264	Hemangioma	Enrichment	RNF213	1.48
265	Acute megakaryocytic leukemia	Enrichment	TP53	1.48
266	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	RANBP2	1.48
267	Hemimegalencephaly	Enrichment	PIK3CA	1.48
268	Genetic motor neuron disease	Enrichment	DCTN1	1.48
269	Gastric cancer	Enrichment	PIK3CA, TP53	1.48
270	Nephrotic syndrome	Enrichment	ATIC, FN1	1.48
271	Microcephaly	Enrichment	MAPK1, MECP2	1.47
272	Complex neurodevelopmental disorder	Enrichment	AGO1, AGO2	1.46
273	Hereditary breast carcinoma	Enrichment	PIK3CA, TP53	1.46
274	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.41
275	Cowden syndrome 1	Enrichment	PIK3CA	1.41
276	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.41
277	Moyamoya disease 1	Enrichment	RNF213	1.41
278	Hemangioma, capillary infantile	Enrichment	MYH9	1.41
279	Inguinal hernia	Enrichment	RNF213	1.41
280	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.41
281	Heart, malformation of	Enrichment	MAPK1	1.38
282	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC	1.36
283	Esophageal cancer	Enrichment	TP53	1.34
284	Nevus, epidermal	Enrichment	PIK3CA	1.34
285	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.34
286	Mitochondrial dna depletion syndrome 4a	Enrichment	RANBP2	1.34
287	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.34
288	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.34
289	Essential thrombocythemia	Enrichment	TP53	1.34
290	Childhood-onset nemaline myopathy	Enrichment	TPM3	1.34
291	Overgrowth syndrome	Enrichment	PIK3R1	1.34
292	Moyamoya angiopathy	Enrichment	RNF213	1.34
293	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.34
294	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC	1.31
295	Schizophrenia	Enrichment	BIRC6	1.29
296	Glioma susceptibility 1	Enrichment	TP53	1.29
297	Mitochondrial dna depletion syndrome 4b	Enrichment	RANBP2	1.29
298	Myeloma, multiple	Enrichment	PIK3R2, TP53	1.27
299	Autoinflammatory disease	Enrichment	PRF1	1.26
300	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	DCTN1, SQSTM1	1.25
301	Rheumatoid arthritis	Enrichment	IL10	1.24
302	Arteriovenous malformation	Enrichment	PIK3CA	1.24
303	Primary hyperaldosteronism	Enrichment	TP53	1.24
304	Cowden syndrome	Enrichment	PIK3CA	1.24
305	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.24
306	Trichothiodystrophy	Enrichment	CARS1	1.24
307	Amyotrophic lateral sclerosis 1	Enrichment	DCTN1	1.19
308	Leukemia, chronic lymphocytic	Enrichment	TP53	1.19
309	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1	1.19
310	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.19
311	Nephrocalcinosis	Enrichment	RNF213	1.19
312	Nemaline myopathy	Enrichment	TPM3	1.19
313	Autosomal dominant macrothrombocytopenia	Enrichment	TPM4	1.19
314	Familial colorectal cancer	Enrichment	TP53	1.19
315	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.19
316	Frontotemporal dementia 1	Enrichment	DCTN1	1.15
317	Myelodysplastic syndrome	Enrichment	TP53	1.15
318	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.15
319	Severe combined immunodeficiency	Enrichment	ZAP70	1.12
320	Meningioma	Enrichment	PIK3CA	1.11
321	Dystonia	Enrichment	MECP2	1.10
322	Non-syndromic x-linked intellectual disability	Enrichment	MECP2	1.09
323	Nk-cell enteropathy	Enrichment	PIK3CB	1.08
324	Epilepsy	Enrichment	MECP2	1.04
325	Congenital myopathy 4a, autosomal dominant	Enrichment	TPM3	1.02
326	Lynch syndrome	Enrichment	PIK3CA	1.02
327	Dilated cardiomyopathy	Enrichment	KIF5B, VCL	1.01
328	Hypertension	Enrichment	MYH9	1.00
329	Gliosarcoma	Enrichment	TP53	1.00
330	Giant cell glioblastoma	Enrichment	TP53	0.97
331	Human immunodeficiency virus type 1	Enrichment	IL10	0.95
332	Spastic ataxia	Enrichment	DNMT1	0.93
333	Behcet syndrome	Enrichment	IL10	0.92
334	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	TFG	0.92
335	Endometrial cancer	Enrichment	PIK3CA	0.88
336	Centronuclear myopathy	Enrichment	TPM3	0.88
337	Hepatoblastoma	Enrichment	TP53	0.88
338	Tooth agenesis	Enrichment	RANBP2	0.87
339	Diamond-blackfan anemia 1	Enrichment	TP53	0.85
340	Pancreatic cancer	Enrichment	TP53	0.81
341	Autism	Enrichment	MECP2	0.80
342	Diamond-blackfan anemia	Enrichment	TP53	0.67
343	Congenital nervous system abnormality	Enrichment	MECP2	0.65
344	Nervous system disease	Enrichment	MECP2	0.65
345	Autism spectrum disorder	Enrichment	MECP2	0.64
346	Myopathy	Enrichment	TPM3	0.63
347	Type 2 diabetes mellitus	Enrichment	IRS1	0.61
348	Hypertrophic cardiomyopathy	Enrichment	KIF5B	0.60
349	Thrombocytopenia	Enrichment	MYH9	0.56
350	Body mass index quantitative trait locus 11	Enrichment	MYH9	0.55
351	Hypertelorism	Enrichment	PIK3CA	0.53
352	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MYH9	0.53
353	Familial isolated dilated cardiomyopathy	Enrichment	VCL	0.53
354	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.51
355	Autosomal recessive non-syndromic intellectual disability	Enrichment	TPR	0.49
356	Deafness, autosomal recessive	Enrichment	MYH9	0.46
357	Autosomal recessive nonsyndromic deafness	Enrichment	MYH9	0.46
358	Rare genetic deafness	Enrichment	MYH9	0.39
359	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MYH9	0.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by ALK fusions and activated point mutants

Pathway Network for Signaling by ALK fusions and activated point mutants

Pathway network for the Signaling by ALK fusions and activated point mutants SuperPath

Member Pathways for Signaling by ALK fusions and activated point mutants

Pathways in the Signaling by ALK fusions and activated point mutants SuperPath

Gene overlap in member pathways for Signaling by ALK fusions and activated point mutants SuperPath

Associated Genes for Signaling by ALK fusions and activated point mutants

Associated Disorders for Signaling by ALK fusions and activated point mutants

Disorders associated with Signaling by ALK fusions and activated point mutants SuperPath

STRING Interaction Network for Signaling by ALK fusions and activated point mutants

Sources for Signaling by ALK fusions and activated point mutants