Signaling by BMP

Pathway network for the Signaling by BMP SuperPath

Sources:

Reactome
PubChem

Pathways in the Signaling by BMP SuperPath

#	Name	Source	Genes
1	Signaling by BMP	Reactome	ACVR2A ACVR2B ACVRL1 AMH AMHR2 BMP10 BMP2 BMPR1A BMPR1B BMPR2 CER1 CHRDL1 FSTL1 GDF2 GREM2 INHA INHBA NOG SKI SMAD1 SMAD4 SMAD5 SMAD6 SMAD7 SMAD9 SMURF1 SMURF2 TGFBR3 UBE2D1 UBE2D3 ZFYVE16 (see all 31) (see less)
2	BMP receptor signaling	PubChem	AHSG BAMBI BMP2 BMP6 BMP7 BMPR1A BMPR2 CER1 CHRD CHRDL1 CTDSP1 FST GREM1 GSK3B MAP3K7 MAPK1 NOG NUP214 PPM1A PPP1CA PPP1R15A SKI SMAD1 SMAD4 SMAD5 SMAD6 SMAD7 SMAD9 SMURF1 SMURF2 SOSTDC1 XIAP ZFYVE16 (see all 33) (see less)
3	BMP Signalling Pathway	PubChem	BMP2 BMPR2 SKI SMAD4 ZFYVE16

Gene overlap in member pathways for Signaling by BMP SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SMAD4	SMAD Family Member 4	Protein Coding	3
2	SKI	SKI Proto-Oncogene	Protein Coding	3
3	BMP2	Bone Morphogenetic Protein 2	Protein Coding	3
4	BMPR2	Bone Morphogenetic Protein Receptor Type 2	Protein Coding	3
5	ZFYVE16	Zinc Finger FYVE-Type Containing 16	Protein Coding	3
6	SMAD1	SMAD Family Member 1	Protein Coding	2
7	SMAD5	SMAD Family Member 5	Protein Coding	2
8	SMAD6	SMAD Family Member 6	Protein Coding	2
9	SMAD7	SMAD Family Member 7	Protein Coding	2
10	SMAD9	SMAD Family Member 9	Protein Coding	2
11	SMURF1	SMAD Specific E3 Ubiquitin Protein Ligase 1	Protein Coding	2
12	SMURF2	SMAD Specific E3 Ubiquitin Protein Ligase 2	Protein Coding	2
13	BMPR1A	Bone Morphogenetic Protein Receptor Type 1A	Protein Coding	2
14	CHRDL1	Chordin Like 1	Protein Coding	2
15	NOG	Noggin	Protein Coding	2
16	CER1	Cerberus 1, DAN Family BMP Antagonist	Protein Coding	2
17	FSTL1	Follistatin Like 1	Protein Coding	1
18	GDF2	Growth Differentiation Factor 2	Protein Coding	1
19	AMH	Anti-Mullerian Hormone	Protein Coding	1
20	AMHR2	Anti-Mullerian Hormone Receptor Type 2	Protein Coding	1
21	BMP10	Bone Morphogenetic Protein 10	Protein Coding	1
22	INHA	Inhibin Subunit Alpha	Protein Coding	1
23	INHBA	Inhibin Subunit Beta A	Protein Coding	1
24	GREM2	Gremlin 2, DAN Family BMP Antagonist	Protein Coding	1
25	BMPR1B	Bone Morphogenetic Protein Receptor Type 1B	Protein Coding	1
26	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
27	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	1
28	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	1
29	ACVR2A	Activin A Receptor Type 2A	Protein Coding	1
30	ACVR2B	Activin A Receptor Type 2B	Protein Coding	1
31	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	1
32	SOSTDC1	Sclerostin Domain Containing 1	Protein Coding	1
33	CHRD	Chordin	Protein Coding	1
34	CTDSP1	CTD Small Phosphatase 1	Protein Coding	1
35	AHSG	Alpha 2-HS Glycoprotein	Protein Coding	1
36	BMP6	Bone Morphogenetic Protein 6	Protein Coding	1
37	BMP7	Bone Morphogenetic Protein 7	Protein Coding	1
38	GREM1	Gremlin 1, DAN Family BMP Antagonist	Protein Coding	1
39	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
40	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	1
41	FST	Follistatin	Protein Coding	1
42	PPM1A	Protein Phosphatase, Mg2+/Mn2+ Dependent 1A	Protein Coding	1
43	BAMBI	BMP And Activin Membrane Bound Inhibitor	Protein Coding	1
44	PPP1R15A	Protein Phosphatase 1 Regulatory Subunit 15A	Protein Coding	1
45	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	1
46	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
47	NUP214	Nucleoporin 214	Protein Coding	1
48	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1

Disorders associated with Signaling by BMP SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Heritable pulmonary arterial hypertension	Enrichment	ACVRL1, BMPR2, GDF2, SMAD9	8.14
2	Hereditary hemorrhagic telangiectasia	Enrichment	ACVRL1, GDF2, SMAD4	6.42
3	Pulmonary hypertension, primary, 1	Enrichment	ACVRL1, BMPR2, GDF2	5.52
4	Craniosynostosis 7	Enrichment	BMP2, SMAD6	5.30
5	Hereditary mixed polyposis syndrome	Enrichment	BMPR1A, GREM1	5.24
6	Juvenile polyposis syndrome	Enrichment	BMPR1A, SMAD4	4.82
7	Pulmonary arterial hypertension associated with congenital heart disease	Enrichment	BMPR2, SMAD9	4.82
8	Brachydactyly, type a2	Enrichment	BMP2, BMPR1B	4.52
9	Persistent mullerian duct syndrome, types i and ii	Enrichment	AMH, AMHR2	4.52
10	Persistent mullerian duct syndrome	Enrichment	AMH, AMHR2	4.52
11	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	BMPR1A, SMAD4	4.30
12	Ventricular septal defect 1	Enrichment	BMP2, BMP7	4.24
13	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SKI, SMAD4	3.99
14	Hemochromatosis, type 1	Enrichment	BMP2, BMP6	3.80
15	Shprintzen-goldberg craniosynostosis syndrome	Enrichment	SKI	3.43
16	20p12.3 microdeletion syndrome	Enrichment	BMP2	3.43
17	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	3.43
18	Heritable thoracic aortic disease	Enrichment	SMAD4	3.43
19	Primary pulmonary hypertension	Enrichment	BMPR2	3.43
20	Pulmonary hypertension	Enrichment	BMPR2	3.43
21	Drug- or toxin-induced pulmonary arterial hypertension	Enrichment	BMPR2	3.43
22	Myhre syndrome	Enrichment	SMAD4	3.13
23	Pulmonary venoocclusive disease 1, autosomal dominant	Enrichment	BMPR2	3.13
24	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	3.13
25	Fibrodysplasia ossificans progressiva	Enrichment	BMPR2	3.13
26	Pulmonary venoocclusive disease 1	Enrichment	BMPR2	3.13
27	Pulmonary venoocclusive disease	Enrichment	BMPR2	3.13
28	Idiopathic/heritable pulmonary arterial hypertension	Enrichment	BMPR2	3.13
29	Heart, malformation of	Enrichment	MAPK1, SMAD6	3.07
30	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	2.96
31	Goldberg-shprintzen syndrome	Enrichment	SKI	2.73
32	Atrial septal defect 1	Enrichment	BMP2	2.66
33	Stapes ankylosis with broad thumbs and toes	Enrichment	NOG	2.64
34	Tarsal-carpal coalition syndrome	Enrichment	NOG	2.64
35	Telangiectasia, hereditary hemorrhagic, type 2	Enrichment	ACVRL1	2.64
36	Polyposis syndrome, hereditary mixed, 2	Enrichment	BMPR1A	2.64
37	Acromesomelic dysplasia 3	Enrichment	BMPR1B	2.64
38	Brachydactyly, type b2	Enrichment	NOG	2.64
39	Symphalangism, proximal, 1a	Enrichment	NOG	2.64
40	Multiple synostoses syndrome 1	Enrichment	NOG	2.64
41	Brachydactyly, type a1, d	Enrichment	BMPR1B	2.64
42	Radioulnar synostosis, nonsyndromic	Enrichment	SMAD6	2.64
43	Tooth agenesis, selective, 9	Enrichment	GREM2	2.64
44	Ovary adenocarcinoma	Enrichment	INHBA	2.64
45	Telangiectasia, hereditary hemorrhagic, type 5	Enrichment	GDF2	2.64
46	Pulmonary hypertension, primary, 2	Enrichment	SMAD9	2.64
47	Colorectal cancer 3	Enrichment	SMAD7	2.64
48	Telangiectasis	Enrichment	ACVRL1	2.64
49	Isolated congenital megalocornea	Enrichment	CHRDL1	2.64
50	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.61
51	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.61
52	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.61
53	Alopecia-intellectual disability syndrome 1	Enrichment	AHSG	2.61
54	Noonan syndrome 13	Enrichment	MAPK1	2.61
55	Iron overload	Enrichment	BMP6	2.61
56	Encephalopathy, acute, infection-induced 9	Enrichment	NUP214	2.61
57	Gallbladder cancer	Enrichment	SMAD4	2.59
58	Tooth agenesis, selective, 1	Enrichment	BMPR2	2.48
59	Heterotaxy, visceral, 4, autosomal	Enrichment	ACVR2B	2.34
60	Aortic valve disease 2	Enrichment	SMAD6	2.34
61	Proximal symphalangism	Enrichment	NOG	2.34
62	Radioulnar synostosis	Enrichment	SMAD6	2.34
63	Juvenile polyposis of infancy	Enrichment	BMPR1A	2.34
64	Chromosome 1p36 deletion syndrome	Enrichment	SKI	2.32
65	Acute myeloid leukemia with t(6;9) (p23;q34.1)	Enrichment	NUP214	2.31
66	Thrombocytopenia	Enrichment	ACVRL1, SMAD4	2.27
67	Brachydactyly, type a1	Enrichment	BMPR1B	2.16
68	Brachydactyly, type c	Enrichment	BMPR1B	2.16
69	Acromesomelic dysplasia 2a	Enrichment	BMPR1B	2.16
70	Acromesomelic dysplasia 2c	Enrichment	BMPR1B	2.16
71	Megalocornea	Enrichment	CHRDL1	2.16
72	Acromesomelic dysplasia 2b	Enrichment	BMPR1B	2.16
73	Arteriovenous malformations of the brain	Enrichment	ZFYVE16	2.16
74	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.14
75	Alopecia - intellectual disability syndrome	Enrichment	AHSG	2.14
76	Hemophilia a	Enrichment	ACVRL1	2.04
77	Factor viii deficiency	Enrichment	ACVRL1	2.04
78	Multiple synostoses syndrome	Enrichment	NOG	2.04
79	Pancreatic cancer	Enrichment	SMAD4	2.04
80	Polyposis syndrome, hereditary mixed, 1	Enrichment	GREM1	2.01
81	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.01
82	Lymphoproliferative syndrome 2	Enrichment	XIAP	2.01
83	Orofacial cleft	Enrichment	FST	2.01
84	Orofacial clefting syndrome	Enrichment	FST	2.01
85	2q23.1 microduplication syndrome	Enrichment	ACVR2A	1.94
86	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	1.94
87	Congenital heart defects, multiple types, 4	Enrichment	BMP7	1.92
88	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	ACVRL1	1.87
89	Gastric cancer	Enrichment	SMAD4	1.80
90	Polydactyly	Enrichment	SMAD6	1.69
91	Familial colorectal cancer	Enrichment	GREM1	1.62
92	Familial colorectal cancer type x	Enrichment	BMPR1A	1.60
93	Specific learning disability	Enrichment	MAPK1	1.58
94	Aortic valve disease 1	Enrichment	SMAD6	1.53
95	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD6	1.50
96	Colorectal cancer	Enrichment	SMAD4	1.50
97	Inherited cancer-predisposing syndrome	Enrichment	BMPR1A, SMAD4	1.44
98	Craniosynostosis	Enrichment	SMAD6	1.35
99	Visceral heterotaxy	Enrichment	ACVR2B	1.31
100	Tooth agenesis	Enrichment	GREM2	1.31
101	Precursor t-cell acute lymphoblastic leukemia	Enrichment	NUP214	1.26
102	Autoinflammatory disease	Enrichment	XIAP	1.25
103	Leukemia, acute myeloid	Enrichment	NUP214	1.03
104	Primary ovarian insufficiency	Enrichment	BMP6	0.87
105	Ovarian cancer	Enrichment	BMPR1A	0.68
106	Microcephaly	Enrichment	MAPK1	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Signaling by BMP

Pathway network for the Signaling by BMP SuperPath

Member Pathways for Signaling by BMP

Pathways in the Signaling by BMP SuperPath

Gene overlap in member pathways for Signaling by BMP SuperPath

Associated Genes for Signaling by BMP

Associated Disorders for Signaling by BMP

Disorders associated with Signaling by BMP SuperPath

STRING Interaction Network for Signaling by BMP

Sources for Signaling by BMP