Signaling by CSF3 (G-CSF)

No Pathway Network information available for Signaling by CSF3 (G-CSF)

Pathways in the Signaling by CSF3 (G-CSF) SuperPath

#	Name	Source	Genes
1	Signaling by CSF3 (G-CSF)	Reactome	CSF3 CSF3R CUL5 ELOB ELOC GAB2 GRB2 HCK JAK1 JAK2 KRAS LYN PTPN11 RNF7 RPS27A SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK TYK2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 (see all 30) (see less)
2	Inactivation of CSF3 (G-CSF) signaling	Reactome	CSF3 CSF3R CUL5 ELOB ELOC HCK JAK1 JAK2 LYN RNF7 RPS27A SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK TYK2 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 (see all 25) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CSF3	Colony Stimulating Factor 3	Protein Coding	2
2	CSF3R	Colony Stimulating Factor 3 Receptor	Protein Coding	2
3	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
4	JAK1	Janus Kinase 1	Protein Coding	2
5	JAK2	Janus Kinase 2	Protein Coding	2
6	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
7	RPS27A	Ribosomal Protein S27a	Protein Coding	2
8	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	2
9	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
10	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	2
11	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	2
12	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	2
13	ELOC	Elongin C	Protein Coding	2
14	ELOB	Elongin B	Protein Coding	2
15	TYK2	Tyrosine Kinase 2	Protein Coding	2
16	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
17	UBB	Ubiquitin B	Protein Coding	2
18	UBC	Ubiquitin C	Protein Coding	2
19	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	2
20	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	2
21	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	2
22	CUL5	Cullin 5	Protein Coding	2
23	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	2
24	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	2
25	RNF7	Ring Finger Protein 7	Protein Coding	2
26	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
27	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
28	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
29	SHC1	SHC Adaptor Protein 1	Protein Coding	1
30	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1

Disorders associated with Signaling by CSF3 (G-CSF) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	8.26
2	Noonan syndrome 3	Enrichment	KRAS, PTPN11	4.01
3	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.60
4	Juvenile myelomonocytic leukemia	Enrichment	KRAS, PTPN11	3.51
5	Noonan syndrome and noonan-related syndrome	Enrichment	KRAS, PTPN11	3.31
6	Diffuse large b-cell lymphoma	Enrichment	SOCS1, STAT3	3.26
7	Noonan syndrome 1	Enrichment	KRAS, PTPN11	2.93
8	Rasopathy	Enrichment	KRAS, PTPN11	2.83
9	Immunodeficiency 35	Enrichment	TYK2	2.73
10	Dermatitis, atopic, 4	Enrichment	SOCS3	2.73
11	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.73
12	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.73
13	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.73
14	Immunodeficiency 31a	Enrichment	STAT1	2.73
15	Immunodeficiency 31b	Enrichment	STAT1	2.73
16	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.73
17	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.73
18	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	2.73
19	Colitis	Enrichment	SYK	2.73
20	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.73
21	Chronic neutrophilic leukemia	Enrichment	CSF3R	2.73
22	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.73
23	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.73
24	Non-immune hydrops fetalis	Enrichment	KRAS, PTPN11	2.68
25	Metachondromatosis	Enrichment	PTPN11	2.66
26	Oculoectodermal syndrome	Enrichment	KRAS	2.66
27	Leopard syndrome 1	Enrichment	PTPN11	2.66
28	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.66
29	Congenital pulmonary airway malformation	Enrichment	KRAS	2.66
30	Malignant astrocytoma	Enrichment	PTPN11	2.66
31	Leukemia, acute myeloid	Enrichment	JAK2, KRAS	2.46
32	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.43
33	Neutrophilia, hereditary	Enrichment	CSF3R	2.43
34	Thrombocythemia 3	Enrichment	JAK2	2.43
35	Neutropenia, severe congenital, 7, autosomal recessive	Enrichment	CSF3R	2.43
36	Immunodeficiency 31c	Enrichment	STAT1	2.43
37	Severe congenital neutropenia 7	Enrichment	CSF3R	2.43
38	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.43
39	Polycythemia	Enrichment	JAK2	2.43
40	Lymphomatoid papulosis	Enrichment	TYK2	2.43
41	Arthritis	Enrichment	SYK	2.43
42	Hypereosinophilic syndrome	Enrichment	JAK2	2.43
43	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.43
44	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.43
45	Submucosal cleft palate	Enrichment	UBB	2.43
46	Cleft hard palate	Enrichment	UBB	2.43
47	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.35
48	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	2.35
49	Werner syndrome	Enrichment	PTPN11	2.35
50	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.26
51	Immune thrombocytopenia	Enrichment	SOCS1	2.26
52	Polycythemia vera	Enrichment	JAK2	2.26
53	Uvula, bifid	Enrichment	UBB	2.26
54	Cleft soft palate	Enrichment	UBB	2.26
55	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	2.26
56	Hyper ige syndrome	Enrichment	STAT3	2.26
57	Tricuspid valve insufficiency	Enrichment	PTPN11	2.18
58	Erythrocytosis, familial, 1	Enrichment	JAK2	2.13
59	Anemia, autoimmune hemolytic	Enrichment	SOCS1	2.13
60	Budd-chiari syndrome	Enrichment	JAK2	2.13
61	Schimmelpenning-feuerstein-mims syndrome	Enrichment	KRAS	2.05
62	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.05
63	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.05
64	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.05
65	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.05
66	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	2.05
67	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.05
68	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.05
69	Pilocytic astrocytoma	Enrichment	KRAS	2.05
70	Myeloproliferative neoplasm	Enrichment	JAK2	2.04
71	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.96
72	Lymphoma	Enrichment	PTPN11	1.96
73	Breast cancer	Enrichment	KRAS, SHC1	1.93
74	Myelofibrosis	Enrichment	JAK2	1.89
75	Essential thrombocythemia	Enrichment	JAK2	1.89
76	Patent ductus arteriosus	Enrichment	PTPN11	1.88
77	Breast adenocarcinoma	Enrichment	KRAS	1.88
78	Lung squamous cell carcinoma	Enrichment	KRAS	1.88
79	Severe congenital neutropenia	Enrichment	CSF3R	1.83
80	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.83
81	Nevus, epidermal	Enrichment	KRAS	1.81
82	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	1.81
83	Leukemia, chronic myeloid	Enrichment	KRAS	1.81
84	Gallbladder cancer	Enrichment	KRAS	1.81
85	Pilomyxoid astrocytoma	Enrichment	KRAS	1.81
86	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.78
87	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	CSF3R	1.78
88	Immune deficiency disease	Enrichment	SYK	1.70
89	Pectus excavatum	Enrichment	PTPN11	1.62
90	Lung non-small cell carcinoma	Enrichment	KRAS	1.62
91	Specific learning disability	Enrichment	PTPN11	1.62
92	Epicanthus	Enrichment	PTPN11	1.58
93	Congenital long qt syndrome	Enrichment	PTPN11	1.58
94	Lung cancer susceptibility 3	Enrichment	KRAS	1.52
95	Lynch syndrome	Enrichment	KRAS	1.49
96	Patent foramen ovale	Enrichment	PTPN11	1.41
97	Arteriovenous malformations of the brain	Enrichment	KRAS	1.38
98	Scoliosis	Enrichment	PTPN11	1.29
99	Pancreatic cancer	Enrichment	KRAS	1.27
100	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.25
101	Strabismus	Enrichment	PTPN11	1.24
102	Bladder cancer	Enrichment	KRAS	1.21
103	Differentiated thyroid carcinoma	Enrichment	KRAS	1.21
104	Long qt syndrome 1	Enrichment	PTPN11	1.19
105	Lung cancer	Enrichment	KRAS	1.16
106	Systemic lupus erythematosus	Enrichment	SOCS1	1.16
107	Gastric cancer	Enrichment	KRAS	1.04
108	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.04
109	Hereditary breast carcinoma	Enrichment	KRAS	1.03
110	Thrombocytopenia	Enrichment	PTPN11	1.00
111	Primary ovarian insufficiency	Enrichment	JAK2	0.99
112	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.94
113	Myeloma, multiple	Enrichment	KRAS	0.93
114	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.93
115	Ovarian cancer	Enrichment	KRAS	0.70
116	Autism spectrum disorder	Enrichment	PTPN11	0.67
117	Microcephaly	Enrichment	PTPN11	0.62
118	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by CSF3 (G-CSF)

Pathway Network for Signaling by CSF3 (G-CSF)

Member Pathways for Signaling by CSF3 (G-CSF)

Pathways in the Signaling by CSF3 (G-CSF) SuperPath

Associated Genes for Signaling by CSF3 (G-CSF)

Associated Disorders for Signaling by CSF3 (G-CSF)

Disorders associated with Signaling by CSF3 (G-CSF) SuperPath

STRING Interaction Network for Signaling by CSF3 (G-CSF)

Sources for Signaling by CSF3 (G-CSF)