Signaling by EGFR

Pathway network for the Signaling by EGFR SuperPath

Sources:

Reactome

Pathways in the Signaling by EGFR SuperPath

#	Name	Source	Genes
1	Signaling by EGFR	Reactome	AAMP ADAM10 ADAM12 ADAM17 AREG ARHGEF7 BTC CBL CDC42 CSK EGF EGFR EPGN EPN1 EPS15 EPS15L1 EREG FAM83A FAM83B FAM83D GAB1 GRB2 HBEGF HGS HRAS KRAS LRIG1 NRAS PAG1 PIK3CA PIK3R1 PLCG1 PTPN11 PTPN12 PTPN3 PTPRK PXN RPS27A SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SHC1 SOS1 SPRY1 SPRY2 SRC STAM STAM2 TGFA UBA52 UBB UBC (see all 53) (see less)
2	EGFR downregulation	Reactome	AREG ARHGEF7 BTC CBL CDC42 EGF EGFR EPGN EPN1 EPS15 EPS15L1 EREG GRB2 HBEGF HGS PTPN12 PTPN3 PTPRK RPS27A SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SPRY1 SPRY2 STAM STAM2 TGFA UBA52 UBB UBC (see all 31) (see less)
3	Negative regulation of MET activity	Reactome	CBL EPS15 GRB2 HGF HGS LRIG1 MET PTPN1 PTPN2 PTPRJ RPS27A SH3GL1 SH3GL2 SH3GL3 SH3KBP1 STAM STAM2 UBA52 UBB UBC USP8 (see all 21) (see less)
4	GAB1 signalosome	Reactome	AREG BTC CSK EGF EGFR EPGN EREG GAB1 GRB2 HBEGF PAG1 PIK3CA PIK3R1 PTPN11 PXN SRC TGFA (see all 17) (see less)

Gene overlap in member pathways for Signaling by EGFR SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	4
2	STAM2	Signal Transducing Adaptor Molecule 2	Protein Coding	3
3	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	3
4	EGF	Epidermal Growth Factor	Protein Coding	3
5	EGFR	Epidermal Growth Factor Receptor	Protein Coding	3
6	EPS15	Epidermal Growth Factor Receptor Pathway Substrate 15	Protein Coding	3
7	EREG	Epiregulin	Protein Coding	3
8	EPGN	Epithelial Mitogen	Protein Coding	3
9	SH3KBP1	SH3 Domain Containing Kinase Binding Protein 1	Protein Coding	3
10	AREG	Amphiregulin	Protein Coding	3
11	RPS27A	Ribosomal Protein S27a	Protein Coding	3
12	SH3GL1	SH3 Domain Containing GRB2 Like 1, Endophilin A2	Protein Coding	3
13	SH3GL2	SH3 Domain Containing GRB2 Like 2, Endophilin A1	Protein Coding	3
14	SH3GL3	SH3 Domain Containing GRB2 Like 3, Endophilin A3	Protein Coding	3
15	BTC	Betacellulin	Protein Coding	3
16	TGFA	Transforming Growth Factor Alpha	Protein Coding	3
17	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
18	UBB	Ubiquitin B	Protein Coding	3
19	UBC	Ubiquitin C	Protein Coding	3
20	STAM	Signal Transducing Adaptor Molecule	Protein Coding	3
21	CBL	Cbl Proto-Oncogene	Protein Coding	3
22	HGS	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate	Protein Coding	3
23	SPRY1	Sprouty RTK Signaling Antagonist 1	Protein Coding	2
24	SPRY2	Sprouty RTK Signaling Antagonist 2	Protein Coding	2
25	CSK	C-Terminal Src Kinase	Protein Coding	2
26	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	2
27	LRIG1	Leucine Rich Repeats And Immunoglobulin Like Domains 1	Protein Coding	2
28	EPN1	Epsin 1	Protein Coding	2
29	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
30	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
31	PAG1	Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1	Protein Coding	2
32	PTPN3	Protein Tyrosine Phosphatase Non-Receptor Type 3	Protein Coding	2
33	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	2
34	PTPN12	Protein Tyrosine Phosphatase Non-Receptor Type 12	Protein Coding	2
35	PTPRK	Protein Tyrosine Phosphatase Receptor Type K	Protein Coding	2
36	PXN	Paxillin	Protein Coding	2
37	EPS15L1	Epidermal Growth Factor Receptor Pathway Substrate 15 Like 1	Protein Coding	2
38	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
39	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	2
40	CDC42	Cell Division Cycle 42	Protein Coding	2
41	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	1
42	AAMP	Angio Associated Migratory Cell Protein	Protein Coding	1
43	FAM83B	Family With Sequence Similarity 83 Member B	Protein Coding	1
44	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
45	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
46	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
47	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
48	SHC1	SHC Adaptor Protein 1	Protein Coding	1
49	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
50	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
51	ADAM12	ADAM Metallopeptidase Domain 12	Protein Coding	1
52	FAM83D	Family With Sequence Similarity 83 Member D	Protein Coding	1
53	FAM83A	Family With Sequence Similarity 83 Member A	Protein Coding	1
54	HGF	Hepatocyte Growth Factor	Protein Coding	1
55	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
56	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
57	PTPN2	Protein Tyrosine Phosphatase Non-Receptor Type 2	Protein Coding	1
58	PTPRJ	Protein Tyrosine Phosphatase Receptor Type J	Protein Coding	1
59	USP8	Ubiquitin Specific Peptidase 8	Protein Coding	1

Disorders associated with Signaling by EGFR SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, HRAS, KRAS, NRAS, PTPN11, SOS1	10.44
2	Noonan syndrome 1	Enrichment	CBL, HRAS, KRAS, NRAS, PTPN11, SOS1	9.55
3	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, NRAS, PIK3CA	9.45
4	Rasopathy	Enrichment	CBL, HRAS, KRAS, NRAS, PTPN11, SOS1	9.24
5	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	8.14
6	Noonan syndrome 3	Enrichment	HRAS, KRAS, PTPN11, SOS1	8.14
7	Juvenile myelomonocytic leukemia	Enrichment	CBL, KRAS, NRAS, PTPN11	7.00
8	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.65
9	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, CDC42, PTPN11	6.65
10	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS, PIK3CA	5.95
11	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.35
12	Bladder cancer	Enrichment	EGFR, HRAS, KRAS, PIK3CA	5.34
13	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, PIK3CA	4.92
14	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.82
15	Colorectal cancer	Enrichment	NRAS, PIK3CA, PIK3R1, PTPN12, SRC	4.66
16	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	4.66
17	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.35
18	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17, EGFR	4.35
19	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	4.28
20	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.05
21	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	3.72
22	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	3.65
23	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS, PTPN11	3.63
24	Lung cancer	Enrichment	EGFR, KRAS, PIK3CA	3.59
25	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.51
26	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	3.51
27	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.51
28	Gallbladder cancer	Enrichment	KRAS, PIK3CA	3.51
29	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.51
30	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	3.38
31	Leukemia, acute myeloid	Enrichment	KRAS, NRAS, SH3GL1	3.30
32	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.28
33	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	3.18
34	Macrodactyly	Enrichment	PIK3CA	2.90
35	Metachondromatosis	Enrichment	PTPN11	2.90
36	Deafness, autosomal recessive 26	Enrichment	GAB1	2.90
37	Hypomagnesemia 4, renal	Enrichment	EGF	2.90
38	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.90
39	Leopard syndrome 1	Enrichment	PTPN11	2.90
40	Cowden syndrome 5	Enrichment	PIK3CA	2.90
41	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.90
42	Short syndrome	Enrichment	PIK3R1	2.90
43	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.90
44	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.90
45	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.90
46	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.90
47	Thrombocytopenia 6	Enrichment	SRC	2.90
48	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.90
49	Hypospadias	Enrichment	PIK3CA	2.90
50	Rare venous malformation	Enrichment	PIK3CA	2.90
51	Diaphragmatic eventration	Enrichment	PIK3CA	2.90
52	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.90
53	Rare combined vascular malformation	Enrichment	PIK3CA	2.90
54	Cavernous lymphangioma	Enrichment	PIK3CA	2.90
55	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.90
56	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.90
57	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.90
58	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.90
59	Macrodactyly of toe	Enrichment	PIK3CA	2.90
60	Malignant astrocytoma	Enrichment	PTPN11	2.90
61	Lung cancer susceptibility 3	Enrichment	EGFR, KRAS	2.88
62	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.82
63	Immunodeficiency 61	Enrichment	SH3KBP1	2.81
64	Deafness, autosomal recessive 39	Enrichment	HGF	2.81
65	Osteofibrous dysplasia	Enrichment	MET	2.81
66	Deafness, autosomal recessive 97	Enrichment	MET	2.81
67	Autism 9	Enrichment	MET	2.81
68	Arthrogryposis, distal, type 11	Enrichment	MET	2.81
69	Autosomal recessive spastic paraplegia type 59	Enrichment	USP8	2.81
70	Thrombocytopenia 10	Enrichment	PTPRJ	2.81
71	Thrombocytopenia	Enrichment	PTPN11, SRC	2.79
72	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.76
73	Iga nephropathy 3	Enrichment	SPRY2	2.64
74	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.64
75	Nocarh syndrome	Enrichment	CDC42	2.64
76	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	2.61
77	Keratosis, seborrheic	Enrichment	PIK3CA	2.60
78	Noonan syndrome 8	Enrichment	PIK3CA	2.60
79	Werner syndrome	Enrichment	PTPN11	2.60
80	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.60
81	Pituitary adenoma 4, acth-secreting	Enrichment	USP8	2.51
82	Ovarian germ cell cancer	Enrichment	CBL	2.51
83	Childhood hepatocellular carcinoma	Enrichment	MET	2.51
84	Papillary renal cell carcinoma	Enrichment	MET	2.51
85	Malignant germ cell tumor of ovary	Enrichment	CBL	2.51
86	Submucosal cleft palate	Enrichment	UBB	2.51
87	Cleft hard palate	Enrichment	UBB	2.51
88	Breast cancer	Enrichment	KRAS, PIK3CA, SHC1	2.51
89	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.43
90	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.43
91	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.43
92	Immunodeficiency 14	Enrichment	PIK3R1	2.43
93	Tricuspid valve insufficiency	Enrichment	PTPN11	2.43
94	Keratoacanthoma	Enrichment	PIK3CA	2.43
95	Oculoectodermal syndrome	Enrichment	KRAS	2.41
96	Noonan syndrome 4	Enrichment	SOS1	2.41
97	Melanosis, neurocutaneous	Enrichment	NRAS	2.41
98	Noonan syndrome 6	Enrichment	NRAS	2.41
99	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.41
100	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.41
101	Alzheimer disease 18	Enrichment	ADAM10	2.41
102	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.41
103	Congenital pulmonary airway malformation	Enrichment	KRAS	2.41
104	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.41
105	Neurocutaneous melanocytosis	Enrichment	NRAS	2.41
106	Immune system disease	Enrichment	CDC42	2.34
107	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.34
108	Uvula, bifid	Enrichment	UBB	2.33
109	Cleft soft palate	Enrichment	UBB	2.33
110	Renal cell carcinoma	Enrichment	MET	2.33
111	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.30
112	Cerebrovascular disease	Enrichment	PIK3CA	2.30
113	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.30
114	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.30
115	Capillary malformations, congenital	Enrichment	PIK3CA	2.20
116	Lymphoma	Enrichment	PTPN11	2.20
117	Hemimegalencephaly	Enrichment	PIK3CA	2.20
118	Ovarian cancer	Enrichment	EGFR, PIK3CA	2.16
119	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.13
120	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.13
121	Patent ductus arteriosus	Enrichment	PTPN11	2.13
122	Myeloproliferative neoplasm	Enrichment	CBL	2.11
123	Aggressive systemic mastocytosis	Enrichment	CBL	2.11
124	Fibromatosis, gingival, 1	Enrichment	SOS1	2.11
125	Costello syndrome	Enrichment	HRAS	2.11
126	Pulmonic stenosis	Enrichment	SOS1	2.11
127	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.11
128	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.11
129	Wooly hair nevus	Enrichment	HRAS	2.11
130	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET	2.08
131	Myelofibrosis	Enrichment	SRC	2.06
132	Squamous cell carcinoma, head and neck	Enrichment	EGFR	2.06
133	Overgrowth syndrome	Enrichment	PIK3R1	2.06
134	Cholangiocarcinoma	Enrichment	PTPN3	2.04
135	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.97
136	Oligoarticular juvenile idiopathic arthritis	Enrichment	PTPN2	1.97
137	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	PTPN2	1.97
138	Cowden syndrome	Enrichment	PIK3CA	1.95
139	Inherited cancer-predisposing syndrome	Enrichment	EGFR, PTPN11	1.93
140	Nuchal bleb, familial	Enrichment	SOS1	1.93
141	Langerhans cell histiocytosis	Enrichment	NRAS	1.93
142	Spermatocytoma	Enrichment	HRAS	1.93
143	Gastric cancer	Enrichment	KRAS, PIK3CA	1.91
144	Arthrogryposis, distal, type 1a	Enrichment	MET	1.91
145	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.90
146	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	1.89
147	Pectus excavatum	Enrichment	PTPN11	1.86
148	Specific learning disability	Enrichment	PTPN11	1.86
149	Primary hyperaldosteronism	Enrichment	USP8	1.86
150	Epicanthus	Enrichment	PTPN11	1.83
151	Meningioma	Enrichment	PIK3CA	1.83
152	Congenital long qt syndrome	Enrichment	PTPN11	1.83
153	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.81
154	Dowling-degos disease 1	Enrichment	ADAM10	1.81
155	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.81
156	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.81
157	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.81
158	Pilocytic astrocytoma	Enrichment	KRAS	1.81
159	Epidermolytic nevus	Enrichment	HRAS	1.81
160	Gingival fibromatosis	Enrichment	SOS1	1.81
161	Osteoporosis	Enrichment	SRC	1.76
162	Isolated split hand-split foot malformation	Enrichment	EPS15L1	1.74
163	Gliosarcoma	Enrichment	EGFR	1.70
164	Giant cell glioblastoma	Enrichment	EGFR	1.68
165	Patent foramen ovale	Enrichment	PTPN11	1.65
166	Renal cell carcinoma, nonpapillary	Enrichment	MET	1.64
167	Endometrial cancer	Enrichment	PIK3CA	1.58
168	Pilomyxoid astrocytoma	Enrichment	KRAS	1.57
169	Hepatocellular carcinoma	Enrichment	PIK3CA	1.56
170	Tooth agenesis	Enrichment	TGFA	1.56
171	Scoliosis	Enrichment	PTPN11	1.53
172	Strabismus	Enrichment	PTPN11	1.48
173	Prostate cancer	Enrichment	PIK3CA	1.45
174	Long qt syndrome 1	Enrichment	PTPN11	1.43
175	Aortic valve disease 1	Enrichment	SOS1	1.30
176	Protein-deficiency anemia	Enrichment	NRAS	1.30
177	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.28
178	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.27
179	Type 2 diabetes mellitus	Enrichment	PTPN1	1.20
180	Hypertelorism	Enrichment	PIK3CA	1.20
181	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.17
182	Sensorineural hearing loss	Enrichment	HGF	1.14
183	Pancreatic cancer	Enrichment	KRAS	1.03
184	Autism spectrum disorder	Enrichment	PTPN11	0.89
185	Microcephaly	Enrichment	PTPN11	0.84
186	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.71
187	Myeloma, multiple	Enrichment	KRAS	0.71

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by EGFR

Pathway Network for Signaling by EGFR

Pathway network for the Signaling by EGFR SuperPath

Member Pathways for Signaling by EGFR

Pathways in the Signaling by EGFR SuperPath

Gene overlap in member pathways for Signaling by EGFR SuperPath

Associated Genes for Signaling by EGFR

Associated Disorders for Signaling by EGFR

Disorders associated with Signaling by EGFR SuperPath

STRING Interaction Network for Signaling by EGFR

Sources for Signaling by EGFR