Signaling by EGFR in Cancer

Pathway network for the Signaling by EGFR in Cancer SuperPath

Sources:

Reactome
PubChem

Pathways in the Signaling by EGFR in Cancer SuperPath

#	Name	Source	Genes
1	Signaling by EGFR in Cancer	Reactome	AREG BTC CBL CDC37 EGF EGFR EPGN EREG GAB1 GRB2 HBEGF HRAS HSP90AA1 KRAS NRAS PIK3CA PIK3R1 PLCG1 RPS27A SHC1 SOS1 TGFA UBA52 UBB UBC (see all 25) (see less)
2	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	Reactome	CBL CDC37 EGF EGFR GAB1 GRB2 HRAS HSP90AA1 KRAS NRAS PIK3CA PIK3R1 PLCG1 RPS27A SHC1 SOS1 UBA52 UBB UBC (see all 19) (see less)
3	Signaling by Ligand-Responsive EGFR Variants in Cancer	Reactome	CBL CDC37 EGF EGFR GAB1 GRB2 HRAS HSP90AA1 KRAS NRAS PIK3CA PIK3R1 PLCG1 RPS27A SHC1 SOS1 UBA52 UBB UBC (see all 19) (see less)
4	Signaling by EGFRvIII in Cancer	Reactome	CBL CDC37 EGF EGFR GAB1 GRB2 HRAS HSP90AA1 KRAS NRAS PIK3CA PIK3R1 PLCG1 SHC1 SOS1 (see all 15) (see less)
5	Constitutive Signaling by EGFRvIII	Reactome	CBL CDC37 EGF EGFR GAB1 GRB2 HRAS HSP90AA1 KRAS NRAS PIK3CA PIK3R1 PLCG1 SHC1 SOS1 (see all 15) (see less)
6	SHC1 events in EGFR signaling	Reactome	AREG BTC EGF EGFR EPGN EREG GRB2 HBEGF HRAS KRAS NRAS SHC1 SOS1 TGFA (see all 14) (see less)
7	GRB2 events in EGFR signaling	Reactome	AREG BTC EGF EGFR EPGN EREG GRB2 HBEGF HRAS KRAS NRAS SOS1 TGFA (see all 13) (see less)
8	EGFR-dependent Endothelin signaling events	PubChem	EDN1 EDNRA EGF EGFR GRB2 HRAS MTOR SHC1 SOS1 (see all 9) (see less)
9	EGFR interacts with phospholipase C-gamma	Reactome	AREG BTC EGF EGFR EPGN EREG HBEGF PLCG1 TGFA (see all 9) (see less)

Gene overlap in member pathways for Signaling by EGFR in Cancer SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EGF	Epidermal Growth Factor	Protein Coding	9
2	EGFR	Epidermal Growth Factor Receptor	Protein Coding	9
3	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	8
4	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	8
5	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	8
6	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	7
7	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	7
8	SHC1	SHC Adaptor Protein 1	Protein Coding	7
9	PLCG1	Phospholipase C Gamma 1	Protein Coding	6
10	CDC37	Cell Division Cycle 37, HSP90 Cochaperone	Protein Coding	5
11	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	5
12	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	5
13	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	5
14	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	5
15	CBL	Cbl Proto-Oncogene	Protein Coding	5
16	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	4
17	EREG	Epiregulin	Protein Coding	4
18	EPGN	Epithelial Mitogen	Protein Coding	4
19	AREG	Amphiregulin	Protein Coding	4
20	BTC	Betacellulin	Protein Coding	4
21	TGFA	Transforming Growth Factor Alpha	Protein Coding	4
22	RPS27A	Ribosomal Protein S27a	Protein Coding	3
23	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
24	UBB	Ubiquitin B	Protein Coding	3
25	UBC	Ubiquitin C	Protein Coding	3
26	EDNRA	Endothelin Receptor Type A	Protein Coding	1
27	EDN1	Endothelin 1	Protein Coding	1
28	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1

Disorders associated with Signaling by EGFR in Cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, NRAS, PIK3CA	10.98
2	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, HRAS, KRAS, NRAS, SOS1	10.57
3	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	10.29
4	Noonan syndrome 1	Enrichment	CBL, HRAS, KRAS, NRAS, SOS1	10.28
5	Rasopathy	Enrichment	CBL, HRAS, KRAS, NRAS, SOS1	10.23
6	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	8.55
7	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS, PIK3CA	7.66
8	Bladder cancer	Enrichment	EGFR, HRAS, KRAS, PIK3CA	7.65
9	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	7.62
10	Juvenile myelomonocytic leukemia	Enrichment	CBL, KRAS, NRAS	6.62
11	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, PIK3CA	6.62
12	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.07
13	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	5.61
14	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.59
15	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.47
16	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.29
17	Lung cancer	Enrichment	EGFR, KRAS, PIK3CA	5.27
18	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	4.77
19	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	4.77
20	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.75
21	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.75
22	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.75
23	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.63
24	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	4.62
25	Gallbladder cancer	Enrichment	KRAS, PIK3CA	4.62
26	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	4.39
27	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	4.39
28	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	4.29
29	Breast cancer	Enrichment	KRAS, PIK3CA, SHC1	4.15
30	Lung cancer susceptibility 3	Enrichment	EGFR, KRAS	4.12
31	Colorectal cancer	Enrichment	NRAS, PIK3CA, PIK3R1	3.96
32	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.93
33	Rhabdomyosarcoma	Enrichment	CBL, HRAS	3.87
34	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	3.84
35	Ovarian cancer	Enrichment	EGFR, KRAS, PIK3CA	3.77
36	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	3.41
37	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	3.19
38	Hypomagnesemia 4, renal	Enrichment	EGF	3.18
39	Noonan syndrome 4	Enrichment	SOS1	3.18
40	Mandibulofacial dysostosis with alopecia	Enrichment	EDNRA	3.18
41	Auriculocondylar syndrome 3	Enrichment	EDN1	3.18
42	Question mark ears, isolated	Enrichment	EDN1	3.18
43	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.18
44	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	3.18
45	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	3.18
46	Oculoectodermal syndrome	Enrichment	KRAS	3.02
47	Melanosis, neurocutaneous	Enrichment	NRAS	3.02
48	Noonan syndrome 6	Enrichment	NRAS	3.02
49	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.02
50	Congenital pulmonary airway malformation	Enrichment	KRAS	3.02
51	Neurocutaneous melanocytosis	Enrichment	NRAS	3.02
52	Gastric cancer	Enrichment	KRAS, PIK3CA	3.00
53	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	2.98
54	Macrodactyly	Enrichment	PIK3CA	2.96
55	Deafness, autosomal recessive 26	Enrichment	GAB1	2.96
56	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.96
57	Cowden syndrome 5	Enrichment	PIK3CA	2.96
58	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.96
59	Short syndrome	Enrichment	PIK3R1	2.96
60	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.96
61	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.96
62	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.96
63	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.96
64	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.96
65	Hypospadias	Enrichment	PIK3CA	2.96
66	Rare venous malformation	Enrichment	PIK3CA	2.96
67	Diaphragmatic eventration	Enrichment	PIK3CA	2.96
68	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.96
69	Rare combined vascular malformation	Enrichment	PIK3CA	2.96
70	Cavernous lymphangioma	Enrichment	PIK3CA	2.96
71	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.96
72	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.96
73	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.96
74	Macrodactyly of toe	Enrichment	PIK3CA	2.96
75	Fibromatosis, gingival, 1	Enrichment	SOS1	2.88
76	Costello syndrome	Enrichment	HRAS	2.88
77	Pulmonic stenosis	Enrichment	SOS1	2.88
78	Cebalid syndrome	Enrichment	MTOR	2.88
79	Smith-kingsmore syndrome	Enrichment	MTOR	2.88
80	Wooly hair nevus	Enrichment	HRAS	2.88
81	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.72
82	Nuchal bleb, familial	Enrichment	SOS1	2.70
83	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.70
84	Spermatocytoma	Enrichment	HRAS	2.70
85	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.70
86	Ovarian germ cell cancer	Enrichment	CBL	2.66
87	Keratosis, seborrheic	Enrichment	PIK3CA	2.66
88	Noonan syndrome 8	Enrichment	PIK3CA	2.66
89	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.66
90	Malignant germ cell tumor of ovary	Enrichment	CBL	2.66
91	Auriculocondylar syndrome 1	Enrichment	EDN1	2.58
92	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.58
93	Epidermolytic nevus	Enrichment	HRAS	2.58
94	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.58
95	Gingival fibromatosis	Enrichment	SOS1	2.58
96	Submucosal cleft palate	Enrichment	UBB	2.55
97	Cleft hard palate	Enrichment	UBB	2.55
98	Langerhans cell histiocytosis	Enrichment	NRAS	2.54
99	Hemimegalencephaly	Enrichment	MTOR	2.48
100	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.48
101	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.48
102	Immunodeficiency 14	Enrichment	PIK3R1	2.48
103	Keratoacanthoma	Enrichment	PIK3CA	2.48
104	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.42
105	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.42
106	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.42
107	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.42
108	Pilocytic astrocytoma	Enrichment	KRAS	2.42
109	Uvula, bifid	Enrichment	UBB	2.38
110	Cleft soft palate	Enrichment	UBB	2.38
111	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.35
112	Cerebrovascular disease	Enrichment	PIK3CA	2.35
113	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	2.35
114	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.35
115	Squamous cell carcinoma, head and neck	Enrichment	EGFR	2.33
116	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	2.33
117	Overgrowth syndrome	Enrichment	MTOR	2.33
118	Capillary malformations, congenital	Enrichment	PIK3CA	2.26
119	Myeloproliferative neoplasm	Enrichment	CBL	2.26
120	Aggressive systemic mastocytosis	Enrichment	CBL	2.26
121	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.18
122	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.18
123	Pilomyxoid astrocytoma	Enrichment	KRAS	2.17
124	Aortic valve disease 1	Enrichment	SOS1	2.07
125	46,xy partial gonadal dysgenesis	Enrichment	SOS1	2.03
126	Cowden syndrome	Enrichment	PIK3CA	2.00
127	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	2.00
128	Rare genetic intellectual disability	Enrichment	MTOR	2.00
129	Gliosarcoma	Enrichment	EGFR	1.98
130	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.96
131	Giant cell glioblastoma	Enrichment	EGFR	1.95
132	Protein-deficiency anemia	Enrichment	NRAS	1.91
133	Meningioma	Enrichment	PIK3CA	1.88
134	Tooth agenesis	Enrichment	TGFA	1.84
135	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.77
136	Cystic fibrosis	Enrichment	EDNRA	1.68
137	Endometrial cancer	Enrichment	PIK3CA	1.64
138	Pancreatic cancer	Enrichment	KRAS	1.63
139	Hepatocellular carcinoma	Enrichment	PIK3CA	1.62
140	Prostate cancer	Enrichment	PIK3CA	1.50
141	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.29
142	Myeloma, multiple	Enrichment	KRAS	1.28
143	Hypertelorism	Enrichment	PIK3CA	1.25
144	Inherited cancer-predisposing syndrome	Enrichment	EGFR	1.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by EGFR in Cancer

Pathway Network for Signaling by EGFR in Cancer

Pathway network for the Signaling by EGFR in Cancer SuperPath

Member Pathways for Signaling by EGFR in Cancer

Pathways in the Signaling by EGFR in Cancer SuperPath

Gene overlap in member pathways for Signaling by EGFR in Cancer SuperPath

Associated Genes for Signaling by EGFR in Cancer

Associated Disorders for Signaling by EGFR in Cancer

Disorders associated with Signaling by EGFR in Cancer SuperPath

STRING Interaction Network for Signaling by EGFR in Cancer

Sources for Signaling by EGFR in Cancer