Signaling by ERBB2

Pathway network for the Signaling by ERBB2 SuperPath

Sources:

Reactome

Pathways in the Signaling by ERBB2 SuperPath

#	Name	Source	Genes
1	Signaling by ERBB2	Reactome	AKT1 AKT2 AKT3 BTC CDC37 CUL5 DIAPH1 EGF EGFR ERBB2 ERBB3 ERBB4 ERBIN EREG FYN GAB1 GRB2 GRB7 HBEGF HRAS HSP90AA1 KRAS MATK MEMO1 NRAS NRG1 NRG2 NRG3 NRG4 PIK3CA PIK3R1 PLCG1 PRKCA PRKCD PRKCE PTK6 PTPN12 PTPN18 RHOA RNF41 RPS27A SHC1 SOS1 SRC STUB1 UBA52 UBB UBC USP8 YES1 (see all 50) (see less)
2	Downregulation of ERBB2 signaling	Reactome	AKT1 AKT2 AKT3 BTC CDC37 CUL5 EGF EGFR ERBB2 ERBB3 ERBB4 ERBIN EREG HBEGF HSP90AA1 MATK NRG1 NRG2 NRG3 NRG4 PTPN12 PTPN18 RNF41 RPS27A STUB1 UBA52 UBB UBC USP8 (see all 29) (see less)
3	ERBB2 Regulates Cell Motility	Reactome	BTC DIAPH1 EGF EGFR ERBB2 ERBB3 ERBB4 EREG HBEGF MEMO1 NRG1 NRG2 NRG3 NRG4 RHOA (see all 15) (see less)
4	Downregulation of ERBB2:ERBB3 signaling	Reactome	AKT1 AKT2 AKT3 ERBB2 ERBB3 NRG1 NRG2 RNF41 RPS27A UBA52 UBB UBC USP8 (see all 13) (see less)
5	ERBB2 Activates PTK6 Signaling	Reactome	BTC EGF EGFR ERBB2 ERBB3 ERBB4 EREG HBEGF NRG1 NRG2 NRG3 NRG4 PTK6 (see all 13) (see less)
6	GRB7 events in ERBB2 signaling	Reactome	ERBB2 ERBB3 GRB7 NRG1 NRG2

Gene overlap in member pathways for Signaling by ERBB2 SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	6
2	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	6
3	NRG1	Neuregulin 1	Protein Coding	6
4	NRG2	Neuregulin 2	Protein Coding	6
5	NRG3	Neuregulin 3	Protein Coding	4
6	NRG4	Neuregulin 4	Protein Coding	4
7	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	4
8	EGF	Epidermal Growth Factor	Protein Coding	4
9	EGFR	Epidermal Growth Factor Receptor	Protein Coding	4
10	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	4
11	EREG	Epiregulin	Protein Coding	4
12	BTC	Betacellulin	Protein Coding	4
13	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	3
14	RNF41	Ring Finger Protein 41	Protein Coding	3
15	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
16	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	3
17	RPS27A	Ribosomal Protein S27a	Protein Coding	3
18	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
19	UBB	Ubiquitin B	Protein Coding	3
20	UBC	Ubiquitin C	Protein Coding	3
21	USP8	Ubiquitin Specific Peptidase 8	Protein Coding	3
22	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	2
23	CDC37	Cell Division Cycle 37, HSP90 Cochaperone	Protein Coding	2
24	DIAPH1	Diaphanous Related Formin 1	Protein Coding	2
25	PTPN18	Protein Tyrosine Phosphatase Non-Receptor Type 18	Protein Coding	2
26	GRB7	Growth Factor Receptor Bound Protein 7	Protein Coding	2
27	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	2
28	RHOA	Ras Homolog Family Member A	Protein Coding	2
29	MATK	Megakaryocyte-Associated Tyrosine Kinase	Protein Coding	2
30	MEMO1	Mediator Of Cell Motility 1	Protein Coding	2
31	ERBIN	Erbb2 Interacting Protein	Protein Coding	2
32	PTK6	Protein Tyrosine Kinase 6	Protein Coding	2
33	PTPN12	Protein Tyrosine Phosphatase Non-Receptor Type 12	Protein Coding	2
34	CUL5	Cullin 5	Protein Coding	2
35	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
36	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
37	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
38	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
39	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
40	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
41	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
42	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
43	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
44	PRKCA	Protein Kinase C Alpha	Protein Coding	1
45	PRKCD	Protein Kinase C Delta	Protein Coding	1
46	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
47	SHC1	SHC Adaptor Protein 1	Protein Coding	1
48	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
49	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
50	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	1

Disorders associated with Signaling by ERBB2 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung non-small cell carcinoma	Enrichment	EGFR, ERBB2, HRAS, KRAS, NRAS, PIK3CA	10.60
2	Bladder cancer	Enrichment	EGFR, ERBB2, ERBB3, HRAS, KRAS, PIK3CA	9.08
3	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	8.25
4	Colorectal cancer	Enrichment	AKT1, ERBB2, NRAS, PIK3CA, PIK3R1, PTPN12, SRC	7.55
5	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.73
6	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	6.66
7	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	6.03
8	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS, PIK3CA	6.03
9	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1	5.86
10	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	5.79
11	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1	5.64
12	Hirschsprung disease 1	Enrichment	ERBB2, ERBB3, NRG3	5.61
13	Lung cancer	Enrichment	EGFR, ERBB2, KRAS, PIK3CA	5.26
14	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, PIK3CA	4.99
15	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.88
16	Lung cancer susceptibility 3	Enrichment	EGFR, ERBB2, KRAS	4.78
17	Ovarian cancer	Enrichment	AKT1, EGFR, ERBB2, KRAS, PIK3CA	4.47
18	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.40
19	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.40
20	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA	4.10
21	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.10
22	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.88
23	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	3.79
24	Breast cancer	Enrichment	AKT1, KRAS, PIK3CA, SHC1	3.79
25	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	3.70
26	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.70
27	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.56
28	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	3.56
29	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.56
30	Gallbladder cancer	Enrichment	KRAS, PIK3CA	3.56
31	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.56
32	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	3.43
33	Erythroleukemia, familial	Enrichment	ERBB3	3.43
34	Paget disease, extramammary	Enrichment	ERBB2	3.43
35	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	3.43
36	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	3.43
37	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	3.43
38	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.33
39	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	3.33
40	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.33
41	Gastric cancer	Enrichment	ERBB2, KRAS, PIK3CA	3.28
42	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA	3.25
43	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	3.23
44	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	3.13
45	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	3.07
46	Meningioma	Enrichment	AKT1, PIK3CA	3.07
47	Proteus syndrome	Enrichment	AKT1	3.02
48	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	3.02
49	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	3.02
50	Cowden syndrome 6	Enrichment	AKT1	3.02
51	Autosomal recessive spastic paraplegia type 59	Enrichment	USP8	3.02
52	Capillary hemangioma	Enrichment	AKT3	3.02
53	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	3.02
54	Hypomagnesemia 4, renal	Enrichment	EGF	3.02
55	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	3.02
56	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	3.02
57	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	2.96
58	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	2.96
59	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.96
60	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	2.96
61	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.96
62	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.87
63	Barrett esophagus	Enrichment	ERBB2	2.83
64	Pituitary adenoma 4, acth-secreting	Enrichment	USP8	2.72
65	Senior-loken syndrome 7	Enrichment	AKT3	2.72
66	Bardet-biedl syndrome 16	Enrichment	AKT3	2.72
67	Submucosal cleft palate	Enrichment	UBB	2.72
68	Cleft hard palate	Enrichment	UBB	2.72
69	Autosomal dominant combined immunodeficiency due to erbin deficiency	Enrichment	ERBIN	2.67
70	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	2.66
71	Uvula, bifid	Enrichment	UBB	2.54
72	Cleft soft palate	Enrichment	UBB	2.54
73	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.54
74	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.54
75	Glioma susceptibility 1	Enrichment	ERBB2	2.53
76	Macrodactyly	Enrichment	PIK3CA	2.43
77	Oculoectodermal syndrome	Enrichment	KRAS	2.43
78	Deafness, autosomal recessive 26	Enrichment	GAB1	2.43
79	Noonan syndrome 4	Enrichment	SOS1	2.43
80	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.43
81	Cowden syndrome 5	Enrichment	PIK3CA	2.43
82	Melanosis, neurocutaneous	Enrichment	NRAS	2.43
83	Noonan syndrome 6	Enrichment	NRAS	2.43
84	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.43
85	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.43
86	Short syndrome	Enrichment	PIK3R1	2.43
87	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.43
88	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.43
89	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.43
90	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.43
91	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.43
92	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.43
93	Thrombocytopenia 6	Enrichment	SRC	2.43
94	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.43
95	Hypospadias	Enrichment	PIK3CA	2.43
96	Congenital pulmonary airway malformation	Enrichment	KRAS	2.43
97	Rare venous malformation	Enrichment	PIK3CA	2.43
98	Diaphragmatic eventration	Enrichment	PIK3CA	2.43
99	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.43
100	Rare combined vascular malformation	Enrichment	PIK3CA	2.43
101	Cavernous lymphangioma	Enrichment	PIK3CA	2.43
102	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.43
103	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.43
104	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.43
105	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.43
106	Macrodactyly of toe	Enrichment	PIK3CA	2.43
107	Neurocutaneous melanocytosis	Enrichment	NRAS	2.43
108	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.42
109	Spinocerebellar ataxia 48	Enrichment	STUB1	2.37
110	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.24
111	Moyamoya disease 1	Enrichment	DIAPH1	2.18
112	Pendred syndrome	Enrichment	DIAPH1	2.18
113	Megacolon	Enrichment	AKT3	2.17
114	Squamous cell carcinoma, head and neck	Enrichment	EGFR	2.17
115	Fibromatosis, gingival, 1	Enrichment	SOS1	2.13
116	Costello syndrome	Enrichment	HRAS	2.13
117	Pulmonic stenosis	Enrichment	SOS1	2.13
118	Keratosis, seborrheic	Enrichment	PIK3CA	2.13
119	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.13
120	Noonan syndrome 8	Enrichment	PIK3CA	2.13
121	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.13
122	Wooly hair nevus	Enrichment	HRAS	2.13
123	Primary hyperaldosteronism	Enrichment	USP8	2.07
124	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.02
125	Polymicrogyria	Enrichment	AKT3	2.02
126	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.96
127	Nuchal bleb, familial	Enrichment	SOS1	1.96
128	Langerhans cell histiocytosis	Enrichment	NRAS	1.96
129	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.96
130	Immunodeficiency 14	Enrichment	PIK3R1	1.96
131	Spermatocytoma	Enrichment	HRAS	1.96
132	Keratoacanthoma	Enrichment	PIK3CA	1.96
133	Nk-cell enteropathy	Enrichment	ERBB4	1.91
134	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	1.89
135	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.83
136	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.83
137	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.83
138	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.83
139	Cerebrovascular disease	Enrichment	PIK3CA	1.83
140	Pilocytic astrocytoma	Enrichment	KRAS	1.83
141	Epidermolytic nevus	Enrichment	HRAS	1.83
142	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.83
143	Gingival fibromatosis	Enrichment	SOS1	1.83
144	Gliosarcoma	Enrichment	EGFR	1.82
145	Giant cell glioblastoma	Enrichment	EGFR	1.79
146	Capillary malformations, congenital	Enrichment	PIK3CA	1.74
147	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.66
148	Myelofibrosis	Enrichment	SRC	1.59
149	Pilomyxoid astrocytoma	Enrichment	KRAS	1.59
150	Overgrowth syndrome	Enrichment	PIK3R1	1.59
151	Auditory neuropathy	Enrichment	DIAPH1	1.55
152	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.44
153	Type 2 diabetes mellitus	Enrichment	AKT2	1.40
154	Epilepsy	Enrichment	DIAPH1	1.36
155	Aortic valve disease 1	Enrichment	SOS1	1.33
156	Protein-deficiency anemia	Enrichment	NRAS	1.33
157	Autosomal dominant non-syndromic intellectual disability	Enrichment	ERBB4	1.33
158	Osteoporosis	Enrichment	SRC	1.30
159	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.30
160	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ERBB4	1.27
161	Rhabdomyosarcoma	Enrichment	HRAS	1.24
162	Endometrial cancer	Enrichment	PIK3CA	1.13
163	Hepatocellular carcinoma	Enrichment	PIK3CA	1.11
164	Rare genetic deafness	Enrichment	DIAPH1	1.08
165	Pancreatic cancer	Enrichment	KRAS	1.05
166	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.04
167	Prostate cancer	Enrichment	PIK3CA	0.99
168	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.92
169	Microcephaly	Enrichment	DIAPH1	0.89
170	Thrombocytopenia	Enrichment	SRC	0.79
171	Hypertelorism	Enrichment	PIK3CA	0.76
172	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.73
173	Myeloma, multiple	Enrichment	KRAS	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by ERBB2

Pathway Network for Signaling by ERBB2

Pathway network for the Signaling by ERBB2 SuperPath

Member Pathways for Signaling by ERBB2

Pathways in the Signaling by ERBB2 SuperPath

Gene overlap in member pathways for Signaling by ERBB2 SuperPath

Associated Genes for Signaling by ERBB2

Associated Disorders for Signaling by ERBB2

Disorders associated with Signaling by ERBB2 SuperPath

STRING Interaction Network for Signaling by ERBB2

Sources for Signaling by ERBB2