Signaling by ERBB2 KD Mutants

Pathway network for the Signaling by ERBB2 KD Mutants SuperPath

Sources:

Reactome

Pathways in the Signaling by ERBB2 KD Mutants SuperPath

#	Name	Source	Genes
1	Signaling by ERBB2 KD Mutants	Reactome	BTC CDC37 EGF EGFR ERBB2 ERBB3 ERBB4 ERBIN EREG GAB1 GRB2 HBEGF HRAS HSP90AA1 KRAS NRAS NRG1 NRG2 NRG3 NRG4 PIK3CA PIK3R1 PLCG1 SHC1 SOS1 (see all 25) (see less)
2	Signaling by ERBB2 in Cancer	Reactome	BTC CDC37 EGF EGFR ERBB2 ERBB3 ERBB4 ERBIN EREG GAB1 GRB2 HBEGF HRAS HSP90AA1 KRAS NRAS NRG1 NRG2 NRG3 NRG4 PIK3CA PIK3R1 PLCG1 PTPN12 SHC1 SOS1 (see all 26) (see less)
3	Signaling by ERBB2 TMD/JMD mutants	Reactome	BTC CDC37 EGF EGFR ERBB2 ERBB3 ERBB4 ERBIN EREG GRB2 HBEGF HRAS HSP90AA1 KRAS NRAS NRG1 NRG2 NRG3 NRG4 PLCG1 SHC1 SOS1 (see all 22) (see less)
4	SHC1 events in ERBB2 signaling	Reactome	BTC EGF EGFR ERBB2 ERBB3 ERBB4 EREG GRB2 HBEGF HRAS KRAS NRAS NRG1 NRG2 NRG3 NRG4 PRKCA PRKCD PRKCE PTPN12 SHC1 SOS1 (see all 22) (see less)
5	GRB2 events in ERBB2 signaling	Reactome	BTC EGF EGFR ERBB2 ERBB4 EREG GRB2 HBEGF HRAS KRAS NRAS NRG1 NRG2 NRG3 NRG4 SOS1 (see all 16) (see less)
6	Signaling by ERBB2 ECD mutants	Reactome	CDC37 EGF EGFR ERBB2 ERBIN GAB1 GRB2 HRAS HSP90AA1 KRAS NRAS PIK3CA PIK3R1 PLCG1 SHC1 SOS1 (see all 16) (see less)
7	PI3K events in ERBB2 signaling	Reactome	BTC EGF EGFR ERBB2 ERBB3 ERBB4 EREG GAB1 GRB2 HBEGF NRG1 NRG2 NRG3 NRG4 PIK3CA PIK3R1 (see all 16) (see less)
8	SHC1 events in ERBB4 signaling	Reactome	BTC ERBB4 EREG GRB2 HBEGF HRAS KRAS NRAS NRG1 NRG2 NRG3 NRG4 SHC1 SOS1 (see all 14) (see less)
9	Constitutive Signaling by Overexpressed ERBB2	Reactome	CDC37 ERBB2 ERBIN GRB2 HRAS HSP90AA1 KRAS NRAS PTPN12 SHC1 SOS1 (see all 11) (see less)
10	PI3K events in ERBB4 signaling	Reactome	BTC ERBB4 EREG HBEGF NRG1 NRG2 NRG3 NRG4 PIK3CA PIK3R1 (see all 10) (see less)
11	PLCG1 events in ERBB2 signaling	Reactome	EGF EGFR ERBB2 PLCG1

Gene overlap in member pathways for Signaling by ERBB2 KD Mutants SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	9
2	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	9
3	NRG3	Neuregulin 3	Protein Coding	8
4	NRG4	Neuregulin 4	Protein Coding	8
5	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	8
6	EGF	Epidermal Growth Factor	Protein Coding	8
7	EGFR	Epidermal Growth Factor Receptor	Protein Coding	8
8	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	8
9	EREG	Epiregulin	Protein Coding	8
10	NRG1	Neuregulin 1	Protein Coding	8
11	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	8
12	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	8
13	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	8
14	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	8
15	BTC	Betacellulin	Protein Coding	8
16	NRG2	Neuregulin 2	Protein Coding	8
17	SHC1	SHC Adaptor Protein 1	Protein Coding	7
18	CDC37	Cell Division Cycle 37, HSP90 Cochaperone	Protein Coding	5
19	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	5
20	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	5
21	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	5
22	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	5
23	PLCG1	Phospholipase C Gamma 1	Protein Coding	5
24	ERBIN	Erbb2 Interacting Protein	Protein Coding	5
25	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	4
26	PTPN12	Protein Tyrosine Phosphatase Non-Receptor Type 12	Protein Coding	3
27	PRKCA	Protein Kinase C Alpha	Protein Coding	1
28	PRKCD	Protein Kinase C Delta	Protein Coding	1
29	PRKCE	Protein Kinase C Epsilon	Protein Coding	1

Disorders associated with Signaling by ERBB2 KD Mutants SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bladder cancer	Enrichment	EGFR, ERBB2, ERBB3, HRAS, KRAS, PIK3CA	16.00
2	Lung non-small cell carcinoma	Enrichment	EGFR, ERBB2, HRAS, KRAS, NRAS, PIK3CA	16.00
3	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	10.18
4	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	9.45
5	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	8.80
6	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1	8.68
7	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1	8.46
8	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	7.86
9	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS, PIK3CA	7.57
10	Lung cancer	Enrichment	EGFR, ERBB2, KRAS, PIK3CA	7.34
11	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, PIK3CA	6.53
12	Lung cancer susceptibility 3	Enrichment	EGFR, ERBB2, KRAS	6.31
13	Colorectal cancer	Enrichment	ERBB2, NRAS, PIK3CA, PIK3R1, PTPN12	6.24
14	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.22
15	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	5.84
16	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.83
17	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.75
18	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.45
19	Hirschsprung disease 1	Enrichment	ERBB2, ERBB3, NRG3	5.32
20	Ovarian cancer	Enrichment	EGFR, ERBB2, KRAS, PIK3CA	5.31
21	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.90
22	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.90
23	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.90
24	Gastric cancer	Enrichment	ERBB2, KRAS, PIK3CA	4.79
25	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.78
26	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	4.71
27	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	4.71
28	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	4.56
29	Gallbladder cancer	Enrichment	KRAS, PIK3CA	4.56
30	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	4.41
31	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	4.33
32	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	4.33
33	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	4.23
34	Breast cancer	Enrichment	KRAS, PIK3CA, SHC1	4.06
35	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.87
36	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	3.66
37	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	3.56
38	Paget disease, extramammary	Enrichment	ERBB2	3.53
39	Hypomagnesemia 4, renal	Enrichment	EGF	3.53
40	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	3.53
41	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	3.53
42	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	3.53
43	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	3.53
44	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	3.34
45	Macrodactyly	Enrichment	PIK3CA	3.13
46	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	3.13
47	Cowden syndrome 5	Enrichment	PIK3CA	3.13
48	Cerebral cavernous malformations 4	Enrichment	PIK3CA	3.13
49	Short syndrome	Enrichment	PIK3R1	3.13
50	Hemifacial myohyperplasia	Enrichment	PIK3CA	3.13
51	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	3.13
52	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	3.13
53	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	3.13
54	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	3.13
55	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	3.13
56	Hypospadias	Enrichment	PIK3CA	3.13
57	Rare venous malformation	Enrichment	PIK3CA	3.13
58	Diaphragmatic eventration	Enrichment	PIK3CA	3.13
59	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	3.13
60	Rare combined vascular malformation	Enrichment	PIK3CA	3.13
61	Cavernous lymphangioma	Enrichment	PIK3CA	3.13
62	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	3.13
63	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	3.13
64	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	3.13
65	Macrodactyly of toe	Enrichment	PIK3CA	3.13
66	Oculoectodermal syndrome	Enrichment	KRAS	3.09
67	Noonan syndrome 4	Enrichment	SOS1	3.09
68	Melanosis, neurocutaneous	Enrichment	NRAS	3.09
69	Noonan syndrome 6	Enrichment	NRAS	3.09
70	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.09
71	Congenital pulmonary airway malformation	Enrichment	KRAS	3.09
72	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.09
73	Autosomal dominant combined immunodeficiency due to erbin deficiency	Enrichment	ERBIN	3.09
74	Neurocutaneous melanocytosis	Enrichment	NRAS	3.09
75	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	3.05
76	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	3.05
77	Barrett esophagus	Enrichment	ERBB2	2.93
78	Deafness, autosomal recessive 26	Enrichment	GAB1	2.93
79	Erythroleukemia, familial	Enrichment	ERBB3	2.93
80	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	2.93
81	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	2.92
82	Keratosis, seborrheic	Enrichment	PIK3CA	2.83
83	Noonan syndrome 8	Enrichment	PIK3CA	2.83
84	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.83
85	Fibromatosis, gingival, 1	Enrichment	SOS1	2.79
86	Costello syndrome	Enrichment	HRAS	2.79
87	Pulmonic stenosis	Enrichment	SOS1	2.79
88	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.79
89	Wooly hair nevus	Enrichment	HRAS	2.79
90	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.79
91	Squamous cell carcinoma, head and neck	Enrichment	EGFR	2.69
92	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.66
93	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.66
94	Immunodeficiency 14	Enrichment	PIK3R1	2.66
95	Keratoacanthoma	Enrichment	PIK3CA	2.66
96	Glioma susceptibility 1	Enrichment	ERBB2	2.63
97	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	2.63
98	Nuchal bleb, familial	Enrichment	SOS1	2.61
99	Langerhans cell histiocytosis	Enrichment	NRAS	2.61
100	Spermatocytoma	Enrichment	HRAS	2.61
101	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.53
102	Cerebrovascular disease	Enrichment	PIK3CA	2.53
103	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.53
104	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.49
105	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.49
106	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.49
107	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.49
108	Pilocytic astrocytoma	Enrichment	KRAS	2.49
109	Epidermolytic nevus	Enrichment	HRAS	2.49
110	Gingival fibromatosis	Enrichment	SOS1	2.49
111	Capillary malformations, congenital	Enrichment	PIK3CA	2.43
112	Hemimegalencephaly	Enrichment	PIK3CA	2.43
113	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.35
114	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.35
115	Gliosarcoma	Enrichment	EGFR	2.33
116	Giant cell glioblastoma	Enrichment	EGFR	2.30
117	Overgrowth syndrome	Enrichment	PIK3R1	2.29
118	Pilomyxoid astrocytoma	Enrichment	KRAS	2.25
119	Cowden syndrome	Enrichment	PIK3CA	2.18
120	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	2.13
121	Meningioma	Enrichment	PIK3CA	2.05
122	Nk-cell enteropathy	Enrichment	ERBB4	2.02
123	Aortic valve disease 1	Enrichment	SOS1	1.98
124	Protein-deficiency anemia	Enrichment	NRAS	1.98
125	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.95
126	Rhabdomyosarcoma	Enrichment	HRAS	1.89
127	Endometrial cancer	Enrichment	PIK3CA	1.81
128	Hepatocellular carcinoma	Enrichment	PIK3CA	1.79
129	Pancreatic cancer	Enrichment	KRAS	1.70
130	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.68
131	Prostate cancer	Enrichment	PIK3CA	1.67
132	Autosomal dominant non-syndromic intellectual disability	Enrichment	ERBB4	1.44
133	Hypertelorism	Enrichment	PIK3CA	1.42
134	Inherited cancer-predisposing syndrome	Enrichment	EGFR	1.42
135	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ERBB4	1.38
136	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.36
137	Myeloma, multiple	Enrichment	KRAS	1.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by ERBB2 KD Mutants

Pathway Network for Signaling by ERBB2 KD Mutants

Pathway network for the Signaling by ERBB2 KD Mutants SuperPath

Member Pathways for Signaling by ERBB2 KD Mutants

Pathways in the Signaling by ERBB2 KD Mutants SuperPath

Gene overlap in member pathways for Signaling by ERBB2 KD Mutants SuperPath

Associated Genes for Signaling by ERBB2 KD Mutants

Associated Disorders for Signaling by ERBB2 KD Mutants

Disorders associated with Signaling by ERBB2 KD Mutants SuperPath

STRING Interaction Network for Signaling by ERBB2 KD Mutants

Sources for Signaling by ERBB2 KD Mutants