Signaling by ERBB4

Pathway network for the Signaling by ERBB4 SuperPath

Sources:

Reactome
PubChem

Pathways in the Signaling by ERBB4 SuperPath

#	Name	Source	Genes
1	Signaling by ERBB4	Reactome	ADAM17 ADAP1 APH1A APH1B APOE BTC CSN2 CXCL12 DLG4 EGF EGFR ERBB3 ERBB4 EREG ESR1 GABRA1 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GFAP GRB2 HBEGF HRAS ITCH KRAS MXD4 NCOR1 NCSTN NEDD4 NRAS NRG1 NRG2 NRG3 NRG4 PGR PIK3CA PIK3R1 PSEN1 PSEN2 PSENEN RPS27A S100B SHC1 SOS1 SPARC SRC STAT5A STMN1 TAB2 UBA52 UBB UBC WWOX WWP1 YAP1 (see all 58) (see less)
2	ErbB4 signaling events	PubChem	ADAM17 BTC CBFA2T3 DLG4 ERBB2 ERBB4 EREG FYN GRB2 GRIN2B HBEGF ITCH JAK2 LRIG1 MAPK3 MDM2 NCOR1 NEDD4 NRG1 NRG2 NRG3 NRG4 PIK3CA PIK3CB PIK3R1 PRL PRLR SHC1 STAT5A STAT5B TAB2 WWOX WWP1 YAP1 (see all 34) (see less)
3	Nuclear signaling by ERBB4	Reactome	ADAM17 ADAP1 APH1A APH1B APOE BTC CSN2 CXCL12 ERBB4 EREG ESR1 GFAP HBEGF MXD4 NCOR1 NCSTN NRG1 NRG2 NRG3 NRG4 PGR PSEN1 PSEN2 PSENEN S100B SPARC SRC STAT5A STMN1 TAB2 WWOX YAP1 (see all 32) (see less)
4	Downregulation of ERBB4 signaling	Reactome	ERBB4 ITCH NEDD4 RPS27A SRC UBA52 UBB UBC WWP1 (see all 9) (see less)

Gene overlap in member pathways for Signaling by ERBB4 SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	4
2	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	3
3	NRG3	Neuregulin 3	Protein Coding	3
4	WWP1	WW Domain Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	3
5	NRG4	Neuregulin 4	Protein Coding	3
6	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	3
7	EREG	Epiregulin	Protein Coding	3
8	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	3
9	NRG1	Neuregulin 1	Protein Coding	3
10	NEDD4	NEDD4 E3 Ubiquitin Protein Ligase	Protein Coding	3
11	WWOX	WW Domain Containing Oxidoreductase	Protein Coding	3
12	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	3
13	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	3
14	BTC	Betacellulin	Protein Coding	3
15	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	3
16	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	3
17	NRG2	Neuregulin 2	Protein Coding	3
18	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	3
19	MXD4	MAX Dimerization Protein 4	Protein Coding	2
20	ADAP1	ArfGAP With Dual PH Domains 1	Protein Coding	2
21	CSN2	Casein Beta	Protein Coding	2
22	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	2
23	ESR1	Estrogen Receptor 1	Protein Coding	2
24	NCSTN	Nicastrin	Protein Coding	2
25	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	2
26	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
27	APOE	Apolipoprotein E	Protein Coding	2
28	STMN1	Stathmin 1	Protein Coding	2
29	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	2
30	PGR	Progesterone Receptor	Protein Coding	2
31	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
32	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
33	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	2
34	PSEN1	Presenilin 1	Protein Coding	2
35	PSEN2	Presenilin 2	Protein Coding	2
36	RPS27A	Ribosomal Protein S27a	Protein Coding	2
37	S100B	S100 Calcium Binding Protein B	Protein Coding	2
38	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	2
39	SHC1	SHC Adaptor Protein 1	Protein Coding	2
40	SPARC	Secreted Protein Acidic And Cysteine Rich	Protein Coding	2
41	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
42	UBB	Ubiquitin B	Protein Coding	2
43	UBC	Ubiquitin C	Protein Coding	2
44	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	2
45	EGF	Epidermal Growth Factor	Protein Coding	1
46	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
47	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	1
48	GABRA1	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha1	Protein Coding	1
49	GABRB1	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta1	Protein Coding	1
50	GABRB2	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta2	Protein Coding	1
51	GABRB3	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta3	Protein Coding	1
52	GABRG2	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma2	Protein Coding	1
53	GABRG3	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma3	Protein Coding	1
54	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
55	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
56	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
57	GABRQ	Gamma-Aminobutyric Acid Type A Receptor Subunit Theta	Protein Coding	1
58	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
59	CBFA2T3	CBFA2/RUNX1 Partner Transcriptional Co-Repressor 3	Protein Coding	1
60	PRL	Prolactin	Protein Coding	1
61	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
62	PRLR	Prolactin Receptor	Protein Coding	1
63	LRIG1	Leucine Rich Repeats And Immunoglobulin Like Domains 1	Protein Coding	1
64	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
65	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
66	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
67	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
68	JAK2	Janus Kinase 2	Protein Coding	1
69	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
70	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1

Disorders associated with Signaling by ERBB4 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, NRAS, PIK3CA	9.26
2	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	7.98
3	Alzheimer disease 4	Enrichment	APOE, PSEN1, PSEN2	7.92
4	Bladder cancer	Enrichment	EGFR, ERBB3, HRAS, KRAS, PIK3CA	6.88
5	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.53
6	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	6.40
7	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS, PIK3CA	5.83
8	Childhood absence epilepsy	Enrichment	GABRA1, GABRB3, GABRG2	5.83
9	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1	5.60
10	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	5.59
11	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1	5.38
12	Alzheimer disease 3	Enrichment	APOE, PSEN1	5.27
13	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, PIK3CA	4.80
14	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.75
15	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.74
16	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.27
17	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17, EGFR	4.27
18	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.97
19	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	3.95
20	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	3.60
21	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	3.57
22	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	3.57
23	Breast cancer	Enrichment	ESR1, KRAS, PIK3CA, SHC1	3.54
24	Migraine with or without aura 1	Enrichment	ESR1, TAB2	3.53
25	Lung cancer	Enrichment	EGFR, KRAS, PIK3CA	3.47
26	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.43
27	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	3.43
28	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.43
29	Gallbladder cancer	Enrichment	KRAS, PIK3CA	3.43
30	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.43
31	Alzheimer's disease	Enrichment	APOE, PSEN1	3.38
32	Nk-cell enteropathy	Enrichment	ERBB4, PIK3CB	3.33
33	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	3.31
34	Lennox-gastaut syndrome	Enrichment	GABRB3, GABRG2	3.31
35	Colorectal cancer	Enrichment	NRAS, PIK3CA, PIK3R1, SRC	3.29
36	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.20
37	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	3.20
38	Epilepsy	Enrichment	GABRA1, GABRB3, WWOX	3.18
39	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	3.18
40	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	3.18
41	Thrombocytopenia 6	Enrichment	SRC	3.18
42	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	3.18
43	Alzheimer disease, familial, 1	Enrichment	APOE, PSEN1	3.14
44	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	3.10
45	Dravet syndrome	Enrichment	GABRA1, GABRG2	3.10
46	Hereditary breast carcinoma	Enrichment	ESR1, KRAS, PIK3CA	3.06
47	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	2.94
48	Submucosal cleft palate	Enrichment	UBB	2.88
49	Cleft hard palate	Enrichment	UBB	2.88
50	Aortic valve disease 1	Enrichment	SOS1, TAB2	2.87
51	Lung cancer susceptibility 3	Enrichment	EGFR, KRAS	2.80
52	46,xy partial gonadal dysgenesis	Enrichment	SOS1, WWOX	2.80
53	Undetermined early-onset epileptic encephalopathy	Enrichment	GABRB2, GABRG2, WWOX	2.76
54	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.74
55	Uvula, bifid	Enrichment	UBB	2.70
56	Cleft soft palate	Enrichment	UBB	2.70
57	Sea-blue histiocyte disease	Enrichment	APOE	2.63
58	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	2.63
59	Acne inversa, familial, 1	Enrichment	NCSTN	2.63
60	Lipoprotein glomerulopathy	Enrichment	APOE	2.63
61	Progesterone resistance	Enrichment	PGR	2.63
62	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	2.63
63	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	2.63
64	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.63
65	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	2.63
66	Acne inversa, familial, 3	Enrichment	PSEN1	2.63
67	Esophagus squamous cell carcinoma	Enrichment	WWOX	2.63
68	Pash syndrome	Enrichment	NCSTN	2.63
69	Huntington's disease-like	Enrichment	PSEN2	2.63
70	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.63
71	Hirschsprung disease 1	Enrichment	ERBB2, NRG3	2.62
72	Macrodactyly	Enrichment	PIK3CA	2.60
73	Paget disease, extramammary	Enrichment	ERBB2	2.60
74	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.60
75	Cowden syndrome 5	Enrichment	PIK3CA	2.60
76	Multiple fibroadenomas of the breast	Enrichment	PRLR	2.60
77	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.60
78	Accelerated tumor formation	Enrichment	MDM2	2.60
79	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.60
80	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.60
81	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.60
82	Lessel-kubisch syndrome	Enrichment	MDM2	2.60
83	Short syndrome	Enrichment	PIK3R1	2.60
84	Hyperprolactinemia	Enrichment	PRLR	2.60
85	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.60
86	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.60
87	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.60
88	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.60
89	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.60
90	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.60
91	Hypospadias	Enrichment	PIK3CA	2.60
92	Familial hyperprolactinemia	Enrichment	PRLR	2.60
93	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.60
94	Rare venous malformation	Enrichment	PIK3CA	2.60
95	Diaphragmatic eventration	Enrichment	PIK3CA	2.60
96	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.60
97	Rare combined vascular malformation	Enrichment	PIK3CA	2.60
98	Cavernous lymphangioma	Enrichment	PIK3CA	2.60
99	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.60
100	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.60
101	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.60
102	Macrodactyly of toe	Enrichment	PIK3CA	2.60
103	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.60
104	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	2.53
105	Erythroleukemia, familial	Enrichment	ERBB3	2.37
106	Oculoectodermal syndrome	Enrichment	KRAS	2.37
107	Hypomagnesemia 4, renal	Enrichment	EGF	2.37
108	Noonan syndrome 4	Enrichment	SOS1	2.37
109	Febrile seizures, familial, 8	Enrichment	GABRG2	2.37
110	Epilepsy, idiopathic generalized 13	Enrichment	GABRA1	2.37
111	Melanosis, neurocutaneous	Enrichment	NRAS	2.37
112	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	2.37
113	Noonan syndrome 6	Enrichment	NRAS	2.37
114	Developmental and epileptic encephalopathy 74	Enrichment	GABRG2	2.37
115	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.37
116	Developmental and epileptic encephalopathy 19	Enrichment	GABRA1	2.37
117	Epilepsy, childhood absence 5	Enrichment	GABRB3	2.37
118	Developmental and epileptic encephalopathy 92	Enrichment	GABRB2	2.37
119	Developmental and epileptic encephalopathy 43	Enrichment	GABRB3	2.37
120	Developmental and epileptic encephalopathy 45	Enrichment	GABRB1	2.37
121	Congenital pulmonary airway malformation	Enrichment	KRAS	2.37
122	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.37
123	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.37
124	Neurocutaneous melanocytosis	Enrichment	NRAS	2.37
125	Myelofibrosis	Enrichment	SRC	2.33
126	Alexander disease	Enrichment	GFAP	2.33
127	Pick disease of brain	Enrichment	PSEN1	2.33
128	Developmental and epileptic encephalopathy 28	Enrichment	WWOX	2.33
129	Spinocerebellar ataxia, autosomal recessive 12	Enrichment	WWOX	2.33
130	Spastic paraplegia, intellectual disability, nystagmus, and obesity	Enrichment	GFAP	2.33
131	Hyperlipoproteinemia, type iii	Enrichment	APOE	2.33
132	Osteogenesis imperfecta, type xvii	Enrichment	SPARC	2.33
133	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.33
134	Congenital heart defects, multiple types, 2	Enrichment	TAB2	2.33
135	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	2.33
136	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.30
137	Keratosis, seborrheic	Enrichment	PIK3CA	2.30
138	Noonan syndrome 8	Enrichment	PIK3CA	2.30
139	Thrombocythemia 3	Enrichment	JAK2	2.30
140	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.30
141	Vulto-van silfhout-de vries syndrome	Enrichment	DLG4	2.30
142	Polycythemia	Enrichment	JAK2	2.30
143	Hypereosinophilic syndrome	Enrichment	JAK2	2.30
144	Acute megakaryoblastic leukemia in children without down syndrome	Enrichment	CBFA2T3	2.30
145	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.30
146	Gastric cancer	Enrichment	ERBB2, PIK3CA	2.29
147	West syndrome	Enrichment	GRIN2B, WWOX	2.27
148	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	2.16
149	Autosomal dominant non-syndromic intellectual disability	Enrichment	ERBB4, GRIN2B	2.16
150	Pelvic organ prolapse	Enrichment	TAB2	2.15
151	Estrogen resistance	Enrichment	ESR1	2.15
152	Migraine without aura	Enrichment	ESR1	2.15
153	Polycythemia vera	Enrichment	JAK2	2.12
154	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.12
155	Heart defects, congenital, and other congenital anomalies	Enrichment	DLG4	2.12
156	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.12
157	Intellectual developmental disorder, autosomal dominant 62	Enrichment	DLG4	2.12
158	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	2.12
159	Dedifferentiated liposarcoma	Enrichment	MDM2	2.12
160	Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizures	Enrichment	DLG4	2.12
161	Immunodeficiency 14	Enrichment	PIK3R1	2.12
162	Dlg4-related synaptopathy	Enrichment	DLG4	2.12
163	Well-differentiated liposarcoma	Enrichment	MDM2	2.12
164	Keratoacanthoma	Enrichment	PIK3CA	2.12
165	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.11
166	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ERBB4, PSEN1	2.09
167	Fibromatosis, gingival, 1	Enrichment	SOS1	2.07
168	Costello syndrome	Enrichment	HRAS	2.07
169	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	2.07
170	Pulmonic stenosis	Enrichment	SOS1	2.07
171	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.07
172	Wooly hair nevus	Enrichment	HRAS	2.07
173	Ovarian cancer	Enrichment	EGFR, KRAS, PIK3CA	2.04
174	Osteoporosis	Enrichment	SRC	2.03
175	Macular degeneration, age-related, 1	Enrichment	APOE	2.03
176	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.03
177	Dowling-degos disease	Enrichment	PSENEN	2.03
178	Malignant epithelioid hemangioendothelioma	Enrichment	YAP1	2.03
179	Primary ovarian insufficiency	Enrichment	JAK2, PRLR	2.02
180	Erythrocytosis, familial, 1	Enrichment	JAK2	2.00
181	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DLG4	2.00
182	Astigmatism	Enrichment	GRIN2B	2.00
183	Budd-chiari syndrome	Enrichment	JAK2	2.00
184	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.00
185	Barrett esophagus	Enrichment	ERBB2	2.00
186	Cerebrovascular disease	Enrichment	PIK3CA	2.00
187	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.00
188	Alzheimer disease 2	Enrichment	APOE	1.93
189	Dementia	Enrichment	PSEN1	1.93
190	Capillary malformations, congenital	Enrichment	PIK3CA	1.90
191	Myeloproliferative neoplasm	Enrichment	JAK2	1.90
192	Hemimegalencephaly	Enrichment	PIK3CA	1.90
193	Sleep disorder	Enrichment	GRIN2B	1.90
194	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.90
195	Nuchal bleb, familial	Enrichment	SOS1	1.89
196	Langerhans cell histiocytosis	Enrichment	NRAS	1.89
197	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.89
198	Spermatocytoma	Enrichment	HRAS	1.89
199	Benign epilepsy with centrotemporal spikes	Enrichment	GABRG2, WWOX	1.88
200	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	1.85
201	Metachromatic leukodystrophy	Enrichment	GFAP	1.85
202	Lipid metabolism disorder	Enrichment	APOE	1.85
203	Centralopathic epilepsy	Enrichment	GABRG2, WWOX	1.84
204	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.83
205	Li-fraumeni syndrome	Enrichment	MDM2	1.83
206	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.83
207	Esophageal cancer	Enrichment	WWOX	1.79
208	Semantic dementia	Enrichment	PSEN1	1.79
209	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.77
210	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.77
211	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.77
212	Autosomal dominant nocturnal frontal lobe epilepsy	Enrichment	GABRG2	1.77
213	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.77
214	Pilocytic astrocytoma	Enrichment	KRAS	1.77
215	Epidermolytic nevus	Enrichment	HRAS	1.77
216	Gingival fibromatosis	Enrichment	SOS1	1.77
217	Essential thrombocythemia	Enrichment	JAK2	1.76
218	Overgrowth syndrome	Enrichment	PIK3R1	1.76
219	Glioma susceptibility 1	Enrichment	ERBB2	1.70
220	Progressive non-fluent aphasia	Enrichment	PSEN1	1.68
221	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	1.68
222	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.65
223	Cowden syndrome	Enrichment	PIK3CA	1.65
224	Myeloma, multiple	Enrichment	KRAS, YAP1	1.62
225	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.61
226	Angelman syndrome	Enrichment	GABRG3	1.60
227	Epilepsy, childhood absence 1	Enrichment	GABRB3	1.60
228	Frontotemporal dementia 1	Enrichment	PSEN1	1.59
229	Congenital nervous system abnormality	Enrichment	PSEN1, WWOX	1.59
230	Nervous system disease	Enrichment	PSEN1, WWOX	1.59
231	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.53
232	Pilomyxoid astrocytoma	Enrichment	KRAS	1.53
233	Meningioma	Enrichment	PIK3CA	1.53
234	Microphthalmia/coloboma 12	Enrichment	YAP1	1.52
235	Osteogenesis imperfecta, type iv	Enrichment	SPARC	1.52
236	Thrombocytopenia	Enrichment	SRC	1.50
237	Acute promyelocytic leukemia	Enrichment	STAT5B	1.49
238	Coloboma of macula	Enrichment	YAP1	1.46
239	Familial hypercholesterolemia	Enrichment	APOE	1.46
240	Complex neurodevelopmental disorder	Enrichment	DLG4, GRIN2B	1.42
241	Human immunodeficiency virus type 1	Enrichment	CXCL12	1.38
242	Patent foramen ovale	Enrichment	TAB2	1.38
243	Epilepsy, myoclonic juvenile	Enrichment	GABRA1	1.34
244	Epilepsy, idiopathic generalized	Enrichment	GABRA1	1.34
245	Craniosynostosis	Enrichment	GRIN2B	1.31
246	Myocardial infarction	Enrichment	ESR1	1.30
247	Skin disease	Enrichment	NCSTN	1.30
248	Endometrial cancer	Enrichment	PIK3CA	1.29
249	Hepatocellular carcinoma	Enrichment	PIK3CA	1.27
250	Protein-deficiency anemia	Enrichment	NRAS	1.27
251	Scoliosis	Enrichment	GFAP	1.26
252	Developmental and epileptic encephalopathy 1	Enrichment	WWOX	1.24
253	Generalized epilepsy with febrile seizures plus	Enrichment	GABRG2	1.23
254	Rhabdomyosarcoma	Enrichment	HRAS	1.18
255	Gliosarcoma	Enrichment	EGFR	1.18
256	Prostate cancer	Enrichment	PIK3CA	1.15
257	Giant cell glioblastoma	Enrichment	EGFR	1.15
258	Cerebral palsy	Enrichment	GRIN2B	1.03
259	Pancreatic cancer	Enrichment	KRAS	0.99
260	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.98
261	Hypertelorism	Enrichment	PIK3CA	0.91
262	Dilated cardiomyopathy	Enrichment	TAB2	0.76
263	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.68
264	Schizophrenia	Enrichment	GABRB2	0.65
265	Autism spectrum disorder	Enrichment	GRIN2B	0.62
266	Microcephaly	Enrichment	GRIN2B	0.57
267	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by ERBB4

Pathway Network for Signaling by ERBB4

Pathway network for the Signaling by ERBB4 SuperPath

Member Pathways for Signaling by ERBB4

Pathways in the Signaling by ERBB4 SuperPath

Gene overlap in member pathways for Signaling by ERBB4 SuperPath

Associated Genes for Signaling by ERBB4

Associated Disorders for Signaling by ERBB4

Disorders associated with Signaling by ERBB4 SuperPath

STRING Interaction Network for Signaling by ERBB4

Sources for Signaling by ERBB4