Signaling by Erythropoietin

Pathway network for the Signaling by Erythropoietin SuperPath

Sources:

Reactome
PubChem

Pathways in the Signaling by Erythropoietin SuperPath

#	Name	Source	Genes
1	Signaling by Erythropoietin	Reactome	CRKL EPO EPOR GAB1 GRB2 HRAS IRS2 JAK2 KRAS LYN NRAS PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R5 PLCG1 PLCG2 RAPGEF1 SHC1 SOS1 STAT5A STAT5B VAV1 (see all 25) (see less)
2	EPO signaling pathway	PubChem	BCL2 BCL2L1 BTK CBL CRKL EPO EPOR GAB1 GRB2 HRAS IRS2 JAK2 LYN MAPK14 MAPK8 NFKB1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RAP1A RAPGEF1 SH2B3 SHC1 SOCS3 SOS1 STAT1 TEC VAV2 XNDC1N (see all 31) (see less)
3	Erythropoietin activates RAS	Reactome	CRKL EPO EPOR GRB2 HRAS IRS2 JAK2 KRAS LYN NRAS RAPGEF1 SHC1 SOS1 VAV1 (see all 14) (see less)
4	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	Reactome	EPO EPOR GAB1 IRS2 JAK2 LYN PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R5 (see all 12) (see less)
5	Erythropoietin activates STAT5	Reactome	EPO EPOR IRS2 JAK2 LYN STAT5A STAT5B (see all 7) (see less)
6	Erythropoietin activates Phospholipase C gamma (PLCG)	Reactome	EPO EPOR IRS2 JAK2 LYN PLCG1 PLCG2 (see all 7) (see less)

Gene overlap in member pathways for Signaling by Erythropoietin SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EPO	Erythropoietin	Protein Coding	6
2	EPOR	Erythropoietin Receptor	Protein Coding	6
3	JAK2	Janus Kinase 2	Protein Coding	6
4	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6
5	IRS2	Insulin Receptor Substrate 2	Protein Coding	6
6	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	3
7	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	3
8	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
9	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	3
10	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
11	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
12	PLCG1	Phospholipase C Gamma 1	Protein Coding	3
13	PLCG2	Phospholipase C Gamma 2	Protein Coding	3
14	SHC1	SHC Adaptor Protein 1	Protein Coding	3
15	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	3
16	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
17	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
18	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
19	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
20	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
21	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	2
22	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	2
23	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	2
24	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	2
25	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	2
26	XNDC1N	XRCC1 N-Terminal Domain Containing 1, N-Terminal Like	Protein Coding	1
27	TEC	Tec Protein Tyrosine Kinase	Protein Coding	1
28	BTK	Bruton Tyrosine Kinase	Protein Coding	1
29	SH2B3	SH2B Adaptor Protein 3	Protein Coding	1
30	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
31	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
32	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
33	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
34	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
35	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
36	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
37	CBL	Cbl Proto-Oncogene	Protein Coding	1
38	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
39	BCL2L1	BCL2 Like 1	Protein Coding	1
40	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
41	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1

Disorders associated with Signaling by Erythropoietin SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	9.49
2	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	9.01
3	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS, PIK3CA	8.53
4	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	8.45
5	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1	8.21
6	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1	7.98
7	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	7.51
8	Erythrocytosis, familial, 1	Enrichment	EPOR, JAK2, SH2B3	7.36
9	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.00
10	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.67
11	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	5.67
12	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	5.67
13	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.53
14	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	5.50
15	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.23
16	Leukemia, acute myeloid	Enrichment	JAK2, KRAS, NRAS	5.07
17	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	4.71
18	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.68
19	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.68
20	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.68
21	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.56
22	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	4.52
23	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	4.49
24	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	4.31
25	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	4.31
26	Myeloproliferative neoplasm	Enrichment	CBL, JAK2	4.30
27	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	4.19
28	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	4.17
29	Gallbladder cancer	Enrichment	KRAS, PIK3CA	4.17
30	Myelofibrosis	Enrichment	JAK2, SH2B3	3.98
31	Essential thrombocythemia	Enrichment	JAK2, SH2B3	3.98
32	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.93
33	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	3.84
34	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.67
35	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.47
36	Breast cancer	Enrichment	KRAS, PIK3CA, SHC1	3.47
37	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	3.34
38	Microvascular complications of diabetes 2	Enrichment	EPO	3.29
39	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	3.29
40	Erythrocytosis, familial, 5	Enrichment	EPO	3.29
41	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	3.29
42	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	3.29
43	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	3.29
44	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	3.29
45	Colorectal cancer	Enrichment	NRAS, PIK3CA, PIK3R1	3.28
46	Rhabdomyosarcoma	Enrichment	CBL, HRAS	3.23
47	Macrodactyly	Enrichment	PIK3CA	3.05
48	Deafness, autosomal recessive 26	Enrichment	GAB1	3.05
49	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	3.05
50	Cowden syndrome 5	Enrichment	PIK3CA	3.05
51	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	3.05
52	Cerebral cavernous malformations 4	Enrichment	PIK3CA	3.05
53	Short syndrome	Enrichment	PIK3R1	3.05
54	Hemifacial myohyperplasia	Enrichment	PIK3CA	3.05
55	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	3.05
56	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	3.05
57	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	3.05
58	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	3.05
59	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	3.05
60	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	3.05
61	Hypospadias	Enrichment	PIK3CA	3.05
62	Rare venous malformation	Enrichment	PIK3CA	3.05
63	Diaphragmatic eventration	Enrichment	PIK3CA	3.05
64	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	3.05
65	Rare combined vascular malformation	Enrichment	PIK3CA	3.05
66	Cavernous lymphangioma	Enrichment	PIK3CA	3.05
67	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	3.05
68	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	3.05
69	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	3.05
70	Macrodactyly of toe	Enrichment	PIK3CA	3.05
71	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.99
72	Thrombocythemia 3	Enrichment	JAK2	2.99
73	Diamond-blackfan anemia-like	Enrichment	EPO	2.99
74	Polycythemia	Enrichment	JAK2	2.99
75	Hypereosinophilic syndrome	Enrichment	JAK2	2.99
76	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.99
77	Oculoectodermal syndrome	Enrichment	KRAS	2.99
78	Noonan syndrome 4	Enrichment	SOS1	2.99
79	Melanosis, neurocutaneous	Enrichment	NRAS	2.99
80	Noonan syndrome 6	Enrichment	NRAS	2.99
81	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.99
82	Congenital pulmonary airway malformation	Enrichment	KRAS	2.99
83	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.99
84	Neurocutaneous melanocytosis	Enrichment	NRAS	2.99
85	Polycythemia vera	Enrichment	JAK2	2.81
86	Primary polycythemia	Enrichment	EPOR	2.81
87	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	2.81
88	Lung cancer	Enrichment	KRAS, PIK3CA	2.81
89	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.80
90	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.75
91	Keratosis, seborrheic	Enrichment	PIK3CA	2.75
92	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.75
93	Noonan syndrome 8	Enrichment	PIK3CA	2.75
94	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.75
95	Immune system disease	Enrichment	PIK3CD	2.75
96	Budd-chiari syndrome	Enrichment	JAK2	2.69
97	Fibromatosis, gingival, 1	Enrichment	SOS1	2.69
98	Costello syndrome	Enrichment	HRAS	2.69
99	Pulmonic stenosis	Enrichment	SOS1	2.69
100	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.69
101	Wooly hair nevus	Enrichment	HRAS	2.69
102	Metachondromatosis	Enrichment	PTPN11	2.64
103	Dermatitis, atopic, 4	Enrichment	SOCS3	2.64
104	Leopard syndrome 1	Enrichment	PTPN11	2.64
105	Transient erythroblastopenia of childhood	Enrichment	TEC	2.64
106	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.64
107	Immunodeficiency 31a	Enrichment	STAT1	2.64
108	Immunodeficiency 31b	Enrichment	STAT1	2.64
109	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.64
110	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.64
111	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.64
112	Growth retardation-mild developmental delay-chronic hepatitis syndrome	Enrichment	SH2B3	2.64
113	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.64
114	Malignant astrocytoma	Enrichment	PTPN11	2.64
115	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.58
116	Keratoacanthoma	Enrichment	PIK3CA	2.58
117	Gastric cancer	Enrichment	KRAS, PIK3CA	2.55
118	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	2.53
119	Autosomal dominant secondary polycythemia	Enrichment	EPO	2.51
120	Nuchal bleb, familial	Enrichment	SOS1	2.51
121	Langerhans cell histiocytosis	Enrichment	NRAS	2.51
122	Spermatocytoma	Enrichment	HRAS	2.51
123	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.45
124	Cerebrovascular disease	Enrichment	PIK3CA	2.45
125	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.45
126	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.38
127	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.38
128	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL	2.38
129	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.38
130	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.38
131	Pilocytic astrocytoma	Enrichment	KRAS	2.38
132	Epidermolytic nevus	Enrichment	HRAS	2.38
133	Gingival fibromatosis	Enrichment	SOS1	2.38
134	Capillary malformations, congenital	Enrichment	PIK3CA	2.35
135	Hemimegalencephaly	Enrichment	PIK3CA	2.35
136	Ovarian germ cell cancer	Enrichment	CBL	2.34
137	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	2.34
138	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.34
139	Immunodeficiency 31c	Enrichment	STAT1	2.34
140	Agammaglobulinemia, x-linked	Enrichment	BTK	2.34
141	Werner syndrome	Enrichment	PTPN11	2.34
142	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.34
143	Malignant germ cell tumor of ovary	Enrichment	CBL	2.34
144	Common variable immunodeficiency 12	Enrichment	NFKB1	2.34
145	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	2.33
146	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.28
147	Cowden syndrome 1	Enrichment	PIK3CA	2.28
148	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.28
149	Overgrowth syndrome	Enrichment	PIK3R1	2.21
150	Acute promyelocytic leukemia	Enrichment	STAT5B	2.17
151	Thrombocythemia 1	Enrichment	SH2B3	2.16
152	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	2.16
153	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.16
154	Agammaglobulinemia 1	Enrichment	BTK	2.16
155	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.16
156	Tricuspid valve insufficiency	Enrichment	PTPN11	2.16
157	Pilomyxoid astrocytoma	Enrichment	KRAS	2.14
158	Adult hepatocellular carcinoma	Enrichment	PIK3CA	2.10
159	Cowden syndrome	Enrichment	PIK3CA	2.10
160	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.04
161	Meningioma	Enrichment	PIK3CA	1.98
162	Follicular lymphoma	Enrichment	BCL2	1.94
163	Lymphoma	Enrichment	PTPN11	1.94
164	Aggressive systemic mastocytosis	Enrichment	CBL	1.94
165	Nk-cell enteropathy	Enrichment	PIK3CB	1.94
166	Aortic valve disease 1	Enrichment	SOS1	1.87
167	Protein-deficiency anemia	Enrichment	NRAS	1.87
168	Patent ductus arteriosus	Enrichment	PTPN11	1.87
169	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.87
170	Lung cancer susceptibility 3	Enrichment	KRAS	1.84
171	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.84
172	Ovarian cancer	Enrichment	KRAS, PIK3CA	1.83
173	Common variable immunodeficiency	Enrichment	NFKB1	1.80
174	Endometrial cancer	Enrichment	PIK3CA	1.73
175	Hepatocellular carcinoma	Enrichment	PIK3CA	1.71
176	Arteriovenous malformations of the brain	Enrichment	KRAS	1.71
177	Type 2 diabetes mellitus	Enrichment	IRS2	1.67
178	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.65
179	Pectus excavatum	Enrichment	PTPN11	1.60
180	Specific learning disability	Enrichment	PTPN11	1.60
181	Prostate cancer	Enrichment	PIK3CA	1.60
182	Pancreatic cancer	Enrichment	KRAS	1.59
183	Epicanthus	Enrichment	PTPN11	1.57
184	Congenital long qt syndrome	Enrichment	PTPN11	1.57
185	Primary ovarian insufficiency	Enrichment	JAK2	1.52
186	Inherited cancer-predisposing syndrome	Enrichment	PTPN11, SH2B3	1.44
187	Patent foramen ovale	Enrichment	PTPN11	1.39
188	Diffuse large b-cell lymphoma	Enrichment	BTK	1.37
189	Hypertelorism	Enrichment	PIK3CA	1.35
190	Scoliosis	Enrichment	PTPN11	1.27
191	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.26
192	Myeloma, multiple	Enrichment	KRAS	1.25
193	Strabismus	Enrichment	PTPN11	1.22
194	Long qt syndrome 1	Enrichment	PTPN11	1.18
195	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.03
196	Thrombocytopenia	Enrichment	PTPN11	0.98
197	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.92
198	Autism spectrum disorder	Enrichment	PTPN11	0.65
199	Microcephaly	Enrichment	PTPN11	0.61

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by Erythropoietin

Pathway Network for Signaling by Erythropoietin

Pathway network for the Signaling by Erythropoietin SuperPath

Member Pathways for Signaling by Erythropoietin

Pathways in the Signaling by Erythropoietin SuperPath

Gene overlap in member pathways for Signaling by Erythropoietin SuperPath

Associated Genes for Signaling by Erythropoietin

Associated Disorders for Signaling by Erythropoietin

Disorders associated with Signaling by Erythropoietin SuperPath

STRING Interaction Network for Signaling by Erythropoietin

Sources for Signaling by Erythropoietin