Signaling by FGFR2

Pathway network for the Signaling by FGFR2 SuperPath

Sources:

Reactome

Pathways in the Signaling by FGFR2 SuperPath

#	Name	Source	Genes
1	Signaling by FGFR2	Reactome	BRAF CBL ESRP1 ESRP2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFBP1 FGFBP2 FGFBP3 FGFR2 FRS2 FRS3 GAB1 GRB2 GTF2F1 GTF2F2 HNRNPA1 HNRNPF HNRNPH1 HNRNPM HRAS KRAS MAPK1 MAPK3 MKNK1 NCBP1 NCBP2 NRAS PIK3CA PIK3R1 PLCG1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PPP2CA PPP2CB PPP2R1A PTBP1 PTPN11 RBFOX2 RPS27A SHC1 SOS1 SPRY2 SRC TIA1 TIAL1 UBA52 UBB UBC (see all 73) (see less)
2	Signaling by FGFR	Reactome	ANOS1 BRAF CBL ESRP1 ESRP2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFBP1 FGFBP2 FGFBP3 FGFR1 FGFR2 FGFR3 FGFR4 FGFRL1 FLRT1 FLRT2 FLRT3 FRS2 FRS3 GAB1 GALNT3 GIPC1 GRB2 GTF2F1 GTF2F2 HNRNPA1 HNRNPF HNRNPH1 HNRNPM HRAS KL KLB KRAS MAPK1 MAPK3 MKNK1 NCBP1 NCBP2 NRAS PIK3CA PIK3R1 PLCG1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PPP2CA PPP2CB PPP2R1A PTBP1 PTPN11 RBFOX2 RPS27A SHC1 SOS1 SPRED1 SPRED2 SPRY2 SRC TGFBR3 TIA1 TIAL1 UBA52 UBB UBC (see all 89) (see less)
3	FGFR2 ligand binding and activation	Reactome	FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFBP1 FGFBP2 FGFBP3 FGFR2 (see all 20) (see less)
4	FGFR2b ligand binding and activation	Reactome	FGF1 FGF10 FGF2 FGF22 FGF3 FGF7 FGFBP1 FGFBP2 FGFBP3 FGFR2 (see all 10) (see less)

Gene overlap in member pathways for Signaling by FGFR2 SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FGFBP3	Fibroblast Growth Factor Binding Protein 3	Protein Coding	4
2	FGF1	Fibroblast Growth Factor 1	Protein Coding	4
3	FGF2	Fibroblast Growth Factor 2	Protein Coding	4
4	FGF3	Fibroblast Growth Factor 3	Protein Coding	4
5	FGF7	Fibroblast Growth Factor 7	Protein Coding	4
6	FGF10	Fibroblast Growth Factor 10	Protein Coding	4
7	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	4
8	FGF22	Fibroblast Growth Factor 22	Protein Coding	4
9	FGFBP2	Fibroblast Growth Factor Binding Protein 2	Protein Coding	4
10	FGFBP1	Fibroblast Growth Factor Binding Protein 1	Protein Coding	4
11	FGF4	Fibroblast Growth Factor 4	Protein Coding	3
12	FGF5	Fibroblast Growth Factor 5	Protein Coding	3
13	FGF6	Fibroblast Growth Factor 6	Protein Coding	3
14	FGF8	Fibroblast Growth Factor 8	Protein Coding	3
15	FGF9	Fibroblast Growth Factor 9	Protein Coding	3
16	FGF20	Fibroblast Growth Factor 20	Protein Coding	3
17	FGF23	Fibroblast Growth Factor 23	Protein Coding	3
18	FGF18	Fibroblast Growth Factor 18	Protein Coding	3
19	FGF17	Fibroblast Growth Factor 17	Protein Coding	3
20	FGF16	Fibroblast Growth Factor 16	Protein Coding	3
21	SPRY2	Sprouty RTK Signaling Antagonist 2	Protein Coding	2
22	FRS3	Fibroblast Growth Factor Receptor Substrate 3	Protein Coding	2
23	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	2
24	NCBP2	Nuclear Cap Binding Protein Subunit 2	Protein Coding	2
25	RBFOX2	RNA Binding Fox-1 Homolog 2	Protein Coding	2
26	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	2
27	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
28	GTF2F1	General Transcription Factor IIF Subunit 1	Protein Coding	2
29	GTF2F2	General Transcription Factor IIF Subunit 2	Protein Coding	2
30	HNRNPA1	Heterogeneous Nuclear Ribonucleoprotein A1	Protein Coding	2
31	HNRNPF	Heterogeneous Nuclear Ribonucleoprotein F	Protein Coding	2
32	HNRNPH1	Heterogeneous Nuclear Ribonucleoprotein H1	Protein Coding	2
33	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
34	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
35	HNRNPM	Heterogeneous Nuclear Ribonucleoprotein M	Protein Coding	2
36	NCBP1	Nuclear Cap Binding Protein Subunit 1	Protein Coding	2
37	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
38	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
39	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
40	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
41	POLR2A	RNA Polymerase II Subunit A	Protein Coding	2
42	POLR2B	RNA Polymerase II Subunit B	Protein Coding	2
43	POLR2C	RNA Polymerase II Subunit C	Protein Coding	2
44	POLR2D	RNA Polymerase II Subunit D	Protein Coding	2
45	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	2
46	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	2
47	POLR2G	RNA Polymerase II Subunit G	Protein Coding	2
48	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	2
49	POLR2I	RNA Polymerase II Subunit I	Protein Coding	2
50	POLR2J	RNA Polymerase II Subunit J	Protein Coding	2
51	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	2
52	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	2
53	ESRP1	Epithelial Splicing Regulatory Protein 1	Protein Coding	2
54	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
55	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
56	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	2
57	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
58	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
59	PTBP1	Polypyrimidine Tract Binding Protein 1	Protein Coding	2
60	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	2
61	RPS27A	Ribosomal Protein S27a	Protein Coding	2
62	SHC1	SHC Adaptor Protein 1	Protein Coding	2
63	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
64	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
65	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
66	TIA1	TIA1 Cytotoxic Granule Associated RNA Binding Protein	Protein Coding	2
67	TIAL1	TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1	Protein Coding	2
68	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
69	UBB	Ubiquitin B	Protein Coding	2
70	UBC	Ubiquitin C	Protein Coding	2
71	ESRP2	Epithelial Splicing Regulatory Protein 2	Protein Coding	2
72	MKNK1	MAPK Interacting Serine/Threonine Kinase 1	Protein Coding	2
73	CBL	Cbl Proto-Oncogene	Protein Coding	2
74	GIPC1	GIPC PDZ Domain Containing Family Member 1	Protein Coding	1
75	KLB	Klotho Beta	Protein Coding	1
76	SPRED1	Sprouty Related EVH1 Domain Containing 1	Protein Coding	1
77	SPRED2	Sprouty Related EVH1 Domain Containing 2	Protein Coding	1
78	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
79	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
80	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
81	FLRT3	Fibronectin Leucine Rich Transmembrane Protein 3	Protein Coding	1
82	FLRT2	Fibronectin Leucine Rich Transmembrane Protein 2	Protein Coding	1
83	FLRT1	Fibronectin Leucine Rich Transmembrane Protein 1	Protein Coding	1
84	GALNT3	Polypeptide N-Acetylgalactosaminyltransferase 3	Protein Coding	1
85	ANOS1	Anosmin 1	Protein Coding	1
86	FGFRL1	Fibroblast Growth Factor Receptor Like 1	Protein Coding	1
87	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
88	KL	Klotho	Protein Coding	1
89	FGF19	Fibroblast Growth Factor 19	Protein Coding	1

Disorders associated with Signaling by FGFR2 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, CBL, HRAS, KRAS, NRAS, PTPN11, SOS1, SPRED1	10.67
2	Noonan syndrome 1	Enrichment	BRAF, CBL, HRAS, KRAS, NRAS, PTPN11, SOS1, SPRED2	10.52
3	Rasopathy	Enrichment	BRAF, CBL, HRAS, KRAS, NRAS, PTPN11, SOS1	10.24
4	Nevus, epidermal	Enrichment	FGFR3, HRAS, KRAS, NRAS, PIK3CA	9.59
5	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS, PIK3CA	8.75
6	Kallmann syndrome	Enrichment	ANOS1, FGF17, FGF8, FGFR1, FLRT3, POLR2F	8.21
7	Noonan syndrome 3	Enrichment	HRAS, KRAS, PTPN11, SOS1	7.57
8	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10, FGFR2, FGFR3	6.56
9	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23, GALNT3, KL	6.56
10	Juvenile myelomonocytic leukemia	Enrichment	CBL, KRAS, NRAS, PTPN11	6.43
11	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.22
12	Colorectal cancer	Enrichment	BRAF, FGFR2, FGFR3, NRAS, PIK3CA, PIK3R1, SRC	5.80
13	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	5.29
14	Gallbladder cancer	Enrichment	BRAF, KRAS, PIK3CA	5.29
15	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	5.29
16	Lung squamous cell carcinoma	Enrichment	FGFR3, KRAS, PIK3CA	5.27
17	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS	5.09
18	Pilomyxoid astrocytoma	Enrichment	BRAF, FGFR1, KRAS	5.03
19	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS	4.78
20	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.54
21	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.54
22	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, PIK3CA	4.50
23	Bladder cancer	Enrichment	FGFR3, HRAS, KRAS, PIK3CA	4.44
24	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	4.37
25	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	4.37
26	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	4.37
27	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	4.37
28	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	4.37
29	Lung cancer susceptibility 3	Enrichment	BRAF, FGF10, KRAS	4.28
30	Langerhans cell histiocytosis	Enrichment	BRAF, NRAS	4.07
31	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.07
32	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.07
33	Crouzon syndrome	Enrichment	FGFR2, FGFR3	3.90
34	Spermatocytoma	Enrichment	FGFR3, HRAS	3.90
35	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS	3.77
36	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS	3.77
37	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.77
38	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	3.77
39	Noonan syndrome with multiple lentigines	Enrichment	BRAF, PTPN11	3.77
40	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF17, FGF8, FGFR1	3.68
41	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	3.60
42	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	3.38
43	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	ANOS1, POLR2F	3.38
44	Holoprosencephaly	Enrichment	FGF8, FGFR1	3.38
45	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	3.37
46	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	3.23
47	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.23
48	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS, PTPN11	3.22
49	Holoprosencephaly 1	Enrichment	FGF8, FGFR1	3.20
50	Lung cancer	Enrichment	BRAF, KRAS, PIK3CA	3.18
51	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	3.13
52	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	3.13
53	Apert syndrome	Enrichment	FGFR2	3.13
54	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	3.13
55	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	3.13
56	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	3.13
57	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	3.13
58	Interstitial lung disease specific to childhood	Enrichment	FGF10	3.13
59	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.00
60	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	2.90
61	Otodental dysplasia	Enrichment	FGF3	2.83
62	Pulmonary hypoplasia, primary	Enrichment	FGF10	2.83
63	Aural atresia, congenital	Enrichment	FGFR2	2.83
64	Deafness, congenital, with inner ear agenesis, microtia, and microdontia	Enrichment	FGF3	2.83
65	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.83
66	Split hand-foot malformation	Enrichment	FGFR2	2.83
67	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.83
68	Oculootodental syndrome	Enrichment	FGF3	2.83
69	Hypogonadotropic hypogonadism 20 with or without anosmia	Enrichment	FGF17	2.83
70	Metacarpal 4-5 fusion	Enrichment	FGF16	2.83
71	Familial isolated trichomegaly	Enrichment	FGF5	2.83
72	Multiple synostoses syndrome 3	Enrichment	FGF9	2.83
73	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	2.83
74	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	2.83
75	Renal hypodysplasia/aplasia 2	Enrichment	FGF20	2.83
76	Short-rib thoracic dysplasia 22 without polydactyly	Enrichment	FGF4	2.83
77	Hypogonadotropic hypogonadism	Enrichment	ANOS1, FGFR1	2.83
78	Specific learning disability	Enrichment	MAPK1, PTPN11	2.82
79	Gastric cancer	Enrichment	FGFR2, KRAS, PIK3CA	2.80
80	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.54
81	Glioma	Enrichment	FGFR2	2.53
82	Trichomegaly	Enrichment	FGF5	2.53
83	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.49
84	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	ANOS1, FGFR1	2.43
85	Split-hand/foot malformation 1	Enrichment	FGFR2	2.35
86	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23	2.35
87	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	2.34
88	Gliosarcoma	Enrichment	FGFR1, FGFR3	2.32
89	Microform holoprosencephaly	Enrichment	FGF8, FGFR1	2.32
90	Lobar holoprosencephaly	Enrichment	FGF8, FGFR1	2.32
91	Macrodactyly	Enrichment	PIK3CA	2.27
92	Metachondromatosis	Enrichment	PTPN11	2.27
93	Oculoectodermal syndrome	Enrichment	KRAS	2.27
94	Deafness, autosomal recessive 26	Enrichment	GAB1	2.27
95	Noonan syndrome 4	Enrichment	SOS1	2.27
96	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.27
97	Noonan syndrome 7	Enrichment	BRAF	2.27
98	Leopard syndrome 3	Enrichment	BRAF	2.27
99	Leopard syndrome 1	Enrichment	PTPN11	2.27
100	Cowden syndrome 5	Enrichment	PIK3CA	2.27
101	Melanosis, neurocutaneous	Enrichment	NRAS	2.27
102	Iga nephropathy 3	Enrichment	SPRY2	2.27
103	Noonan syndrome 6	Enrichment	NRAS	2.27
104	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 3	Enrichment	HNRNPA1	2.27
105	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.27
106	Noonan syndrome 13	Enrichment	MAPK1	2.27
107	Short syndrome	Enrichment	PIK3R1	2.27
108	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.27
109	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.27
110	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.27
111	Lymphangioma	Enrichment	BRAF	2.27
112	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.27
113	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.27
114	Phace association	Enrichment	BRAF	2.27
115	Myopathy, distal, 3	Enrichment	HNRNPA1	2.27
116	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.27
117	Amyotrophic lateral sclerosis 20	Enrichment	HNRNPA1	2.27
118	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.27
119	Thrombocytopenia 6	Enrichment	SRC	2.27
120	Finnish upper limb-onset distal myopathy	Enrichment	HNRNPA1	2.27
121	Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia	Enrichment	TIA1	2.27
122	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.27
123	Hypospadias	Enrichment	PIK3CA	2.27
124	Relapsing-remitting multiple sclerosis	Enrichment	HNRNPA1	2.27
125	Congenital pulmonary airway malformation	Enrichment	KRAS	2.27
126	Rare venous malformation	Enrichment	PIK3CA	2.27
127	Diaphragmatic eventration	Enrichment	PIK3CA	2.27
128	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.27
129	Syringocystadenoma papilliferum	Enrichment	BRAF	2.27
130	Rare combined vascular malformation	Enrichment	PIK3CA	2.27
131	Ganglioglioma	Enrichment	BRAF	2.27
132	Cavernous lymphangioma	Enrichment	PIK3CA	2.27
133	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.27
134	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.27
135	Phace syndrome	Enrichment	BRAF	2.27
136	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.27
137	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.27
138	Classic hairy cell leukemia	Enrichment	BRAF	2.27
139	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.27
140	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.27
141	Macrodactyly of toe	Enrichment	PIK3CA	2.27
142	Neurocutaneous melanocytosis	Enrichment	NRAS	2.27
143	Malignant astrocytoma	Enrichment	PTPN11	2.27
144	Giant cell glioblastoma	Enrichment	FGFR1, FGFR3	2.27
145	Endometrial cancer	Enrichment	FGFR2, PIK3CA	2.25
146	Multiple synostoses syndrome	Enrichment	FGF9	2.23
147	Myeloma, multiple	Enrichment	BRAF, FGFR3, KRAS	2.23
148	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8, KLB, PTPN11	2.23
149	Semilobar holoprosencephaly	Enrichment	FGF8, FGFR1	2.22
150	Hypochondroplasia	Enrichment	FGFR3	2.18
151	Osteoglophonic dysplasia	Enrichment	FGFR1	2.18
152	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.18
153	Trigonocephaly 1	Enrichment	FGFR1	2.18
154	Muenke syndrome	Enrichment	FGFR3	2.18
155	Legius syndrome	Enrichment	SPRED1	2.18
156	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.18
157	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.18
158	Tumoral calcinosis, hyperphosphatemic, familial, 3	Enrichment	KL	2.18
159	Noonan syndrome 14	Enrichment	SPRED2	2.18
160	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.18
161	Oculopharyngodistal myopathy 2	Enrichment	GIPC1	2.18
162	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.18
163	Hartsfield syndrome	Enrichment	FGFR1	2.18
164	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.18
165	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.18
166	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.18
167	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.18
168	Orofacial cleft 1	Enrichment	FGF10	2.18
169	Meier-gorlin syndrome 1	Enrichment	FGFR2	2.13
170	Craniosynostosis	Enrichment	FGFR2, FGFR3	2.13
171	Breast cancer	Enrichment	KRAS, PIK3CA, SHC1	2.12
172	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.07
173	Hypophosphatemic rickets	Enrichment	FGF23	1.99
174	Fibromatosis, gingival, 1	Enrichment	SOS1	1.97
175	Costello syndrome	Enrichment	HRAS	1.97
176	Ovarian germ cell cancer	Enrichment	CBL	1.97
177	Waardenburg syndrome, type 4c	Enrichment	POLR2F	1.97
178	Welander distal myopathy	Enrichment	TIA1	1.97
179	Noonan syndrome 8	Enrichment	PIK3CA	1.97
180	Deafness, autosomal recessive 109	Enrichment	ESRP1	1.97
181	Werner syndrome	Enrichment	PTPN11	1.97
182	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	POLR2F	1.97
183	Neurodevelopmental disorder with craniofacial dysmorphism and skeletal defects	Enrichment	HNRNPH1	1.97
184	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.97
185	Malignant germ cell tumor of ovary	Enrichment	CBL	1.97
186	Submucosal cleft palate	Enrichment	UBB	1.97
187	Cleft hard palate	Enrichment	UBB	1.97
188	Wooly hair nevus	Enrichment	HRAS	1.97
189	Hydrocephalus	Enrichment	FGFR2	1.96
190	Cervical cancer	Enrichment	FGFR3	1.88
191	Spastic paraplegia, optic atrophy, and neuropathy	Enrichment	FLRT1	1.88
192	Hypogonadotropic hypogonadism 21 with or without anosmia	Enrichment	FLRT3	1.88
193	Cervix carcinoma	Enrichment	FGFR3	1.88
194	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.88
195	Renal agenesis, bilateral	Enrichment	FGF20	1.88
196	Ataxia-telangiectasia	Enrichment	BRAF	1.79
197	Waardenburg syndrome, type 2a	Enrichment	POLR2F	1.79
198	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.79
199	Uvula, bifid	Enrichment	UBB	1.79
200	Nuchal bleb, familial	Enrichment	SOS1	1.79
201	Cleft soft palate	Enrichment	UBB	1.79
202	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.79
203	Tethered spinal cord syndrome	Enrichment	BRAF	1.79
204	Distal myopathy	Enrichment	HNRNPA1	1.79
205	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	HNRNPA1	1.79
206	Immunodeficiency 14	Enrichment	PIK3R1	1.79
207	Tricuspid valve insufficiency	Enrichment	PTPN11	1.79
208	Keratoacanthoma	Enrichment	PIK3CA	1.79
209	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.71
210	Achondroplasia	Enrichment	FGFR3	1.71
211	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.71
212	Larsen syndrome	Enrichment	FGFR3	1.71
213	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.71
214	Hamartoma	Enrichment	FGFR3	1.71
215	Testicular germ cell cancer	Enrichment	FGFR3	1.71
216	Testicular cancer	Enrichment	FGFR3	1.71
217	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.67
218	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.67
219	Intellectual developmental disorder, x-linked, syndromic, bain type	Enrichment	HNRNPH1	1.67
220	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.67
221	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.67
222	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	1.67
223	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.67
224	Cerebrovascular disease	Enrichment	PIK3CA	1.67
225	Craniopharyngioma	Enrichment	BRAF	1.67
226	Pilocytic astrocytoma	Enrichment	KRAS	1.67
227	Newborn respiratory distress syndrome	Enrichment	BRAF	1.67
228	Epidermolytic nevus	Enrichment	HRAS	1.67
229	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.67
230	Intellectual disability, x-linked, syndromic, bain type	Enrichment	HNRNPH1	1.67
231	Gingival fibromatosis	Enrichment	SOS1	1.67
232	Septopreoptic holoprosencephaly	Enrichment	FGF8	1.66
233	Midline interhemispheric variant of holoprosencephaly	Enrichment	FGF8	1.66
234	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	1.63
235	Alobar holoprosencephaly	Enrichment	FGF8	1.61
236	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.59
237	Capillary malformations, congenital	Enrichment	PIK3CA	1.57
238	Lymphoma	Enrichment	PTPN11	1.57
239	Myeloproliferative neoplasm	Enrichment	CBL	1.57
240	Hemimegalencephaly	Enrichment	PIK3CA	1.57
241	Aggressive systemic mastocytosis	Enrichment	CBL	1.57
242	Thrombocytopenia	Enrichment	PTPN11, SRC	1.56
243	Hypertelorism	Enrichment	FGFR2, PIK3CA	1.50
244	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.50
245	Cowden syndrome 1	Enrichment	PIK3CA	1.50
246	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.50
247	Waardenburg syndrome, type 4a	Enrichment	POLR2F	1.50
248	Wilms tumor 5	Enrichment	BRAF	1.50
249	Patent ductus arteriosus	Enrichment	PTPN11	1.50
250	Waardenburg syndrome	Enrichment	POLR2F	1.50
251	Cleft lip with or without cleft palate	Enrichment	ESRP2	1.50
252	Martsolf syndrome 1	Enrichment	ANOS1	1.49
253	Pseudovaginal perineoscrotal hypospadias	Enrichment	ANOS1	1.49
254	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.49
255	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	1.49
256	Waardenburg syndrome, type 1	Enrichment	POLR2F	1.43
257	Myelofibrosis	Enrichment	SRC	1.43
258	Waardenburg syndrome, type 2e	Enrichment	POLR2F	1.43
259	Overgrowth syndrome	Enrichment	PIK3R1	1.43
260	Testicular germ cell tumor	Enrichment	FGFR3	1.41
261	46,xy disorder of sex development	Enrichment	FGFR3	1.41
262	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.37
263	Oculopharyngodistal myopathy 1	Enrichment	GIPC1	1.35
264	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.32
265	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.32
266	Primary hyperaldosteronism	Enrichment	BRAF	1.32
267	Ventricular septal defect	Enrichment	BRAF	1.32
268	Cowden syndrome	Enrichment	PIK3CA	1.32
269	Melanoma	Enrichment	BRAF	1.28
270	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.28
271	Neurofibromatosis, type i	Enrichment	SPRED1	1.24
272	Pectus excavatum	Enrichment	PTPN11	1.24
273	Epicanthus	Enrichment	PTPN11	1.20
274	Meningioma	Enrichment	PIK3CA	1.20
275	Congenital long qt syndrome	Enrichment	PTPN11	1.20
276	Primary bone dysplasia	Enrichment	FGFR3	1.20
277	Aortic valve disease 1	Enrichment	SOS1	1.17
278	Protein-deficiency anemia	Enrichment	NRAS	1.17
279	Osteochondrodysplasia	Enrichment	FGFR3	1.16
280	Osteoporosis	Enrichment	SRC	1.14
281	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.14
282	Septooptic dysplasia	Enrichment	FGFR1	1.12
283	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.12
284	Wilms tumor 1	Enrichment	BRAF	1.11
285	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.06
286	Dandy-walker syndrome	Enrichment	BRAF	1.06
287	Heart, malformation of	Enrichment	MAPK1	1.03
288	Patent foramen ovale	Enrichment	PTPN11	1.03
289	Male infertility with spermatogenesis disorder	Enrichment	SPRED1	1.03
290	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.01
291	Esophageal atresia/tracheoesophageal fistula	Enrichment	POLR2B	1.01
292	Ovarian cancer	Enrichment	KRAS, PIK3CA	0.99
293	Hepatocellular carcinoma	Enrichment	PIK3CA	0.95
294	Scoliosis	Enrichment	PTPN11	0.92
295	Pancreatic cancer	Enrichment	KRAS	0.90
296	Hepatoblastoma	Enrichment	FGFR3	0.89
297	Tooth agenesis	Enrichment	FGFR1	0.87
298	Strabismus	Enrichment	PTPN11	0.87
299	Microcephaly	Enrichment	MAPK1, PTPN11	0.85
300	Hirschsprung disease 1	Enrichment	POLR2F	0.84
301	Prostate cancer	Enrichment	PIK3CA	0.84
302	Long qt syndrome 1	Enrichment	PTPN11	0.83
303	Connective tissue disease	Enrichment	FGFR3	0.72
304	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.68
305	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.59
306	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	HNRNPA1	0.57
307	Rare genetic deafness	Enrichment	POLR2F	0.46
308	Dilated cardiomyopathy	Enrichment	BRAF	0.45
309	Autism spectrum disorder	Enrichment	PTPN11	0.35
310	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.31
311	Congenital nervous system abnormality	Enrichment	FGFR3	0.30
312	Nervous system disease	Enrichment	FGFR3	0.30
313	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.29

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by FGFR2

Pathway Network for Signaling by FGFR2

Pathway network for the Signaling by FGFR2 SuperPath

Member Pathways for Signaling by FGFR2

Pathways in the Signaling by FGFR2 SuperPath

Gene overlap in member pathways for Signaling by FGFR2 SuperPath

Associated Genes for Signaling by FGFR2

Associated Disorders for Signaling by FGFR2

Disorders associated with Signaling by FGFR2 SuperPath

STRING Interaction Network for Signaling by FGFR2

Sources for Signaling by FGFR2