Signaling by FGFR2 in disease

Pathway network for the Signaling by FGFR2 in disease SuperPath

Sources:

Reactome

Pathways in the Signaling by FGFR2 in disease SuperPath

#	Name	Source	Genes
1	Signaling by FGFR2 in disease	Reactome	FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 FRS2 GAB1 GRB2 GTF2F1 GTF2F2 HRAS KRAS NCBP1 NCBP2 NRAS PIK3CA PIK3R1 PLCG1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SOS1 (see all 43) (see less)
2	Signaling by FGFR in disease	Reactome	BCR CEP43 CNTRL CPSF6 CUX1 ERLIN2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR1OP2 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GAB2 GRB2 GTF2F1 GTF2F2 HRAS KRAS LRRFIP1 MYO18A NCBP1 NCBP2 NRAS PIK3CA PIK3R1 PLCG1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SOS1 STAT1 STAT3 STAT5A STAT5B TRIM24 ZMYM2 (see all 62) (see less)
3	FGFR2 mutant receptor activation	Reactome	FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 GTF2F1 GTF2F2 NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L (see all 33) (see less)
4	Signaling by FGFR2 IIIa TM	Reactome	FGF1 FGF2 FGFR2 GTF2F1 GTF2F2 NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L (see all 19) (see less)

Gene overlap in member pathways for Signaling by FGFR2 in disease SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FGF1	Fibroblast Growth Factor 1	Protein Coding	4
2	FGF2	Fibroblast Growth Factor 2	Protein Coding	4
3	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	4
4	NCBP2	Nuclear Cap Binding Protein Subunit 2	Protein Coding	4
5	GTF2F1	General Transcription Factor IIF Subunit 1	Protein Coding	4
6	GTF2F2	General Transcription Factor IIF Subunit 2	Protein Coding	4
7	NCBP1	Nuclear Cap Binding Protein Subunit 1	Protein Coding	4
8	POLR2A	RNA Polymerase II Subunit A	Protein Coding	4
9	POLR2B	RNA Polymerase II Subunit B	Protein Coding	4
10	POLR2C	RNA Polymerase II Subunit C	Protein Coding	4
11	POLR2D	RNA Polymerase II Subunit D	Protein Coding	4
12	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	4
13	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	4
14	POLR2G	RNA Polymerase II Subunit G	Protein Coding	4
15	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	4
16	POLR2I	RNA Polymerase II Subunit I	Protein Coding	4
17	POLR2J	RNA Polymerase II Subunit J	Protein Coding	4
18	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	4
19	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	4
20	FGF3	Fibroblast Growth Factor 3	Protein Coding	3
21	FGF4	Fibroblast Growth Factor 4	Protein Coding	3
22	FGF5	Fibroblast Growth Factor 5	Protein Coding	3
23	FGF6	Fibroblast Growth Factor 6	Protein Coding	3
24	FGF7	Fibroblast Growth Factor 7	Protein Coding	3
25	FGF8	Fibroblast Growth Factor 8	Protein Coding	3
26	FGF9	Fibroblast Growth Factor 9	Protein Coding	3
27	FGF10	Fibroblast Growth Factor 10	Protein Coding	3
28	FGF20	Fibroblast Growth Factor 20	Protein Coding	3
29	FGF22	Fibroblast Growth Factor 22	Protein Coding	3
30	FGF23	Fibroblast Growth Factor 23	Protein Coding	3
31	FGF18	Fibroblast Growth Factor 18	Protein Coding	3
32	FGF17	Fibroblast Growth Factor 17	Protein Coding	3
33	FGF16	Fibroblast Growth Factor 16	Protein Coding	3
34	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	2
35	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	2
36	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
37	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
38	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
39	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
40	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
41	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
42	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
43	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
44	CPSF6	Cleavage And Polyadenylation Specific Factor 6	Protein Coding	1
45	CNTRL	Centriolin	Protein Coding	1
46	CEP43	Centrosomal Protein 43	Protein Coding	1
47	ERLIN2	ER Lipid Raft Associated 2	Protein Coding	1
48	CUX1	Cut Like Homeobox 1	Protein Coding	1
49	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
50	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
51	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
52	FGFR1OP2	FGFR1 Oncogene Partner 2	Protein Coding	1
53	MYO18A	Myosin XVIIIA	Protein Coding	1
54	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	1
55	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
56	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
57	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
58	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
59	ZMYM2	Zinc Finger MYM-Type Containing 2	Protein Coding	1
60	TRIM24	Tripartite Motif Containing 24	Protein Coding	1
61	LRRFIP1	LRR Binding FLII Interacting Protein 1	Protein Coding	1
62	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1

Disorders associated with Signaling by FGFR2 in disease SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bone development disease	Direct
2	Apert syndrome	Direct

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by FGFR2 in disease

Pathway Network for Signaling by FGFR2 in disease

Pathway network for the Signaling by FGFR2 in disease SuperPath

Member Pathways for Signaling by FGFR2 in disease

Pathways in the Signaling by FGFR2 in disease SuperPath

Gene overlap in member pathways for Signaling by FGFR2 in disease SuperPath

Associated Genes for Signaling by FGFR2 in disease

Associated Disorders for Signaling by FGFR2 in disease

Disorders associated with Signaling by FGFR2 in disease SuperPath

STRING Interaction Network for Signaling by FGFR2 in disease

Sources for Signaling by FGFR2 in disease