Signaling by Hippo

No Pathway Network information available for Signaling by Hippo

Pathways in the Signaling by Hippo SuperPath

#	Name	Source	Genes
1	Signaling by Hippo	Reactome	AMOT AMOTL1 AMOTL2 DVL2 LATS1 LATS2 MOB1A MOB1B NPHP4 SAV1 STK3 STK4 TJP1 TJP2 WWC1 WWTR1 YAP1 YWHAB YWHAE (see all 19) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	1
2	AMOT	Angiomotin	Protein Coding	1
3	AMOTL1	Angiomotin Like 1	Protein Coding	1
4	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	1
5	WWC1	WW And C2 Domain Containing 1	Protein Coding	1
6	WWTR1	WW Domain Containing Transcription Regulator 1	Protein Coding	1
7	NPHP4	Nephrocystin 4	Protein Coding	1
8	LATS2	Large Tumor Suppressor Kinase 2	Protein Coding	1
9	AMOTL2	Angiomotin Like 2	Protein Coding	1
10	MOB1A	MOB Kinase Activator 1A	Protein Coding	1
11	SAV1	Salvador Family WW Domain Containing Protein 1	Protein Coding	1
12	STK3	Serine/Threonine Kinase 3	Protein Coding	1
13	STK4	Serine/Threonine Kinase 4	Protein Coding	1
14	TJP1	Tight Junction Protein 1	Protein Coding	1
15	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
16	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
17	LATS1	Large Tumor Suppressor Kinase 1	Protein Coding	1
18	MOB1B	MOB Kinase Activator 1B	Protein Coding	1
19	TJP2	Tight Junction Protein 2	Protein Coding	1

Disorders associated with Signaling by Hippo SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Malignant peritoneal mesothelioma	Enrichment	LATS1, LATS2	5.73
2	Malignant epithelioid hemangioendothelioma	Enrichment	WWTR1, YAP1	4.95
3	Deafness, autosomal dominant 51	Enrichment	TJP2	2.85
4	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	2.85
5	Memory quantitative trait locus	Enrichment	WWC1	2.85
6	Immunodeficiency 110 with lymphoproliferation	Enrichment	STK4	2.85
7	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	2.85
8	Senior-loken syndrome 4	Enrichment	NPHP4	2.85
9	Craniofaciocardiohepatic syndrome	Enrichment	AMOTL1	2.85
10	Orofacial clefting-cardiac anomalies-facial dysmorphism syndrome	Enrichment	AMOTL1	2.85
11	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.85
12	Myeloma, multiple	Enrichment	LATS1, YAP1	2.56
13	Nephronophthisis 4	Enrichment	NPHP4	2.55
14	Cholestasis, progressive familial intrahepatic, 4	Enrichment	TJP2	2.55
15	Hypercholanemia, familial 1	Enrichment	TJP2	2.38
16	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	2.38
17	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	2.38
18	Tethered spinal cord syndrome	Enrichment	AMOTL1	2.38
19	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	2.25
20	Pseudomyogenic hemangioendothelioma	Enrichment	WWTR1	2.25
21	Endometrial stromal sarcoma	Enrichment	YWHAE	2.16
22	Branchiootorenal syndrome 1	Enrichment	TJP2	2.08
23	Familial hypercholanemia	Enrichment	TJP2	2.08
24	Kidney clear cell sarcoma	Enrichment	YWHAE	2.08
25	Infertility	Enrichment	NPHP4	2.08
26	Branchiootorenal syndrome	Enrichment	TJP2	2.01
27	Primary biliary cholangitis	Enrichment	TJP2	1.90
28	Microphthalmia/coloboma 12	Enrichment	YAP1	1.74
29	Senior-loken syndrome 1	Enrichment	NPHP4	1.74
30	Cleft lip/palate	Enrichment	AMOTL1	1.71
31	Coloboma of macula	Enrichment	YAP1	1.68
32	Kidney disease	Enrichment	NPHP4	1.68
33	Nephronophthisis	Enrichment	NPHP4	1.34
34	Severe combined immunodeficiency	Enrichment	STK4	1.34
35	Cakut	Enrichment	NPHP4	1.33
36	Bardet-biedl syndrome	Enrichment	NPHP4	1.24
37	Joubert syndrome 1	Enrichment	NPHP4	1.17
38	Hypertelorism	Enrichment	AMOTL1	1.15
39	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TJP2	1.15
40	Retinitis pigmentosa	Enrichment	NPHP4	0.59
41	Hereditary retinal dystrophy	Enrichment	NPHP4	0.47
42	Fundus dystrophy	Enrichment	NPHP4	0.47

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by Hippo

Pathway Network for Signaling by Hippo

Member Pathways for Signaling by Hippo

Pathways in the Signaling by Hippo SuperPath

Associated Genes for Signaling by Hippo

Associated Disorders for Signaling by Hippo

Disorders associated with Signaling by Hippo SuperPath

STRING Interaction Network for Signaling by Hippo

Sources for Signaling by Hippo