Signaling by NODAL

No Pathway Network information available for Signaling by NODAL

Pathways in the Signaling by NODAL SuperPath

#	Name	Source	Genes
1	Signaling by NODAL	Reactome	ACVR1B ACVR1C ACVR2A ACVR2B CER1 CFC1 CRIPTO CRIPTO3 DAND5 DRAP1 FOXH1 FOXO3 FURIN GDF1 LEFTY1 LEFTY2 MAPK1 MAPK3 NODAL PCSK6 SMAD2 SMAD3 SMAD4 (see all 23) (see less)
2	Regulation of signaling by NODAL	Reactome	ACVR1B ACVR1C ACVR2A ACVR2B CER1 CFC1 CRIPTO CRIPTO3 DAND5 LEFTY1 LEFTY2 NODAL (see all 12) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LEFTY1	Left-Right Determination Factor 1	Protein Coding	2
2	ACVR1C	Activin A Receptor Type 1C	Protein Coding	2
3	DAND5	DAN Domain BMP Antagonist Family Member 5	Protein Coding	2
4	NODAL	Nodal Growth Differentiation Factor	Protein Coding	2
5	CFC1	Cryptic, EGF-CFC Family Member 1	Protein Coding	2
6	CRIPTO	Cripto, EGF-CFC Family Member	Protein Coding	2
7	CRIPTO3	Cripto, EGF-CFC Family Member 3	Protein Coding	2
8	LEFTY2	Left-Right Determination Factor 2	Protein Coding	2
9	ACVR1B	Activin A Receptor Type 1B	Protein Coding	2
10	ACVR2A	Activin A Receptor Type 2A	Protein Coding	2
11	ACVR2B	Activin A Receptor Type 2B	Protein Coding	2
12	CER1	Cerberus 1, DAN Family BMP Antagonist	Protein Coding	2
13	DRAP1	DR1 Associated Protein 1	Protein Coding	1
14	FOXO3	Forkhead Box O3	Protein Coding	1
15	GDF1	Growth Differentiation Factor 1	Protein Coding	1
16	SMAD2	SMAD Family Member 2	Protein Coding	1
17	SMAD3	SMAD Family Member 3	Protein Coding	1
18	SMAD4	SMAD Family Member 4	Protein Coding	1
19	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
20	PCSK6	Proprotein Convertase Subtilisin/Kexin Type 6	Protein Coding	1
21	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
22	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
23	FOXH1	Forkhead Box H1	Protein Coding	1

Disorders associated with Signaling by NODAL SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Visceral heterotaxy	Enrichment	ACVR2B, CFC1, DAND5, LEFTY2, NODAL	10.47
2	Septopreoptic holoprosencephaly	Enrichment	CRIPTO, FOXH1, NODAL	5.72
3	Midline interhemispheric variant of holoprosencephaly	Enrichment	CRIPTO, FOXH1, NODAL	5.72
4	Microform holoprosencephaly	Enrichment	CRIPTO, FOXH1, NODAL	5.63
5	Lobar holoprosencephaly	Enrichment	CRIPTO, FOXH1, NODAL	5.63
6	Alobar holoprosencephaly	Enrichment	CRIPTO, FOXH1, NODAL	5.55
7	Heart, malformation of	Enrichment	GDF1, MAPK1, NODAL	5.47
8	Semilobar holoprosencephaly	Enrichment	CRIPTO, FOXH1, NODAL	5.47
9	Isolated congenitally uncorrected transposition of the great arteries	Enrichment	CFC1, GDF1	4.78
10	Visceral heterotaxy 5	Enrichment	DAND5, GDF1, NODAL	4.73
11	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4	4.27
12	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3	4.01
13	Pancreatic cancer	Enrichment	ACVR1B, SMAD4	3.09
14	Heterotaxy, visceral, 5, autosomal	Enrichment	NODAL	3.05
15	Heterotaxy, visceral, 2, autosomal	Enrichment	CFC1	3.05
16	Heterotaxy, visceral, 13, autosomal	Enrichment	DAND5	3.05
17	Congenitally uncorrected transposition of the great arteries with coarctation	Enrichment	CFC1	3.05
18	Biliary atresia with splenic malformation syndrome	Enrichment	CFC1	3.05
19	Congenitally uncorrected transposition of the great arteries with cardiac malformation	Enrichment	CFC1	3.05
20	Noonan syndrome 13	Enrichment	MAPK1	2.77
21	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.77
22	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.77
23	Heritable thoracic aortic disease	Enrichment	SMAD4	2.77
24	Heterotaxy, visceral, 4, autosomal	Enrichment	ACVR2B	2.75
25	Transposition of the great arteries, dextro-looped	Enrichment	ACVR1B	2.58
26	Myhre syndrome	Enrichment	SMAD4	2.47
27	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.47
28	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.47
29	Epilepsy, progressive myoclonic, 8	Enrichment	GDF1	2.47
30	2q23.1 microduplication syndrome	Enrichment	ACVR2A	2.35
31	Right atrial isomerism	Enrichment	GDF1	2.29
32	Juvenile polyposis syndrome	Enrichment	SMAD4	2.29
33	Congenital heart defects, multiple types, 6	Enrichment	GDF1	2.29
34	Loeys-dietz syndrome 1	Enrichment	SMAD2	2.29
35	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.17
36	Aortic aneurysm	Enrichment	SMAD3	2.17
37	Transposition of the great arteries	Enrichment	GDF1	2.17
38	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	2.07
39	Conotruncal heart malformations	Enrichment	GDF1	1.99
40	Double outlet right ventricle	Enrichment	GDF1	1.99
41	Gallbladder cancer	Enrichment	SMAD4	1.93
42	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.93
43	Wolff-parkinson-white syndrome	Enrichment	NODAL	1.85
44	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.82
45	Specific learning disability	Enrichment	MAPK1	1.73
46	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.63
47	Ehlers-danlos syndrome	Enrichment	SMAD3	1.50
48	Tetralogy of fallot	Enrichment	GDF1	1.36
49	Connective tissue disease	Enrichment	SMAD3	1.28
50	Gastric cancer	Enrichment	SMAD4	1.15
51	Thrombocytopenia	Enrichment	SMAD4	1.11
52	Colorectal cancer	Enrichment	SMAD4	0.86
53	Microcephaly	Enrichment	MAPK1	0.72
54	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.70

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by NODAL

Pathway Network for Signaling by NODAL

Member Pathways for Signaling by NODAL

Pathways in the Signaling by NODAL SuperPath

Associated Genes for Signaling by NODAL

Associated Disorders for Signaling by NODAL

Disorders associated with Signaling by NODAL SuperPath

STRING Interaction Network for Signaling by NODAL

Sources for Signaling by NODAL