Signaling by NTRKs

Pathway network for the Signaling by NTRKs SuperPath

Sources:

Reactome

Pathways in the Signaling by NTRKs SuperPath

#	Name	Source	Genes
1	Signaling by NTRKs	Reactome	ADCYAP1 ADCYAP1R1 ADORA2A AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARC ASCL1 ATF1 ATF2 BDNF BRAF CDK5 CDK5R1 CDK5R2 CHD4 CLTA CLTC CREB1 CRK CRKL DNAL4 DNM1 DNM2 DNM3 DOCK3 DUSP3 DUSP4 DUSP6 DUSP7 EGR1 EGR2 EGR3 EGR4 ELK1 EP300 F3 FOS FOSB FOSL1 FRS2 FRS3 FURIN FYN GAB1 GRB2 GRIN2B HRAS ID1 ID2 ID3 ID4 IRS1 IRS2 JUNB JUND KIDINS220 KRAS LYL1 MAP2K1 MAP2K2 MAP2K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MEF2D NAB1 NAB2 NELFB NGF NRAS NTF3 NTF4 NTRK1 NTRK2 NTRK3 PCSK5 PCSK6 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PTPN11 PTPRO PTPRS RAC1 RALA RALB RALGDS RAP1A RAPGEF1 REST RHOA RIT1 RIT2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RRAD SGK1 SH3GL2 SH3GL3 SHC1 SHC2 SHC3 SOS1 SRC SRF STAT3 TCF12 TIAM1 TPH1 TRIB1 VGF VRK3 YWHAB (see all 133) (see less)
2	Signaling by NTRK1 (TRKA)	Reactome	ADCYAP1 ADCYAP1R1 ADORA2A AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARC ASCL1 ATF1 ATF2 BRAF CDK5 CDK5R1 CDK5R2 CHD4 CLTA CLTC CREB1 CRK CRKL DNAL4 DNM1 DNM2 DNM3 DUSP3 DUSP4 DUSP6 DUSP7 EGR1 EGR2 EGR3 EGR4 ELK1 EP300 F3 FOS FOSB FOSL1 FRS2 GRB2 HRAS ID1 ID2 ID3 ID4 IRS1 IRS2 JUNB JUND KIDINS220 KRAS LYL1 MAP2K1 MAP2K2 MAP2K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPKAPK2 MAPKAPK3 MEF2A MEF2C MEF2D NAB1 NAB2 NGF NRAS NTRK1 NTRK2 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RALA RALB RALGDS RAP1A RAPGEF1 REST RHOA RIT1 RIT2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RRAD SGK1 SH3GL2 SH3GL3 SHC1 SHC2 SHC3 SOS1 SRC SRF STAT3 TCF12 TPH1 TRIB1 VGF VRK3 YWHAB (see all 115) (see less)
3	Signaling by NTRK3 (TRKC)	Reactome	GRB2 HRAS IRS1 KRAS NELFB NRAS NTF3 NTRK3 PIK3CA PIK3R1 PLCG1 PTPRO PTPRS SHC1 SOS1 SRC (see all 16) (see less)
4	Retrograde neurotrophin signalling	Reactome	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CLTA CLTC DNAL4 DNM1 DNM2 DNM3 NGF NTRK1 SH3GL2 (see all 14) (see less)
5	PI3K/AKT activation	Reactome	IRS1 IRS2 NGF NTRK1 PIK3CA PIK3CB PIK3R1 PIK3R2 RHOA (see all 9) (see less)
6	Activated NTRK3 signals through RAS	Reactome	GRB2 HRAS KRAS NRAS NTF3 NTRK3 SHC1 SOS1 (see all 8) (see less)
7	Activated NTRK3 signals through PI3K	Reactome	IRS1 NTF3 NTRK3 PIK3CA PIK3R1 SRC (see all 6) (see less)
8	Activation of TRKA receptors	Reactome	ADCYAP1 ADCYAP1R1 ADORA2A NGF NTRK1 NTRK2 (see all 6) (see less)
9	NGF-independant TRKA activation	Reactome	ADCYAP1 ADCYAP1R1 ADORA2A NTRK1 NTRK2
10	Activated NTRK3 signals through PLCG1	Reactome	NTF3 NTRK3 PLCG1
11	NTF3 activates NTRK3 signaling	Reactome	NTF3 NTRK3
12	NTRK3 as a dependence receptor	Reactome	NELFB NTRK3

Gene overlap in member pathways for Signaling by NTRKs SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	7
2	NTF3	Neurotrophin 3	Protein Coding	6
3	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	6
4	IRS1	Insulin Receptor Substrate 1	Protein Coding	5
5	NGF	Nerve Growth Factor	Protein Coding	5
6	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	5
7	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	5
8	ADCYAP1	Adenylate Cyclase Activating Polypeptide 1	Protein Coding	4
9	ADCYAP1R1	ADCYAP Receptor Type I	Protein Coding	4
10	ADORA2A	Adenosine A2a Receptor	Protein Coding	4
11	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	4
12	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	4
13	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	4
14	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	4
15	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	4
16	PLCG1	Phospholipase C Gamma 1	Protein Coding	4
17	SHC1	SHC Adaptor Protein 1	Protein Coding	4
18	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	4
19	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	4
20	DNAL4	Dynein Axonemal Light Chain 4	Protein Coding	3
21	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	3
22	AP2S1	Adaptor Related Protein Complex 2 Subunit Sigma 1	Protein Coding	3
23	CLTA	Clathrin Light Chain A	Protein Coding	3
24	CLTC	Clathrin Heavy Chain	Protein Coding	3
25	AP2A1	Adaptor Related Protein Complex 2 Subunit Alpha 1	Protein Coding	3
26	AP2A2	Adaptor Related Protein Complex 2 Subunit Alpha 2	Protein Coding	3
27	AP2B1	Adaptor Related Protein Complex 2 Subunit Beta 1	Protein Coding	3
28	DNM1	Dynamin 1	Protein Coding	3
29	DNM2	Dynamin 2	Protein Coding	3
30	NELFB	Negative Elongation Factor Complex Member B	Protein Coding	3
31	DNM3	Dynamin 3	Protein Coding	3
32	RHOA	Ras Homolog Family Member A	Protein Coding	3
33	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	3
34	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
35	SH3GL2	SH3 Domain Containing GRB2 Like 2, Endophilin A1	Protein Coding	3
36	IRS2	Insulin Receptor Substrate 2	Protein Coding	3
37	CDK5	Cyclin Dependent Kinase 5	Protein Coding	2
38	TRIB1	Tribbles Pseudokinase 1	Protein Coding	2
39	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	2
40	CHD4	Chromodomain Helicase DNA Binding Protein 4	Protein Coding	2
41	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
42	ATF2	Activating Transcription Factor 2	Protein Coding	2
43	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	2
44	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	2
45	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
46	DUSP3	Dual Specificity Phosphatase 3	Protein Coding	2
47	DUSP4	Dual Specificity Phosphatase 4	Protein Coding	2
48	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	2
49	DUSP7	Dual Specificity Phosphatase 7	Protein Coding	2
50	EGR1	Early Growth Response 1	Protein Coding	2
51	EGR2	Early Growth Response 2	Protein Coding	2
52	EGR3	Early Growth Response 3	Protein Coding	2
53	EGR4	Early Growth Response 4	Protein Coding	2
54	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
55	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
56	F3	Coagulation Factor III, Tissue Factor	Protein Coding	2
57	ARC	Activity Regulated Cytoskeleton Associated Protein	Protein Coding	2
58	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
59	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
60	SHC2	SHC Adaptor Protein 2	Protein Coding	2
61	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	2
62	ID1	Inhibitor Of DNA Binding 1	Protein Coding	2
63	ID2	Inhibitor Of DNA Binding 2	Protein Coding	2
64	ID3	Inhibitor Of DNA Binding 3	Protein Coding	2
65	ID4	Inhibitor Of DNA Binding 4	Protein Coding	2
66	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
67	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
68	LYL1	LYL1 Basic Helix-Loop-Helix Family Member	Protein Coding	2
69	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	2
70	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	2
71	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	2
72	ASCL1	Achaete-Scute Family BHLH Transcription Factor 1	Protein Coding	2
73	ATF1	Activating Transcription Factor 1	Protein Coding	2
74	NAB1	NGFI-A Binding Protein 1	Protein Coding	2
75	NAB2	NGFI-A Binding Protein 2	Protein Coding	2
76	VRK3	VRK Serine/Threonine Kinase 3	Protein Coding	2
77	SHC3	SHC Adaptor Protein 3	Protein Coding	2
78	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
79	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
80	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	2
81	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	2
82	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	2
83	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
84	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
85	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	2
86	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
87	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
88	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
89	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
90	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	2
91	KIDINS220	Kinase D Interacting Substrate 220	Protein Coding	2
92	PTPRO	Protein Tyrosine Phosphatase Receptor Type O	Protein Coding	2
93	PTPRS	Protein Tyrosine Phosphatase Receptor Type S	Protein Coding	2
94	RALA	RAS Like Proto-Oncogene A	Protein Coding	2
95	RALB	RAS Like Proto-Oncogene B	Protein Coding	2
96	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	2
97	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	2
98	REST	RE1 Silencing Transcription Factor	Protein Coding	2
99	RIT2	Ras Like Without CAAX 2	Protein Coding	2
100	RIT1	Ras Like Without CAAX 1	Protein Coding	2
101	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	2
102	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	2
103	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	2
104	RRAD	RRAD, Ras Related Glycolysis Inhibitor And Calcium Channel Regulator	Protein Coding	2
105	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
106	SGK1	Serum/Glucocorticoid Regulated Kinase 1	Protein Coding	2
107	SH3GL3	SH3 Domain Containing GRB2 Like 3, Endophilin A3	Protein Coding	2
108	SRF	Serum Response Factor	Protein Coding	2
109	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
110	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
111	TCF12	Transcription Factor 12	Protein Coding	2
112	TPH1	Tryptophan Hydroxylase 1	Protein Coding	2
113	VGF	VGF Nerve Growth Factor Inducible	Protein Coding	2
114	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	2
115	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	2
116	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	2
117	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	2
118	CDK5R2	Cyclin Dependent Kinase 5 Regulatory Subunit 2	Protein Coding	2
119	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	2
120	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	2
121	FRS3	Fibroblast Growth Factor Receptor Substrate 3	Protein Coding	1
122	DOCK3	Dedicator Of Cytokinesis 3	Protein Coding	1
123	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
124	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
125	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
126	NTF4	Neurotrophin 4	Protein Coding	1
127	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
128	PCSK6	Proprotein Convertase Subtilisin/Kexin Type 6	Protein Coding	1
129	PCSK5	Proprotein Convertase Subtilisin/Kexin Type 5	Protein Coding	1
130	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
131	RAC1	Rac Family Small GTPase 1	Protein Coding	1
132	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
133	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1

Disorders associated with Signaling by NTRKs SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RIT1, SOS1	16.00
2	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RIT1, SOS1	10.82
3	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RIT1, SOS1	10.69
4	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	10.18
5	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS, PIK3CA	9.84
6	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	9.24
7	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS, NTRK3	8.92
8	Noonan syndrome 3	Enrichment	CLTC, HRAS, KRAS, PTPN11, SOS1	8.75
9	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.31
10	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.31
11	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.52
12	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	6.31
13	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	6.23
14	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	6.04
15	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.74
16	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	5.63
17	Colorectal cancer	Enrichment	NRAS, PIK3CA, PIK3R1, SRC	5.57
18	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF, NTRK1	5.47
19	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	5.32
20	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	5.23
21	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	5.20
22	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	5.20
23	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	5.20
24	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	5.07
25	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	4.71
26	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	4.71
27	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	4.70
28	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA	4.69
29	Gallbladder cancer	Enrichment	BRAF, KRAS, PIK3CA	4.69
30	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, NTRK2	4.69
31	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	4.33
32	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	4.23
33	Fibromatosis, gingival, 1	Enrichment	REST, SOS1	4.15
34	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.15
35	Noonan syndrome 8	Enrichment	PIK3CA, RIT1	4.15
36	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	4.07
37	Breast cancer	Enrichment	KRAS, PIK3CA, SHC1	4.06
38	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.87
39	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	3.85
40	Specific learning disability	Enrichment	MAPK1, PTPN11, RPS6KA3	3.84
41	Lung cancer	Enrichment	BRAF, KRAS, PIK3CA, PPP2R1B	3.83
42	Melanoma of soft tissue	Enrichment	ATF1, CREB1	3.67
43	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	3.66
44	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	3.63
45	Congenital mesoblastic nephroma	Enrichment	NTRK3	3.53
46	Fibrosarcoma	Enrichment	NTRK3	3.53
47	Type 2 diabetes mellitus	Enrichment	IRS1, IRS2	3.48
48	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	3.43
49	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	3.43
50	Acute encephalopathy with biphasic seizures and late reduced diffusion	Enrichment	ADORA2A	3.43
51	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL, MAPK1	3.37
52	Gingival fibromatosis	Enrichment	REST, SOS1	3.37
53	Macrodactyly	Enrichment	PIK3CA	3.35
54	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	3.35
55	Cowden syndrome 5	Enrichment	PIK3CA	3.35
56	Cerebral cavernous malformations 4	Enrichment	PIK3CA	3.35
57	Short syndrome	Enrichment	PIK3R1	3.35
58	Hemifacial myohyperplasia	Enrichment	PIK3CA	3.35
59	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	3.35
60	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	3.35
61	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	3.35
62	Thrombocytopenia 6	Enrichment	SRC	3.35
63	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	3.35
64	Hypospadias	Enrichment	PIK3CA	3.35
65	Rare venous malformation	Enrichment	PIK3CA	3.35
66	Diaphragmatic eventration	Enrichment	PIK3CA	3.35
67	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	3.35
68	Rare combined vascular malformation	Enrichment	PIK3CA	3.35
69	Cavernous lymphangioma	Enrichment	PIK3CA	3.35
70	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	3.35
71	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	3.35
72	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	3.35
73	Macrodactyly of toe	Enrichment	PIK3CA	3.35
74	Noonan syndrome with multiple lentigines	Enrichment	BRAF, PTPN11	3.25
75	Glioma	Enrichment	NTRK3	3.23
76	Oculoectodermal syndrome	Enrichment	KRAS	3.23
77	Noonan syndrome 4	Enrichment	SOS1	3.23
78	Melanosis, neurocutaneous	Enrichment	NRAS	3.23
79	Noonan syndrome 6	Enrichment	NRAS	3.23
80	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.23
81	Congenital pulmonary airway malformation	Enrichment	KRAS	3.23
82	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.23
83	Neurocutaneous melanocytosis	Enrichment	NRAS	3.23
84	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	3.18
85	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	3.18
86	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.15
87	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	3.13
88	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	3.13
89	Keratosis, seborrheic	Enrichment	PIK3CA	3.05
90	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	3.05
91	Hypocalciuric hypercalcemia, familial, type iii	Enrichment	AP2S1	2.99
92	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	2.99
93	Mirror movements 3	Enrichment	DNAL4	2.99
94	Lethal congenital contracture syndrome 5	Enrichment	DNM2	2.99
95	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	2.99
96	Thyroid carcinoma, familial medullary	Enrichment	NTRK1	2.96
97	Gastric cancer	Enrichment	KRAS, PIK3CA	2.94
98	Costello syndrome	Enrichment	HRAS	2.93
99	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.93
100	Wooly hair nevus	Enrichment	HRAS	2.93
101	Nephrotic syndrome, type 6	Enrichment	PTPRO	2.93
102	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	2.92
103	Myeloma, multiple	Enrichment	BRAF, KRAS, PIK3R2, SGK1	2.89
104	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.88
105	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.88
106	Immunodeficiency 14	Enrichment	PIK3R1	2.88
107	Keratoacanthoma	Enrichment	PIK3CA	2.88
108	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC, DNM1	2.83
109	Cerebrovascular disease	Enrichment	PIK3CA	2.75
110	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.75
111	Nuchal bleb, familial	Enrichment	SOS1	2.75
112	Spermatocytoma	Enrichment	HRAS	2.75
113	Ovarian cancer	Enrichment	NTRK1, PIK3CA	2.72
114	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11, RIT1	2.69
115	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1	2.69
116	Capillary malformations, congenital	Enrichment	PIK3CA	2.66
117	Hemimegalencephaly	Enrichment	PIK3CA	2.66
118	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.63
119	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.63
120	Pilocytic astrocytoma	Enrichment	KRAS	2.63
121	Epidermolytic nevus	Enrichment	HRAS	2.63
122	Ventricular septal defect	Enrichment	BRAF, RPS6KA3	2.61
123	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.58
124	Cowden syndrome 1	Enrichment	PIK3CA	2.58
125	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.58
126	Myelofibrosis	Enrichment	SRC	2.51
127	Overgrowth syndrome	Enrichment	PIK3R1	2.51
128	Myopathy, centronuclear, x-linked	Enrichment	DNM2	2.51
129	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	2.51
130	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	2.51
131	Adult hepatocellular carcinoma	Enrichment	PIK3CA	2.40
132	Cowden syndrome	Enrichment	PIK3CA	2.40
133	Mirror movements 1	Enrichment	DNAL4	2.38
134	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	2.38
135	Autism spectrum disorder	Enrichment	GRIN2B, MAP2K1, MEF2C, PTPN11, TCF12	2.36
136	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	2.35
137	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	2.29
138	Meningioma	Enrichment	PIK3CA	2.28
139	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	2.22
140	Myopathy, centronuclear, 1	Enrichment	DNM2	2.21
141	Inflammatory myofibroblastic tumor	Enrichment	CLTC	2.21
142	Osteoporosis	Enrichment	SRC	2.21
143	Nk-cell enteropathy	Enrichment	PIK3CB, PTPRS	2.16
144	Wilms tumor 1	Enrichment	BRAF, REST	2.16
145	Renal cell carcinoma with mit translocations	Enrichment	CLTC	2.14
146	Complex neurodevelopmental disorder	Enrichment	DOCK3, GRIN2B, PPP2CA, RALA, TIAM1	2.13
147	Aortic valve disease 1	Enrichment	SOS1	2.12
148	Protein-deficiency anemia	Enrichment	NRAS	2.12
149	Lennox-gastaut syndrome	Enrichment	DNM1	2.08
150	46,xy partial gonadal dysgenesis	Enrichment	SOS1	2.08
151	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.07
152	Charcot-marie-tooth disease, demyelinating, type 1d	Enrichment	EGR2	2.07
153	Melorheostosis, isolated	Enrichment	MAP2K1	2.07
154	Noonan syndrome 7	Enrichment	BRAF	2.07
155	Leopard syndrome 3	Enrichment	BRAF	2.07
156	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.07
157	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.07
158	Wilms tumor 6	Enrichment	REST	2.07
159	Hiatt-neu-cooper neurodevelopmental syndrome	Enrichment	RALA	2.07
160	Ventriculomegaly and arthrogryposis	Enrichment	KIDINS220	2.07
161	Noonan syndrome 13	Enrichment	MAPK1	2.07
162	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.07
163	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.07
164	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.07
165	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.07
166	Lymphangioma	Enrichment	BRAF	2.07
167	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.07
168	Phace association	Enrichment	BRAF	2.07
169	Melorheostosis	Enrichment	MAP2K1	2.07
170	Deafness, autosomal dominant 27	Enrichment	REST	2.07
171	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.07
172	Craniosynostosis 3	Enrichment	TCF12	2.07
173	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	2.07
174	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.07
175	Fibromatosis, gingival, 5	Enrichment	REST	2.07
176	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.07
177	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.07
178	Charcot-marie-tooth disease type 1d	Enrichment	EGR2	2.07
179	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.07
180	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.07
181	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.07
182	Syringocystadenoma papilliferum	Enrichment	BRAF	2.07
183	Ganglioglioma	Enrichment	BRAF	2.07
184	Hypogonadotropic hypogonadism 26 with or without anosmia	Enrichment	TCF12	2.07
185	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.07
186	Phace syndrome	Enrichment	BRAF	2.07
187	Mef2c-related disorder	Enrichment	MEF2C	2.07
188	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.07
189	Classic hairy cell leukemia	Enrichment	BRAF	2.07
190	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.07
191	West syndrome	Enrichment	DNM1, GRIN2B, NTRK2	2.04
192	Myoclonic-atonic epilepsy	Enrichment	AP2M1	2.03
193	Endometrial cancer	Enrichment	PIK3CA	2.03
194	Rhabdomyosarcoma	Enrichment	HRAS	2.03
195	Hepatocellular carcinoma	Enrichment	PIK3CA	2.01
196	Hypertelorism	Enrichment	PIK3CA, RIT1, RPS6KA3	2.01
197	Metachondromatosis	Enrichment	PTPN11	2.01
198	Deafness, autosomal recessive 26	Enrichment	GAB1	2.01
199	Leopard syndrome 1	Enrichment	PTPN11	2.01
200	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.01
201	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.01
202	Glaucoma 1, open angle, o	Enrichment	NTF4	2.01
203	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.01
204	Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia	Enrichment	DOCK3	2.01
205	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.01
206	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.01
207	Malignant astrocytoma	Enrichment	PTPN11	2.01
208	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	1.96
209	Diffuse large b-cell lymphoma	Enrichment	BRAF, STAT3	1.96
210	Prostate cancer	Enrichment	PIK3CA	1.89
211	Stereotypic movement disorder	Enrichment	DNM1	1.87
212	Peripheral nervous system disease	Enrichment	NGF	1.85
213	Neuropathy	Enrichment	NGF	1.85
214	Pancreatic cancer	Enrichment	KRAS	1.83
215	Craniosynostosis	Enrichment	GRIN2B, TCF12	1.79
216	Scoliosis, isolated 1	Enrichment	MAPK7	1.77
217	Hemangiopericytoma, malignant	Enrichment	NAB2	1.77
218	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.77
219	Neuropathy, congenital hypomyelinating, 1, autosomal recessive	Enrichment	EGR2	1.77
220	Sifrim-hitz-weiss syndrome	Enrichment	CHD4	1.77
221	Spastic paraplegia, intellectual disability, nystagmus, and obesity	Enrichment	KIDINS220	1.77
222	Houge-janssens syndrome 1	Enrichment	PPP2R5D	1.77
223	Menke-hennekam syndrome 2	Enrichment	EP300	1.77
224	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.77
225	Tafro syndrome	Enrichment	MAP2K2	1.77
226	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.71
227	Werner syndrome	Enrichment	PTPN11	1.71
228	Thrombocytopenia	Enrichment	SRC	1.68
229	Centronuclear myopathy	Enrichment	DNM2	1.67
230	Primary ovarian insufficiency	Enrichment	NTRK1	1.67
231	Scoliosis	Enrichment	GRIN2B, PTPN11	1.64
232	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.60
233	Ataxia-telangiectasia	Enrichment	BRAF	1.60
234	Tethered spinal cord syndrome	Enrichment	BRAF	1.60
235	Bacteremia 2	Enrichment	MAPKAPK3	1.60
236	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.60
237	Hyper ige syndrome	Enrichment	STAT3	1.60
238	Charcot-marie-tooth disease type 1	Enrichment	EGR2	1.60
239	Tricuspid valve insufficiency	Enrichment	PTPN11	1.54
240	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.50
241	Microcephaly	Enrichment	EP300, GRIN2B, MAPK1, PTPN11	1.48
242	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.48
243	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.48
244	Congenital generalized lipodystrophy	Enrichment	FOS	1.48
245	Craniopharyngioma	Enrichment	BRAF	1.48
246	Tuberculosis	Enrichment	MAPKAPK3	1.48
247	Newborn respiratory distress syndrome	Enrichment	BRAF	1.48
248	Non-syndromic bicoronal craniosynostosis	Enrichment	TCF12	1.48
249	Haddad syndrome	Enrichment	ASCL1	1.48
250	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.48
251	Astigmatism	Enrichment	GRIN2B	1.41
252	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.41
253	Genetic steroid-resistant nephrotic syndrome	Enrichment	PTPRO	1.40
254	Myopathy	Enrichment	DNM2	1.39
255	Charcot-marie-tooth disease	Enrichment	DNM2	1.38
256	Hypertrophic neuropathy of dejerine-sottas	Enrichment	EGR2	1.38
257	Chondrosarcoma, extraskeletal myxoid	Enrichment	TCF12	1.38
258	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.38
259	Lymphoma	Enrichment	PTPN11	1.32
260	Sleep disorder	Enrichment	GRIN2B	1.32
261	Kabuki syndrome 1	Enrichment	KIDINS220	1.30
262	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.30
263	Wilms tumor 5	Enrichment	BRAF	1.30
264	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.30
265	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC	1.30
266	Cerebral palsy	Enrichment	GRIN2B, KIDINS220	1.25
267	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	1.24
268	Patent ductus arteriosus	Enrichment	PTPN11	1.24
269	Gastroesophageal reflux	Enrichment	RPS6KA3	1.18
270	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.18
271	Orthostatic intolerance	Enrichment	RPS6KA3	1.18
272	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.18
273	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.13
274	Charge syndrome	Enrichment	EP300	1.13
275	Primary hyperaldosteronism	Enrichment	BRAF	1.13
276	Melanoma	Enrichment	BRAF	1.09
277	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.07
278	Congenital central hypoventilation syndrome	Enrichment	BDNF	1.07
279	Pectus excavatum	Enrichment	PTPN11	0.99
280	Acute promyelocytic leukemia	Enrichment	STAT3	0.98
281	Epicanthus	Enrichment	PTPN11	0.95
282	Congenital long qt syndrome	Enrichment	PTPN11	0.95
283	Heart disease	Enrichment	RIT1	0.95
284	Polydactyly, postaxial, type a1	Enrichment	EP300	0.92
285	Rare genetic intellectual disability	Enrichment	EP300	0.92
286	Melanoma, cutaneous malignant 1	Enrichment	BRAF	0.87
287	Dandy-walker syndrome	Enrichment	BRAF	0.87
288	Heart, malformation of	Enrichment	MAPK1	0.85
289	Charcot-marie-tooth disease type 4	Enrichment	EGR2	0.85
290	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	0.85
291	Patent foramen ovale	Enrichment	PTPN11	0.79
292	Malaria	Enrichment	MAPKAPK3	0.75
293	Kallmann syndrome	Enrichment	DUSP6	0.75
294	Strabismus	Enrichment	PTPN11	0.63
295	Long qt syndrome 1	Enrichment	PTPN11	0.59
296	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.58
297	Epilepsy	Enrichment	GRIN2B	0.49
298	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.46
299	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	REST	0.45
300	Body mass index quantitative trait locus 11	Enrichment	BDNF	0.41
301	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.41
302	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.37
303	Dilated cardiomyopathy	Enrichment	BRAF	0.31
304	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.14

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by NTRKs

Pathway Network for Signaling by NTRKs

Pathway network for the Signaling by NTRKs SuperPath

Member Pathways for Signaling by NTRKs

Pathways in the Signaling by NTRKs SuperPath

Gene overlap in member pathways for Signaling by NTRKs SuperPath

Associated Genes for Signaling by NTRKs

Associated Disorders for Signaling by NTRKs

Disorders associated with Signaling by NTRKs SuperPath

STRING Interaction Network for Signaling by NTRKs

Sources for Signaling by NTRKs