Signaling by Overexpressed Wild-Type EGFR in Cancer

Pathway network for the Signaling by Overexpressed Wild-Type EGFR in Cancer SuperPath

Sources:

Reactome

Pathways in the Signaling by Overexpressed Wild-Type EGFR in Cancer SuperPath

#	Name	Source	Genes
1	Signaling by Overexpressed Wild-Type EGFR in Cancer	Reactome	AREG BTC EGF EGFR EPGN EREG HBEGF TGFA (see all 8) (see less)
2	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Reactome	AKT1 AKT2 AKT3 AREG BCL2 BTC CCND1 CDKN1B CREB1 EGF EGFR ELK1 EPGN EREG FOS FOXO3 HBEGF MAPK1 MAPK3 PTK2 SRF TGFA UHMK1 XPO1 (see all 24) (see less)
3	Inhibition of Signaling by Overexpressed EGFR	Reactome	AREG BTC EGF EGFR EPGN EREG HBEGF TGFA (see all 8) (see less)

Gene overlap in member pathways for Signaling by Overexpressed Wild-Type EGFR in Cancer SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	3
2	EGF	Epidermal Growth Factor	Protein Coding	3
3	EGFR	Epidermal Growth Factor Receptor	Protein Coding	3
4	EREG	Epiregulin	Protein Coding	3
5	EPGN	Epithelial Mitogen	Protein Coding	3
6	AREG	Amphiregulin	Protein Coding	3
7	BTC	Betacellulin	Protein Coding	3
8	TGFA	Transforming Growth Factor Alpha	Protein Coding	3
9	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
10	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
11	UHMK1	U2AF Homology Motif Kinase 1	Protein Coding	1
12	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
13	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
14	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
15	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
16	FOXO3	Forkhead Box O3	Protein Coding	1
17	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
18	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
19	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
20	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
21	CCND1	Cyclin D1	Protein Coding	1
22	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
23	SRF	Serum Response Factor	Protein Coding	1
24	XPO1	Exportin 1	Protein Coding	1

Disorders associated with Signaling by Overexpressed Wild-Type EGFR in Cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hypomagnesemia 4, renal	Enrichment	EGF	3.23
2	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	3.23
3	Ovarian cancer	Enrichment	AKT1, CDKN1B, EGFR	3.14
4	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.75
5	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.75
6	Proteus syndrome	Enrichment	AKT1	2.75
7	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.75
8	Noonan syndrome 13	Enrichment	MAPK1	2.75
9	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.75
10	Neuroendocrine tumor	Enrichment	CDKN1B	2.75
11	Cowden syndrome 6	Enrichment	AKT1	2.75
12	Capillary hemangioma	Enrichment	AKT3	2.75
13	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.75
14	Cowden syndrome 1	Enrichment	EGFR	2.45
15	Lung squamous cell carcinoma	Enrichment	EGFR	2.45
16	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.45
17	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.45
18	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.45
19	Senior-loken syndrome 7	Enrichment	AKT3	2.45
20	Bardet-biedl syndrome 16	Enrichment	AKT3	2.45
21	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	2.45
22	Squamous cell carcinoma, head and neck	Enrichment	EGFR	2.38
23	Adult hepatocellular carcinoma	Enrichment	EGF	2.28
24	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.28
25	Melanoma of soft tissue	Enrichment	CREB1	2.28
26	Lung non-small cell carcinoma	Enrichment	EGFR	2.19
27	Lip and oral cavity carcinoma	Enrichment	EGFR	2.15
28	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.15
29	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.15
30	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.15
31	Congenital generalized lipodystrophy	Enrichment	FOS	2.15
32	Mantle cell lymphoma	Enrichment	CCND1	2.15
33	Primary hyperparathyroidism	Enrichment	CDKN1B	2.15
34	Lung cancer susceptibility 3	Enrichment	EGFR	2.08
35	Von hippel-lindau syndrome	Enrichment	CCND1	2.05
36	Follicular lymphoma	Enrichment	BCL2	2.05
37	Histiocytoid hemangioma	Enrichment	FOS	2.05
38	Hemimegalencephaly	Enrichment	AKT3	2.05
39	Gliosarcoma	Enrichment	EGFR	2.03
40	Giant cell glioblastoma	Enrichment	EGFR	2.00
41	Colorectal cancer	Enrichment	AKT1, CCND1	1.99
42	Breast adenocarcinoma	Enrichment	AKT1	1.98
43	Arteriovenous malformations of the brain	Enrichment	EGFR	1.95
44	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.91
45	Megacolon	Enrichment	AKT3	1.91
46	Tooth agenesis	Enrichment	TGFA	1.89
47	Cowden syndrome	Enrichment	AKT1	1.80
48	Bladder cancer	Enrichment	EGFR	1.77
49	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.76
50	Polymicrogyria	Enrichment	AKT3	1.76
51	Lung cancer	Enrichment	EGFR	1.73
52	Specific learning disability	Enrichment	MAPK1	1.71
53	Meningioma	Enrichment	AKT1	1.68
54	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, EGFR	1.65
55	Heart, malformation of	Enrichment	MAPK1	1.50
56	Type 2 diabetes mellitus	Enrichment	AKT2	1.14
57	Hereditary breast carcinoma	Enrichment	AKT1	1.12
58	Myeloma, multiple	Enrichment	CCND1	1.02
59	Breast cancer	Enrichment	AKT1	0.90
60	Microcephaly	Enrichment	MAPK1	0.71

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by Overexpressed Wild-Type EGFR in Cancer

Pathway Network for Signaling by Overexpressed Wild-Type EGFR in Cancer

Pathway network for the Signaling by Overexpressed Wild-Type EGFR in Cancer SuperPath

Member Pathways for Signaling by Overexpressed Wild-Type EGFR in Cancer

Pathways in the Signaling by Overexpressed Wild-Type EGFR in Cancer SuperPath

Gene overlap in member pathways for Signaling by Overexpressed Wild-Type EGFR in Cancer SuperPath

Associated Genes for Signaling by Overexpressed Wild-Type EGFR in Cancer

Associated Disorders for Signaling by Overexpressed Wild-Type EGFR in Cancer

Disorders associated with Signaling by Overexpressed Wild-Type EGFR in Cancer SuperPath

STRING Interaction Network for Signaling by Overexpressed Wild-Type EGFR in Cancer

Sources for Signaling by Overexpressed Wild-Type EGFR in Cancer