Signaling by PDGF

No Pathway Network information available for Signaling by PDGF

Pathways in the Signaling by PDGF SuperPath

#	Name	Source	Genes
1	Signaling by PDGF	Reactome	BCAR1 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL5A1 COL5A2 COL5A3 COL6A1 COL6A2 COL6A3 COL6A5 COL6A6 COL9A1 COL9A2 COL9A3 CRK CRKL FURIN GRB2 GRB7 HRAS KRAS NCK1 NCK2 NRAS PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PIK3CA PIK3CB PIK3R1 PIK3R2 PLAT PLCG1 PLG PTPN11 PTPN12 RAPGEF1 RASA1 SOS1 SPP1 SRC STAT1 STAT3 STAT5A STAT5B STAT6 THBS1 THBS2 THBS3 THBS4 (see all 58) (see less)
2	Downstream signal transduction	Reactome	BCAR1 CRK CRKL GRB2 GRB7 HRAS KRAS NCK1 NCK2 NRAS PDGFA PDGFB PDGFRA PDGFRB PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PTPN11 RAPGEF1 RASA1 SOS1 SRC STAT1 STAT3 STAT5A STAT5B STAT6 (see all 29) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	2
2	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	2
3	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
4	GRB7	Growth Factor Receptor Bound Protein 7	Protein Coding	2
5	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	2
6	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
7	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
8	NCK1	NCK Adaptor Protein 1	Protein Coding	2
9	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
10	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	2
11	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	2
12	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	2
13	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	2
14	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
15	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
16	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
17	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
18	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
19	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	2
20	RASA1	RAS P21 Protein Activator 1	Protein Coding	2
21	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
22	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
23	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	2
24	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
25	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	2
26	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	2
27	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	2
28	NCK2	NCK Adaptor Protein 2	Protein Coding	2
29	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	2
30	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	1
31	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	1
32	COL4A1	Collagen Type IV Alpha 1 Chain	Protein Coding	1
33	COL4A2	Collagen Type IV Alpha 2 Chain	Protein Coding	1
34	COL4A3	Collagen Type IV Alpha 3 Chain	Protein Coding	1
35	COL4A4	Collagen Type IV Alpha 4 Chain	Protein Coding	1
36	COL4A5	Collagen Type IV Alpha 5 Chain	Protein Coding	1
37	COL5A1	Collagen Type V Alpha 1 Chain	Protein Coding	1
38	COL5A2	Collagen Type V Alpha 2 Chain	Protein Coding	1
39	COL6A1	Collagen Type VI Alpha 1 Chain	Protein Coding	1
40	COL6A2	Collagen Type VI Alpha 2 Chain	Protein Coding	1
41	COL6A3	Collagen Type VI Alpha 3 Chain	Protein Coding	1
42	COL9A1	Collagen Type IX Alpha 1 Chain	Protein Coding	1
43	COL9A2	Collagen Type IX Alpha 2 Chain	Protein Coding	1
44	COL9A3	Collagen Type IX Alpha 3 Chain	Protein Coding	1
45	COL6A6	Collagen Type VI Alpha 6 Chain	Protein Coding	1
46	COL6A5	Collagen Type VI Alpha 5 Chain	Protein Coding	1
47	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
48	COL5A3	Collagen Type V Alpha 3 Chain	Protein Coding	1
49	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	1
50	PLG	Plasminogen	Protein Coding	1
51	PDGFC	Platelet Derived Growth Factor C	Protein Coding	1
52	PTPN12	Protein Tyrosine Phosphatase Non-Receptor Type 12	Protein Coding	1
53	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
54	THBS1	Thrombospondin 1	Protein Coding	1
55	THBS2	Thrombospondin 2	Protein Coding	1
56	THBS3	Thrombospondin 3	Protein Coding	1
57	THBS4	Thrombospondin 4	Protein Coding	1
58	PDGFD	Platelet Derived Growth Factor D	Protein Coding	1

Disorders associated with Signaling by PDGF SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, PTPN11, SOS1	9.96
2	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	9.22
3	Noonan syndrome 3	Enrichment	HRAS, KRAS, PTPN11, SOS1	9.22
4	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, PTPN11, SOS1	8.99
5	Rasopathy	Enrichment	HRAS, KRAS, NRAS, PTPN11, SOS1	8.71
6	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS, PIK3CA	8.26
7	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.45
8	Stickler syndrome	Enrichment	COL2A1, COL9A1, COL9A2, COL9A3	7.21
9	Multiple epiphyseal dysplasia due to collagen 9 anomaly	Enrichment	COL9A1, COL9A2, COL9A3	7.13
10	Collagen vi-related dystrophies	Enrichment	COL6A1, COL6A2, COL6A3	7.13
11	Intermediate collagen vi-related muscular dystrophy	Enrichment	COL6A1, COL6A2, COL6A3	7.13
12	Digenic alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	7.13
13	Autosomal recessive stickler syndrome	Enrichment	COL9A1, COL9A2, COL9A3	6.53
14	Bethlem muscular dystrophy	Enrichment	COL6A1, COL6A2, COL6A3	6.53
15	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA, RASA1	6.51
16	Arteriovenous malformation	Enrichment	HRAS, PIK3CA, RASA1	6.14
17	Alport syndrome 3a, autosomal dominant	Enrichment	COL4A3, COL4A4, COL4A5	6.13
18	Ullrich congenital muscular dystrophy 1a	Enrichment	COL6A1, COL6A2, COL6A3	6.13
19	Autosomal dominant alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	6.13
20	Alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	6.13
21	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA, RASA1	5.98
22	Ehlers-danlos syndrome	Enrichment	COL3A1, COL5A1, COL5A2, THBS2	5.95
23	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, PTPN11	5.72
24	Bethlem myopathy 1a	Enrichment	COL6A1, COL6A2, COL6A3	5.59
25	Intervertebral disc disease	Enrichment	COL9A2, COL9A3, THBS2	5.59
26	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.36
27	Connective tissue disease	Enrichment	COL2A1, COL5A1, COL9A1, COL9A3	5.00
28	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.88
29	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.88
30	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.58
31	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.58
32	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	4.51
33	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	4.51
34	Kidney disease	Enrichment	COL4A3, COL4A4, COL4A5	4.49
35	Colorectal cancer	Enrichment	NRAS, PIK3CA, PIK3R1, SRC	4.48
36	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS, PTPN11	4.42
37	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	4.36
38	Primary hypereosinophilic syndrome	Enrichment	PDGFRA, PDGFRB	4.36
39	Hematuria, benign familial, 1	Enrichment	COL4A3, COL4A4	4.27
40	Ehlers-danlos syndrome, classic type, 2	Enrichment	COL5A1, COL5A2	4.27
41	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	4.18
42	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	4.18
43	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	4.18
44	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.04
45	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.04
46	Gallbladder cancer	Enrichment	KRAS, PIK3CA	4.04
47	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.04
48	Brain small vessel disease 1 with or without ocular anomalies	Enrichment	COL4A1, COL4A2	3.97
49	Alport syndrome 2, autosomal recessive	Enrichment	COL4A3, COL4A4	3.97
50	Autosomal recessive alport syndrome	Enrichment	COL4A3, COL4A4	3.97
51	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	3.91
52	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	3.91
53	Retinal detachment	Enrichment	COL2A1, COL9A3	3.75
54	Familial porencephaly	Enrichment	COL4A1, COL4A2	3.75
55	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL5A1, COL5A2	3.57
56	Hemorrhage, intracerebral	Enrichment	COL4A1, COL4A2	3.57
57	Keratoconus	Enrichment	COL4A1, COL5A2	3.57
58	Classic ehlers-danlos syndrome	Enrichment	COL5A1, COL5A2	3.57
59	Meningioma	Enrichment	PDGFB, PIK3CA	3.54
60	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.54
61	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.47
62	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.34
63	Cerebral palsy	Enrichment	COL4A1, COL4A2, PDGFRB	3.22
64	Myopathy	Enrichment	COL6A1, COL6A2, COL6A3	3.18
65	Nephrotic syndrome	Enrichment	COL4A3, COL4A4, COL4A5	3.09
66	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL3A1, COL5A1, COL5A2	3.06
67	Ovarian cancer	Enrichment	KRAS, PDGFRA, PIK3CA	2.90
68	Chronic kidney disease	Enrichment	COL4A4, COL4A5	2.87
69	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.86
70	Myopia	Enrichment	COL2A1, COL4A4	2.74
71	Hypertension	Enrichment	COL4A4, COL4A5	2.68
72	Lung cancer	Enrichment	KRAS, PIK3CA	2.68
73	Macrodactyly	Enrichment	PIK3CA	2.67
74	Metachondromatosis	Enrichment	PTPN11	2.67
75	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.67
76	Oculoectodermal syndrome	Enrichment	KRAS	2.67
77	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.67
78	Noonan syndrome 4	Enrichment	SOS1	2.67
79	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	2.67
80	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.67
81	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.67
82	Leopard syndrome 1	Enrichment	PTPN11	2.67
83	Cowden syndrome 5	Enrichment	PIK3CA	2.67
84	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.67
85	Melanosis, neurocutaneous	Enrichment	NRAS	2.67
86	Noonan syndrome 6	Enrichment	NRAS	2.67
87	Gist-plus syndrome	Enrichment	PDGFRA	2.67
88	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.67
89	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.67
90	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.67
91	Short syndrome	Enrichment	PIK3R1	2.67
92	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.67
93	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	2.67
94	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.67
95	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.67
96	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.67
97	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.67
98	Immunodeficiency 31a	Enrichment	STAT1	2.67
99	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.67
100	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.67
101	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.67
102	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.67
103	Immunodeficiency 31b	Enrichment	STAT1	2.67
104	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.67
105	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.67
106	Thrombocytopenia 6	Enrichment	SRC	2.67
107	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.67
108	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.67
109	Hypospadias	Enrichment	PIK3CA	2.67
110	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.67
111	Congenital pulmonary airway malformation	Enrichment	KRAS	2.67
112	Rare venous malformation	Enrichment	PIK3CA	2.67
113	Gorham's disease	Enrichment	RASA1	2.67
114	Diaphragmatic eventration	Enrichment	PIK3CA	2.67
115	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.67
116	Rare combined vascular malformation	Enrichment	PIK3CA	2.67
117	Cavernous lymphangioma	Enrichment	PIK3CA	2.67
118	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.67
119	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.67
120	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.67
121	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.67
122	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.67
123	Macrodactyly of toe	Enrichment	PIK3CA	2.67
124	Neurocutaneous melanocytosis	Enrichment	NRAS	2.67
125	Malignant astrocytoma	Enrichment	PTPN11	2.67
126	Focal segmental glomerulosclerosis	Enrichment	COL4A4, COL4A5	2.49
127	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.49
128	Gastric cancer	Enrichment	KRAS, PIK3CA	2.42
129	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	2.40
130	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.37
131	Fibromatosis, gingival, 1	Enrichment	SOS1	2.37
132	Costello syndrome	Enrichment	HRAS	2.37
133	Hemangiopericytoma, malignant	Enrichment	STAT6	2.37
134	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.37
135	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.37
136	Pulmonic stenosis	Enrichment	SOS1	2.37
137	Keratosis, seborrheic	Enrichment	PIK3CA	2.37
138	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.37
139	Noonan syndrome 8	Enrichment	PIK3CA	2.37
140	Immunodeficiency 31c	Enrichment	STAT1	2.37
141	Werner syndrome	Enrichment	PTPN11	2.37
142	Infantile myofibromatosis	Enrichment	PDGFRB	2.37
143	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.37
144	Chronic eosinophilic leukemia	Enrichment	PDGFRA	2.37
145	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	2.37
146	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.37
147	Wooly hair nevus	Enrichment	HRAS	2.37
148	Stickler syndrome, type i	Enrichment	COL2A1	2.37
149	Epiphyseal dysplasia, multiple, with myopia and conductive deafness	Enrichment	COL2A1	2.37
150	Spondylometaphyseal dysplasia, algerian type	Enrichment	COL2A1	2.37
151	Alport syndrome 1, x-linked	Enrichment	COL4A5	2.37
152	Osteoarthritis with mild chondrodysplasia	Enrichment	COL2A1	2.37
153	Avascular necrosis of femoral head, primary, 1	Enrichment	COL2A1	2.37
154	Czech dysplasia	Enrichment	COL2A1	2.37
155	Kniest dysplasia	Enrichment	COL2A1	2.37
156	Platyspondylic lethal skeletal dysplasia, torrance type	Enrichment	COL2A1	2.37
157	Spondyloepiphyseal dysplasia, stanescu type	Enrichment	COL2A1	2.37
158	Acrogeria, gottron type	Enrichment	COL3A1	2.37
159	Epiphyseal dysplasia, multiple, 6	Enrichment	COL9A1	2.37
160	Achondrogenesis, type ii	Enrichment	COL2A1	2.37
161	Angioedema, hereditary, 4	Enrichment	PLG	2.37
162	Epiphyseal dysplasia, multiple, 2	Enrichment	COL9A2	2.37
163	Ullrich congenital muscular dystrophy 1b	Enrichment	COL6A2	2.37
164	Spondyloperipheral dysplasia	Enrichment	COL2A1	2.37
165	Myosclerosis, autosomal recessive	Enrichment	COL6A2	2.37
166	Porencephaly	Enrichment	COL4A1	2.37
167	Ullrich congenital muscular dystrophy 1c	Enrichment	COL6A3	2.37
168	Epiphyseal dysplasia, multiple, 3	Enrichment	COL9A3	2.37
169	Stickler syndrome, type i, nonsyndromic ocular	Enrichment	COL2A1	2.37
170	Stickler syndrome, type iv	Enrichment	COL9A1	2.37
171	Dystonia 27	Enrichment	COL6A3	2.37
172	Stickler syndrome, type v	Enrichment	COL9A2	2.37
173	Qualitative or quantitative defects of collagen 6	Enrichment	COL6A2	2.37
174	Vitreoretinopathy with phalangeal epiphyseal dysplasia	Enrichment	COL2A1	2.37
175	Bethlem myopathy 1b	Enrichment	COL6A2	2.37
176	Col4a1-related disorders	Enrichment	COL4A1	2.37
177	Bethlem myopathy 1c	Enrichment	COL6A3	2.37
178	Retinal lattice degeneration	Enrichment	COL9A3	2.37
179	Autosomal dominant rhegmatogenous retinal detachment	Enrichment	COL2A1	2.37
180	Col4a1 or col4a2-related cerebral small vessel disease	Enrichment	COL4A1	2.37
181	Multiple epiphyseal dysplasia with myopia and deafness	Enrichment	COL2A1	2.37
182	Hypochondrogenesis	Enrichment	COL2A1	2.37
183	X-linked alport syndrome	Enrichment	COL4A5	2.37
184	Pneumothorax	Enrichment	COL5A1	2.37
185	Dysspondyloenchondromatosis	Enrichment	COL2A1	2.37
186	Abdominal aortic aneurysm	Enrichment	COL3A1	2.37
187	Lethal hydranencephaly-diaphragmatic hernia syndrome	Enrichment	PLAT	2.37
188	Type 2 collagen-related bone disorder	Enrichment	COL2A1	2.37
189	Scoliosis	Enrichment	COL2A1, PTPN11	2.33
190	Thrombocytopenia	Enrichment	PTPN11, SRC	2.33
191	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1, KRAS	2.21
192	Myeloma, multiple	Enrichment	KRAS, PIK3R2	2.20
193	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.19
194	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.19
195	Nuchal bleb, familial	Enrichment	SOS1	2.19
196	Langerhans cell histiocytosis	Enrichment	NRAS	2.19
197	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.19
198	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.19
199	Hyper ige syndrome	Enrichment	STAT3	2.19
200	Wieacker-wolff syndrome	Enrichment	RASA1	2.19
201	Immunodeficiency 14	Enrichment	PIK3R1	2.19
202	Spermatocytoma	Enrichment	HRAS	2.19
203	Tricuspid valve insufficiency	Enrichment	PTPN11	2.19
204	Keratoacanthoma	Enrichment	PIK3CA	2.19
205	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.07
206	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.07
207	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL	2.07
208	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.07
209	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.07
210	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.07
211	Cerebrovascular disease	Enrichment	PIK3CA	2.07
212	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.07
213	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.07
214	Pilocytic astrocytoma	Enrichment	KRAS	2.07
215	Epidermolytic nevus	Enrichment	HRAS	2.07
216	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.07
217	Gingival fibromatosis	Enrichment	SOS1	2.07
218	Ehlers-danlos syndrome, vascular type	Enrichment	COL3A1	2.07
219	Ehlers-danlos syndrome, hypermobility type	Enrichment	COL3A1	2.07
220	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	COL2A1	2.07
221	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	COL2A1	2.07
222	Plasminogen deficiency, type i	Enrichment	PLG	2.07
223	Otospondylomegaepiphyseal dysplasia, autosomal recessive	Enrichment	COL2A1	2.07
224	Legg-calve-perthes disease	Enrichment	COL2A1	2.07
225	Specific language impairment 5	Enrichment	COL4A4	2.07
226	Otospondylomegaepiphyseal dysplasia, autosomal dominant	Enrichment	COL2A1	2.07
227	Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1	Enrichment	COL4A2	2.07
228	Stickler syndrome, type vi	Enrichment	COL9A3	2.07
229	Fibromuscular dysplasia, multifocal	Enrichment	COL5A1	2.07
230	Polymicrogyria with or without vascular-type ehlers-danlos syndrome	Enrichment	COL3A1	2.07
231	Aortic dissection	Enrichment	COL3A1	2.07
232	Glomerulonephritis	Enrichment	COL4A4	2.07
233	Hereditary angioedema	Enrichment	PLG	2.07
234	Familial avascular necrosis of the femoral head	Enrichment	COL2A1	2.07
235	X-linked diffuse leiomyomatosis-alport syndrome	Enrichment	COL4A5	2.07
236	Lymphoma	Enrichment	PTPN11	1.97
237	Hemimegalencephaly	Enrichment	PIK3CA	1.97
238	Breast cancer	Enrichment	KRAS, PIK3CA	1.95
239	Cowden syndrome 1	Enrichment	PIK3CA	1.89
240	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.89
241	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.89
242	Hemangioma, capillary infantile	Enrichment	RASA1	1.89
243	Basal cell carcinoma 1	Enrichment	RASA1	1.89
244	Patent ductus arteriosus	Enrichment	PTPN11	1.89
245	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.89
246	Mccune-albright syndrome	Enrichment	COL2A1	1.89
247	Retinal arteries, tortuosity of	Enrichment	COL4A1	1.89
248	Angioedema, hereditary, 1	Enrichment	PLG	1.89
249	Spondyloepiphyseal dysplasia congenita	Enrichment	COL2A1	1.89
250	Telecanthus	Enrichment	COL5A2	1.89
251	Brain small vessel disease 2	Enrichment	COL4A2	1.89
252	Microangiopathy and leukoencephalopathy, pontine, autosomal dominant	Enrichment	COL4A1	1.89
253	Pilarowski-bjornsson syndrome	Enrichment	COL4A3	1.89
254	Alport syndrome 3b, autosomal recessive	Enrichment	COL4A3	1.89
255	Ehlers-danlos syndrome, classic-like, 3	Enrichment	THBS2	1.89
256	Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps	Enrichment	COL4A1	1.89
257	Hematuria, benign familial, 2	Enrichment	COL4A3	1.89
258	Multiple epiphyseal dysplasia	Enrichment	COL2A1	1.89
259	Myelofibrosis	Enrichment	SRC	1.83
260	Gastrointestinal stromal tumor	Enrichment	PDGFRA	1.83
261	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.83
262	Pilomyxoid astrocytoma	Enrichment	KRAS	1.83
263	Overgrowth syndrome	Enrichment	PIK3R1	1.83
264	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.77
265	Schizencephaly	Enrichment	COL4A1	1.77
266	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.77
267	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.72
268	Cowden syndrome	Enrichment	PIK3CA	1.72
269	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.67
270	Familial cerebral saccular aneurysm	Enrichment	COL3A1	1.67
271	Pectus excavatum	Enrichment	PTPN11	1.63
272	Meningioma, familial	Enrichment	PDGFB	1.63
273	Specific learning disability	Enrichment	PTPN11	1.63
274	Epicanthus	Enrichment	PTPN11	1.60
275	Congenital long qt syndrome	Enrichment	PTPN11	1.60
276	Developmental dysplasia of the hip 1	Enrichment	COL2A1	1.60
277	Anterior segment dysgenesis 5	Enrichment	COL4A1	1.60
278	Inguinal hernia	Enrichment	COL5A1	1.60
279	Pain disorder	Enrichment	COL5A1	1.60
280	Aortic valve disease 1	Enrichment	SOS1	1.56
281	Protein-deficiency anemia	Enrichment	NRAS	1.56
282	Nk-cell enteropathy	Enrichment	PIK3CB	1.56
283	Osteoporosis	Enrichment	SRC	1.53
284	Lung cancer susceptibility 3	Enrichment	KRAS	1.53
285	Cleft lip/palate	Enrichment	PDGFRA	1.53
286	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.53
287	Multiple enchondromatosis, maffucci type	Enrichment	COL2A1	1.53
288	Hydrocephalus	Enrichment	PDGFRB	1.50
289	Inherited cancer-predisposing syndrome	Enrichment	PDGFRA, PTPN11	1.49
290	Rhabdomyosarcoma	Enrichment	HRAS	1.47
291	Gastroesophageal reflux	Enrichment	COL5A1	1.47
292	Spastic paraplegia 4, autosomal dominant	Enrichment	COL3A1	1.47
293	Orthostatic intolerance	Enrichment	COL5A1	1.47
294	Dandy-walker syndrome	Enrichment	PDGFRB	1.45
295	Patent foramen ovale	Enrichment	PTPN11	1.42
296	Familial thoracic aortic aneurysm and dissection	Enrichment	COL3A1	1.42
297	Arteriovenous malformations of the brain	Enrichment	KRAS	1.40
298	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.40
299	Marfan syndrome	Enrichment	COL2A1	1.38
300	Peters-plus syndrome	Enrichment	COL4A1	1.38
301	Endometrial cancer	Enrichment	PIK3CA	1.36
302	Hepatocellular carcinoma	Enrichment	PIK3CA	1.34
303	Cutis laxa	Enrichment	COL5A1	1.30
304	Pancreatic cancer	Enrichment	KRAS	1.28
305	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	COL5A1	1.27
306	Clubfoot	Enrichment	COL5A1	1.27
307	Strabismus	Enrichment	PTPN11	1.25
308	Aortic aneurysm, familial thoracic 1	Enrichment	COL3A1	1.23
309	Walker-warburg syndrome	Enrichment	COL4A1	1.23
310	Cataract	Enrichment	COL5A1	1.23
311	Isolated macular dystrophy	Enrichment	COL4A5	1.23
312	Prostate cancer	Enrichment	PIK3CA	1.22
313	Long qt syndrome 1	Enrichment	PTPN11	1.21
314	Corpus callosum, agenesis of	Enrichment	COL4A1	1.21
315	Anterior segment dysgenesis	Enrichment	COL4A1	1.21
316	Atypical hemolytic-uremic syndrome	Enrichment	COL4A5	1.21
317	Isolated corpus callosum agenesis	Enrichment	COL4A1	1.21
318	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	COL4A1	1.21
319	Beckwith-wiedemann syndrome	Enrichment	COL6A1	1.13
320	Heart, malformation of	Enrichment	COL2A1	1.13
321	Polycystic kidney disease	Enrichment	COL4A4	1.13
322	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.06
323	Microcephaly	Enrichment	COL4A1, PTPN11	1.01
324	Muscular dystrophy	Enrichment	COL6A2	1.01
325	Hypertelorism	Enrichment	PIK3CA	0.98
326	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.95
327	Stargardt disease 1	Enrichment	COL2A1	0.92
328	Cystic fibrosis	Enrichment	PLG	0.89
329	Cakut	Enrichment	COL4A1	0.87
330	Genetic steroid-resistant nephrotic syndrome	Enrichment	COL4A3	0.87
331	Systemic lupus erythematosus	Enrichment	SPP1	0.81
332	Sensorineural hearing loss	Enrichment	COL9A1	0.73
333	Autism spectrum disorder	Enrichment	PTPN11	0.68
334	Primary ovarian insufficiency	Enrichment	THBS1	0.65
335	Rare genetic deafness	Enrichment	COL4A5	0.54
336	Hereditary retinal dystrophy	Enrichment	COL2A1, COL9A1	0.45
337	Fundus dystrophy	Enrichment	COL2A1, COL9A1	0.45

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by PDGF

Pathway Network for Signaling by PDGF

Member Pathways for Signaling by PDGF

Pathways in the Signaling by PDGF SuperPath

Associated Genes for Signaling by PDGF

Associated Disorders for Signaling by PDGF

Disorders associated with Signaling by PDGF SuperPath

STRING Interaction Network for Signaling by PDGF

Sources for Signaling by PDGF