Signaling by PDGFR in disease

Pathway network for the Signaling by PDGFR in disease SuperPath

Sources:

Reactome

Pathways in the Signaling by PDGFR in disease SuperPath

#	Name	Source	Genes
1	Signaling by PDGFR in disease	Reactome	BIN2 ETV6 FIP1L1 GOLGA4 GRB2 HRAS KANK1 KDR KRAS NRAS PDGFRA PIK3CA PIK3CB PIK3R1 PIK3R2 SOS1 STAT1 STAT3 STRN WDR48 (see all 20) (see less)
2	Signaling by PDGFRA extracellular domain mutants	Reactome	GRB2 HRAS KRAS NRAS PDGFRA PIK3CA PIK3CB PIK3R1 PIK3R2 SOS1 STAT1 STAT3 (see all 12) (see less)
3	Signaling by LTK	Reactome	ALKAL1 ALKAL2 GRB2 IRS1 LTK PIK3CA PIK3CB PIK3R1 PIK3R2 SHC1 SOS1 TNK2 (see all 12) (see less)
4	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	Reactome	GRB2 HRAS KRAS NRAS PDGFRA PIK3CA PIK3CB PIK3R1 PIK3R2 SOS1 STAT1 STAT3 (see all 12) (see less)
5	Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	Reactome	BIN2 ETV6 GOLGA4 KANK1 KDR
6	Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	Reactome	FIP1L1 STRN WDR48

Gene overlap in member pathways for Signaling by PDGFR in disease SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	4
2	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	4
3	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	4
4	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	4
5	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	4
6	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	4
7	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
8	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	3
9	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	3
10	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	3
11	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	3
12	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	3
13	ETV6	ETS Variant Transcription Factor 6	Protein Coding	2
14	KANK1	KN Motif And Ankyrin Repeat Domains 1	Protein Coding	2
15	GOLGA4	Golgin A4	Protein Coding	2
16	KDR	Kinase Insert Domain Receptor	Protein Coding	2
17	BIN2	Bridging Integrator 2	Protein Coding	2
18	WDR48	WD Repeat Domain 48	Protein Coding	2
19	STRN	Striatin	Protein Coding	2
20	FIP1L1	Factor Interacting With PAPOLA And CPSF1	Protein Coding	2
21	TNK2	Tyrosine Kinase Non Receptor 2	Protein Coding	1
22	ALKAL2	ALK And LTK Ligand 2	Protein Coding	1
23	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
24	ALKAL1	ALK And LTK Ligand 1	Protein Coding	1
25	LTK	Leukocyte Receptor Tyrosine Kinase	Protein Coding	1
26	SHC1	SHC Adaptor Protein 1	Protein Coding	1

Disorders associated with Signaling by PDGFR in disease SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	10.51
2	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS, PIK3CA	9.91
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	9.31
4	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	8.67
5	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1	8.51
6	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1	8.28
7	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	7.73
8	Primary hypereosinophilic syndrome	Enrichment	ETV6, FIP1L1, PDGFRA	7.56
9	Differentiated thyroid carcinoma	Enrichment	ETV6, HRAS, KRAS, NRAS	7.10
10	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.14
11	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	5.72
12	Chronic eosinophilic leukemia	Enrichment	FIP1L1, PDGFRA	5.69
13	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.67
14	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.67
15	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	5.37
16	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.37
17	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	4.97
18	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	4.97
19	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.82
20	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	4.82
21	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.82
22	Gallbladder cancer	Enrichment	KRAS, PIK3CA	4.82
23	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.82
24	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.70
25	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	4.59
26	Leukemia, acute myeloid	Enrichment	ETV6, KRAS, NRAS	4.58
27	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	4.49
28	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	4.33
29	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	4.33
30	Colorectal cancer	Enrichment	NRAS, PIK3CA, PIK3R1	4.27
31	Lynch syndrome	Enrichment	KRAS, PIK3CA	4.13
32	Ovarian cancer	Enrichment	KRAS, PDGFRA, PIK3CA	4.08
33	Acute promyelocytic leukemia	Enrichment	FIP1L1, STAT3	3.80
34	Autosomal recessive spastic paraplegia type 60	Enrichment	WDR48	3.66
35	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	3.48
36	Diffuse large b-cell lymphoma	Enrichment	ETV6, STAT3	3.46
37	Lung cancer	Enrichment	KRAS, PIK3CA	3.46
38	Cerebral palsy, spastic quadriplegic, 2	Enrichment	KANK1	3.43
39	Tufted angioma of skin	Enrichment	KDR	3.43
40	B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1)	Enrichment	ETV6	3.43
41	Gastric cancer	Enrichment	KRAS, PIK3CA	3.20
42	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	3.18
43	Angioma, tufted	Enrichment	KDR	3.13
44	Hematologic cancer	Enrichment	ETV6	3.13
45	Congenital mesoblastic nephroma	Enrichment	ETV6	3.13
46	Fibrosarcoma	Enrichment	ETV6	3.13
47	Macrodactyly	Enrichment	PIK3CA	3.05
48	Oculoectodermal syndrome	Enrichment	KRAS	3.05
49	Noonan syndrome 4	Enrichment	SOS1	3.05
50	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	3.05
51	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	3.05
52	Cowden syndrome 5	Enrichment	PIK3CA	3.05
53	Melanosis, neurocutaneous	Enrichment	NRAS	3.05
54	Noonan syndrome 6	Enrichment	NRAS	3.05
55	Gist-plus syndrome	Enrichment	PDGFRA	3.05
56	Cerebral cavernous malformations 4	Enrichment	PIK3CA	3.05
57	Short syndrome	Enrichment	PIK3R1	3.05
58	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	3.05
59	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.05
60	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.05
61	Hemifacial myohyperplasia	Enrichment	PIK3CA	3.05
62	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	3.05
63	Immunodeficiency 31a	Enrichment	STAT1	3.05
64	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	3.05
65	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	3.05
66	Immunodeficiency 31b	Enrichment	STAT1	3.05
67	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.05
68	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	3.05
69	Hypospadias	Enrichment	PIK3CA	3.05
70	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.05
71	Congenital pulmonary airway malformation	Enrichment	KRAS	3.05
72	Rare venous malformation	Enrichment	PIK3CA	3.05
73	Diaphragmatic eventration	Enrichment	PIK3CA	3.05
74	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	3.05
75	Rare combined vascular malformation	Enrichment	PIK3CA	3.05
76	Cavernous lymphangioma	Enrichment	PIK3CA	3.05
77	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	3.05
78	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.05
79	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	3.05
80	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.05
81	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	3.05
82	Macrodactyly of toe	Enrichment	PIK3CA	3.05
83	Neurocutaneous melanocytosis	Enrichment	NRAS	3.05
84	Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression	Enrichment	TNK2	3.05
85	Myeloma, multiple	Enrichment	KRAS, PIK3R2	2.97
86	Thrombocytopenia 5	Enrichment	ETV6	2.96
87	Chronic myelomonocytic leukemia	Enrichment	ETV6	2.83
88	Spastic quadriplegic cerebral palsy	Enrichment	KANK1	2.83
89	Fibromatosis, gingival, 1	Enrichment	SOS1	2.75
90	Costello syndrome	Enrichment	HRAS	2.75
91	Pulmonic stenosis	Enrichment	SOS1	2.75
92	Keratosis, seborrheic	Enrichment	PIK3CA	2.75
93	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.75
94	Noonan syndrome 8	Enrichment	PIK3CA	2.75
95	Immunodeficiency 31c	Enrichment	STAT1	2.75
96	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.75
97	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	2.75
98	Wooly hair nevus	Enrichment	HRAS	2.75
99	Autosomal thrombocytopenia with normal platelets	Enrichment	ETV6	2.73
100	Breast cancer	Enrichment	KRAS, PIK3CA	2.72
101	Hemangioma, capillary infantile	Enrichment	KDR	2.66
102	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.58
103	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.58
104	Nuchal bleb, familial	Enrichment	SOS1	2.58
105	Langerhans cell histiocytosis	Enrichment	NRAS	2.58
106	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.58
107	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.58
108	Hyper ige syndrome	Enrichment	STAT3	2.58
109	Immunodeficiency 14	Enrichment	PIK3R1	2.58
110	Spermatocytoma	Enrichment	HRAS	2.58
111	Keratoacanthoma	Enrichment	PIK3CA	2.58
112	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.45
113	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.45
114	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.45
115	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.45
116	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.45
117	Cerebrovascular disease	Enrichment	PIK3CA	2.45
118	Pilocytic astrocytoma	Enrichment	KRAS	2.45
119	Epidermolytic nevus	Enrichment	HRAS	2.45
120	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.45
121	Gingival fibromatosis	Enrichment	SOS1	2.45
122	Leukemia, acute lymphoblastic	Enrichment	ETV6	2.39
123	Capillary malformations, congenital	Enrichment	PIK3CA	2.35
124	Hemimegalencephaly	Enrichment	PIK3CA	2.35
125	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.28
126	Cowden syndrome 1	Enrichment	PIK3CA	2.28
127	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.28
128	Chronic mucocutaneous candidiasis	Enrichment	STAT1	2.28
129	Hermansky-pudlak syndrome 1	Enrichment	ETV6	2.23
130	Gastrointestinal stromal tumor	Enrichment	PDGFRA	2.21
131	Pilomyxoid astrocytoma	Enrichment	KRAS	2.21
132	Overgrowth syndrome	Enrichment	PIK3R1	2.21
133	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.15
134	Adult hepatocellular carcinoma	Enrichment	PIK3CA	2.10
135	Cowden syndrome	Enrichment	PIK3CA	2.10
136	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	2.05
137	Tetralogy of fallot	Enrichment	KDR	2.02
138	Meningioma	Enrichment	PIK3CA	1.98
139	Aortic valve disease 1	Enrichment	SOS1	1.94
140	Protein-deficiency anemia	Enrichment	NRAS	1.94
141	Nk-cell enteropathy	Enrichment	PIK3CB	1.94
142	Lung cancer susceptibility 3	Enrichment	KRAS	1.91
143	Cleft lip/palate	Enrichment	PDGFRA	1.91
144	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.91
145	Rhabdomyosarcoma	Enrichment	HRAS	1.85
146	Arteriovenous malformations of the brain	Enrichment	KRAS	1.78
147	Parkinson's disease	Enrichment	TNK2	1.78
148	Thrombocytopenia	Enrichment	ETV6	1.76
149	Endometrial cancer	Enrichment	PIK3CA	1.73
150	Hepatocellular carcinoma	Enrichment	PIK3CA	1.71
151	Primary ovarian insufficiency	Enrichment	KDR	1.67
152	Pancreatic cancer	Enrichment	KRAS	1.66
153	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.64
154	Prostate cancer	Enrichment	PIK3CA	1.60
155	Type 2 diabetes mellitus	Enrichment	IRS1	1.44
156	Hypertelorism	Enrichment	PIK3CA	1.35
157	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.32
158	Inherited cancer-predisposing syndrome	Enrichment	PDGFRA	0.96

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by PDGFR in disease

Pathway Network for Signaling by PDGFR in disease

Pathway network for the Signaling by PDGFR in disease SuperPath

Member Pathways for Signaling by PDGFR in disease

Pathways in the Signaling by PDGFR in disease SuperPath

Gene overlap in member pathways for Signaling by PDGFR in disease SuperPath

Associated Genes for Signaling by PDGFR in disease

Associated Disorders for Signaling by PDGFR in disease

Disorders associated with Signaling by PDGFR in disease SuperPath

STRING Interaction Network for Signaling by PDGFR in disease

Sources for Signaling by PDGFR in disease