Signaling by PTK6

Pathway network for the Signaling by PTK6 SuperPath

Sources:

Reactome

Pathways in the Signaling by PTK6 SuperPath

#	Name	Source	Genes
1	Signaling by PTK6	Reactome	AKT1 ARAP1 ARHGAP35 BCAR1 BTC CBL CCND1 CCNE1 CDK2 CDK4 CDKN1B CRK DOCK1 DOK1 EGF EGFR ELMO1 ELMO2 EPAS1 ERBB2 ERBB3 ERBB4 EREG GPNMB HBEGF HIF1A HRAS KHDRBS1 KHDRBS2 KHDRBS3 KRAS LRRK2 NR3C1 NRAS NRG1 NRG2 NRG3 NRG4 PELP1 PTK6 PTPN1 PXN RAC1 RASA1 RHOA RPS27A SFPQ SOCS3 SRMS STAP2 STAT3 UBA52 UBB UBC (see all 54) (see less)
2	Signaling by Non-Receptor Tyrosine Kinases	Reactome	AKT1 ARAP1 ARHGAP35 BCAR1 BTC CBL CCND1 CCNE1 CDK2 CDK4 CDKN1B CRK DOCK1 DOK1 EGF EGFR ELMO1 ELMO2 EPAS1 ERBB2 ERBB3 ERBB4 EREG GPNMB HBEGF HIF1A HRAS KHDRBS1 KHDRBS2 KHDRBS3 KRAS LRRK2 NR3C1 NRAS NRG1 NRG2 NRG3 NRG4 PELP1 PTK6 PTPN1 PXN RAC1 RASA1 RHOA RPS27A SFPQ SOCS3 SRMS STAP2 STAT3 UBA52 UBB UBC (see all 54) (see less)
3	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Reactome	ARHGAP35 BCAR1 CRK DOCK1 ELMO1 ELMO2 HRAS KRAS NRAS PTK6 PXN RAC1 RASA1 RHOA (see all 14) (see less)
4	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	Reactome	AKT1 ARAP1 CBL DOK1 PTK6 RPS27A UBA52 UBB UBC (see all 9) (see less)
5	PTK6 promotes HIF1A stabilization	Reactome	EGFR GPNMB HBEGF HIF1A LRRK2 PTK6 (see all 6) (see less)
6	PTK6 Regulates Proteins Involved in RNA Processing	Reactome	KHDRBS1 KHDRBS2 KHDRBS3 PTK6 SFPQ
7	PTK6 Expression	Reactome	EPAS1 HIF1A NR3C1 PELP1 PTK6
8	PTK6 Activates STAT3	Reactome	PTK6 SOCS3 STAP2 STAT3
9	PTK6 Down-Regulation	Reactome	PTK6 PTPN1 SRMS

Gene overlap in member pathways for Signaling by PTK6 SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PTK6	Protein Tyrosine Kinase 6	Protein Coding	9
2	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	4
3	GPNMB	Glycoprotein Nmb	Protein Coding	3
4	KHDRBS3	KH RNA Binding Domain Containing, Signal Transduction Associated 3	Protein Coding	3
5	KHDRBS1	KH RNA Binding Domain Containing, Signal Transduction Associated 1	Protein Coding	3
6	ARAP1	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1	Protein Coding	3
7	LRRK2	Leucine Rich Repeat Kinase 2	Protein Coding	3
8	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	3
9	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	3
10	DOK1	Docking Protein 1	Protein Coding	3
11	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	3
12	EGFR	Epidermal Growth Factor Receptor	Protein Coding	3
13	KHDRBS2	KH RNA Binding Domain Containing, Signal Transduction Associated 2	Protein Coding	3
14	EPAS1	Endothelial PAS Domain Protein 1	Protein Coding	3
15	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
16	PELP1	Proline, Glutamate And Leucine Rich Protein 1	Protein Coding	3
17	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	3
18	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	3
19	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
20	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	3
21	RHOA	Ras Homolog Family Member A	Protein Coding	3
22	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	3
23	STAP2	Signal Transducing Adaptor Family Member 2	Protein Coding	3
24	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	3
25	PXN	Paxillin	Protein Coding	3
26	RAC1	Rac Family Small GTPase 1	Protein Coding	3
27	RASA1	RAS P21 Protein Activator 1	Protein Coding	3
28	RPS27A	Ribosomal Protein S27a	Protein Coding	3
29	ELMO2	Engulfment And Cell Motility 2	Protein Coding	3
30	SFPQ	Splicing Factor Proline And Glutamine Rich	Protein Coding	3
31	SRMS	Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-Terminal Myristylation Sites	Protein Coding	3
32	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	3
33	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
34	UBB	Ubiquitin B	Protein Coding	3
35	UBC	Ubiquitin C	Protein Coding	3
36	CBL	Cbl Proto-Oncogene	Protein Coding	3
37	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	3
38	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	3
39	ELMO1	Engulfment And Cell Motility 1	Protein Coding	3
40	CDK2	Cyclin Dependent Kinase 2	Protein Coding	2
41	CDK4	Cyclin Dependent Kinase 4	Protein Coding	2
42	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	2
43	NRG3	Neuregulin 3	Protein Coding	2
44	NRG4	Neuregulin 4	Protein Coding	2
45	EGF	Epidermal Growth Factor	Protein Coding	2
46	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	2
47	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	2
48	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	2
49	EREG	Epiregulin	Protein Coding	2
50	NRG1	Neuregulin 1	Protein Coding	2
51	CCND1	Cyclin D1	Protein Coding	2
52	BTC	Betacellulin	Protein Coding	2
53	CCNE1	Cyclin E1	Protein Coding	2
54	NRG2	Neuregulin 2	Protein Coding	2

Disorders associated with Signaling by PTK6 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung non-small cell carcinoma	Enrichment	EGFR, ERBB2, HRAS, KRAS, NRAS	9.43
2	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	8.45
3	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	7.51
4	Bladder cancer	Enrichment	EGFR, ERBB2, ERBB3, HRAS, KRAS	7.04
5	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, HRAS, KRAS, NRAS	6.53
6	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.00
7	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS	5.81
8	Rasopathy	Enrichment	HRAS, KRAS, NRAS	5.65
9	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.53
10	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	5.50
11	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.23
12	Juvenile myelomonocytic leukemia	Enrichment	CBL, KRAS, NRAS	4.89
13	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.68
14	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, RASA1	4.68
15	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.68
16	Noonan syndrome 3	Enrichment	HRAS, KRAS	4.68
17	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.68
18	Lung cancer susceptibility 3	Enrichment	EGFR, ERBB2, KRAS	4.68
19	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.56
20	Arteriovenous malformation	Enrichment	HRAS, RASA1	4.45
21	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, RASA1	4.35
22	Ovarian cancer	Enrichment	AKT1, CDKN1B, EGFR, ERBB2, KRAS	4.31
23	Hirschsprung disease 1	Enrichment	ERBB2, ERBB3, NRG3	3.69
24	Breast adenocarcinoma	Enrichment	AKT1, KRAS	3.64
25	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS	3.64
26	Lung cancer	Enrichment	EGFR, ERBB2, KRAS	3.56
27	Dermatitis, atopic, 4	Enrichment	SOCS3	3.53
28	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.53
29	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.53
30	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.53
31	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.53
32	Glucocorticoid resistance, generalized	Enrichment	NR3C1	3.43
33	Erythrocytosis, familial, 4	Enrichment	EPAS1	3.43
34	Multiple paragangliomas associated with polycythemia	Enrichment	EPAS1	3.43
35	Colorectal cancer	Enrichment	AKT1, CCND1, ERBB2, NRAS	3.41
36	Amyloidosis, primary localized cutaneous, 3	Enrichment	GPNMB	3.35
37	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	3.34
38	Gastric cancer	Enrichment	CDK4, ERBB2, KRAS	3.18
39	Proteus syndrome	Enrichment	AKT1	3.18
40	Cowden syndrome 6	Enrichment	AKT1	3.18
41	Galactosemia ii	Enrichment	NR3C1	3.13
42	Erythrocytosis, familial, 3	Enrichment	EPAS1	3.13
43	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	3.12
44	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	3.05
45	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	3.05
46	Hyper ige syndrome	Enrichment	STAT3	3.05
47	Parkinson disease 8, autosomal dominant	Enrichment	LRRK2	3.05
48	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS	3.00
49	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.99
50	Ramon syndrome	Enrichment	ELMO2	2.99
51	Oculoectodermal syndrome	Enrichment	KRAS	2.99
52	Melanosis, neurocutaneous	Enrichment	NRAS	2.99
53	Noonan syndrome 6	Enrichment	NRAS	2.99
54	Vascular malformation, primary intraosseous	Enrichment	ELMO2	2.99
55	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.99
56	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.99
57	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.99
58	Primary intraosseous venous malformation	Enrichment	ELMO2	2.99
59	Congenital pulmonary airway malformation	Enrichment	KRAS	2.99
60	Gorham's disease	Enrichment	RASA1	2.99
61	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.99
62	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.99
63	Neurocutaneous melanocytosis	Enrichment	NRAS	2.99
64	Temporomandibular joint anomaly	Enrichment	DOCK1	2.99
65	Enchondromatosis	Enrichment	HIF1A	2.96
66	Klippel-feil syndrome 1, autosomal dominant	Enrichment	LRRK2	2.88
67	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.88
68	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.88
69	Ovarian germ cell cancer	Enrichment	CBL	2.88
70	Myopia 28, autosomal recessive	Enrichment	DOK1	2.88
71	Malignant germ cell tumor of ovary	Enrichment	CBL	2.88
72	Submucosal cleft palate	Enrichment	UBB	2.88
73	Cleft hard palate	Enrichment	UBB	2.88
74	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1, KRAS	2.85
75	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.74
76	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	2.73
77	Uvula, bifid	Enrichment	UBB	2.70
78	Cleft soft palate	Enrichment	UBB	2.70
79	Costello syndrome	Enrichment	HRAS	2.69
80	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.69
81	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.69
82	Wooly hair nevus	Enrichment	HRAS	2.69
83	Autosomal dominant secondary polycythemia	Enrichment	EPAS1	2.66
84	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	EPAS1	2.66
85	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.63
86	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	2.59
87	Renal cell carcinoma with mit translocations	Enrichment	SFPQ	2.59
88	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	2.59
89	Machado-joseph disease	Enrichment	LRRK2	2.58
90	Cowden syndrome 1	Enrichment	EGFR	2.58
91	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	2.58
92	Squamous cell carcinoma, head and neck	Enrichment	EGFR	2.51
93	Langerhans cell histiocytosis	Enrichment	NRAS	2.51
94	Wieacker-wolff syndrome	Enrichment	RASA1	2.51
95	Spermatocytoma	Enrichment	HRAS	2.51
96	Myeloproliferative neoplasm	Enrichment	CBL	2.48
97	Aggressive systemic mastocytosis	Enrichment	CBL	2.48
98	Primary hyperaldosteronism	Enrichment	NR3C1	2.48
99	Acute promyelocytic leukemia	Enrichment	STAT3	2.42
100	Autosomal dominant cerebellar ataxia	Enrichment	LRRK2	2.40
101	Erythroleukemia, familial	Enrichment	ERBB3	2.40
102	Paget disease, extramammary	Enrichment	ERBB2	2.40
103	Hypomagnesemia 4, renal	Enrichment	EGF	2.40
104	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.40
105	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	2.40
106	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.40
107	Neuroendocrine tumor	Enrichment	CDKN1B	2.40
108	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	2.40
109	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.40
110	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.40
111	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.38
112	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.38
113	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.38
114	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.38
115	Pilocytic astrocytoma	Enrichment	KRAS	2.38
116	Epidermolytic nevus	Enrichment	HRAS	2.38
117	Capillary malformations, congenital	Enrichment	RASA1	2.29
118	Martsolf syndrome 1	Enrichment	ARHGAP35	2.29
119	Early-onset parkinson's disease	Enrichment	LRRK2	2.28
120	Diffuse large b-cell lymphoma	Enrichment	STAT3	2.25
121	Cowden syndrome	Enrichment	AKT1	2.22
122	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	2.21
123	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	2.21
124	Hemihyperplasia, isolated	Enrichment	RHOA	2.21
125	Hemangioma, capillary infantile	Enrichment	RASA1	2.21
126	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	2.21
127	Basal cell carcinoma 1	Enrichment	RASA1	2.21
128	Gliosarcoma	Enrichment	EGFR	2.15
129	Gallbladder cancer	Enrichment	KRAS	2.14
130	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	2.14
131	Pilomyxoid astrocytoma	Enrichment	KRAS	2.14
132	Giant cell glioblastoma	Enrichment	EGFR	2.13
133	Meningioma	Enrichment	AKT1	2.10
134	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	2.10
135	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.10
136	Parkinson's disease	Enrichment	LRRK2	2.08
137	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.03
138	Type 2 diabetes mellitus	Enrichment	PTPN1	2.03
139	Peters-plus syndrome	Enrichment	ARHGAP35	1.99
140	Parkinson disease, late-onset	Enrichment	LRRK2	1.98
141	Dedifferentiated liposarcoma	Enrichment	CDK4	1.92
142	Well-differentiated liposarcoma	Enrichment	CDK4	1.92
143	Hereditary breast carcinoma	Enrichment	AKT1, KRAS	1.88
144	Protein-deficiency anemia	Enrichment	NRAS	1.87
145	Lynch syndrome	Enrichment	KRAS	1.81
146	Inherited cancer-predisposing syndrome	Enrichment	CDK4, CDKN1B, EGFR	1.81
147	Barrett esophagus	Enrichment	ERBB2	1.80
148	Mantle cell lymphoma	Enrichment	CCND1	1.80
149	Primary hyperparathyroidism	Enrichment	CDKN1B	1.80
150	Von hippel-lindau syndrome	Enrichment	CCND1	1.70
151	Myeloma, multiple	Enrichment	CCND1, KRAS	1.68
152	Primary ovarian insufficiency	Enrichment	KHDRBS1	1.67
153	Pancreatic cancer	Enrichment	KRAS	1.59
154	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.58
155	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.56
156	Glioma susceptibility 1	Enrichment	ERBB2	1.50
157	Adult hepatocellular carcinoma	Enrichment	EGF	1.45
158	Breast cancer	Enrichment	AKT1, KRAS	1.45
159	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.41
160	Nk-cell enteropathy	Enrichment	ERBB4	1.30
161	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.18
162	Autosomal dominant non-syndromic intellectual disability	Enrichment	ERBB4	0.74
163	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ERBB4	0.68

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by PTK6

Pathway Network for Signaling by PTK6

Pathway network for the Signaling by PTK6 SuperPath

Member Pathways for Signaling by PTK6

Pathways in the Signaling by PTK6 SuperPath

Gene overlap in member pathways for Signaling by PTK6 SuperPath

Associated Genes for Signaling by PTK6

Associated Disorders for Signaling by PTK6

Disorders associated with Signaling by PTK6 SuperPath

STRING Interaction Network for Signaling by PTK6

Sources for Signaling by PTK6