Signaling by Retinoic Acid

No Pathway Network information available for Signaling by Retinoic Acid

Pathways in the Signaling by Retinoic Acid SuperPath

#	Name	Source	Genes
1	Signaling by Retinoic Acid	Reactome	ADH1A ADH1C ADH4 AKR1C3 ALDH1A1 ALDH1A2 ALDH1A3 ALDH8A1 CRABP1 CRABP2 CYP26A1 CYP26B1 CYP26C1 DHRS3 DHRS4 DHRS9 DLAT DLD FABP5 PDHA1 PDHA2 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PPARD RARA RARB RARG RDH10 RDH11 RDH13 RDH14 RDH16 RDH5 RXRA RXRB RXRG SDR16C5 (see all 41) (see less)
2	RA biosynthesis pathway	Reactome	ADH1A ADH1C ADH4 AKR1C3 ALDH1A1 ALDH1A2 ALDH1A3 ALDH8A1 CRABP1 CYP26A1 CYP26B1 CYP26C1 DHRS3 DHRS4 DHRS9 RDH10 RDH11 RDH13 RDH14 RDH16 RDH5 SDR16C5 (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DHRS9	Dehydrogenase/Reductase 9	Protein Coding	2
2	DHRS4	Dehydrogenase/Reductase 4	Protein Coding	2
3	RDH13	Retinol Dehydrogenase 13	Protein Coding	2
4	ADH1A	Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide	Protein Coding	2
5	ADH1C	Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide	Protein Coding	2
6	ADH4	Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide	Protein Coding	2
7	CRABP1	Cellular Retinoic Acid Binding Protein 1	Protein Coding	2
8	RDH10	Retinol Dehydrogenase 10	Protein Coding	2
9	CYP26A1	Cytochrome P450 Family 26 Subfamily A Member 1	Protein Coding	2
10	SDR16C5	Short Chain Dehydrogenase/Reductase Family 16C Member 5	Protein Coding	2
11	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	2
12	ALDH1A3	Aldehyde Dehydrogenase 1 Family Member A3	Protein Coding	2
13	CYP26C1	Cytochrome P450 Family 26 Subfamily C Member 1	Protein Coding	2
14	RDH11	Retinol Dehydrogenase 11	Protein Coding	2
15	CYP26B1	Cytochrome P450 Family 26 Subfamily B Member 1	Protein Coding	2
16	RDH14	Retinol Dehydrogenase 14	Protein Coding	2
17	RDH5	Retinol Dehydrogenase 5	Protein Coding	2
18	ALDH8A1	Aldehyde Dehydrogenase 8 Family Member A1	Protein Coding	2
19	RDH16	Retinol Dehydrogenase 16	Protein Coding	2
20	AKR1C3	Aldo-Keto Reductase Family 1 Member C3	Protein Coding	2
21	ALDH1A2	Aldehyde Dehydrogenase 1 Family Member A2	Protein Coding	2
22	DHRS3	Dehydrogenase/Reductase 3	Protein Coding	2
23	CRABP2	Cellular Retinoic Acid Binding Protein 2	Protein Coding	1
24	DLAT	Dihydrolipoamide S-Acetyltransferase	Protein Coding	1
25	DLD	Dihydrolipoamide Dehydrogenase	Protein Coding	1
26	FABP5	Fatty Acid Binding Protein 5	Protein Coding	1
27	PDHA1	Pyruvate Dehydrogenase E1 Subunit Alpha 1	Protein Coding	1
28	PDHA2	Pyruvate Dehydrogenase E1 Subunit Alpha 2	Protein Coding	1
29	PDHB	Pyruvate Dehydrogenase E1 Subunit Beta	Protein Coding	1
30	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1
31	PDK2	Pyruvate Dehydrogenase Kinase 2	Protein Coding	1
32	PDK3	Pyruvate Dehydrogenase Kinase 3	Protein Coding	1
33	PDK4	Pyruvate Dehydrogenase Kinase 4	Protein Coding	1
34	PPARD	Peroxisome Proliferator Activated Receptor Delta	Protein Coding	1
35	RARA	Retinoic Acid Receptor Alpha	Protein Coding	1
36	RARB	Retinoic Acid Receptor Beta	Protein Coding	1
37	RARG	Retinoic Acid Receptor Gamma	Protein Coding	1
38	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
39	RXRB	Retinoid X Receptor Beta	Protein Coding	1
40	RXRG	Retinoid X Receptor Gamma	Protein Coding	1
41	PDHX	Pyruvate Dehydrogenase Complex Component X	Protein Coding	1

Disorders associated with Signaling by Retinoic Acid SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	PDHA1, PDHX	4.27
2	Diaphragmatic hernia 4, with cardiovascular defects	Enrichment	ALDH1A2	2.79
3	Radiohumeral fusions with other skeletal and craniofacial anomalies	Enrichment	CYP26B1	2.79
4	Focal facial dermal dysplasia 4	Enrichment	CYP26C1	2.79
5	Lethal occipital encephalocele-skeletal dysplasia syndrome	Enrichment	CYP26B1	2.79
6	Microphthalmia	Enrichment	ALDH1A3, RARB	2.70
7	Charcot-marie-tooth disease, x-linked dominant, 6	Enrichment	PDK3	2.52
8	Microphthalmia, syndromic 12	Enrichment	RARB	2.52
9	Spermatogenic failure 70	Enrichment	PDHA2	2.52
10	Retinal dystrophy, juvenile cataracts, and short stature syndrome	Enrichment	RDH11	2.49
11	Microphthalmia, isolated 8	Enrichment	ALDH1A3	2.49
12	Isolated anophthalmia-microphthalmia syndrome	Enrichment	ALDH1A3	2.31
13	Dihydrolipoamide dehydrogenase deficiency	Enrichment	DLD	2.22
14	Methemoglobinemia due to deficiency of methemoglobin reductase	Enrichment	DLD	2.22
15	Pyruvate dehydrogenase e2 deficiency	Enrichment	DLAT	2.22
16	Pyruvate dehydrogenase e1-beta deficiency	Enrichment	PDHB	2.22
17	Pyruvate dehydrogenase e3-binding protein deficiency	Enrichment	PDHX	2.22
18	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RARB	2.22
19	Parkinson disease, mitochondrial	Enrichment	ADH1C	2.19
20	Alcohol dependence	Enrichment	ADH1C	2.01
21	Fundus albipunctatus	Enrichment	RDH5	1.95
22	Spermatogenic failure 1	Enrichment	PDHA2	1.92
23	Nanophthalmos	Enrichment	ALDH1A3	1.75
24	Macs syndrome	Enrichment	ALDH1A3	1.50
25	Lactic acidosis	Enrichment	DLD	1.45
26	Congenital stationary night blindness	Enrichment	RDH5	1.44
27	Parkinson disease, late-onset	Enrichment	ADH1C	1.42
28	Microphthalmia/coloboma 12	Enrichment	RARB	1.41
29	Acute promyelocytic leukemia	Enrichment	RARA	1.41
30	Coloboma of macula	Enrichment	RARB	1.35
31	Sudden infant death syndrome	Enrichment	PDHA1	1.30
32	Azoospermia	Enrichment	PDHA2	1.23
33	Optic atrophy plus syndrome	Enrichment	RDH5	1.16
34	Hereditary retinal dystrophy	Enrichment	RDH11, RDH5	1.10
35	Fundus dystrophy	Enrichment	RDH11, RDH5	1.10
36	Autism	Enrichment	ALDH1A3	0.96
37	Myeloma, multiple	Enrichment	RXRA	0.81
38	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PDHA2	0.81
39	Mitochondrial disease	Enrichment	PDHX	0.63
40	Retinitis pigmentosa	Enrichment	RDH5	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by Retinoic Acid

Pathway Network for Signaling by Retinoic Acid

Member Pathways for Signaling by Retinoic Acid

Pathways in the Signaling by Retinoic Acid SuperPath

Associated Genes for Signaling by Retinoic Acid

Associated Disorders for Signaling by Retinoic Acid

Disorders associated with Signaling by Retinoic Acid SuperPath

STRING Interaction Network for Signaling by Retinoic Acid

Sources for Signaling by Retinoic Acid