Signaling by Rho GTPases

Pathway network for the Signaling by Rho GTPases SuperPath

Sources:

Reactome

Pathways in the Signaling by Rho GTPases SuperPath

#	Name	Source	Genes
1	Signaling by Rho GTPases	Reactome	AAAS ABCD3 ABI1 ABI2 ABL1 ABL2 ABR ACBD5 ACTB ACTC1 ACTG1 ACTN1 ACTR2 ACTR3 ADD3 AHCTF1 AKAP12 AKAP13 ALDH3A2 ALS2 AMIGO2 ANKFY1 ANKLE2 ANKRD26 ANLN AR ARAP1 ARAP2 ARAP3 ARFGAP2 ARFGAP3 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP18 ARHGAP19 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP25 ARHGAP26 ARHGAP27 ARHGAP28 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP40 ARHGAP42 ARHGAP44 ARHGAP45 ARHGAP5 ARHGAP6 ARHGAP8 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF26 ARHGEF28 ARHGEF3 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 ARL13B ARMCX3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ATP6AP1 AURKB B9D2 BAIAP2 BAIAP2L1 BAIAP2L2 BASP1 BCAP31 BCR BIRC5 BLTP3B BRK1 BTK BUB1 BUB1B BUB1B-PAK6 BUB3 C1QBP CALM1 CALM2 CALM3 CAPZB CAV1 CAVIN1 CCDC187 CCDC88A CCP110 CCT2 CCT6A CCT7 CDC20 CDC25C CDC37 CDC42 CDC42BPA CDC42BPB CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE2 CDCA8 CDKN1B CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPS-CORT CENPT CENPU CEP97 CFL1 CFTR CHN1 CHN2 CIT CKAP4 CKAP5 CKB CLASP1 CLASP2 CLIP1 CLTC COPS2 COPS4 CPD CPNE8 CPSF7 CSK CTNNA1 CTNNB1 CTTN CUL3 CYBA CYBB CYFIP1 CYFIP2 DAAM1 DBN1 DBT DDRGK1 DDX39B DDX4 DEF6 DEPDC1B DIAPH1 DIAPH2 DIAPH3 DLC1 DLG4 DLG5 DNMBP DOCK1 DOCK10 DOCK11 DOCK2 DOCK3 DOCK4 DOCK5 DOCK6 DOCK7 DOCK8 DOCK9 DSN1 DST DVL1 DVL2 DVL3 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ECT2 EFHD2 ELMO2 EMC3 EMD EPHA2 EPSTI1 ERBIN ERCC6L ESYT1 EVL FAF2 FAM135A FAM13A FAM13B FAM169A FAM83B FAM91A1 FARP1 FARP2 FERMT2 FGD1 FGD2 FGD3 FGD4 FGD5 FILIP1 FLNA FMNL1 FMNL2 FMNL3 FNBP1 FNBP1L FRS2 FRS3 GARRE1 GFOD1 GIT1 GIT2 GJA1 GMIP GNA13 GOLGA3 GOLGA8R GOPC GPS1 GRB2 GRB7 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HGS HINT2 HMOX2 HNRNPC HSP90AA1 HSP90AB1 HSPE1 IL32 INCENP IQGAP1 IQGAP2 IQGAP3 ITGB1 ITGB3BP ITSN1 ITSN2 JAG1 JUP KALRN KCTD13 KCTD3 KDM1A KDM4C KIDINS220 KIF14 KIF18A KIF2A KIF2B KIF2C KIF5A KIF5B KLC1 KLC2 KLC3 KLC4 KLK2 KLK3 KNL1 KNTC1 KTN1 LAMTOR1 LBR LCK LEMD3 LETM1 LIMK1 LIMK2 LIN7B LMAN1 LMNB1 LRRC1 MACO1 MAD1L1 MAD2L1 MAP3K11 MAPK1 MAPK11 MAPK14 MAPK3 MAPRE1 MCAM MCF2 MCF2L MEN1 MIS12 MOSPD2 MPP7 MRTFA MSI2 MTMR1 MTR MTX1 MUC13 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLK MYO6 MYO9A MYO9B NCF1 NCF2 NCF4 NCK1 NCK2 NCKAP1 NCKAP1L NCKIPSD NCOA2 NDC80 NDE1 NDEL1 NDUFA5 NDUFS3 NET1 NF2 NGEF NHS NIPSNAP2 NISCH NOX1 NOX3 NOXA1 NOXO1 NSFL1C NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 OCRL OPHN1 OSBPL11 PAFAH1B1 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PARD6A PARD6B PCDH7 PDE5A PDPK1 PEAK1 PFN1 PFN2 PGRMC2 PHIP PICALM PIK3C3 PIK3CA PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIN1 PKN1 PKN2 PKN3 PKP4 PLD1 PLD2 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG4B PLEKHG5 PLEKHG6 PLK1 PLXNA1 PLXNB1 PLXND1 PMF1 PMF1-BGLAP POTEE PPP1CB PPP1CC PPP1R12A PPP1R12B PPP1R14A PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRAG1 PRC1 PREX1 PREX2 PRKCA PRKCB PRKCD PRKCZ PTK2 PTK2B PTPN13 RAB7A RAC1 RAC2 RAC3 RACGAP1 RALBP1 RALGAPA1 RANBP2 RANGAP1 RAPGEF1 RASAL2 RASGRF2 RBBP6 RBMX RCC2 RHOA RHOB RHOBTB1 RHOBTB2 RHOC RHOD RHOF RHOG RHOH RHOJ RHOQ RHOU RHOV RHPN1 RHPN2 RND1 RND2 RND3 RNF20 ROCK1 ROCK2 ROPN1 RPS27 RRAS2 RTKN S100A8 S100A9 SAMM50 SCAI SCFD1 SCRIB SEC13 SEH1L SEMA4F SENP1 SFN SGO1 SGO2 SH3BP1 SH3PXD2A SH3RF1 SHKBP1 SHMT2 SKA1 SKA2 SLC1A5 SLC4A7 SLITRK3 SLITRK5 SLK SNAP23 SOS1 SOS2 SOWAHC SPATA13 SPC24 SPC25 SPDL1 SPEN SPTAN1 SPTBN1 SRC SRF SRGAP1 SRGAP2 SRGAP3 SRRM1 STAM STAM2 STARD13 STARD8 STBD1 STEAP3 STIP1 STK10 STK38 STMN2 STOM STX5 SWAP70 SYDE1 SYDE2 TAGAP TAOK1 TAOK3 TAX1BP3 TEX2 TFRC TIAM1 TIAM2 TJP2 TMEM59 TMEM87A TMOD3 TMPO TNFAIP1 TOR1AIP1 TPM3 TPM4 TRA2B TRIO TRIP10 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B TWF1 TXNL1 UACA UBXN11 USP9X VAMP3 VANGL1 VANGL2 VAPB VAV1 VAV2 VAV3 VCP VIM VMA22 VRK2 WAS WASF1 WASF2 WASF3 WASL WDR11 WDR6 WDR81 WDR91 WHAMM WIPF1 WIPF2 WIPF3 WWP2 XPO1 YKT6 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 ZNF512B ZW10 ZWILCH ZWINT (see all 702) (see less)
2	Signaling by Rho GTPases, Miro GTPases and RHOBTB3	Reactome	AAAS ABCD3 ABI1 ABI2 ABL1 ABL2 ABR ACBD5 ACTB ACTC1 ACTG1 ACTN1 ACTR2 ACTR3 ADD3 AHCTF1 AKAP12 AKAP13 ALDH3A2 ALS2 AMIGO2 ANKFY1 ANKLE2 ANKRD26 ANLN AR ARAP1 ARAP2 ARAP3 ARFGAP2 ARFGAP3 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP18 ARHGAP19 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP25 ARHGAP26 ARHGAP27 ARHGAP28 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP40 ARHGAP42 ARHGAP44 ARHGAP45 ARHGAP5 ARHGAP6 ARHGAP8 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF26 ARHGEF28 ARHGEF3 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 ARL13B ARMCX3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ATP6AP1 AURKB B9D2 BAIAP2 BAIAP2L1 BAIAP2L2 BASP1 BCAP31 BCR BIRC5 BLTP3B BRK1 BTK BUB1 BUB1B BUB1B-PAK6 BUB3 C1QBP CALM1 CALM2 CALM3 CAPZB CAV1 CAVIN1 CCDC187 CCDC88A CCNE1 CCP110 CCT2 CCT6A CCT7 CDC20 CDC25C CDC37 CDC42 CDC42BPA CDC42BPB CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE2 CDCA8 CDKN1B CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPS-CORT CENPT CENPU CEP97 CFL1 CFTR CHN1 CHN2 CIT CKAP4 CKAP5 CKB CLASP1 CLASP2 CLIP1 CLTC COPS2 COPS4 CPD CPNE8 CPSF7 CSK CTNNA1 CTNNB1 CTTN CUL3 CYBA CYBB CYFIP1 CYFIP2 DAAM1 DBN1 DBT DDRGK1 DDX39B DDX4 DEF6 DEPDC1B DIAPH1 DIAPH2 DIAPH3 DLC1 DLG4 DLG5 DNMBP DOCK1 DOCK10 DOCK11 DOCK2 DOCK3 DOCK4 DOCK5 DOCK6 DOCK7 DOCK8 DOCK9 DSN1 DST DVL1 DVL2 DVL3 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ECT2 EFHD2 ELMO2 EMC3 EMD EPHA2 EPSTI1 ERBIN ERCC6L ESYT1 EVL FAF2 FAM135A FAM13A FAM13B FAM169A FAM83B FAM91A1 FARP1 FARP2 FERMT2 FGD1 FGD2 FGD3 FGD4 FGD5 FILIP1 FLNA FMNL1 FMNL2 FMNL3 FNBP1 FNBP1L FRS2 FRS3 GARRE1 GFOD1 GIT1 GIT2 GJA1 GMIP GNA13 GOLGA3 GOLGA8R GOPC GPS1 GRB2 GRB7 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HGS HINT2 HMOX2 HNRNPC HSP90AA1 HSP90AB1 HSPE1 HTR7 IL32 INCENP IQGAP1 IQGAP2 IQGAP3 ITGB1 ITGB3BP ITSN1 ITSN2 JAG1 JUP KALRN KCTD13 KCTD3 KDM1A KDM4C KIDINS220 KIF14 KIF18A KIF2A KIF2B KIF2C KIF5A KIF5B KLC1 KLC2 KLC3 KLC4 KLK2 KLK3 KNL1 KNTC1 KTN1 LAMTOR1 LBR LCK LEMD3 LETM1 LIMK1 LIMK2 LIN7B LMAN1 LMNB1 LRRC1 LRRC41 MACO1 MAD1L1 MAD2L1 MAP3K11 MAPK1 MAPK11 MAPK14 MAPK3 MAPRE1 MCAM MCF2 MCF2L MEN1 MFN1 MFN2 MIS12 MOSPD2 MPP7 MRTFA MSI2 MTMR1 MTR MTX1 MUC13 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLK MYO19 MYO6 MYO9A MYO9B NCF1 NCF2 NCF4 NCK1 NCK2 NCKAP1 NCKAP1L NCKIPSD NCOA2 NDC80 NDE1 NDEL1 NDUFA5 NDUFS3 NET1 NF2 NGEF NHS NIPSNAP2 NISCH NOX1 NOX3 NOXA1 NOXO1 NSFL1C NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 OCRL OPHN1 OSBPL11 PAFAH1B1 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PARD6A PARD6B PCDH7 PDE5A PDPK1 PEAK1 PFN1 PFN2 PGRMC2 PHIP PICALM PIK3C3 PIK3CA PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIN1 PKN1 PKN2 PKN3 PKP4 PLD1 PLD2 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG4B PLEKHG5 PLEKHG6 PLIN3 PLK1 PLXNA1 PLXNB1 PLXND1 PMF1 PMF1-BGLAP POTEE PPP1CB PPP1CC PPP1R12A PPP1R12B PPP1R14A PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRAG1 PRC1 PREX1 PREX2 PRKCA PRKCB PRKCD PRKCZ PTK2 PTK2B PTPN13 RAB7A RAB9A RAB9B RAC1 RAC2 RAC3 RACGAP1 RALBP1 RALGAPA1 RANBP2 RANGAP1 RAP1GDS1 RAPGEF1 RASAL2 RASGRF2 RBBP6 RBMX RCC2 RHOA RHOB RHOBTB1 RHOBTB2 RHOBTB3 RHOC RHOD RHOF RHOG RHOH RHOJ RHOQ RHOT1 RHOT2 RHOU RHOV RHPN1 RHPN2 RND1 RND2 RND3 RNF20 ROCK1 ROCK2 ROPN1 RPS27 RRAS2 RTKN S100A8 S100A9 SAMM50 SCAI SCFD1 SCRIB SEC13 SEH1L SEMA4F SENP1 SFN SGO1 SGO2 SH3BP1 SH3PXD2A SH3RF1 SHKBP1 SHMT2 SKA1 SKA2 SLC1A5 SLC4A7 SLITRK3 SLITRK5 SLK SNAP23 SOS1 SOS2 SOWAHC SPATA13 SPC24 SPC25 SPDL1 SPEN SPTAN1 SPTBN1 SRC SRF SRGAP1 SRGAP2 SRGAP3 SRRM1 STAM STAM2 STARD13 STARD8 STBD1 STEAP3 STIP1 STK10 STK38 STMN2 STOM STX5 SWAP70 SYDE1 SYDE2 TAGAP TAOK1 TAOK3 TAX1BP3 TEX2 TFRC TIAM1 TIAM2 TJP2 TMEM59 TMEM87A TMOD3 TMPO TNFAIP1 TOR1AIP1 TPM3 TPM4 TRA2B TRAK1 TRAK2 TRIO TRIP10 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B TWF1 TXNL1 UACA UBXN11 USP9X VAMP3 VANGL1 VANGL2 VAPB VAV1 VAV2 VAV3 VCP VHL VIM VMA22 VRK2 WAS WASF1 WASF2 WASF3 WASL WDR11 WDR6 WDR81 WDR91 WHAMM WIPF1 WIPF2 WIPF3 WWP2 XPO1 YKT6 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 ZNF512B ZW10 ZWILCH ZWINT (see all 718) (see less)
3	RHO GTPase cycle	Reactome	AAAS ABCD3 ABI1 ABI2 ABL2 ABR ACBD5 ACTB ACTC1 ACTG1 ACTN1 ADD3 AKAP12 AKAP13 ALDH3A2 ALS2 AMIGO2 ANKFY1 ANKLE2 ANKRD26 ANLN ARAP1 ARAP2 ARAP3 ARFGAP2 ARFGAP3 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP18 ARHGAP19 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP25 ARHGAP26 ARHGAP27 ARHGAP28 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP40 ARHGAP42 ARHGAP44 ARHGAP45 ARHGAP5 ARHGAP6 ARHGAP8 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF26 ARHGEF28 ARHGEF3 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 ARL13B ARMCX3 ATP6AP1 BAIAP2 BAIAP2L1 BAIAP2L2 BASP1 BCAP31 BCR BLTP3B BRK1 BUB1B-PAK6 C1QBP CAPZB CAV1 CAVIN1 CCDC187 CCDC88A CCP110 CCT2 CCT6A CCT7 CDC37 CDC42 CDC42BPA CDC42BPB CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE2 CEP97 CFTR CHN1 CHN2 CIT CKAP4 CKB CLTC COPS2 COPS4 CPD CPNE8 CPSF7 CSK CUL3 CYBA CYBB CYFIP1 CYFIP2 DAAM1 DBN1 DBT DDRGK1 DDX39B DDX4 DEF6 DEPDC1B DIAPH1 DIAPH2 DIAPH3 DLC1 DLG5 DNMBP DOCK1 DOCK10 DOCK11 DOCK2 DOCK3 DOCK4 DOCK5 DOCK6 DOCK7 DOCK8 DOCK9 DST ECT2 EFHD2 ELMO2 EMC3 EMD EPHA2 EPSTI1 ERBIN ESYT1 FAF2 FAM135A FAM13A FAM13B FAM169A FAM83B FAM91A1 FARP1 FARP2 FERMT2 FGD1 FGD2 FGD3 FGD4 FGD5 FILIP1 FMNL1 FMNL2 FMNL3 FNBP1 FNBP1L FRS2 FRS3 GARRE1 GFOD1 GIT1 GIT2 GJA1 GMIP GNA13 GOLGA3 GOLGA8R GOPC GPS1 GRB2 GRB7 HGS HINT2 HMOX2 HNRNPC HSP90AA1 HSP90AB1 HSPE1 IL32 IQGAP1 IQGAP2 IQGAP3 ITGB1 ITSN1 ITSN2 JAG1 JUP KALRN KCTD13 KCTD3 KIDINS220 KIF14 KTN1 LAMTOR1 LBR LCK LEMD3 LETM1 LMAN1 LMNB1 LRRC1 MACO1 MAP3K11 MCAM MCF2 MCF2L MOSPD2 MPP7 MSI2 MTMR1 MTR MTX1 MUC13 MYO6 MYO9A MYO9B NCF1 NCF2 NCF4 NCK1 NCK2 NCKAP1 NCKAP1L NDUFA5 NDUFS3 NET1 NGEF NHS NIPSNAP2 NISCH NOX1 NOX3 NOXA1 NOXO1 NSFL1C NUDC OCRL OPHN1 OSBPL11 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PARD6A PARD6B PCDH7 PDE5A PEAK1 PGRMC2 PHIP PICALM PIK3CA PIK3R1 PIK3R2 PIK3R3 PKN1 PKN2 PKN3 PKP4 PLD1 PLD2 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG4B PLEKHG5 PLEKHG6 PLXNA1 PLXNB1 PLXND1 POTEE PRAG1 PREX1 PREX2 PTK2B PTPN13 RAB7A RAC1 RAC2 RAC3 RACGAP1 RALBP1 RALGAPA1 RAPGEF1 RASAL2 RASGRF2 RBBP6 RBMX RHOA RHOB RHOBTB1 RHOBTB2 RHOC RHOD RHOF RHOG RHOH RHOJ RHOQ RHOU RHOV RHPN1 RHPN2 RND1 RND2 RND3 RNF20 ROCK1 ROCK2 RRAS2 RTKN SAMM50 SCFD1 SCRIB SEMA4F SENP1 SH3BP1 SH3PXD2A SH3RF1 SHKBP1 SHMT2 SLC1A5 SLC4A7 SLITRK3 SLITRK5 SLK SNAP23 SOS1 SOS2 SOWAHC SPATA13 SPEN SPTAN1 SPTBN1 SRC SRGAP1 SRGAP2 SRGAP3 SRRM1 STAM STAM2 STARD13 STARD8 STBD1 STEAP3 STIP1 STK10 STK38 STMN2 STOM STX5 SWAP70 SYDE1 SYDE2 TAGAP TAOK3 TEX2 TFRC TIAM1 TIAM2 TJP2 TMEM59 TMEM87A TMOD3 TMPO TNFAIP1 TOR1AIP1 TPM3 TPM4 TRA2B TRIO TRIP10 TUBA1B TWF1 TXNL1 UACA UBXN11 USP9X VAMP3 VANGL1 VANGL2 VAPB VAV1 VAV2 VAV3 VCP VIM VMA22 VRK2 WAS WASF1 WASF2 WASF3 WASL WDR11 WDR6 WDR81 WDR91 WHAMM WIPF1 WIPF2 WIPF3 WWP2 YKT6 ZAP70 ZNF512B (see all 445) (see less)
4	RHO GTPase Effectors	Reactome	ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 AHCTF1 AR ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 AURKB B9D2 BAIAP2 BIRC5 BRK1 BTK BUB1 BUB1B BUB3 CALM1 CALM2 CALM3 CDC20 CDC25C CDC42 CDCA8 CDKN1B CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPS-CORT CENPT CENPU CFL1 CFTR CIT CKAP5 CLASP1 CLASP2 CLIP1 CTNNA1 CTNNB1 CTTN CYBA CYBB CYFIP1 CYFIP2 DAAM1 DIAPH1 DIAPH2 DIAPH3 DLG4 DSN1 DVL1 DVL2 DVL3 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ERCC6L EVL FLNA FMNL1 FMNL2 FMNL3 GOPC GRB2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 INCENP IQGAP1 IQGAP2 IQGAP3 ITGB1 ITGB3BP KDM1A KDM4C KIF14 KIF18A KIF2A KIF2B KIF2C KIF5A KIF5B KLC1 KLC2 KLC3 KLC4 KLK2 KLK3 KNL1 KNTC1 KTN1 LIMK1 LIMK2 LIN7B MAD1L1 MAD2L1 MAPK1 MAPK11 MAPK14 MAPK3 MAPRE1 MEN1 MIS12 MRTFA MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLK NCF1 NCF2 NCF4 NCK1 NCKAP1 NCKAP1L NCKIPSD NCOA2 NDC80 NDE1 NDEL1 NF2 NOX1 NOX3 NOXA1 NOXO1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PAK1 PAK2 PAK3 PDPK1 PFN1 PFN2 PIK3C3 PIK3R4 PIN1 PKN1 PKN2 PKN3 PLK1 PMF1 PMF1-BGLAP PPP1CB PPP1CC PPP1R12A PPP1R12B PPP1R14A PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRC1 PRKCA PRKCB PRKCD PRKCZ PTK2 RAC1 RAC2 RANBP2 RANGAP1 RCC2 RHOA RHOB RHOC RHOD RHOG RHOQ RHPN1 RHPN2 ROCK1 ROCK2 ROPN1 RPS27 RTKN S100A8 S100A9 SCAI SEC13 SEH1L SFN SGO1 SGO2 SKA1 SKA2 SPC24 SPC25 SPDL1 SRC SRF SRGAP2 TAOK1 TAX1BP3 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 XPO1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZW10 ZWILCH ZWINT (see all 326) (see less)

Gene overlap in member pathways for Signaling by Rho GTPases SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABI1	Abl Interactor 1	Protein Coding	4
2	ABI2	Abl Interactor 2	Protein Coding	4
3	WASF2	WASP Family Member 2	Protein Coding	4
4	TUBA1B	Tubulin Alpha 1b	Protein Coding	4
5	BAIAP2	BAR/IMD Domain Containing Adaptor Protein 2	Protein Coding	4
6	NUDC	Nuclear Distribution C, Dynein Complex Regulator	Protein Coding	4
7	NCKAP1	NCK Associated Protein 1	Protein Coding	4
8	IQGAP2	IQ Motif Containing GTPase Activating Protein 2	Protein Coding	4
9	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	4
10	WASF3	WASP Family Member 3	Protein Coding	4
11	NOXA1	NADPH Oxidase Activator 1	Protein Coding	4
12	CIT	Citron Rho-Interacting Serine/Threonine Kinase	Protein Coding	4
13	FMNL2	Formin Like 2	Protein Coding	4
14	RHPN1	Rhophilin Rho GTPase Binding Protein 1	Protein Coding	4
15	NOXO1	NADPH Oxidase Organizer 1	Protein Coding	4
16	IQGAP3	IQ Motif Containing GTPase Activating Protein 3	Protein Coding	4
17	WIPF2	WAS/WASL Interacting Protein Family Member 2	Protein Coding	4
18	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	4
19	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	4
20	DIAPH1	Diaphanous Related Formin 1	Protein Coding	4
21	DIAPH2	Diaphanous Related Formin 2	Protein Coding	4
22	DAAM1	Dishevelled Associated Activator Of Morphogenesis 1	Protein Coding	4
23	CYFIP1	Cytoplasmic FMR1 Interacting Protein 1	Protein Coding	4
24	SRGAP2	SLIT-ROBO Rho GTPase Activating Protein 2	Protein Coding	4
25	RHOQ	Ras Homolog Family Member Q	Protein Coding	4
26	CYFIP2	Cytoplasmic FMR1 Interacting Protein 2	Protein Coding	4
27	NOX1	NADPH Oxidase 1	Protein Coding	4
28	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	4
29	PKN3	Protein Kinase N3	Protein Coding	4
30	RHOD	Ras Homolog Family Member D	Protein Coding	4
31	NCKAP1L	NCK Associated Protein 1 Like	Protein Coding	4
32	ITGB1	Integrin Subunit Beta 1	Protein Coding	4
33	RHOA	Ras Homolog Family Member A	Protein Coding	4
34	RHOB	Ras Homolog Family Member B	Protein Coding	4
35	RHOC	Ras Homolog Family Member C	Protein Coding	4
36	KTN1	Kinectin 1	Protein Coding	4
37	RHOG	Ras Homolog Family Member G	Protein Coding	4
38	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	4
39	NCF4	Neutrophil Cytosolic Factor 4	Protein Coding	4
40	NCK1	NCK Adaptor Protein 1	Protein Coding	4
41	NOX3	NADPH Oxidase 3	Protein Coding	4
42	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	4
43	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	4
44	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	4
45	BRK1	BRICK1 Subunit Of SCAR/WAVE Actin Nucleating Complex	Protein Coding	4
46	PKN1	Protein Kinase N1	Protein Coding	4
47	PKN2	Protein Kinase N2	Protein Coding	4
48	GOPC	Golgi Associated PDZ And Coiled-Coil Motif Containing	Protein Coding	4
49	RAC1	Rac Family Small GTPase 1	Protein Coding	4
50	RAC2	Rac Family Small GTPase 2	Protein Coding	4
51	ACTB	Actin Beta	Protein Coding	4
52	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	4
53	RTKN	Rhotekin	Protein Coding	4
54	WIPF3	WAS/WASL Interacting Protein Family Member 3	Protein Coding	4
55	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	4
56	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	4
57	ACTG1	Actin Gamma 1	Protein Coding	4
58	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	4
59	WIPF1	WAS/WASL Interacting Protein Family Member 1	Protein Coding	4
60	FMNL1	Formin Like 1	Protein Coding	4
61	DIAPH3	Diaphanous Related Formin 3	Protein Coding	4
62	RHPN2	Rhophilin Rho GTPase Binding Protein 2	Protein Coding	4
63	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	4
64	WASF1	WASP Family Member 1	Protein Coding	4
65	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	4
66	FMNL3	Formin Like 3	Protein Coding	4
67	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	4
68	KIF14	Kinesin Family Member 14	Protein Coding	4
69	CDC42	Cell Division Cycle 42	Protein Coding	4
70	CENPS-CORT	CENPS-CORT Readthrough	Protein Coding	3
71	PMF1-BGLAP	PMF1-BGLAP Readthrough	Protein Coding	3
72	ARPC5	Actin Related Protein 2/3 Complex Subunit 5	Protein Coding	3
73	ARPC4	Actin Related Protein 2/3 Complex Subunit 4	Protein Coding	3
74	ARPC3	Actin Related Protein 2/3 Complex Subunit 3	Protein Coding	3
75	ARPC1B	Actin Related Protein 2/3 Complex Subunit 1B	Protein Coding	3
76	ACTR3	Actin Related Protein 3	Protein Coding	3
77	ACTR2	Actin Related Protein 2	Protein Coding	3
78	GOLGA8R	Golgin A8 Family Member R	Protein Coding	3
79	ARPC2	Actin Related Protein 2/3 Complex Subunit 2	Protein Coding	3
80	BCAP31	B Cell Receptor Associated Protein 31	Protein Coding	3
81	FAM13A	Family With Sequence Similarity 13 Member A	Protein Coding	3
82	FARP1	FERM, ARH/RhoGEF And Pleckstrin Domain Protein 1	Protein Coding	3
83	SRRM1	Serine And Arginine Repetitive Matrix 1	Protein Coding	3
84	STAM2	Signal Transducing Adaptor Molecule 2	Protein Coding	3
85	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	3
86	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	3
87	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	3
88	TUBB3	Tubulin Beta 3 Class III	Protein Coding	3
89	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	3
90	TUBB4B	Tubulin Beta 4B Class IVb	Protein Coding	3
91	MYL12B	Myosin Light Chain 12B	Protein Coding	3
92	DLC1	DLC1 Rho GTPase Activating Protein	Protein Coding	3
93	MYL9	Myosin Light Chain 9	Protein Coding	3
94	NDC80	NDC80 Kinetochore Complex Component	Protein Coding	3
95	BASP1	Brain Abundant Membrane Attached Signal Protein 1	Protein Coding	3
96	PGRMC2	Progesterone Receptor Membrane Component 2	Protein Coding	3
97	CDC42EP2	CDC42 Effector Protein 2	Protein Coding	3
98	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	3
99	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	3
100	SEMA4F	Ssemaphorin 4F	Protein Coding	3
101	ARPC1A	Actin Related Protein 2/3 Complex Subunit 1A	Protein Coding	3
102	CCT7	Chaperonin Containing TCP1 Subunit 7	Protein Coding	3
103	CCT2	Chaperonin Containing TCP1 Subunit 2	Protein Coding	3
104	CENPA	Centromere Protein A	Protein Coding	3
105	CENPC	Centromere Protein C	Protein Coding	3
106	CDC42EP3	CDC42 Effector Protein 3	Protein Coding	3
107	CENPE	Centromere Protein E	Protein Coding	3
108	CENPF	Centromere Protein F	Protein Coding	3
109	YKT6	YKT6 Vesicular SNARE Protein	Protein Coding	3
110	GNA13	G Protein Subunit Alpha 13	Protein Coding	3
111	BUB1B-PAK6	BUB1B-PAK6 Readthrough	Protein Coding	3
112	CFL1	Cofilin 1	Protein Coding	3
113	FRS3	Fibroblast Growth Factor Receptor Substrate 3	Protein Coding	3
114	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	3
115	RALBP1	RalA Binding Protein 1	Protein Coding	3
116	STIP1	Stress Induced Phosphoprotein 1	Protein Coding	3
117	CKAP4	Cytoskeleton Associated Protein 4	Protein Coding	3
118	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	3
119	FERMT2	FERM Domain Containing Kindlin 2	Protein Coding	3
120	KIF2C	Kinesin Family Member 2C	Protein Coding	3
121	WWP2	WW Domain Containing E3 Ubiquitin Protein Ligase 2	Protein Coding	3
122	STMN2	Stathmin 2	Protein Coding	3
123	ZWINT	ZW10 Interacting Kinetochore Protein	Protein Coding	3
124	CDC42EP1	CDC42 Effector Protein 1	Protein Coding	3
125	CDC37	Cell Division Cycle 37, HSP90 Cochaperone	Protein Coding	3
126	WDR6	WD Repeat Domain 6	Protein Coding	3
127	NISCH	Nischarin	Protein Coding	3
128	AKAP13	A-Kinase Anchoring Protein 13	Protein Coding	3
129	CHN1	Chimerin 1	Protein Coding	3
130	CHN2	Chimerin 2	Protein Coding	3
131	PMF1	Polyamine Modulated Factor 1	Protein Coding	3
132	TUBA3E	Tubulin Alpha 3e	Protein Coding	3
133	STK38	Serine/Threonine Kinase 38	Protein Coding	3
134	TUBA3D	Tubulin Alpha 3d	Protein Coding	3
135	OSBPL11	Oxysterol Binding Protein Like 11	Protein Coding	3
136	CKB	Creatine Kinase B	Protein Coding	3
137	ARHGEF25	Rho Guanine Nucleotide Exchange Factor 25	Protein Coding	3
138	ARHGAP33	Rho GTPase Activating Protein 33	Protein Coding	3
139	ARAP2	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2	Protein Coding	3
140	ARAP1	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1	Protein Coding	3
141	TAGAP	T Cell Activation RhoGTPase Activating Protein	Protein Coding	3
142	ADD3	Adducin 3	Protein Coding	3
143	CLTC	Clathrin Heavy Chain	Protein Coding	3
144	H4C16	H4 Histone 16	Protein Coding	3
145	FGD4	FYVE, RhoGEF And PH Domain Containing 4	Protein Coding	3
146	WHAMM	WASP Homolog Associated With Actin, Golgi Membranes And Microtubules	Protein Coding	3
147	MSI2	Musashi RNA Binding Protein 2	Protein Coding	3
148	WDR81	WD Repeat Domain 81	Protein Coding	3
149	H3C14	H3 Clustered Histone 14	Protein Coding	3
150	ARHGEF19	Rho Guanine Nucleotide Exchange Factor 19	Protein Coding	3
151	H2BC26	H2B Clustered Histone 26	Protein Coding	3
152	CPD	Carboxypeptidase D	Protein Coding	3
153	DOCK11	Dedicator Of Cytokinesis 11	Protein Coding	3
154	DYNLL2	Dynein Light Chain LC8-Type 2	Protein Coding	3
155	MPP7	MAGUK P55 Scaffold Protein 7	Protein Coding	3
156	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	3
157	ARHGAP42	Rho GTPase Activating Protein 42	Protein Coding	3
158	CPNE8	Copine 8	Protein Coding	3
159	CSK	C-Terminal Src Kinase	Protein Coding	3
160	KLC3	Kinesin Light Chain 3	Protein Coding	3
161	SPC24	SPC24 Component Of NDC80 Kinetochore Complex	Protein Coding	3
162	CDC42EP5	CDC42 Effector Protein 5	Protein Coding	3
163	CTNNA1	Catenin Alpha 1	Protein Coding	3
164	CTNNB1	Catenin Beta 1	Protein Coding	3
165	SGO2	Shugoshin 2	Protein Coding	3
166	SGO1	Shugoshin 1	Protein Coding	3
167	FGD5	FYVE, RhoGEF And PH Domain Containing 5	Protein Coding	3
168	PLEKHG4B	Pleckstrin Homology And RhoGEF Domain Containing G4B	Protein Coding	3
169	PRAG1	PEAK1 Related, Kinase-Activating Pseudokinase 1	Protein Coding	3
170	FAM91A1	Family With Sequence Similarity 91 Member A1	Protein Coding	3
171	MOSPD2	Motile Sperm Domain Containing 2	Protein Coding	3
172	DBN1	Drebrin 1	Protein Coding	3
173	DBT	Dihydrolipoamide Branched Chain Transacylase E2	Protein Coding	3
174	RHOV	Ras Homolog Family Member V	Protein Coding	3
175	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	3
176	DYNC1H1	Dynein Cytoplasmic 1 Heavy Chain 1	Protein Coding	3
177	DYNC1I1	Dynein Cytoplasmic 1 Intermediate Chain 1	Protein Coding	3
178	DYNC1I2	Dynein Cytoplasmic 1 Intermediate Chain 2	Protein Coding	3
179	DYNC1LI2	Dynein Cytoplasmic 1 Light Intermediate Chain 2	Protein Coding	3
180	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	3
181	DOCK2	Dedicator Of Cytokinesis 2	Protein Coding	3
182	DOCK3	Dedicator Of Cytokinesis 3	Protein Coding	3
183	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	3
184	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	3
185	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	3
186	DVL3	Dishevelled Segment Polarity Protein 3	Protein Coding	3
187	ECT2	Epithelial Cell Transforming 2	Protein Coding	3
188	EPHA2	EPH Receptor A2	Protein Coding	3
189	ARL13B	ARF Like GTPase 13B	Protein Coding	3
190	EMD	Emerin	Protein Coding	3
191	ARHGAP27	Rho GTPase Activating Protein 27	Protein Coding	3
192	CTTN	Cortactin	Protein Coding	3
193	STOM	Stomatin	Protein Coding	3
194	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	3
195	SKA1	Spindle And Kinetochore Associated Complex Subunit 1	Protein Coding	3
196	SPATA13	Spermatogenesis Associated 13	Protein Coding	3
197	FGD2	FYVE, RhoGEF And PH Domain Containing 2	Protein Coding	3
198	FAM83B	Family With Sequence Similarity 83 Member B	Protein Coding	3
199	ALDH3A2	Aldehyde Dehydrogenase 3 Family Member A2	Protein Coding	3
200	FGD1	FYVE, RhoGEF And PH Domain Containing 1	Protein Coding	3
201	RRAS2	RAS Related 2	Protein Coding	3
202	ANKRD26	Ankyrin Repeat Domain Containing 26	Protein Coding	3
203	SLITRK3	SLIT And NTRK Like Family Member 3	Protein Coding	3
204	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	3
205	MAPRE1	Microtubule Associated Protein RP/EB Family Member 1	Protein Coding	3
206	SPEN	Spen Family Transcriptional Repressor	Protein Coding	3
207	KDM1A	Lysine Demethylase 1A	Protein Coding	3
208	FNBP1	Formin Binding Protein 1	Protein Coding	3
209	BLTP3B	Bridge-Like Lipid Transfer Protein Family Member 3B	Protein Coding	3
210	SWAP70	Switching B Cell Complex Subunit SWAP70	Protein Coding	3
211	KDM4C	Lysine Demethylase 4C	Protein Coding	3
212	ARHGAP26	Rho GTPase Activating Protein 26	Protein Coding	3
213	CLASP2	Cytoplasmic Linker Associated Protein 2	Protein Coding	3
214	PLXND1	Plexin D1	Protein Coding	3
215	ANKLE2	Ankyrin Repeat And LEM Domain Containing 2	Protein Coding	3
216	FLNA	Filamin A	Protein Coding	3
217	FAF2	Fas Associated Factor Family Member 2	Protein Coding	3
218	RHOBTB2	Rho Related BTB Domain Containing 2	Protein Coding	3
219	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	3
220	SCFD1	Sec1 Family Domain Containing 1	Protein Coding	3
221	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	3
222	DNMBP	Dynamin Binding Protein	Protein Coding	3
223	NUP160	Nucleoporin 160	Protein Coding	3
224	CLASP1	Cytoplasmic Linker Associated Protein 1	Protein Coding	3
225	ESYT1	Extended Synaptotagmin 1	Protein Coding	3
226	DOCK9	Dedicator Of Cytokinesis 9	Protein Coding	3
227	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	3
228	ARHGEF18	Rho/Rac Guanine Nucleotide Exchange Factor 18	Protein Coding	3
229	ITGB3BP	Integrin Subunit Beta 3 Binding Protein	Protein Coding	3
230	SCRIB	Scribble Planar Cell Polarity Protein	Protein Coding	3
231	ARHGAP45	Rho GTPase Activating Protein 45	Protein Coding	3
232	CDC42EP4	CDC42 Effector Protein 4	Protein Coding	3
233	LEMD3	LEM Domain Containing 3	Protein Coding	3
234	SH3BP1	SH3 Domain Binding Protein 1	Protein Coding	3
235	ARHGAP8	Rho GTPase Activating Protein 8	Protein Coding	3
236	CENPI	Centromere Protein I	Protein Coding	3
237	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	3
238	RALGAPA1	Ral GTPase Activating Protein Catalytic Subunit Alpha 1	Protein Coding	3
239	KCTD13	Potassium Channel Tetramerization Domain Containing 13	Protein Coding	3
240	H2BC1	H2B Clustered Histone 1	Protein Coding	3
241	ARHGAP30	Rho GTPase Activating Protein 30	Protein Coding	3
242	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	3
243	SAMM50	SAMM50 Sorting And Assembly Machinery Component	Protein Coding	3
244	PLEKHG4	Pleckstrin Homology And RhoGEF Domain Containing G4	Protein Coding	3
245	AHCTF1	AT-Hook Containing Transcription Factor 1	Protein Coding	3
246	NSL1	NSL1 Component Of MIS12 Kinetochore Complex	Protein Coding	3
247	TMEM87A	Transmembrane Protein 87A	Protein Coding	3
248	PLEKHG3	Pleckstrin Homology And RhoGEF Domain Containing G3	Protein Coding	3
249	TUBB8B	Tubulin Beta 8B	Protein Coding	3
250	FAM169A	Family With Sequence Similarity 169 Member A	Protein Coding	3
251	SLITRK5	SLIT And NTRK Like Family Member 5	Protein Coding	3
252	ARHGEF26	Rho Guanine Nucleotide Exchange Factor 26	Protein Coding	3
253	TOR1AIP1	Torsin 1A Interacting Protein 1	Protein Coding	3
254	TIAM2	TIAM Rac1 Associated GEF 2	Protein Coding	3
255	ARFGAP3	ARF GTPase Activating Protein 3	Protein Coding	3
256	NIPSNAP2	Nipsnap Homolog 2	Protein Coding	3
257	GJA1	Gap Junction Protein Alpha 1	Protein Coding	3
258	ABL2	ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase	Protein Coding	3
259	FILIP1	Filamin A Interacting Protein 1	Protein Coding	3
260	ARHGEF16	Rho Guanine Nucleotide Exchange Factor 16	Protein Coding	3
261	RND1	Rho Family GTPase 1	Protein Coding	3
262	RBMX	RNA Binding Motif Protein X-Linked	Protein Coding	3
263	GOLGA3	Golgin A3	Protein Coding	3
264	SFN	Stratifin	Protein Coding	3
265	CAVIN1	Caveolae Associated Protein 1	Protein Coding	3
266	SCAI	Suppressor Of Cancer Cell Invasion	Protein Coding	3
267	GPS1	G Protein Pathway Suppressor 1	Protein Coding	3
268	GRB7	Growth Factor Receptor Bound Protein 7	Protein Coding	3
269	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	3
270	GIT1	GIT ArfGAP 1	Protein Coding	3
271	ABR	ABR Activator Of RhoGEF And GTPase	Protein Coding	3
272	WDR91	WD Repeat Domain 91	Protein Coding	3
273	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	3
274	RACGAP1	Rac GTPase Activating Protein 1	Protein Coding	3
275	TMOD3	Tropomodulin 3	Protein Coding	3
276	SENP1	SUMO Specific Peptidase 1	Protein Coding	3
277	H2AC8	H2A Clustered Histone 8	Protein Coding	3
278	H2AC7	H2A Clustered Histone 7	Protein Coding	3
279	H2AX	H2A.X Variant Histone	Protein Coding	3
280	H2BC5	H2B Clustered Histone 5	Protein Coding	3
281	H2BC3	H2B Clustered Histone 3	Protein Coding	3
282	H3-3A	H3.3 Histone A	Protein Coding	3
283	H3-3B	H3.3 Histone B	Protein Coding	3
284	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	3
285	TAX1BP3	Tax1 Binding Protein 3	Protein Coding	3
286	HMOX2	Heme Oxygenase 2	Protein Coding	3
287	HNRNPC	Heterogeneous Nuclear Ribonucleoprotein C	Protein Coding	3
288	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	3
289	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	3
290	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	3
291	HSPE1	Heat Shock Protein Family E (Hsp10) Member 1	Protein Coding	3
292	H3C15	H3 Clustered Histone 15	Protein Coding	3
293	ARHGAP40	Rho GTPase Activating Protein 40	Protein Coding	3
294	TUBB8	Tubulin Beta 8 Class VIII	Protein Coding	3
295	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	3
296	AMIGO2	Adhesion Molecule With Ig Like Domain 2	Protein Coding	3
297	SKA2	Spindle And Kinetochore Associated Complex Subunit 2	Protein Coding	3
298	NUP43	Nucleoporin 43	Protein Coding	3
299	KLK3	Kallikrein Related Peptidase 3	Protein Coding	3
300	INCENP	Inner Centromere Protein	Protein Coding	3
301	AR	Androgen Receptor	Protein Coding	3
302	JUP	Junction Plakoglobin	Protein Coding	3
303	CENPS	Centromere Protein S	Protein Coding	3
304	KIF2A	Kinesin Family Member 2A	Protein Coding	3
305	KIF5A	Kinesin Family Member 5A	Protein Coding	3
306	KIF5B	Kinesin Family Member 5B	Protein Coding	3
307	KLK2	Kallikrein Related Peptidase 2	Protein Coding	3
308	KLC1	Kinesin Light Chain 1	Protein Coding	3
309	RND3	Rho Family GTPase 3	Protein Coding	3
310	ARHGAP1	Rho GTPase Activating Protein 1	Protein Coding	3
311	ARHGAP4	Rho GTPase Activating Protein 4	Protein Coding	3
312	LBR	Lamin B Receptor	Protein Coding	3
313	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
314	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	3
315	ARHGAP6	Rho GTPase Activating Protein 6	Protein Coding	3
316	LETM1	Leucine Zipper And EF-Hand Containing Transmembrane Protein 1	Protein Coding	3
317	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	3
318	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	3
319	ARHGDIG	Rho GDP Dissociation Inhibitor Gamma	Protein Coding	3
320	LIMK1	LIM Domain Kinase 1	Protein Coding	3
321	LIMK2	LIM Domain Kinase 2	Protein Coding	3
322	RHOH	Ras Homolog Family Member H	Protein Coding	3
323	CCDC187	Coiled-Coil Domain Containing 187	Protein Coding	3
324	LMAN1	Lectin, Mannose Binding 1	Protein Coding	3
325	LMNB1	Lamin B1	Protein Coding	3
326	CENPP	Centromere Protein P	Protein Coding	3
327	MAD2L1	Mitotic Arrest Deficient 2 Like 1	Protein Coding	3
328	MCAM	Melanoma Cell Adhesion Molecule	Protein Coding	3
329	MCF2	MCF.2 Cell Line Derived Transforming Sequence	Protein Coding	3
330	MEN1	Menin 1	Protein Coding	3
331	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	3
332	POTEE	POTE Ankyrin Domain Family Member E	Protein Coding	3
333	MTR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase	Protein Coding	3
334	MTX1	Metaxin 1	Protein Coding	3
335	MYH9	Myosin Heavy Chain 9	Protein Coding	3
336	MYH10	Myosin Heavy Chain 10	Protein Coding	3
337	MYH11	Myosin Heavy Chain 11	Protein Coding	3
338	MYL6	Myosin Light Chain 6	Protein Coding	3
339	MYLK	Myosin Light Chain Kinase	Protein Coding	3
340	MYO6	Myosin VI	Protein Coding	3
341	MYO9A	Myosin IXA	Protein Coding	3
342	MYO9B	Myosin IXB	Protein Coding	3
343	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	3
344	PPP1R12B	Protein Phosphatase 1 Regulatory Subunit 12B	Protein Coding	3
345	NDUFA5	NADH:Ubiquinone Oxidoreductase Subunit A5	Protein Coding	3
346	NDUFS3	NADH:Ubiquinone Oxidoreductase Core Subunit S3	Protein Coding	3
347	H2AB1	H2A.B Variant Histone 1	Protein Coding	3
348	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	3
349	NHS	NHS Actin Remodeling Regulator	Protein Coding	3
350	NUP98	Nucleoporin 98 And 96 Precursor	Protein Coding	3
351	OCRL	OCRL Inositol Polyphosphate-5-Phosphatase	Protein Coding	3
352	OPHN1	Oligophrenin 1	Protein Coding	3
353	PAFAH1B1	Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1	Protein Coding	3
354	ITSN2	Intersectin 2	Protein Coding	3
355	DEF6	DEF6 Guanine Nucleotide Exchange Factor	Protein Coding	3
356	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	3
357	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	3
358	PARD6A	Par-6 Family Cell Polarity Regulator Alpha	Protein Coding	3
359	PCDH7	Protocadherin 7	Protein Coding	3
360	KCTD3	Potassium Channel Tetramerization Domain Containing 3	Protein Coding	3
361	COPS4	COP9 Signalosome Subunit 4	Protein Coding	3
362	DYNC1LI1	Dynein Cytoplasmic 1 Light Intermediate Chain 1	Protein Coding	3
363	GMIP	GEM Interacting Protein	Protein Coding	3
364	FAM13B	Family With Sequence Similarity 13 Member B	Protein Coding	3
365	TAOK3	TAO Kinase 3	Protein Coding	3
366	EVL	Enah/Vasp-Like	Protein Coding	3
367	ANKFY1	Ankyrin Repeat And FYVE Domain Containing 1	Protein Coding	3
368	NCKIPSD	NCK Interacting Protein With SH3 Domain	Protein Coding	3
369	ARMCX3	Armadillo Repeat Containing X-Linked 3	Protein Coding	3
370	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	3
371	TUBA8	Tubulin Alpha 8	Protein Coding	3
372	PFN1	Profilin 1	Protein Coding	3
373	PFN2	Profilin 2	Protein Coding	3
374	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	3
375	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
376	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
377	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
378	PIN1	Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1	Protein Coding	3
379	PLD1	Phospholipase D1	Protein Coding	3
380	PLD2	Phospholipase D2	Protein Coding	3
381	PLK1	Polo Like Kinase 1	Protein Coding	3
382	PLXNA1	Plexin A1	Protein Coding	3
383	PLXNB1	Plexin B1	Protein Coding	3
384	ATP6AP1	ATPase H+ Transporting Accessory Protein 1	Protein Coding	3
385	H2BC12L	H2B Clustered Histone 12 Like	Protein Coding	3
386	GFOD1	Gfo/Idh/MocA-Like Oxidoreductase Domain Containing 1	Protein Coding	3
387	ANLN	Anillin, Actin Binding Protein	Protein Coding	3
388	RHOF	Ras Homolog Family Member F, Filopodia Associated	Protein Coding	3
389	DDX4	DEAD-Box Helicase 4	Protein Coding	3
390	ROPN1	Rhophilin Associated Tail Protein 1	Protein Coding	3
391	NDE1	NudE Neurodevelopment Protein 1	Protein Coding	3
392	ERCC6L	ERCC Excision Repair 6 Like, Spindle Assembly Checkpoint Helicase	Protein Coding	3
393	FNBP1L	Formin Binding Protein 1 Like	Protein Coding	3
394	SPDL1	Spindle Apparatus Coiled-Coil Protein 1	Protein Coding	3
395	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	3
396	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	3
397	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	3
398	PHIP	PHIP Subunit Of CUL4-Ring Ligase Complex	Protein Coding	3
399	ZWILCH	Zwilch Kinetochore Protein	Protein Coding	3
400	UACA	Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats	Protein Coding	3
401	ARHGAP17	Rho GTPase Activating Protein 17	Protein Coding	3
402	CDCA8	Cell Division Cycle Associated 8	Protein Coding	3
403	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	3
404	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	3
405	ARHGEF10L	Rho Guanine Nucleotide Exchange Factor 10 Like	Protein Coding	3
406	CENPQ	Centromere Protein Q	Protein Coding	3
407	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	3
408	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	3
409	PLEKHG6	Pleckstrin Homology And RhoGEF Domain Containing G6	Protein Coding	3
410	MACO1	Macoilin 1	Protein Coding	3
411	LRRC1	Leucine Rich Repeat Containing 1	Protein Coding	3
412	STEAP3	STEAP3 Metalloreductase	Protein Coding	3
413	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	3
414	PPP2R5B	Protein Phosphatase 2 Regulatory Subunit B''Beta	Protein Coding	3
415	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	3
416	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	3
417	PPP2R5E	Protein Phosphatase 2 Regulatory Subunit B''Epsilon	Protein Coding	3
418	H4C15	H4 Clustered Histone 15	Protein Coding	3
419	DOCK10	Dedicator Of Cytokinesis 10	Protein Coding	3
420	ARHGEF40	Rho Guanine Nucleotide Exchange Factor 40	Protein Coding	3
421	CCDC88A	Coiled-Coil And HOOK Domain Protein 88A	Protein Coding	3
422	WDR11	WD Repeat Domain 11	Protein Coding	3
423	NUP133	Nucleoporin 133	Protein Coding	3
424	H2AJ	H2A.J Histone	Protein Coding	3
425	PRKCA	Protein Kinase C Alpha	Protein Coding	3
426	DEPDC1B	DEP Domain Containing 1B	Protein Coding	3
427	PRKCB	Protein Kinase C Beta	Protein Coding	3
428	PRKCD	Protein Kinase C Delta	Protein Coding	3
429	EMC3	ER Membrane Protein Complex Subunit 3	Protein Coding	3
430	CENPN	Centromere Protein N	Protein Coding	3
431	ARHGAP15	Rho GTPase Activating Protein 15	Protein Coding	3
432	TEX2	Testis Expressed 2	Protein Coding	3
433	PRKCZ	Protein Kinase C Zeta	Protein Coding	3
434	ERBIN	Erbb2 Interacting Protein	Protein Coding	3
435	RCC2	Regulator Of Chromosome Condensation 2	Protein Coding	3
436	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
437	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
438	NSFL1C	NSFL1 Cofactor	Protein Coding	3
439	BAIAP2L1	BAR/IMD Domain Containing Adaptor Protein 2 Like 1	Protein Coding	3
440	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	3
441	RNF20	Ring Finger Protein 20	Protein Coding	3
442	MUC13	Mucin 13, Cell Surface Associated	Protein Coding	3
443	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	3
444	CDC42SE2	CDC42 Small Effector 2	Protein Coding	3
445	KNL1	Kinetochore Scaffold 1	Protein Coding	3
446	NUP107	Nucleoporin 107	Protein Coding	3
447	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	3
448	VANGL2	VANGL Planar Cell Polarity Protein 2	Protein Coding	3
449	RHOJ	Ras Homolog Family Member J	Protein Coding	3
450	SPC25	SPC25 Component Of NDC80 Kinetochore Complex	Protein Coding	3
451	PLEKHG5	Pleckstrin Homology And RhoGEF Domain Containing G5	Protein Coding	3
452	PTK2	Protein Tyrosine Kinase 2	Protein Coding	3
453	ZNF512B	Zinc Finger Protein 512B	Protein Coding	3
454	PLEKHG1	Pleckstrin Homology And RhoGEF Domain Containing G1	Protein Coding	3
455	KIDINS220	Kinase D Interacting Substrate 220	Protein Coding	3
456	ARHGAP31	Rho GTPase Activating Protein 31	Protein Coding	3
457	SRGAP1	SLIT-ROBO Rho GTPase Activating Protein 1	Protein Coding	3
458	TAOK1	TAO Kinase 1	Protein Coding	3
459	TWF1	Twinfilin Actin Binding Protein 1	Protein Coding	3
460	ARHGAP20	Rho GTPase Activating Protein 20	Protein Coding	3
461	DOCK6	Dedicator Of Cytokinesis 6	Protein Coding	3
462	FAM135A	Family With Sequence Similarity 135 Member A	Protein Coding	3
463	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	3
464	ARHGAP21	Rho GTPase Activating Protein 21	Protein Coding	3
465	MRTFA	Myocardin Related Transcription Factor A	Protein Coding	3
466	SH3RF1	SH3 Domain Containing Ring Finger 1	Protein Coding	3
467	ARHGAP23	Rho GTPase Activating Protein 23	Protein Coding	3
468	ALS2	Alsin Rho Guanine Nucleotide Exchange Factor ALS2	Protein Coding	3
469	PTPN13	Protein Tyrosine Phosphatase Non-Receptor Type 13	Protein Coding	3
470	ABCD3	ATP Binding Cassette Subfamily D Member 3	Protein Coding	3
471	RHOU	Ras Homolog Family Member U	Protein Coding	3
472	ARHGAP22	Rho GTPase Activating Protein 22	Protein Coding	3
473	RAC3	Rac Family Small GTPase 3	Protein Coding	3
474	RANBP2	RAN Binding Protein 2	Protein Coding	3
475	RANGAP1	Ran GTPase Activating Protein 1	Protein Coding	3
476	RASGRF2	Ras Protein Specific Guanine Nucleotide Releasing Factor 2	Protein Coding	3
477	RBBP6	RB Binding Protein 6, Ubiquitin Ligase	Protein Coding	3
478	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	3
479	RPS27	Ribosomal Protein S27	Protein Coding	3
480	CLIP1	CAP-Gly Domain Containing Linker Protein 1	Protein Coding	3
481	S100A8	S100 Calcium Binding Protein A8	Protein Coding	3
482	S100A9	S100 Calcium Binding Protein A9	Protein Coding	3
483	ELMO2	Engulfment And Cell Motility 2	Protein Coding	3
484	SEC13	SEC13 Homolog, Nuclear Pore And COPII Component	Protein Coding	3
485	CENPK	Centromere Protein K	Protein Coding	3
486	LIN7B	Lin-7 Cell Polarity Scaffold B	Protein Coding	3
487	ARHGEF28	Rho Guanine Nucleotide Exchange Factor 28	Protein Coding	3
488	ARHGAP9	Rho GTPase Activating Protein 9	Protein Coding	3
489	TRA2B	Transformer 2 Beta Homolog	Protein Coding	3
490	ARAP3	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 3	Protein Coding	3
491	ITSN1	Intersectin 1	Protein Coding	3
492	SHMT2	Serine Hydroxymethyltransferase 2	Protein Coding	3
493	KLC2	Kinesin Light Chain 2	Protein Coding	3
494	PLEKHG2	Pleckstrin Homology And RhoGEF Domain Containing G2	Protein Coding	3
495	CENPH	Centromere Protein H	Protein Coding	3
496	SLC1A5	Solute Carrier Family 1 Member 5	Protein Coding	3
497	SOWAHC	Sosondowah Ankyrin Repeat Domain Family Member C	Protein Coding	3
498	H3C13	H3 Clustered Histone 13	Protein Coding	3
499	DDRGK1	DDRGK Domain Containing 1	Protein Coding	3
500	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	3
501	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	3
502	DST	Dystonin	Protein Coding	3
503	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	3
504	SPTBN1	Spectrin Beta, Non-Erythrocytic 1	Protein Coding	3
505	SRF	Serum Response Factor	Protein Coding	3
506	STK10	Serine/Threonine Kinase 10	Protein Coding	3
507	STX5	Syntaxin 5	Protein Coding	3
508	BTK	Bruton Tyrosine Kinase	Protein Coding	3
509	BUB1	BUB1 Mitotic Checkpoint Serine/Threonine Kinase	Protein Coding	3
510	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	3
511	BUB1B	BUB1 Mitotic Checkpoint Serine/Threonine Kinase B	Protein Coding	3
512	TFRC	Transferrin Receptor	Protein Coding	3
513	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	3
514	C1QBP	Complement C1q Binding Protein	Protein Coding	3
515	TMPO	Thymopoietin	Protein Coding	3
516	TNFAIP1	TNF Alpha Induced Protein 1	Protein Coding	3
517	TPM3	Tropomyosin 3	Protein Coding	3
518	TPM4	Tropomyosin 4	Protein Coding	3
519	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	3
520	H2AC19	H2A Clustered Histone 19	Protein Coding	3
521	TUBA4A	Tubulin Alpha 4a	Protein Coding	3
522	TUBA3C	Tubulin Alpha 3c	Protein Coding	3
523	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	3
524	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	3
525	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	3
526	VCP	Valosin Containing Protein	Protein Coding	3
527	VIM	Vimentin	Protein Coding	3
528	VRK2	VRK Serine/Threonine Kinase 2	Protein Coding	3
529	XPO1	Exportin 1	Protein Coding	3
530	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	3
531	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	3
532	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	3
533	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	3
534	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	3
535	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	3
536	TUBA1A	Tubulin Alpha 1a	Protein Coding	3
537	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	3
538	MIS12	MIS12 Kinetochore Complex Component	Protein Coding	3
539	CENPM	Centromere Protein M	Protein Coding	3
540	NUP37	Nucleoporin 37	Protein Coding	3
541	CENPO	Centromere Protein O	Protein Coding	3
542	EFHD2	EF-Hand Domain Family Member D2	Protein Coding	3
543	DDX39B	DExD-Box Helicase 39B	Protein Coding	3
544	CEP97	Centrosomal Protein 97	Protein Coding	3
545	ARHGAP10	Rho GTPase Activating Protein 10	Protein Coding	3
546	CENPU	Centromere Protein U	Protein Coding	3
547	MYH14	Myosin Heavy Chain 14	Protein Coding	3
548	ARHGAP28	Rho GTPase Activating Protein 28	Protein Coding	3
549	PEAK1	Pseudopodium Enriched Atypical Kinase 1	Protein Coding	3
550	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	3
551	TUBAL3	Tubulin Alpha Like 3	Protein Coding	3
552	CPSF7	Cleavage And Polyadenylation Specific Factor 7	Protein Coding	3
553	NUP85	Nucleoporin 85	Protein Coding	3
554	DSN1	DSN1 Component Of MIS12 Kinetochore Complex	Protein Coding	3
555	DOCK5	Dedicator Of Cytokinesis 5	Protein Coding	3
556	TUBA4B	Tubulin Alpha 4b	Protein Coding	3
557	CALM1	Calmodulin 1	Protein Coding	3
558	BAIAP2L2	BAR/IMD Domain Containing Adaptor Protein 2 Like 2	Protein Coding	3
559	CENPT	Centromere Protein T	Protein Coding	3
560	PREX2	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2	Protein Coding	3
561	STAM	Signal Transducing Adaptor Molecule	Protein Coding	3
562	CALM2	Calmodulin 2	Protein Coding	3
563	ARHGAP39	Rho GTPase Activating Protein 39	Protein Coding	3
564	B9D2	B9 Domain Containing 2	Protein Coding	3
565	CALM3	Calmodulin 3	Protein Coding	3
566	AAAS	Aladin WD Repeat Nucleoporin	Protein Coding	3
567	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	3
568	RND2	Rho Family GTPase 2	Protein Coding	3
569	NDEL1	NudE Neurodevelopment Protein 1 Like 1	Protein Coding	3
570	DOCK8	Dedicator Of Cytokinesis 8	Protein Coding	3
571	VANGL1	VANGL Planar Cell Polarity Protein 1	Protein Coding	3
572	SEH1L	SEH1 Like Nucleoporin	Protein Coding	3
573	KIF18A	Kinesin Family Member 18A	Protein Coding	3
574	USP9X	Ubiquitin Specific Peptidase 9 X-Linked	Protein Coding	3
575	H4C9	H4 Clustered Histone 9	Protein Coding	3
576	PICALM	Phosphatidylinositol Binding Clathrin Assembly Protein	Protein Coding	3
577	CAPZB	Capping Actin Protein Of Muscle Z-Line Subunit Beta	Protein Coding	3
578	H2AC14	H2A Clustered Histone 14	Protein Coding	3
579	H2AC6	H2A Clustered Histone 6	Protein Coding	3
580	H2AC4	H2A Clustered Histone 4	Protein Coding	3
581	H2AC18	H2A Clustered Histone 18	Protein Coding	3
582	H2AC20	H2A Clustered Histone 20	Protein Coding	3
583	H2BC8	H2B Clustered Histone 8	Protein Coding	3
584	H2BC13	H2B Clustered Histone 13	Protein Coding	3
585	H2BC15	H2B Clustered Histone 15	Protein Coding	3
586	H2BC14	H2B Clustered Histone 14	Protein Coding	3
587	H2BC7	H2B Clustered Histone 7	Protein Coding	3
588	H2BC6	H2B Clustered Histone 6	Protein Coding	3
589	H2BC9	H2B Clustered Histone 9	Protein Coding	3
590	H2BC10	H2B Clustered Histone 10	Protein Coding	3
591	H2BC4	H2B Clustered Histone 4	Protein Coding	3
592	ARHGAP24	Rho GTPase Activating Protein 24	Protein Coding	3
593	H2BC17	H2B Clustered Histone 17	Protein Coding	3
594	H2BC21	H2B Clustered Histone 21	Protein Coding	3
595	H3C1	H3 Clustered Histone 1	Protein Coding	3
596	H3C4	H3 Clustered Histone 4	Protein Coding	3
597	H3C3	H3 Clustered Histone 3	Protein Coding	3
598	H3C6	H3 Clustered Histone 6	Protein Coding	3
599	H3C11	H3 Clustered Histone 11	Protein Coding	3
600	NUF2	NUF2 Component Of NDC80 Kinetochore Complex	Protein Coding	3
601	H3C8	H3 Clustered Histone 8	Protein Coding	3
602	H3C12	H3 Clustered Histone 12	Protein Coding	3
603	H3C10	H3 Clustered Histone 10	Protein Coding	3
604	H3C2	H3 Clustered Histone 2	Protein Coding	3
605	H4C1	H4 Clustered Histone 1	Protein Coding	3
606	H4C4	H4 Clustered Histone 4	Protein Coding	3
607	H4C6	H4 Clustered Histone 6	Protein Coding	3
608	H4C12	H4 Clustered Histone 12	Protein Coding	3
609	H4C11	H4 Clustered Histone 11	Protein Coding	3
610	H4C3	H4 Clustered Histone 3	Protein Coding	3
611	H4C8	H4 Clustered Histone 8	Protein Coding	3
612	H4C2	H4 Clustered Histone 2	Protein Coding	3
613	H4C5	H4 Clustered Histone 5	Protein Coding	3
614	H4C13	H4 Clustered Histone 13	Protein Coding	3
615	H4C14	H4 Clustered Histone 14	Protein Coding	3
616	MAD1L1	Mitotic Arrest Deficient 1 Like 1	Protein Coding	3
617	SYDE2	Synapse Defective Rho GTPase Homolog 2	Protein Coding	3
618	VMA22	Vacuolar ATPase Assembly Factor VMA22	Protein Coding	3
619	ARFGAP2	ARF GTPase Activating Protein 2	Protein Coding	3
620	NCK2	NCK Adaptor Protein 2	Protein Coding	3
621	CUL3	Cullin 3	Protein Coding	3
622	PARD6B	Par-6 Family Cell Polarity Regulator Beta	Protein Coding	3
623	TUBB6	Tubulin Beta 6 Class V	Protein Coding	3
624	KIF2B	Kinesin Family Member 2B	Protein Coding	3
625	HINT2	Histidine Triad Nucleotide Binding Protein 2	Protein Coding	3
626	CDC42BPA	CDC42 Binding Protein Kinase Alpha	Protein Coding	3
627	TUBA1C	Tubulin Alpha 1c	Protein Coding	3
628	ARHGEF39	Rho Guanine Nucleotide Exchange Factor 39	Protein Coding	3
629	ARHGAP19	Rho GTPase Activating Protein 19	Protein Coding	3
630	PKP4	Plakophilin 4	Protein Coding	3
631	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	3
632	H2BC12	H2B Clustered Histone 12	Protein Coding	3
633	SYDE1	Synapse Defective Rho GTPase Activating Protein 1	Protein Coding	3
634	DOCK7	Dedicator Of Cytokinesis 7	Protein Coding	3
635	CAV1	Caveolin 1	Protein Coding	3
636	PDE5A	Phosphodiesterase 5A	Protein Coding	3
637	DYNLL1	Dynein Light Chain LC8-Type 1	Protein Coding	3
638	ACTN1	Actinin Alpha 1	Protein Coding	3
639	SNAP23	Synaptosome Associated Protein 23	Protein Coding	3
640	MTMR1	Myotubularin Related Protein 1	Protein Coding	3
641	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	3
642	H3C7	H3 Clustered Histone 7	Protein Coding	3
643	H2BC11	H2B Clustered Histone 11	Protein Coding	3
644	ARHGAP11B	Rho GTPase Activating Protein 11B	Protein Coding	3
645	FGD3	FYVE, RhoGEF And PH Domain Containing 3	Protein Coding	3
646	STBD1	Starch Binding Domain 1	Protein Coding	3
647	KLC4	Kinesin Light Chain 4	Protein Coding	3
648	KALRN	Kalirin RhoGEF Kinase	Protein Coding	3
649	PRC1	Protein Regulator Of Cytokinesis 1	Protein Coding	3
650	STARD13	StAR Related Lipid Transfer Domain Containing 13	Protein Coding	3
651	CCT6A	Chaperonin Containing TCP1 Subunit 6A	Protein Coding	3
652	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	3
653	ACBD5	Acyl-CoA Binding Domain Containing 5	Protein Coding	3
654	HGS	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate	Protein Coding	3
655	UBXN11	UBX Domain Protein 11	Protein Coding	3
656	CENPL	Centromere Protein L	Protein Coding	3
657	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	3
658	ZW10	Zw10 Kinetochore Protein	Protein Coding	3
659	BUB3	BUB3 Mitotic Checkpoint Protein	Protein Coding	3
660	AURKB	Aurora Kinase B	Protein Coding	3
661	VAPB	VAMP Associated Protein B And C	Protein Coding	3
662	DLG5	Discs Large MAGUK Scaffold Protein 5	Protein Coding	3
663	IL32	Interleukin 32	Protein Coding	3
664	SHKBP1	SH3KBP1 Binding Protein 1	Protein Coding	3
665	COPS2	COP9 Signalosome Subunit 2	Protein Coding	3
666	TRIP10	Thyroid Hormone Receptor Interactor 10	Protein Coding	3
667	VAMP3	Vesicle Associated Membrane Protein 3	Protein Coding	3
668	TXNL1	Thioredoxin Like 1	Protein Coding	3
669	ARHGAP18	Rho GTPase Activating Protein 18	Protein Coding	3
670	ARHGAP29	Rho GTPase Activating Protein 29	Protein Coding	3
671	ARHGAP12	Rho GTPase Activating Protein 12	Protein Coding	3
672	TJP2	Tight Junction Protein 2	Protein Coding	3
673	H2AZ2	H2A.Z Variant Histone 2	Protein Coding	3
674	EPSTI1	Epithelial Stromal Interaction 1	Protein Coding	3
675	PPP1R14A	Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A	Protein Coding	3
676	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	3
677	RASAL2	RAS Protein Activator Like 2	Protein Coding	3
678	SLC4A7	Solute Carrier Family 4 Member 7	Protein Coding	3
679	TMEM59	Transmembrane Protein 59	Protein Coding	3
680	CDC42BPB	CDC42 Binding Protein Kinase Beta	Protein Coding	3
681	AKAP12	A-Kinase Anchoring Protein 12	Protein Coding	3
682	ARHGEF10	Rho Guanine Nucleotide Exchange Factor 10	Protein Coding	3
683	SH3PXD2A	SH3 And PX Domains 2A	Protein Coding	3
684	GARRE1	Granule Associated Rac And RHOG Effector 1	Protein Coding	3
685	DOCK4	Dedicator Of Cytokinesis 4	Protein Coding	3
686	KNTC1	Kinetochore Associated 1	Protein Coding	3
687	CCP110	Centriolar Coiled-Coil Protein 110	Protein Coding	3
688	ARHGAP32	Rho GTPase Activating Protein 32	Protein Coding	3
689	SLK	STE20 Like Kinase	Protein Coding	3
690	STARD8	StAR Related Lipid Transfer Domain Containing 8	Protein Coding	3
691	CKAP5	Cytoskeleton Associated Protein 5	Protein Coding	3
692	GIT2	GIT ArfGAP 2	Protein Coding	3
693	ARHGAP11A	Rho GTPase Activating Protein 11A	Protein Coding	3
694	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	3
695	ARHGEF17	Rho Guanine Nucleotide Exchange Factor 17	Protein Coding	3
696	FARP2	FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2	Protein Coding	3
697	RHOBTB1	Rho Related BTB Domain Containing 1	Protein Coding	3
698	SRGAP3	SLIT-ROBO Rho GTPase Activating Protein 3	Protein Coding	3
699	CDC20	Cell Division Cycle 20	Protein Coding	3
700	ARHGAP44	Rho GTPase Activating Protein 44	Protein Coding	3
701	ARHGAP25	Rho GTPase Activating Protein 25	Protein Coding	3
702	CDC25C	Cell Division Cycle 25C	Protein Coding	3
703	PLIN3	Perilipin 3	Protein Coding	1
704	LRRC41	Leucine Rich Repeat Containing 41	Protein Coding	1
705	RHOBTB3	Rho Related BTB Domain Containing 3	Protein Coding	1
706	TRAK1	Trafficking Kinesin Protein 1	Protein Coding	1
707	HTR7	5-Hydroxytryptamine Receptor 7	Protein Coding	1
708	RAB9B	RAB9B, Member RAS Oncogene Family	Protein Coding	1
709	RHOT1	Ras Homolog Family Member T1	Protein Coding	1
710	MFN1	Mitofusin 1	Protein Coding	1
711	RAP1GDS1	Rap1 GTPase-GDP Dissociation Stimulator 1	Protein Coding	1
712	TRAK2	Trafficking Kinesin Protein 2	Protein Coding	1
713	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	1
714	MYO19	Myosin XIX	Protein Coding	1
715	CCNE1	Cyclin E1	Protein Coding	1
716	RHOT2	Ras Homolog Family Member T2	Protein Coding	1
717	RAB9A	RAB9A, Member RAS Oncogene Family	Protein Coding	1
718	MFN2	Mitofusin 2	Protein Coding	1

Disorders associated with Signaling by Rho GTPases SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lissencephaly	Enrichment	ACTG1, DYNC1H1, PAFAH1B1, TUBA1A, TUBA3E, TUBB2B, TUBB3	6.42
2	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1, BUB1B, BUB1B-PAK6, BUB3, MAD1L1, PAK6	6.32
3	Chronic granulomatous disease	Enrichment	CYBA, CYBB, NCF1, NCF2, NCF4	6.04
4	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12, H4C1, H4C9	4.86
5	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB2B, TUBB3	4.86
6	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B, BUB1B-PAK6, MAD1L1, PAK6	4.47
7	Neural tube defects	Enrichment	DLC1, ITGB1, SCRIB, VANGL1, VANGL2	4.42
8	Genetic steroid-resistant nephrotic syndrome	Enrichment	ANKFY1, ANLN, ARHGAP24, ARHGDIA, NUP107, NUP133, NUP160, NUP37, NUP85	4.38
9	Tubulinopathy	Enrichment	TUBA1A, TUBB2A, TUBB2B	4.27
10	Inflammatory myofibroblastic tumor	Enrichment	CLTC, RANBP2, TPM3, TPM4	4.01
11	Microcephaly	Enrichment	ABL1, ACTB, ACTG1, CTNNB1, DIAPH1, DYNC1H1, MAPK1, NUF2, PAK3, TUBB4A, YWHAG	3.74
12	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB2B, TUBB3	3.58
13	Aortic aneurysm, familial thoracic 4	Enrichment	MYH11, NDE1	3.24
14	Wiskott-aldrich syndrome	Enrichment	WAS, WIPF1	3.24
15	Megacystis-microcolon-intestinal hypoperistalsis syndrome 2	Enrichment	MYH11, NDE1	3.24
16	Immunodeficiency 72 with autoinflammation and lymphoproliferation	Enrichment	NCKAP1, NCKAP1L	3.24
17	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	3.24
18	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	3.24
19	Visceral myopathy 2	Enrichment	MYH11, NDE1	3.24
20	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	3.24
21	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	3.24
22	Immunodeficiency 72	Enrichment	NCKAP1, NCKAP1L	3.24
23	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	3.15
24	Primary autosomal recessive microcephaly	Enrichment	CENPE, CIT, KIF14, KNL1, NUP37	3.04
25	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1, TPM4, TUBA8, TUBB1	2.93
26	Robinow syndrome, autosomal dominant 2	Enrichment	CHN1, DVL1, DVL3	2.89
27	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	MYH9, TUBB1	2.77
28	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1, NCF2	2.77
29	Miller-dieker lissencephaly syndrome	Enrichment	PAFAH1B1, YWHAE	2.77
30	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	PAFAH1B1, YWHAE	2.77
31	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	2.77
32	Cellular ependymoma	Enrichment	MEN1, NF2	2.77
33	Tanycytic ependymoma	Enrichment	MEN1, NF2	2.77
34	Papillary ependymoma	Enrichment	MEN1, NF2	2.77
35	Tricuspid valve insufficiency	Enrichment	MYH11, NDE1	2.77
36	Clear cell ependymoma	Enrichment	MEN1, NF2	2.77
37	Complex neurodevelopmental disorder	Enrichment	CUL3, DLG4, DOCK3, H4C3, H4C5, H4C9, HNRNPC, MYH10, PAK3, PLXNA1, PPP2CA, RAC3, SPTBN1, TIAM1, WASF1	2.73
38	Alagille syndrome 1	Enrichment	FAM13A, JAG1	2.50
39	Nuchal bleb, familial	Enrichment	CFTR, SOS1	2.50
40	Hypercholanemia, familial 1	Enrichment	DOCK6, TJP2	2.50
41	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	2.50
42	Adams-oliver syndrome 1	Enrichment	ARHGAP31, DOCK6	2.50
43	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DLG4, DVL2	2.48
44	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, DVL3	2.48
45	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYH11, MYLK	2.48
46	Granulomatous disease, chronic, x-linked	Enrichment	CYBB, NCF1	2.48
47	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42, YWHAZ	2.48
48	Autosomal dominant robinow syndrome	Enrichment	DVL1, DVL3	2.48
49	Mitral valve insufficiency	Enrichment	MYH11, NDE1	2.48
50	Primary hyperparathyroidism	Enrichment	CDKN1B, MEN1	2.48
51	Benign ependymoma	Enrichment	MEN1, NF2	2.48
52	Cerebral palsy	Enrichment	ADD3, ALDH3A2, ARHGAP31, KIDINS220, MFN2, TUBA1A, TUBB4A	2.40
53	Visceral myopathy 1	Enrichment	MYH11, MYLK	2.26
54	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, DVL3	2.26
55	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	2.21
56	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, CENPP, DIAPH3, MYH14, MYH9	2.10
57	Hyperpigmentation of the skin	Enrichment	MFN2, USP9X	2.09
58	Autosomal recessive robinow syndrome	Enrichment	DVL1, DVL3	2.09
59	Intestinal pseudo-obstruction	Enrichment	MYH11, NDE1	2.09
60	Moebius syndrome	Enrichment	CHN1, PLXND1	2.00
61	Martsolf syndrome 1	Enrichment	ARHGAP35, ARHGAP5	2.00
62	Auditory neuropathy	Enrichment	DIAPH1, KIF5A, MFN2, RAB9B, TUBB4A	1.97
63	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B, MEN1	1.95
64	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A, TUBB2B	1.95
65	Glioma susceptibility 1	Enrichment	H3-3A, H3C1	1.83
66	Fanconi anemia, complementation group c	Enrichment	FLNA, TAOK1	1.83
67	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	1.83
68	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR, MAPK1	1.82
69	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	EMD, KIF5A, MFN2, VCP	1.80
70	Combined immunodeficiency	Enrichment	ARPC1B, TFRC, ZAP70	1.78
71	Combined t cell and b cell immunodeficiency	Enrichment	ARPC1B, TFRC, ZAP70	1.78
72	Combined t and b cell immunodeficiency	Enrichment	ARPC1B, TFRC, ZAP70	1.78
73	Cataract 44	Enrichment	DNMBP, EPHA2, NHS	1.77
74	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A, TUBB2B	1.73
75	Familial thoracic aortic aneurysm and dissection	Enrichment	MYH11, MYLK	1.73
76	Noonan syndrome 3	Enrichment	CLTC, SOS1	1.69
77	Adams-oliver syndrome	Enrichment	ARHGAP31, DOCK6	1.69
78	Galloway-mowat syndrome	Enrichment	NUP107, NUP133	1.64
79	Granulomatous disease, chronic, autosomal recessive, 4	Enrichment	CYBA	1.62
80	Baraitser-winter syndrome 1	Enrichment	ACTB	1.62
81	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	1.62
82	Thrombocytopenia 1	Enrichment	WAS	1.62
83	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	1.62
84	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	1.62
85	Androgen insensitivity, partial	Enrichment	AR	1.62
86	Spastic paraplegia 10, autosomal dominant	Enrichment	KIF5A	1.62
87	Immunodeficiency 34	Enrichment	CYBB	1.62
88	Otopalatodigital syndrome, type i	Enrichment	FLNA	1.62
89	Intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked	Enrichment	FLNA	1.62
90	Deafness, autosomal dominant 17	Enrichment	MYH9	1.62
91	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	1.62
92	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	1.62
93	Schwannomatosis, vestibular	Enrichment	NF2	1.62
94	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	1.62
95	Amyotrophic lateral sclerosis 18	Enrichment	PFN1	1.62
96	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	1.62
97	Wiskott-aldrich syndrome 2	Enrichment	WIPF1	1.62
98	Cortical dysplasia, complex, with other brain malformations 3	Enrichment	KIF2A	1.62
99	Premature chromatid separation trait	Enrichment	BUB1B	1.62
100	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	1.62
101	Neurodevelopmental disorder with absent language and variable seizures	Enrichment	WASF1	1.62
102	Developmental delay with or without intellectual impairment or behavioral abnormalities	Enrichment	TAOK1	1.62
103	Noonan syndrome 13	Enrichment	MAPK1	1.62
104	Leber congenital amaurosis with early-onset deafness	Enrichment	TUBB4B	1.62
105	Nephrotic syndrome, type 19	Enrichment	NUP160	1.62
106	Knobloch syndrome 2	Enrichment	PAK2	1.62
107	Deafness, autosomal dominant 4a	Enrichment	MYH14	1.62
108	Terminal osseous dysplasia	Enrichment	FLNA	1.62
109	Oocyte/zygote/embryo maturation arrest 14	Enrichment	CDC20	1.62
110	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	1.62
111	Houge-janssens syndrome 4	Enrichment	PPP2R5C	1.62
112	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	1.62
113	Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia	Enrichment	ARPC1B	1.62
114	Fg syndrome 2	Enrichment	FLNA	1.62
115	Premature ovarian failure 2a	Enrichment	DIAPH2	1.62
116	Adrenal cortical adenoma	Enrichment	MEN1	1.62
117	Galloway-mowat syndrome 8	Enrichment	NUP133	1.62
118	Isolated growth hormone deficiency type iii	Enrichment	BTK	1.62
119	Oocyte/zygote/embryo maturation arrest 24	Enrichment	TUBA1C	1.62
120	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	1.62
121	Myoclonus, intractable, neonatal	Enrichment	KIF5A	1.62
122	Auditory neuropathy, autosomal dominant 1	Enrichment	DIAPH3	1.62
123	Houge-janssens syndrome 2	Enrichment	PPP2R1A	1.62
124	Amyotrophic lateral sclerosis 25	Enrichment	KIF5A	1.62
125	Otopalatodigital syndrome spectrum disorder	Enrichment	FLNA	1.62
126	Microcephaly 4, primary, autosomal recessive	Enrichment	KNL1	1.62
127	Microcephaly 24, primary, autosomal recessive	Enrichment	NUP37	1.62
128	Becker nevus syndrome	Enrichment	ACTB	1.62
129	Microhydranencephaly	Enrichment	NDE1	1.62
130	Galloway-mowat syndrome 7	Enrichment	NUP107	1.62
131	Dystonia-deafness syndrome 1	Enrichment	ACTB	1.62
132	Neuroendocrine tumor	Enrichment	CDKN1B	1.62
133	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	1.62
134	Long qt syndrome 16	Enrichment	CALM3	1.62
135	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	1.62
136	Lissencephaly 4 with microcephaly	Enrichment	NDE1	1.62
137	Peripheral neuropathy, myopathy, hoarseness, and hearing loss	Enrichment	MYH14	1.62
138	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	1.62
139	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	1.62
140	Meckel syndrome, type 10	Enrichment	B9D2	1.62
141	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	1.62
142	Nephrotic syndrome, type 11	Enrichment	NUP107	1.62
143	Dync1h1-related disorders	Enrichment	DYNC1H1	1.62
144	Microcephaly 13, primary, autosomal recessive	Enrichment	CENPE	1.62
145	Thrombocytopenia 6	Enrichment	SRC	1.62
146	Was-related disorders	Enrichment	WAS	1.62
147	X-linked ehlers-danlos syndrome	Enrichment	FLNA	1.62
148	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	1.62
149	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	1.62
150	Takenouchi-kosaki syndrome	Enrichment	CDC42	1.62
151	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	1.62
152	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	1.62
153	Microcephaly 20, primary, autosomal recessive	Enrichment	KIF14	1.62
154	Ovarian dysgenesis 6	Enrichment	NUP107	1.62
155	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	1.62
156	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	1.62
157	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	1.62
158	Short stature and microcephaly with genital anomalies	Enrichment	CENPT	1.62
159	Nephrotic syndrome, type 18	Enrichment	NUP133	1.62
160	Neurodevelopmental disorder with microcephaly and structural brain anomalies	Enrichment	DYNC1I2	1.62
161	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	1.62
162	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	1.62
163	Hydranencephaly	Enrichment	NDE1	1.62
164	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	1.62
165	Microcephaly 30, primary, autosomal recessive	Enrichment	BUB1	1.62
166	Adenoid ameloblastoma	Enrichment	CTNNB1	1.62
167	Long qt syndrome 15	Enrichment	CALM2	1.62
168	Meckel syndrome 12	Enrichment	KIF14	1.62
169	Baraitser-winter syndrome	Enrichment	ACTB	1.62
170	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	1.62
171	Mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition	Enrichment	MAD1L1	1.62
172	Nde1-related microhydranencephaly	Enrichment	NDE1	1.62
173	Congenital myopathy 26	Enrichment	TUBA4A	1.62
174	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	1.62
175	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	1.62
176	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	1.62
177	Neurodegeneration, early-childhood-onset, with retinitis pigmentosa, sensorineural hearing loss, and demyelinating peripheral neuropathy	Enrichment	KLC4	1.62
178	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	1.62
179	Autosomal dominant nonsyndromic hearing loss 17	Enrichment	MYH9	1.62
180	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	1.62
181	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	1.62
182	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	1.62
183	Adrenal adenoma	Enrichment	MEN1	1.62
184	Acoustic neuroma	Enrichment	NF2	1.62
185	Complete androgen insensitivity syndrome	Enrichment	AR	1.62
186	Congenital smooth muscle hamartoma	Enrichment	ACTB	1.62
187	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	1.62
188	Nocarh syndrome	Enrichment	CDC42	1.62
189	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	1.62
190	Familial acute necrotizing encephalopathy	Enrichment	RANBP2	1.62
191	X-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome	Enrichment	FLNA	1.62
192	Lissencephaly due to lis1 mutation	Enrichment	PAFAH1B1	1.62
193	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	1.62
194	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	1.62
195	Autosomal dominant charcot-marie-tooth disease type 2 due to kif5a mutation	Enrichment	KIF5A	1.62
196	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	1.62
197	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	1.62
198	Microcystic stromal tumor	Enrichment	CTNNB1	1.62
199	Immunodeficiency 47	Enrichment	ATP6AP1, VMA22	1.58
200	Specific learning disability	Enrichment	MAPK1, YWHAG	1.56
201	Thrombocytopenia	Enrichment	MYH9, SRC, TUBB1, WAS	1.56
202	Noonan syndrome 1	Enrichment	PPP1CB, RRAS2, SOS1, SOS2	1.54
203	Palmoplantar keratoderma and congenital alopecia 1	Enrichment	GJA1	1.48
204	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	1.48
205	Macrodactyly	Enrichment	PIK3CA	1.48
206	Buschke-ollendorff syndrome	Enrichment	LEMD3	1.48
207	Hypoplastic left heart syndrome 1	Enrichment	GJA1	1.48
208	Ramon syndrome	Enrichment	ELMO2	1.48
209	Intellectual developmental disorder, x-linked, syndromic, gustavson type	Enrichment	RBMX	1.48
210	Amyotrophic lateral sclerosis 2, juvenile	Enrichment	ALS2	1.48
211	Intellectual developmental disorder, x-linked 99	Enrichment	USP9X	1.48
212	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	1.48
213	Nance-horan syndrome	Enrichment	NHS	1.48
214	Autoinflammatory disease, multisystem, with immune dysregulation, x-linked	Enrichment	DOCK11	1.48
215	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	1.48
216	Noonan syndrome 4	Enrichment	SOS1	1.48
217	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	1.48
218	Deafness, autosomal dominant 51	Enrichment	TJP2	1.48
219	Type 1 diabetes mellitus 21	Enrichment	TAGAP	1.48
220	Spastic paralysis, infantile-onset ascending	Enrichment	ALS2	1.48
221	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	1.48
222	Oculodentodigital dysplasia	Enrichment	GJA1	1.48
223	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1	Enrichment	VCP	1.48
224	Deafness, autosomal dominant 22	Enrichment	MYO6	1.48
225	Congenital myopathy 4b, autosomal recessive	Enrichment	TPM3	1.48
226	Developmental and epileptic encephalopathy 5	Enrichment	SPTAN1	1.48
227	Cowden syndrome 5	Enrichment	PIK3CA	1.48
228	Cardiac valvular dysplasia 1	Enrichment	PLD1	1.48
229	Pseudohypoaldosteronism, type iie	Enrichment	CUL3	1.48
230	Noonan syndrome 9	Enrichment	SOS2	1.48
231	Hypogonadotropic hypogonadism 14 with or without anosmia	Enrichment	WDR11	1.48
232	Focal segmental glomerulosclerosis 8	Enrichment	ANLN	1.48
233	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	1.48
234	Charcot-marie-tooth disease, demyelinating, type 4h	Enrichment	FGD4	1.48
235	Greenberg dysplasia	Enrichment	LBR	1.48
236	Pulmonary hypertension, primary, 3	Enrichment	CAV1	1.48
237	Joubert syndrome 8	Enrichment	ARL13B	1.48
238	Pelger-huet anomaly	Enrichment	LBR	1.48
239	Thrombocytopenia 2	Enrichment	ANKRD26	1.48
240	Microcephaly 16, primary, autosomal recessive	Enrichment	ANKLE2	1.48
241	Spinal muscular atrophy, facioscapulohumeral type	Enrichment	PLEKHG5	1.48
242	Spinal muscular atrophy, late-onset, finkel type	Enrichment	VAPB	1.48
243	Craniometaphyseal dysplasia, autosomal recessive	Enrichment	GJA1	1.48
244	Immunodeficiency 62	Enrichment	ARHGEF1	1.48
245	Naxos disease	Enrichment	JUP	1.48
246	Cerebral cavernous malformations 4	Enrichment	PIK3CA	1.48
247	Immunodeficiency 87 and autoimmunity	Enrichment	DEF6	1.48
248	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	1.48
249	Ventriculomegaly and arthrogryposis	Enrichment	KIDINS220	1.48
250	Retinal dystrophy with leukodystrophy	Enrichment	ACBD5	1.48
251	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	1.48
252	Retinitis pigmentosa 78	Enrichment	ARHGEF18	1.48
253	Intellectual developmental disorder, x-linked, syndromic, billuart type	Enrichment	OPHN1	1.48
254	Intellectual developmental disorder, autosomal recessive 78	Enrichment	WDR11	1.48
255	Rhizomelic skeletal dysplasia with or without pelger-huet anomaly	Enrichment	LBR	1.48
256	Bleeding disorder, platelet-type, 25	Enrichment	TPM4	1.48
257	Combined oxidative phosphorylation deficiency 33	Enrichment	C1QBP	1.48
258	Maple syrup urine disease, type ii	Enrichment	DBT	1.48
259	Neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction	Enrichment	LETM1	1.48
260	Charcot-marie-tooth disease, axonal, type 2b	Enrichment	RAB7A	1.48
261	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	1.48
262	Immunodeficiency 48	Enrichment	ZAP70	1.48
263	Short syndrome	Enrichment	PIK3R1	1.48
264	Mitochondrial complex i deficiency, nuclear type 8	Enrichment	NDUFS3	1.48
265	Charcot-marie-tooth disease type 2b	Enrichment	RAB7A	1.48
266	Vascular malformation, primary intraosseous	Enrichment	ELMO2	1.48
267	Deafness, autosomal recessive 37	Enrichment	MYO6	1.48
268	Intellectual developmental disorder, x-linked 99, syndromic, female-restricted	Enrichment	USP9X	1.48
269	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	1.48
270	Deafness, dystonia, and cerebral hypomyelination	Enrichment	BCAP31	1.48
271	Lowe oculocerebrorenal syndrome	Enrichment	OCRL	1.48
272	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	1.48
273	Developmental delay, impaired speech, and behavioral abnormalities	Enrichment	SPTBN1	1.48
274	Cerebral palsy, spastic quadriplegic, 3	Enrichment	ADD3	1.48
275	Oculodentodigital dysplasia, autosomal recessive	Enrichment	GJA1	1.48
276	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	1.48
277	Charcot-marie-tooth disease type 4h	Enrichment	FGD4	1.48
278	Amyotrophic lateral sclerosis 8	Enrichment	VAPB	1.48
279	Slowed nerve conduction velocity, autosomal dominant	Enrichment	ARHGEF10	1.48
280	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2	Enrichment	WDR81	1.48
281	Hemifacial myohyperplasia	Enrichment	PIK3CA	1.48
282	Spondyloepimetaphyseal dysplasia, shohat type	Enrichment	DDRGK1	1.48
283	Immunodeficiency 40	Enrichment	DOCK2	1.48
284	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	1.48
285	Microlissencephaly	Enrichment	WDR81	1.48
286	Celiac disease 4	Enrichment	MYO9B	1.48
287	Congenital disorder of glycosylation, type iiaa	Enrichment	STX5	1.48
288	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	1.48
289	Immunodeficiency 46	Enrichment	TFRC	1.48
290	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	1.48
291	Neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities	Enrichment	SHMT2	1.48
292	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	1.48
293	Radio-tartaglia syndrome	Enrichment	SPEN	1.48
294	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	1.48
295	Reynolds syndrome	Enrichment	LBR	1.48
296	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	1.48
297	Lipodystrophy, congenital generalized, type 4	Enrichment	CAVIN1	1.48
298	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Enrichment	VCP	1.48
299	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	1.48
300	Immunodeficiency 22	Enrichment	LCK	1.48
301	Neurodevelopmental disorder with or without autism or seizures	Enrichment	CUL3	1.48
302	Als2-related disorder	Enrichment	ALS2	1.48
303	Bile acid synthesis defect, congenital, 5	Enrichment	ABCD3	1.48
304	Erythrokeratodermia variabilis et progressiva 3	Enrichment	GJA1	1.48
305	Chilton-okur-chung neurodevelopmental syndrome	Enrichment	CDC42BPB	1.48
306	Hydrocephalus, congenital, 3, with brain anomalies	Enrichment	WDR81	1.48
307	Developmental and epileptic encephalopathy 64	Enrichment	RHOBTB2	1.48
308	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	1.48
309	Myasthenic syndrome, congenital, 24, presynaptic	Enrichment	MYO9A	1.48
310	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	1.48
311	Neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation	Enrichment	RALGAPA1	1.48
312	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	1.48
313	Peho-like syndrome	Enrichment	CCDC88A	1.48
314	Multisystem proteinopathy	Enrichment	VCP	1.48
315	Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia	Enrichment	DOCK3	1.48
316	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	1.48
317	Immunodeficiency 129	Enrichment	RHOH	1.48
318	Melorheostosis with osteopoikilosis	Enrichment	LEMD3	1.48
319	Intellectual developmental disorder, autosomal dominant 74	Enrichment	HNRNPC	1.48
320	Primary intraosseous venous malformation	Enrichment	ELMO2	1.48
321	Dworschak-punetha neurodevelopmental syndrome	Enrichment	PLXNA1	1.48
322	Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia	Enrichment	SPTAN1	1.48
323	Developmental delay with or without epilepsy	Enrichment	SPTAN1	1.48
324	Adult-onset distal myopathy due to vcp mutation	Enrichment	VCP	1.48
325	Neuronopathy, distal hereditary motor, autosomal dominant 11	Enrichment	SPTAN1	1.48
326	Female-restricted syndromic x-linked intellectual disability 99	Enrichment	USP9X	1.48
327	Hypospadias	Enrichment	PIK3CA	1.48
328	T-cell immunodeficiency with epidermodysplasia verruciformis	Enrichment	RHOH	1.48
329	Autosomal dominant adult-onset proximal spinal muscular atrophy	Enrichment	VAPB	1.48
330	Yuksel-vogel-bauer syndrome	Enrichment	DLG5	1.48
331	Congenital dyserythropoietic anemia type iiib	Enrichment	RACGAP1	1.48
332	Progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome	Enrichment	MYO6	1.48
333	Rare venous malformation	Enrichment	PIK3CA	1.48
334	Diaphragmatic eventration	Enrichment	PIK3CA	1.48
335	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	1.48
336	Autosomal dominant nonsyndromic hearing loss 22	Enrichment	MYO6	1.48
337	Rare combined vascular malformation	Enrichment	PIK3CA	1.48
338	Anemia, congenital dyserythropoietic, type iiib, autosomal recessive	Enrichment	RACGAP1	1.48
339	Cavernous lymphangioma	Enrichment	PIK3CA	1.48
340	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	1.48
341	Isolated osteopoikilosis	Enrichment	LEMD3	1.48
342	Premature aging	Enrichment	VIM	1.48
343	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	1.48
344	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	1.48
345	Autosomal dominant combined immunodeficiency due to erbin deficiency	Enrichment	ERBIN	1.48
346	Congenital generalized hypercontractile muscle stiffness syndrome	Enrichment	TPM3	1.48
347	Macrodactyly of toe	Enrichment	PIK3CA	1.48
348	Infantile-onset ascending hereditary spastic paralysis	Enrichment	ALS2	1.48
349	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	1.48
350	Temporomandibular joint anomaly	Enrichment	DOCK1	1.48
351	Juvenile amyotrophic lateral sclerosis	Enrichment	ALS2, PLEKHG5	1.48
352	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	1.46
353	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B, WDR81	1.46
354	Rasopathy	Enrichment	PPP1CB, RRAS2, SOS1, SOS2	1.37
355	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC, DOCK8, DYNC1H1, ITSN1, TAOK1, YWHAZ	1.36
356	Aortic aneurysm, familial thoracic 1	Enrichment	MYH11, MYLK	1.36
357	Seckel syndrome	Enrichment	CENPE, NUP85	1.36
358	Leukemia, chronic myeloid	Enrichment	ABL1, BCR	1.33
359	Gallbladder cancer	Enrichment	CTNNB1, PIK3CA	1.33
360	Moyamoya angiopathy	Enrichment	ABL1, ARHGEF25	1.33
361	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, BCR	1.33
362	Spinal muscular atrophy, lower extremity-predominant, 1, autosomal dominant	Enrichment	DYNC1H1	1.32
363	Dystonia 4, torsion, autosomal dominant	Enrichment	TUBB4A	1.32
364	Microcephalic osteodysplastic primordial dwarfism, type i	Enrichment	CLASP1	1.32
365	Stromme syndrome	Enrichment	CENPF	1.32
366	Lowry-wood syndrome	Enrichment	CLASP1	1.32
367	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	1.32
368	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	FLNA	1.32
369	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	1.32
370	Neutropenia, severe congenital, x-linked	Enrichment	WAS	1.32
371	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	1.32
372	Otopalatodigital syndrome, type ii	Enrichment	FLNA	1.32
373	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.32
374	Melnick-needles syndrome	Enrichment	FLNA	1.32
375	Cataract 35	Enrichment	MYH9	1.32
376	Frontometaphyseal dysplasia 1	Enrichment	FLNA	1.32
377	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.32
378	Nephronophthisis-like nephropathy 1	Enrichment	RANGAP1	1.32
379	Hyperparathyroidism 1	Enrichment	MEN1	1.32
380	Macroglossia	Enrichment	TAOK1	1.32
381	Schwannomatosis 1	Enrichment	NF2	1.32
382	Spastic paraplegia, optic atrophy, and neuropathy	Enrichment	KLC2	1.32
383	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.32
384	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.32
385	Granulomatous disease, chronic, autosomal recessive, 3	Enrichment	NCF4	1.32
386	Melanoma, cutaneous malignant 6	Enrichment	KLC1	1.32
387	Lissencephaly 1	Enrichment	PAFAH1B1	1.32
388	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.32
389	Robinow syndrome, autosomal dominant 3	Enrichment	DVL3	1.32
390	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	1.32
391	Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies	Enrichment	DYNC1I2	1.32
392	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.32
393	Long qt syndrome 14	Enrichment	CALM1	1.32
394	Houge-janssens syndrome 1	Enrichment	PPP2R5D	1.32
395	Roifman syndrome	Enrichment	CLASP1	1.32
396	Cortical dysplasia, complex, with other brain malformations 13	Enrichment	DYNC1H1	1.32
397	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	1.32
398	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.32
399	Developmental delay, language impairment, and ocular abnormalities	Enrichment	ARPC4	1.32
400	Agammaglobulinemia, x-linked	Enrichment	BTK	1.32
401	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	1.32
402	Cardiac valvular dysplasia, x-linked	Enrichment	FLNA	1.32
403	46,xy sex reversal 1	Enrichment	AR	1.32
404	Androgen insensitivity syndrome	Enrichment	AR	1.32
405	Nephrotic syndrome, type 17	Enrichment	NUP85	1.32
406	Immunodeficiency 66	Enrichment	MRTFA	1.32
407	Keratoconus 9	Enrichment	TUBA3D	1.32
408	Neurodevelopmental disorder with developmental delay and with or without motor or speech delay	Enrichment	TAOK1	1.32
409	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	1.32
410	Hypospadias 1, x-linked	Enrichment	AR	1.32
411	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.32
412	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	1.32
413	Lissencephaly 3	Enrichment	TUBA1A	1.32
414	Spinal muscular atrophy with lower extremity predominant	Enrichment	DYNC1H1	1.32
415	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	KIF5A	1.32
416	Vulto-van silfhout-de vries syndrome	Enrichment	DLG4	1.32
417	Body mass index quantitative trait locus 19	Enrichment	CENPO	1.32
418	Medullary thyroid carcinoma	Enrichment	MEN1	1.32
419	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	1.32
420	Charcot-marie-tooth disease, axonal, type 2o	Enrichment	DYNC1H1	1.32
421	Immunodeficiency 113 with autoimmunity and autoinflammation	Enrichment	ARPC5	1.32
422	Pseudosarcomatous fibromatosis	Enrichment	MYH9	1.32
423	Immune system disease	Enrichment	CDC42	1.32
424	Insulinoma	Enrichment	MEN1	1.32
425	Degenerative disc disease	Enrichment	CENPP	1.32
426	Methylmalonic aciduria and homocystinuria, cbll type	Enrichment	CENPT	1.32
427	Rnu4atac-opathy	Enrichment	CLASP1	1.32
428	Chronic atrial and intestinal dysrhythmia	Enrichment	SGO1	1.32
429	Diamond-blackfan anemia 17	Enrichment	RPS27	1.32
430	Torsion dystonia 4	Enrichment	TUBB4A	1.32
431	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	1.32
432	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.32
433	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.32
434	Demyelinating polyneuropathy	Enrichment	KIF5A	1.32
435	Crohn's disease	Enrichment	FMNL2	1.32
436	Posterior hypospadias	Enrichment	AR	1.32
437	Immunodeficiency 133	Enrichment	ARPC5	1.32
438	Teratoma	Enrichment	CTNNB1	1.32
439	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	1.32
440	Skeletal muscle disease	Enrichment	KIF5B	1.32
441	Null pituitary adenoma	Enrichment	MEN1	1.32
442	Acute necrotizing encephalopathy of childhood	Enrichment	RANBP2	1.32
443	Silent pituitary adenoma	Enrichment	MEN1	1.32
444	Continuous spikes and waves during sleep	Enrichment	TUBA1A	1.32
445	Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)	Enrichment	MRTFA	1.32
446	Gigantism	Enrichment	MEN1	1.32
447	Myopia	Enrichment	MYH11, NDE1	1.31
448	Multiple symmetric lipomatosis	Enrichment	MFN2	1.28
449	Charcot-marie-tooth disease, axonal, autosomal dominant, type 2a2a	Enrichment	MFN2	1.28
450	Charcot-marie-tooth disease, axonal, autosomal recessive, type 2a2b	Enrichment	MFN2	1.28
451	Alfadhel syndrome	Enrichment	RAP1GDS1	1.28
452	Developmental and epileptic encephalopathy 68	Enrichment	TRAK1	1.28
453	Charcot-marie-tooth disease type 5	Enrichment	MFN2	1.28
454	Charcot-marie-tooth disease type 2a2b	Enrichment	MFN2	1.28
455	Retinal hemangioblastoma	Enrichment	VHL	1.28
456	Hypertension	Enrichment	MEN1, MYH9	1.26
457	Colorectal cancer	Enrichment	BUB1, BUB1B, CTNNA1, CTNNB1, SRC	1.23
458	Dandy-walker syndrome	Enrichment	PPP1CB, TUBA1A	1.21
459	Anemia, congenital dyserythropoietic, type iiia	Enrichment	RACGAP1	1.19
460	Fibromatosis, gingival, 1	Enrichment	SOS1	1.19
461	Intellectual developmental disorder, x-linked, syndromic, raymond type	Enrichment	SPTAN1	1.19
462	Cataract 40	Enrichment	NHS	1.19
463	Myopathy, x-linked, with postural muscle atrophy	Enrichment	EMD	1.19
464	Pulmonic stenosis	Enrichment	SOS1	1.19
465	Intellectual developmental disorder, x-linked, syndromic, shashi type	Enrichment	RBMX	1.19
466	Dent disease 2	Enrichment	OCRL	1.19
467	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	VCP	1.19
468	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	1.19
469	Pseudohypoaldosteronism, type i, autosomal dominant	Enrichment	CUL3	1.19
470	Deafness, autosomal recessive 28	Enrichment	TRIO	1.19
471	Keratosis, seborrheic	Enrichment	PIK3CA	1.19
472	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	1.19
473	Primary lateral sclerosis, juvenile	Enrichment	ALS2	1.19
474	Anemia, hypochromic microcytic, with iron overload 2	Enrichment	STEAP3	1.19
475	Duane retraction syndrome 2	Enrichment	CHN1	1.19
476	Hallermann-streiff syndrome	Enrichment	GJA1	1.19
477	Cholestasis, progressive familial intrahepatic, 4	Enrichment	TJP2	1.19
478	Noonan syndrome 8	Enrichment	PIK3CA	1.19
479	Syndactyly, type iii	Enrichment	GJA1	1.19
480	Syndactyly, type v	Enrichment	GJA1	1.19
481	Neuronopathy, distal hereditary motor, autosomal recessive 4	Enrichment	PLEKHG5	1.19
482	Adams-oliver syndrome 2	Enrichment	DOCK6	1.19
483	Spastic paraplegia, intellectual disability, nystagmus, and obesity	Enrichment	KIDINS220	1.19
484	Charcot-marie-tooth disease, recessive intermediate c	Enrichment	PLEKHG5	1.19
485	Atrial septal defect 5	Enrichment	ACTC1	1.19
486	Sjogren-larsson syndrome	Enrichment	ALDH3A2	1.19
487	Spondyloepiphyseal dysplasia, nishimura type	Enrichment	WWP2	1.19
488	Noonan syndrome 12	Enrichment	RRAS2	1.19
489	Spastic paraplegia 70, autosomal recessive	Enrichment	ARHGAP9	1.19
490	Congenital heart defects, multiple types, 9	Enrichment	PLXND1	1.19
491	Craniometaphyseal dysplasia	Enrichment	GJA1	1.19
492	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.19
493	Syndromic x-linked intellectual disability	Enrichment	NHS	1.19
494	Cataract 30	Enrichment	VIM	1.19
495	Syndromic x-linked intellectual disability shashi type	Enrichment	RBMX	1.19
496	Congenital disorder of glycosylation, type iio	Enrichment	VMA22	1.19
497	Hypobetalipoproteinemia, familial, 2	Enrichment	DOCK7	1.19
498	Osteopoikilosis	Enrichment	LEMD3	1.19
499	Neuromuscular disorder, congenital, with dysmorphic facies	Enrichment	FILIP1	1.19
500	Developmental and epileptic encephalopathy 23	Enrichment	DOCK7	1.19
501	Autosomal dominant primary microcephaly	Enrichment	LMNB1	1.19
502	Paget's disease of bone	Enrichment	DOCK6	1.19
503	Disorders of intracellular cobalamin metabolism	Enrichment	MTR	1.19
504	Aarskog syndrome	Enrichment	FGD1	1.19
505	Cataract 48	Enrichment	DNMBP	1.19
506	Isolated anencephaly	Enrichment	VANGL2	1.19
507	Combined deficiency of factor v and factor viii	Enrichment	LMAN1	1.19
508	12q14 microdeletion syndrome	Enrichment	LEMD3	1.19
509	Cadds	Enrichment	BCAP31	1.19
510	Isolated exencephaly	Enrichment	VANGL2	1.19
511	Malignant peripheral nerve sheath tumor with perineurial differentiation	Enrichment	SH3PXD2A	1.19
512	X-linked emery-dreifuss muscular dystrophy	Enrichment	EMD	1.19
513	Malignant triton tumor	Enrichment	SH3PXD2A	1.19
514	Spastic paraplegia-paget disease of bone syndrome	Enrichment	VCP	1.19
515	Desmoid disease, hereditary	Enrichment	CTNNB1	1.15
516	Prune belly syndrome	Enrichment	FLNA	1.15
517	Spondyloepiphyseal dysplasia congenita	Enrichment	CLASP1	1.15
518	Arterial tortuosity syndrome	Enrichment	FLNA	1.15
519	Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	Enrichment	CYBA	1.15
520	Methylmalonic aciduria and homocystinuria, cblx type	Enrichment	CENPT	1.15
521	Periventricular nodular heterotopia 1	Enrichment	FLNA	1.15
522	Band heterotopia	Enrichment	PAFAH1B1	1.15
523	Heart defects, congenital, and other congenital anomalies	Enrichment	DLG4	1.15
524	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.15
525	Leukodystrophy, hypomyelinating, 6	Enrichment	TUBB4A	1.15
526	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.15
527	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	1.15
528	Congenital short bowel syndrome	Enrichment	FLNA	1.15
529	Pituitary adenoma 1, multiple types	Enrichment	MEN1	1.15
530	Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.15
531	Oocyte/zygote/embryo maturation arrest 2	Enrichment	TUBB8	1.15
532	Anus, imperforate	Enrichment	CTNNB1	1.15
533	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	1.15
534	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.15
535	Developmental and epileptic encephalopathy 65	Enrichment	CYFIP2	1.15
536	Agammaglobulinemia 1	Enrichment	BTK	1.15
537	Intellectual developmental disorder, autosomal dominant 62	Enrichment	DLG4	1.15
538	Desmoid tumor	Enrichment	CTNNB1	1.15
539	Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizures	Enrichment	DLG4	1.15
540	Frontometaphyseal dysplasia	Enrichment	FLNA	1.15
541	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.15
542	Microcephaly 17, primary, autosomal recessive	Enrichment	CIT	1.15
543	Parathyroid adenoma	Enrichment	MEN1	1.15
544	Growth hormone secreting pituitary adenoma	Enrichment	MEN1	1.15
545	Dlg4-related synaptopathy	Enrichment	DLG4	1.15
546	Aip familial isolated pituitary adenomas	Enrichment	MEN1	1.15
547	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	1.15
548	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	KDM1A	1.15
549	Familial isolated hyperparathyroidism	Enrichment	MEN1	1.15
550	Autoimmune polyendocrine syndrome type 1	Enrichment	CYBA	1.15
551	Spindle cell sarcoma	Enrichment	NF2	1.15
552	Adult hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	1.12
553	Williams-beuren syndrome	Enrichment	LIMK1, NCF1	1.08
554	Lynch syndrome	Enrichment	CFTR, PIK3CA	1.07
555	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	FLNA, MYH11, MYLK	1.05
556	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CTNNA1	1.03
557	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.03
558	Cystinuria	Enrichment	CENPF	1.03
559	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	1.03
560	Pilomatrixoma	Enrichment	CTNNB1	1.03
561	Ciliary dyskinesia, primary, 29	Enrichment	CENPF	1.03
562	Aminoacylase 1 deficiency	Enrichment	ACTB	1.03
563	Alazami syndrome	Enrichment	CTNNB1	1.03
564	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.03
565	Ectodermal dysplasia	Enrichment	RANBP2	1.03
566	Craniopharyngioma	Enrichment	CTNNB1	1.03
567	Prolactinoma	Enrichment	MEN1	1.03
568	Idiopathic bronchiectasis	Enrichment	CFTR	1.03
569	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	MYH11	1.03
570	Knobloch syndrome	Enrichment	PAK2	1.03
571	Full schwannomatosis	Enrichment	NF2	1.03
572	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.03
573	Severe combined immunodeficiency	Enrichment	DOCK8, LCK, ZAP70	1.03
574	Pseudohypoaldosteronism, type iia	Enrichment	CUL3	1.02
575	Maple syrup urine disease, type ia	Enrichment	DBT	1.02
576	Homocystinuria-megaloblastic anemia, cblg type	Enrichment	MTR	1.02
577	Hyper-ige syndrome 2, autosomal recessive, with recurrent infections	Enrichment	DOCK8	1.02
578	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.02
579	Aarskog-scott syndrome	Enrichment	FGD1	1.02
580	Factor v and factor viii, combined deficiency of, 1	Enrichment	LMAN1	1.02
581	Intellectual developmental disorder, x-linked, syndromic, claes-jensen type	Enrichment	FGD1	1.02
582	Spinocerebellar ataxia 4	Enrichment	PLEKHG4	1.02
583	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	1.02
584	Estrogen resistance	Enrichment	TMEM59	1.02
585	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	1.02
586	Polycystic kidney disease 2 with or without polycystic liver disease	Enrichment	FAM13A	1.02
587	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.02
588	Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy	Enrichment	SPTBN1	1.02
589	Epidermolysis bullosa simplex 3, localized or generalized intermediate, with bp230 deficiency	Enrichment	DST	1.02
590	Short-rib thoracic dysplasia 11 with or without polydactyly	Enrichment	SPTAN1	1.02
591	Myopathy, autosomal recessive, with rigid spine and distal joint contractures	Enrichment	TOR1AIP1	1.02
592	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	1.02
593	Hyper-ige syndrome 3, autosomal recessive, with recurrent infections	Enrichment	DOCK8	1.02
594	Dent disease	Enrichment	OCRL	1.02
595	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	VCP	1.02
596	Polycystic kidney disease 2	Enrichment	FAM13A	1.02
597	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	1.02
598	Leukodystrophy and acquired microcephaly with or without dystonia	Enrichment	PLEKHG2	1.02
599	Immunodeficiency 14	Enrichment	PIK3R1	1.02
600	Squamous cell carcinoma	Enrichment	FAM13A	1.02
601	Duane retraction syndrome	Enrichment	CHN1	1.02
602	Chung-jansen syndrome	Enrichment	PHIP	1.02
603	Syndromic x-linked intellectual disability claes-jensen type	Enrichment	FGD1	1.02
604	Cap myopathy	Enrichment	TPM3	1.02
605	Homocystinuria	Enrichment	MTR	1.02
606	Keratoacanthoma	Enrichment	PIK3CA	1.02
607	Tyrosinemia	Enrichment	ALS2	1.02
608	Intermittent maple syrup urine disease	Enrichment	DBT	1.02
609	Classic maple syrup urine disease	Enrichment	DBT	1.02
610	Lipomatosis, multiple symmetric, with or without axonal peripheral neuropathy	Enrichment	MFN2	0.99
611	Glycosylphosphatidylinositol biosynthesis defect 11	Enrichment	MYO19	0.99
612	Axonal neuropathy	Enrichment	MFN2	0.99
613	Acute leukemia of ambiguous lineage	Enrichment	VHL	0.99
614	Multiple system atrophy, cerebellar type	Enrichment	MFN2	0.99
615	Syndromic intellectual disability	Enrichment	PHIP, TRIO	0.98
616	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6, ATP6AP1, USP9X	0.95
617	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, BCR, PICALM	0.95
618	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	RANBP2	0.94
619	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	0.94
620	Kearns-sayre syndrome	Enrichment	KIF5B	0.94
621	Deafness, autosomal recessive 63	Enrichment	MYH9	0.94
622	Knobloch syndrome 1	Enrichment	PAK2	0.94
623	Chromosome 15q11.2 deletion syndrome	Enrichment	PAFAH1B1	0.94
624	Lissencephaly 2	Enrichment	NDE1	0.94
625	Congenital ptosis	Enrichment	MYH10	0.94
626	Spinal muscular atrophy	Enrichment	DYNC1H1	0.94
627	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	RANBP2	0.94
628	Female infertility due to oocyte meiotic arrest	Enrichment	TUBB8	0.94
629	Coloboma of choroid and retina	Enrichment	ACTG1	0.94
630	Endometrial stromal sarcoma	Enrichment	YWHAE	0.94
631	Neuromuscular disease	Enrichment	EMD, SPTAN1	0.93
632	Early-onset nuclear cataract	Enrichment	EPHA2, NHS	0.93
633	Body mass index quantitative trait locus 11	Enrichment	CENPO, MYH9, NUDC	0.93
634	Trichorhinophalangeal syndrome, type ii	Enrichment	STMN2	0.90
635	Intellectual developmental disorder, autosomal dominant 1	Enrichment	ITSN1	0.90
636	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	EMD	0.90
637	Sacral defect with anterior meningocele	Enrichment	VANGL1	0.90
638	Achalasia-addisonianism-alacrima syndrome	Enrichment	AAAS	0.90
639	Neural tube defects, folate-sensitive	Enrichment	MTR	0.90
640	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	0.90
641	Neuropathy, hereditary sensory and autonomic, type vi	Enrichment	DST	0.90
642	Congenital generalized lipodystrophy	Enrichment	CAVIN1	0.90
643	Imerslund-grasbeck syndrome 2	Enrichment	CDC42BPB	0.90
644	Fetal akinesia deformation sequence 3	Enrichment	DOCK7	0.90
645	Emery-dreifuss muscular dystrophy	Enrichment	EMD	0.90
646	Cerebrovascular disease	Enrichment	PIK3CA	0.90
647	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	0.90
648	Blood platelet disease	Enrichment	ANKRD26	0.90
649	Spastic quadriplegic cerebral palsy	Enrichment	ADD3	0.90
650	Oligohydramnios	Enrichment	OPHN1	0.90
651	Familial cerebral cavernous malformations	Enrichment	PIK3CA	0.90
652	Charcot-marie-tooth hereditary neuropathy	Enrichment	SPTAN1	0.90
653	Intermediate maple syrup urine disease	Enrichment	DBT	0.90
654	Intermediate nemaline myopathy	Enrichment	TPM3	0.90
655	Middle aortic syndrome	Enrichment	JAG1	0.90
656	Gingival fibromatosis	Enrichment	SOS1	0.90
657	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	0.90
658	Meningioma	Enrichment	NF2, PIK3CA	0.90
659	Lip and oral cavity carcinoma	Enrichment	ABL1, PIK3CA	0.90
660	Arteriovenous malformations of the brain	Enrichment	LEMD3, PREX2	0.89
661	Weyers acrofacial dysostosis	Enrichment	CTNNB1	0.87
662	Moyamoya disease 1	Enrichment	DIAPH1	0.87
663	Hemangioma, capillary infantile	Enrichment	MYH9	0.87
664	Pendred syndrome	Enrichment	DIAPH1	0.87
665	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	0.87
666	Patent ductus arteriosus	Enrichment	FLNA	0.87
667	Adrenocortical carcinoma	Enrichment	CTNNB1	0.87
668	Early myoclonic encephalopathy	Enrichment	TUBA1A	0.87
669	Kidney clear cell sarcoma	Enrichment	YWHAE	0.87
670	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ, SPEN	0.84
671	Nk-cell enteropathy	Enrichment	AURKB, CUL3	0.84
672	Centronuclear myopathy	Enrichment	TOR1AIP1, TPM3	0.82
673	Myasthenic syndrome, congenital, 6, presynaptic	Enrichment	VHL	0.82
674	Pelizaeus-merzbacher disease	Enrichment	RAB9B	0.82
675	Spastic paraplegia 2, x-linked	Enrichment	RAB9B	0.82
676	Neuropathy, hereditary motor and sensory, type via, with optic atrophy	Enrichment	MFN2	0.82
677	Primary polycythemia	Enrichment	VHL	0.82
678	Pelizeaus-merzbacher spectrum disorder	Enrichment	RAB9B	0.82
679	Undetermined early-onset epileptic encephalopathy	Enrichment	CYFIP2, LIMK1, YWHAG	0.82
680	Prostate cancer	Enrichment	AR, MAD1L1	0.81
681	Cataract 6, multiple types	Enrichment	EPHA2	0.81
682	Capillary malformations, congenital	Enrichment	PIK3CA	0.81
683	Dementia, lewy body	Enrichment	VCP	0.81
684	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	VCP	0.81
685	Pervasive developmental disorder	Enrichment	SPTBN1	0.81
686	Histiocytoid hemangioma	Enrichment	VIM	0.81
687	Cleft upper lip	Enrichment	GJA1	0.81
688	Autosomal thrombocytopenia with normal platelets	Enrichment	ANKRD26	0.81
689	Hemimegalencephaly	Enrichment	PIK3CA	0.81
690	Aniridia	Enrichment	EPHA2	0.81
691	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	0.81
692	Persistent truncus arteriosus	Enrichment	PLXND1	0.81
693	Rare pervasive developmental disorder	Enrichment	SPTBN1	0.81
694	Mitochondrial dna depletion syndrome 4a	Enrichment	RANBP2	0.81
695	Myelofibrosis	Enrichment	SRC	0.81
696	Gastrointestinal stromal tumor	Enrichment	MEN1	0.81
697	Charcot-marie-tooth disease	Enrichment	ARHGEF10, DST, DYNC1H1, MFN2	0.77
698	Long qt syndrome	Enrichment	CALM1, CALM2	0.77
699	Mitochondrial dna depletion syndrome 4b	Enrichment	RANBP2	0.75
700	Perrault syndrome	Enrichment	SGO2	0.75
701	Exudative vitreoretinopathy	Enrichment	CTNNB1	0.75
702	Cryptorchidism	Enrichment	TUBA1A	0.75
703	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	0.75
704	Male infertility due to globozoospermia	Enrichment	GOPC	0.75
705	Difference of sex development	Enrichment	AR	0.75
706	Peripheral nervous system disease	Enrichment	DYNC1H1, KIF5A	0.75
707	Neuropathy	Enrichment	DYNC1H1, KIF5A	0.75
708	Hereditary spastic paraplegia	Enrichment	KIF5A, PLEKHG5, RAB9B, SPTAN1	0.74
709	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	0.74
710	Branchiootorenal syndrome 1	Enrichment	TJP2	0.74
711	Kabuki syndrome 1	Enrichment	KIDINS220	0.74
712	Cowden syndrome 1	Enrichment	PIK3CA	0.74
713	Wolf-hirschhorn syndrome	Enrichment	LETM1	0.74
714	Muscular dystrophy, limb-girdle, autosomal recessive 1	Enrichment	TOR1AIP1	0.74
715	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	MYO6	0.74
716	Testicular germ cell tumor	Enrichment	STK10	0.74
717	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	0.74
718	Megaloblastic anemia	Enrichment	CDC42BPB	0.74
719	Limited scleroderma	Enrichment	CAV1	0.74
720	Breast adenocarcinoma	Enrichment	PIK3CA	0.74
721	Lung squamous cell carcinoma	Enrichment	PIK3CA	0.74
722	Familial hypercholanemia	Enrichment	TJP2	0.74
723	Erythrocytosis, familial, 2	Enrichment	VHL	0.71
724	Au-kline syndrome	Enrichment	VHL	0.71
725	Male infertility	Enrichment	AR, CFTR	0.71
726	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	0.71
727	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	0.71
728	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	0.71
729	Cryptorchidism, unilateral or bilateral	Enrichment	TUBA1A	0.71
730	Inflammatory bowel disease 1	Enrichment	FMNL2	0.71
731	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	0.71
732	Jeune thoracic dystrophy	Enrichment	LBR, SPTAN1	0.70
733	Oculopharyngodistal myopathy 1	Enrichment	ABCD3	0.68
734	Nevus, epidermal	Enrichment	PIK3CA	0.68
735	Thyroid cancer, nonmedullary, 2	Enrichment	SRGAP1	0.68
736	Imerslund-grasbeck syndrome 1	Enrichment	CDC42BPB	0.68
737	Rett syndrome	Enrichment	RHOBTB2	0.68
738	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	0.68
739	Renal cell carcinoma with mit translocations	Enrichment	CLTC	0.68
740	Branchiootorenal syndrome	Enrichment	TJP2	0.68
741	Pilomyxoid astrocytoma	Enrichment	SRGAP3	0.68
742	Focal epilepsy	Enrichment	SPTAN1	0.68
743	Follicular thyroid carcinoma	Enrichment	SRGAP1	0.68
744	Childhood-onset nemaline myopathy	Enrichment	TPM3	0.68
745	Overgrowth syndrome	Enrichment	PIK3R1	0.68
746	Non-syndromic genetic deafness	Enrichment	ACTG1, MYH14	0.67
747	Cat eye syndrome	Enrichment	ACTG1	0.67
748	Polymicrogyria	Enrichment	DYNC1H1	0.67
749	Ovarian cancer	Enrichment	AR, BUB1B, CDKN1B, CTNNB1	0.65
750	Cleft palate, isolated	Enrichment	FLNA, MYO19	0.65
751	Asphyxiating thoracic dystrophy	Enrichment	LBR, SPTAN1	0.63
752	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJA1	0.63
753	Spondylocostal dysostosis 1, autosomal recessive	Enrichment	PLEKHG2	0.63
754	Alternating hemiplegia of childhood	Enrichment	RHOBTB2	0.63
755	Choreatic disease	Enrichment	RHOBTB2	0.63
756	Hypoplastic left heart syndrome	Enrichment	GJA1	0.63
757	Early-onset posterior polar cataract	Enrichment	EPHA2	0.63
758	Meningioma, familial	Enrichment	NF2	0.63
759	46,xy complete gonadal dysgenesis	Enrichment	AR	0.63
760	Diabetes mellitus	Enrichment	MEN1	0.63
761	Fanconi anemia, complementation group d2	Enrichment	VHL	0.62
762	Von hippel-lindau syndrome	Enrichment	VHL	0.62
763	Genetic motor neuron disease	Enrichment	MFN2	0.62
764	Heart, malformation of	Enrichment	JAG1, MAPK1	0.62
765	Charcot-marie-tooth disease type 4	Enrichment	DYNC1H1, FGD4	0.62
766	Patent foramen ovale	Enrichment	ACTC1, FLNA	0.62
767	Congenital nervous system abnormality	Enrichment	CTNNB1, DYNC1H1, TUBA1A, TUBB4A	0.60
768	Nervous system disease	Enrichment	CTNNB1, DYNC1H1, TUBA1A, TUBB4A	0.60
769	Short-rib thoracic dysplasia 3 with or without polydactyly	Enrichment	DYNC1H1	0.60
770	Congenital hypothyroidism	Enrichment	TUBB1	0.60
771	46 xx gonadal dysgenesis	Enrichment	NUP107	0.60
772	Coronary heart disease 5	Enrichment	KALRN	0.59
773	Arteriovenous malformation	Enrichment	PIK3CA	0.59
774	Leukoencephalopathy with vanishing white matter	Enrichment	ANKLE2	0.59
775	Progressive non-fluent aphasia	Enrichment	VCP	0.59
776	Primary biliary cholangitis	Enrichment	TJP2	0.59
777	Cowden syndrome	Enrichment	PIK3CA	0.59
778	Behavioral variant of frontotemporal dementia	Enrichment	VCP	0.59
779	Nonsyndromic hearing loss	Enrichment	ACTG1, MYH14	0.57
780	Microphthalmia/coloboma 12	Enrichment	MYH10	0.57
781	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	VHL	0.56
782	Cataract 30, multiple types	Enrichment	VIM	0.55
783	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	VCP	0.55
784	Peters-plus syndrome	Enrichment	ARHGAP35	0.55
785	Amelogenesis imperfecta, type ie	Enrichment	ARHGAP6	0.55
786	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	0.55
787	Nemaline myopathy	Enrichment	TPM3	0.55
788	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	0.55
789	Osteoporosis	Enrichment	SRC	0.54
790	Medulloblastoma	Enrichment	CTNNB1	0.54
791	Periventricular nodular heterotopia	Enrichment	FLNA	0.54
792	Heart disease	Enrichment	ABL1	0.54
793	Hereditary chronic pancreatitis	Enrichment	CFTR	0.54
794	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	LBR, SPTAN1	0.53
795	Rare genetic deafness	Enrichment	ACTG1, DIAPH1, MYH9	0.53
796	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ALS2, VAPB, VCP	0.53
797	Hepatoblastoma	Enrichment	CTNNB1, JAG1	0.53
798	Coloboma of macula	Enrichment	MYH10	0.51
799	Corpus callosum, agenesis of	Enrichment	TUBA1A	0.51
800	Isolated corpus callosum agenesis	Enrichment	TUBA1A	0.51
801	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	TUBA1A	0.51
802	Lung non-small cell carcinoma	Enrichment	PIK3CA	0.51
803	Heritable pulmonary arterial hypertension	Enrichment	CAV1	0.51
804	Presynaptic congenital myasthenic syndromes	Enrichment	MYO9A	0.51
805	Cakut	Enrichment	ACTG1, SRGAP1	0.51
806	Hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	0.50
807	Renal cell carcinoma, papillary, 1	Enrichment	VHL	0.50
808	Multiple enchondromatosis, maffucci type	Enrichment	VHL	0.50
809	Isolated congenital microcephaly	Enrichment	TUBA3E	0.49
810	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	TOR1AIP1	0.48
811	Juvenile myelomonocytic leukemia	Enrichment	ARHGAP26	0.48
812	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP	0.48
813	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP	0.48
814	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15, SPTAN1	0.48
815	Pancreatitis, hereditary	Enrichment	CFTR	0.47
816	Sudden infant death syndrome	Enrichment	CALM2	0.47
817	Polycystic liver disease	Enrichment	CTNNB1	0.47
818	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	0.47
819	Joubert syndrome 1	Enrichment	B9D2, KIF14	0.47
820	Myopathy	Enrichment	DYNC1H1, EMD, TPM3	0.47
821	Aortic valve disease 1	Enrichment	SOS1	0.45
822	Hypercholesterolemia, familial, 1	Enrichment	DOCK6	0.45
823	Alzheimer's disease	Enrichment	VCP	0.45
824	Amelogenesis imperfecta	Enrichment	ARHGAP6	0.45
825	Diffuse large b-cell lymphoma	Enrichment	BTK	0.43
826	Multiple sclerosis	Enrichment	DST	0.43
827	Cataract	Enrichment	EPHA2	0.43
828	Cleft lip/palate	Enrichment	ARHGAP29	0.43
829	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP	0.43
830	Pituitary stalk interruption syndrome	Enrichment	WDR11	0.43
831	46,xy partial gonadal dysgenesis	Enrichment	SOS1	0.43
832	Epilepsy	Enrichment	DIAPH1, MTR	0.42
833	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1, MEN1	0.42
834	Craniosynostosis	Enrichment	CTNNA1	0.41
835	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR, CFTR	0.41
836	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, CTNNA1, MEN1, NF2	0.41
837	Congenital myopathy 4a, autosomal dominant	Enrichment	TPM3	0.40
838	Familial hypercholesterolemia	Enrichment	DOCK6	0.40
839	Noonan syndrome and noonan-related syndrome	Enrichment	SOS1	0.40
840	West syndrome	Enrichment	RALGAPA1, SPTAN1, TUBA1A	0.40
841	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	KCTD3	0.38
842	Wolff-parkinson-white syndrome	Enrichment	JUP	0.38
843	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	JUP	0.38
844	Attention deficit-hyperactivity disorder	Enrichment	KIF5B	0.38
845	Tooth agenesis	Enrichment	RANBP2	0.38
846	Alzheimer disease, familial, 1	Enrichment	VCP	0.36
847	Interstitial lung disease 2	Enrichment	FAM13A	0.36
848	Bladder cancer	Enrichment	CTNNB1, PIK3CA	0.35
849	Severe covid-19	Enrichment	CENPF, DOCK8	0.35
850	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	WDR11	0.35
851	Isolated joubert syndrome	Enrichment	ARL13B, B9D2	0.33
852	Esophageal atresia/tracheoesophageal fistula	Enrichment	ITSN1	0.33
853	Dilated cardiomyopathy	Enrichment	ACTC1, EMD, JUP	0.31
854	Lung cancer	Enrichment	PIK3CA, PPP2R1B	0.30
855	Endometrial cancer	Enrichment	PIK3CA	0.30
856	Hirschsprung disease 1	Enrichment	NUP98	0.30
857	Meckel syndrome, type 1	Enrichment	B9D2	0.30
858	Myocardial infarction	Enrichment	CCT7	0.28
859	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1, TMPO	0.28
860	Pheochromocytoma	Enrichment	VHL	0.27
861	Kallmann syndrome	Enrichment	WDR11	0.27
862	Cystic fibrosis	Enrichment	CFTR	0.27
863	Ear malformation	Enrichment	MYO6	0.26
864	Nephronophthisis	Enrichment	INCENP	0.26
865	Renal cell carcinoma, nonpapillary	Enrichment	VHL	0.25
866	Tetralogy of fallot	Enrichment	JAG1	0.24
867	Diamond-blackfan anemia	Enrichment	RPS27	0.23
868	Fetal akinesia deformation sequence 1	Enrichment	TUBA1A	0.23
869	Beckwith-wiedemann syndrome	Enrichment	MFN2	0.20
870	Hypertrophic cardiomyopathy	Enrichment	KIF5B	0.19
871	Optic atrophy plus syndrome	Enrichment	TUBB6	0.18
872	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1	0.18
873	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	VHL	0.17
874	Left ventricular noncompaction	Enrichment	ACTC1	0.16
875	Dystonia	Enrichment	RHOBTB2	0.16
876	Autism spectrum disorder	Enrichment	CDC42BPB, CUL3, SPEN	0.16
877	Hypertelorism	Enrichment	MYH10	0.14
878	Mitochondrial complex i deficiency, nuclear type 1	Enrichment	NDUFS3	0.14
879	Spastic ataxia	Enrichment	TUBB3	0.14
880	Leukemia, acute myeloid	Enrichment	PICALM	0.13
881	Myeloma, multiple	Enrichment	H3C1	0.13
882	Benign epilepsy with centrotemporal spikes	Enrichment	SPTAN1	0.13
883	Distal arthrogryposis	Enrichment	ACTC1	0.12
884	Autosomal recessive non-syndromic intellectual disability	Enrichment	CLIP1	0.12
885	Centralopathic epilepsy	Enrichment	SPTAN1	0.12
886	Gastric cancer	Enrichment	PIK3CA	0.12
887	Primary ovarian insufficiency	Enrichment	SGO2	0.12
888	Hereditary breast carcinoma	Enrichment	PIK3CA	0.11
889	Deafness, autosomal recessive	Enrichment	MYH9	0.11
890	Autosomal recessive nonsyndromic deafness	Enrichment	MYH9	0.10
891	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJA1, MYO6	0.10
892	Breast cancer	Enrichment	KLC1	0.08
893	Fanconi anemia, complementation group a	Enrichment	VHL	0.07
894	Schizophrenia	Enrichment	PHIP	0.07
895	Leber plus disease	Enrichment	TUBB4B	0.04
896	Autism	Enrichment	DOCK4	0.04
897	Mitochondrial disease	Enrichment	C1QBP	0.02
898	Retinitis pigmentosa	Enrichment	ARHGEF18	0.00
899	Hereditary retinal dystrophy	Enrichment	CTNNA1	0.00
900	Fundus dystrophy	Enrichment	CTNNA1	0.00

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by Rho GTPases

Pathway Network for Signaling by Rho GTPases

Pathway network for the Signaling by Rho GTPases SuperPath

Member Pathways for Signaling by Rho GTPases

Pathways in the Signaling by Rho GTPases SuperPath

Gene overlap in member pathways for Signaling by Rho GTPases SuperPath

Associated Genes for Signaling by Rho GTPases

Associated Disorders for Signaling by Rho GTPases

Disorders associated with Signaling by Rho GTPases SuperPath

STRING Interaction Network for Signaling by Rho GTPases

Sources for Signaling by Rho GTPases