Signaling by Slit

No Pathway Network information available for Signaling by Slit

Pathways in the Signaling by Slit SuperPath

#	Name	Source	Genes
1	Signaling by Slit	QIAGEN	ABL1 ABL2 ACTR2 ACTR3 ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 CDC42 CLASP1 CLASP2 CXCL12 CXCR4 DCC ENAH GNA11 GNA12 GNA13 GNA14 GNA15 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG2 GNG3 GNG4 MCF2L NET1 ROBO1 SLIT1 SLIT2 SLIT3 SRGAP1 SRGAP2 SRGAP3 WASL (see all 48) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
2	ABL2	ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase	Protein Coding	1
3	ACTR2	Actin Related Protein 2	Protein Coding	1
4	ACTR3	Actin Related Protein 3	Protein Coding	1
5	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
6	ARHGEF10	Rho Guanine Nucleotide Exchange Factor 10	Protein Coding	1
7	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	1
8	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	1
9	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	1
10	ARHGEF16	Rho Guanine Nucleotide Exchange Factor 16	Protein Coding	1
11	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	1
12	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	1
13	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	1
14	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	1
15	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	1
16	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
17	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	1
18	CDC42	Cell Division Cycle 42	Protein Coding	1
19	CLASP1	Cytoplasmic Linker Associated Protein 1	Protein Coding	1
20	CLASP2	Cytoplasmic Linker Associated Protein 2	Protein Coding	1
21	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	1
22	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
23	DCC	DCC Netrin 1 Receptor	Protein Coding	1
24	ENAH	ENAH Actin Regulator	Protein Coding	1
25	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
26	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
27	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
28	GNA14	G Protein Subunit Alpha 14	Protein Coding	1
29	GNA15	G Protein Subunit Alpha 15	Protein Coding	1
30	GNAS	GNAS Complex Locus	Protein Coding	1
31	GNB1	G Protein Subunit Beta 1	Protein Coding	1
32	GNB2	G Protein Subunit Beta 2	Protein Coding	1
33	GNB3	G Protein Subunit Beta 3	Protein Coding	1
34	GNB4	G Protein Subunit Beta 4	Protein Coding	1
35	GNB5	G Protein Subunit Beta 5	Protein Coding	1
36	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
37	GNG3	G Protein Subunit Gamma 3	Protein Coding	1
38	GNG4	G Protein Subunit Gamma 4	Protein Coding	1
39	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	1
40	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	1
41	ROBO1	Roundabout Guidance Receptor 1	Protein Coding	1
42	SLIT1	Slit Guidance Ligand 1	Protein Coding	1
43	SLIT2	Slit Guidance Ligand 2	Protein Coding	1
44	SLIT3	Slit Guidance Ligand 3	Protein Coding	1
45	SRGAP1	SLIT-ROBO Rho GTPase Activating Protein 1	Protein Coding	1
46	SRGAP2	SLIT-ROBO Rho GTPase Activating Protein 2	Protein Coding	1
47	SRGAP3	SLIT-ROBO Rho GTPase Activating Protein 3	Protein Coding	1
48	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1

Disorders associated with Signaling by Slit SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Anastomosing haemangioma	Enrichment	GNA11, GNA14	4.44
2	Cakut	Enrichment	ROBO1, SLIT2, SRGAP1	3.64
3	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.45
4	Nystagmus 8, congenital, autosomal recessive	Enrichment	ROBO1	2.45
5	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	2.45
6	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.45
7	Osseous heteroplasia, progressive	Enrichment	GNAS	2.45
8	Whim syndrome 1	Enrichment	CXCR4	2.45
9	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.45
10	Immunodeficiency 62	Enrichment	ARHGEF1	2.45
11	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.45
12	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.45
13	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.45
14	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.45
15	Slowed nerve conduction velocity, autosomal dominant	Enrichment	ARHGEF10	2.45
16	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.45
17	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.45
18	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.45
19	Disorders of gnas inactivation	Enrichment	GNAS	2.45
20	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	2.45
21	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.45
22	Gaze palsy, familial horizontal, with progressive scoliosis 2, with impaired intellectual development	Enrichment	DCC	2.45
23	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.45
24	Autosomal recessive congenital nystagmus	Enrichment	ROBO1	2.45
25	Sick sinus syndrome 4	Enrichment	GNB2	2.45
26	Pituitary hormone deficiency, combined or isolated, 8	Enrichment	ROBO1	2.45
27	Neurooculorenal syndrome	Enrichment	ROBO1	2.45
28	Nocarh syndrome	Enrichment	CDC42	2.45
29	Monostotic fibrous dysplasia	Enrichment	GNAS	2.45
30	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.45
31	Kaposiform hemangioendothelioma	Enrichment	GNA14	2.45
32	Mazabraud syndrome	Enrichment	GNAS	2.45
33	Congenital nystagmus	Enrichment	ROBO1	2.45
34	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.15
35	Microcephalic osteodysplastic primordial dwarfism, type i	Enrichment	CLASP1	2.15
36	Lowry-wood syndrome	Enrichment	CLASP1	2.15
37	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	2.15
38	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.15
39	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.15
40	Angioma, tufted	Enrichment	GNA14	2.15
41	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.15
42	Roifman syndrome	Enrichment	CLASP1	2.15
43	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.15
44	Autosomal dominant hypocalcemia	Enrichment	GNA11	2.15
45	Pseudohypoparathyroidism	Enrichment	GNAS	2.15
46	Immune system disease	Enrichment	CDC42	2.15
47	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.15
48	Rnu4atac-opathy	Enrichment	CLASP1	2.15
49	Horizontal gaze palsy with progressive scoliosis	Enrichment	DCC	2.15
50	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.15
51	Cerebral visual impairment	Enrichment	GNB1	2.15
52	Phakomatosis cesioflammea	Enrichment	GNA11	2.15
53	Mccune-albright syndrome	Enrichment	GNAS	1.98
54	Spondyloepiphyseal dysplasia congenita	Enrichment	CLASP1	1.98
55	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	1.98
56	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.98
57	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.98
58	Mirror movements 1	Enrichment	DCC	1.85
59	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.85
60	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.85
61	Amyotrophy, monomelic	Enrichment	SLIT1	1.85
62	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.85
63	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.85
64	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.85
65	Familial sick sinus syndrome	Enrichment	GNB2	1.85
66	Capillary malformations, congenital	Enrichment	GNA11	1.76
67	Melanoma, uveal	Enrichment	GNA11	1.68
68	Esophageal cancer	Enrichment	DCC	1.61
69	Thyroid cancer, nonmedullary, 2	Enrichment	SRGAP1	1.61
70	Leukemia, chronic myeloid	Enrichment	ABL1	1.61
71	Brachydactyly	Enrichment	GNAS	1.61
72	Pilomyxoid astrocytoma	Enrichment	SRGAP3	1.61
73	Follicular thyroid carcinoma	Enrichment	SRGAP1	1.61
74	Moyamoya angiopathy	Enrichment	ABL1	1.61
75	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.61
76	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.55
77	Hypothyroidism	Enrichment	GNB1	1.55
78	Primary hyperaldosteronism	Enrichment	GNAS	1.50
79	Renal agenesis, bilateral	Enrichment	ROBO1	1.50
80	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.42
81	Myelodysplastic syndrome	Enrichment	GNB1	1.42
82	Lip and oral cavity carcinoma	Enrichment	ABL1	1.38
83	Heart disease	Enrichment	ABL1	1.31
84	Pituitary stalk interruption syndrome	Enrichment	ROBO1	1.31
85	Corpus callosum, agenesis of	Enrichment	DCC	1.29
86	Isolated corpus callosum agenesis	Enrichment	DCC	1.29
87	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	DCC	1.29
88	Autism spectrum disorder	Enrichment	DCC, GNB1	1.25
89	Hypertension, essential	Enrichment	GNB3	1.23
90	Cleft palate, isolated	Enrichment	GNB1	1.23
91	Human immunodeficiency virus type 1	Enrichment	CXCL12	1.21
92	Microcephaly	Enrichment	ABL1, GNB1	1.15
93	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.12
94	Congenital stationary night blindness	Enrichment	GNB3	1.11
95	Kallmann syndrome	Enrichment	DCC	1.11
96	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.11
97	Tetralogy of fallot	Enrichment	ROBO1	1.05
98	Strabismus	Enrichment	GNB1	1.04
99	Dystonia	Enrichment	GNB1	0.93
100	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	0.92
101	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15	0.92
102	Cerebral palsy	Enrichment	GNB1	0.89
103	Charcot-marie-tooth disease	Enrichment	ARHGEF10	0.87
104	Body mass index quantitative trait locus 11	Enrichment	GNAS	0.79
105	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	0.79
106	Breast cancer	Enrichment	GNG3	0.63
107	Colorectal cancer	Enrichment	DCC	0.57
108	Congenital nervous system abnormality	Enrichment	GNB5	0.50
109	Nervous system disease	Enrichment	GNB5	0.50
110	Complex neurodevelopmental disorder	Enrichment	GNB2	0.45

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Signaling by Slit

Member Pathways for Signaling by Slit

Pathways in the Signaling by Slit SuperPath

Associated Genes for Signaling by Slit

Associated Disorders for Signaling by Slit

Disorders associated with Signaling by Slit SuperPath

STRING Interaction Network for Signaling by Slit

Sources for Signaling by Slit