Signaling by TGFBR3

Pathway network for the Signaling by TGFBR3 SuperPath

Sources:

Reactome

Pathways in the Signaling by TGFBR3 SuperPath

#	Name	Source	Genes
1	Signaling by TGFBR3	Reactome	ACVR2A AGO1 AGO2 AGO3 AGO4 APH1A APH1B ARRB1 ARRB2 EP300 FGF2 GIPC1 HELLS INHA INHBA KLF16 MMP14 MMP16 MOV10 MYCN MYF5 MYF6 MYOD1 MYOG NCSTN PSEN1 PSEN2 PSENEN RARA RXRA SMAD3 SMAD4 SP1 TCF12 TCF3 TCF4 TGFB1 TGFB2 TGFBR1 TGFBR2 TGFBR3 TIMP1 TIMP2 TNRC6A TNRC6B TNRC6C (see all 46) (see less)
2	TGFBR3 expression	Reactome	AGO1 AGO2 AGO3 AGO4 EP300 HELLS KLF16 MOV10 MYCN MYF5 MYF6 MYOD1 MYOG RARA RXRA SMAD3 SMAD4 SP1 TCF12 TCF3 TCF4 TGFBR3 TNRC6A TNRC6B TNRC6C (see all 25) (see less)
3	TGFBR3 PTM regulation	Reactome	APH1A APH1B MMP14 MMP16 NCSTN PSEN1 PSEN2 PSENEN TGFBR3 TIMP1 TIMP2 (see all 11) (see less)
4	TGFBR3 regulates TGF-beta signaling	Reactome	ARRB1 ARRB2 GIPC1 TGFB1 TGFB2 TGFBR1 TGFBR2 TGFBR3 (see all 8) (see less)

Gene overlap in member pathways for Signaling by TGFBR3 SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	4
2	GIPC1	GIPC PDZ Domain Containing Family Member 1	Protein Coding	2
3	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	2
4	AGO4	Argonaute RISC Component 4	Protein Coding	2
5	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
6	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	2
7	NCSTN	Nicastrin	Protein Coding	2
8	AGO1	Argonaute RISC Component 1	Protein Coding	2
9	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	2
10	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	2
11	HELLS	Helicase, Lymphoid Specific	Protein Coding	2
12	ARRB1	Arrestin Beta 1	Protein Coding	2
13	SMAD3	SMAD Family Member 3	Protein Coding	2
14	SMAD4	SMAD Family Member 4	Protein Coding	2
15	ARRB2	Arrestin Beta 2	Protein Coding	2
16	MMP14	Matrix Metallopeptidase 14	Protein Coding	2
17	MMP16	Matrix Metallopeptidase 16	Protein Coding	2
18	MOV10	Mov10 RNA Helicase	Protein Coding	2
19	MYCN	MYCN Proto-Oncogene, BHLH Transcription Factor	Protein Coding	2
20	MYF5	Myogenic Factor 5	Protein Coding	2
21	MYF6	Myogenic Factor 6	Protein Coding	2
22	MYOD1	Myogenic Differentiation 1	Protein Coding	2
23	MYOG	Myogenin	Protein Coding	2
24	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	2
25	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	2
26	PSEN1	Presenilin 1	Protein Coding	2
27	PSEN2	Presenilin 2	Protein Coding	2
28	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	2
29	RARA	Retinoic Acid Receptor Alpha	Protein Coding	2
30	RXRA	Retinoid X Receptor Alpha	Protein Coding	2
31	SP1	Sp1 Transcription Factor	Protein Coding	2
32	TCF4	Transcription Factor 4	Protein Coding	2
33	TCF3	Transcription Factor 3	Protein Coding	2
34	TCF12	Transcription Factor 12	Protein Coding	2
35	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	2
36	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	2
37	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	2
38	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	2
39	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	2
40	TIMP2	TIMP Metallopeptidase Inhibitor 2	Protein Coding	2
41	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	2
42	KLF16	KLF Transcription Factor 16	Protein Coding	2
43	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
44	INHA	Inhibin Subunit Alpha	Protein Coding	1
45	INHBA	Inhibin Subunit Beta A	Protein Coding	1
46	ACVR2A	Activin A Receptor Type 2A	Protein Coding	1

Disorders associated with Signaling by TGFBR3 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	7.95
2	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	7.79
3	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	6.52
4	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3, SMAD4, TGFB2, TGFBR1, TGFBR2	6.45
5	Loeys-dietz syndrome 1	Enrichment	TGFBR1, TGFBR2	6.04
6	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	5.75
7	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	4.90
8	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	4.47
9	Myopathy, centronuclear, 1	Enrichment	MYF6, MYOD1	4.31
10	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	4.17
11	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	3.23
12	Camurati-engelmann disease 2	Enrichment	TGFB2	3.23
13	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	3.23
14	Oculopharyngodistal myopathy 2	Enrichment	GIPC1	3.23
15	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	3.09
16	Acne inversa, familial, 1	Enrichment	NCSTN	3.09
17	Winchester syndrome	Enrichment	MMP14	3.09
18	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	3.09
19	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	3.09
20	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	3.09
21	Acne inversa, familial, 3	Enrichment	PSEN1	3.09
22	Pash syndrome	Enrichment	NCSTN	3.09
23	Huntington's disease-like	Enrichment	PSEN2	3.09
24	Autism spectrum disorder	Enrichment	TCF12, TCF4, TNRC6B	2.99
25	Camurati-engelmann disease 1	Enrichment	TGFB1	2.93
26	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.93
27	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.93
28	Camurati-engelmann disease	Enrichment	TGFB1	2.93
29	Loeys-dietz syndrome 4	Enrichment	TGFB2	2.93
30	Complex neurodevelopmental disorder	Enrichment	AGO1, AGO2, TNRC6B	2.83
31	Alzheimer disease 3	Enrichment	PSEN1	2.79
32	Pick disease of brain	Enrichment	PSEN1	2.79
33	Immunodeficiency-centromeric instability-facial anomalies syndrome 4	Enrichment	HELLS	2.73
34	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	2.73
35	Agammaglobulinemia 8b, autosomal recessive	Enrichment	TCF3	2.73
36	Agammaglobulinemia 8a, autosomal dominant	Enrichment	TCF3	2.73
37	Ophthalmoplegia, external, with rib and vertebral anomalies	Enrichment	MYF5	2.73
38	Craniosynostosis 3	Enrichment	TCF12	2.73
39	Congenital myopathy 17	Enrichment	MYOD1	2.73
40	Corneal dystrophy, fuchs endothelial, 3	Enrichment	TCF4	2.73
41	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	2.73
42	Heritable thoracic aortic disease	Enrichment	SMAD4	2.73
43	Hypogonadotropic hypogonadism 26 with or without anosmia	Enrichment	TCF12	2.73
44	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP14	2.61
45	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	2.53
46	Dowling-degos disease	Enrichment	PSENEN	2.49
47	Ovary adenocarcinoma	Enrichment	INHBA	2.47
48	Atrial septal defect 1	Enrichment	TGFB2	2.45
49	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	2.45
50	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	2.45
51	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	2.45
52	Myhre syndrome	Enrichment	SMAD4	2.43
53	Premature ovarian failure 3	Enrichment	AGO2	2.43
54	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.43
55	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.43
56	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	2.43
57	Menke-hennekam syndrome 2	Enrichment	EP300	2.43
58	Megalencephaly-polydactyly syndrome	Enrichment	MYCN	2.43
59	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	TCF3	2.43
60	Familial retinoblastoma	Enrichment	MYCN	2.43
61	B-lymphoblastic leukemia/lymphoma with t(17;19)	Enrichment	TCF3	2.43
62	Dementia	Enrichment	PSEN1	2.39
63	Esophageal cancer	Enrichment	TGFBR2	2.38
64	Oculopharyngodistal myopathy 1	Enrichment	GIPC1	2.38
65	Myeloma, multiple	Enrichment	RXRA, TCF3	2.33
66	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	2.31
67	Connective tissue disease	Enrichment	SMAD3, TGFBR2	2.28
68	Retinoblastoma	Enrichment	MYCN	2.26
69	Juvenile polyposis syndrome	Enrichment	SMAD4	2.26
70	Lessel-kreienkamp syndrome	Enrichment	AGO2	2.26
71	Semantic dementia	Enrichment	PSEN1	2.25
72	Pectus excavatum	Enrichment	TGFBR1	2.19
73	Progressive non-fluent aphasia	Enrichment	PSEN1	2.14
74	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	2.14
75	Pitt-hopkins syndrome	Enrichment	TCF4	2.13
76	Non-syndromic bicoronal craniosynostosis	Enrichment	TCF12	2.13
77	Lynch syndrome	Enrichment	TGFBR2	2.05
78	Frontotemporal dementia 1	Enrichment	PSEN1	2.05
79	Feingold syndrome 1	Enrichment	MYCN	2.04
80	Chondrosarcoma, extraskeletal myxoid	Enrichment	TCF12	2.04
81	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.04
82	Cholangitis, primary sclerosing	Enrichment	TCF4	2.04
83	Fuchs' endothelial dystrophy	Enrichment	TCF4	2.04
84	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	2.04
85	Alzheimer's disease	Enrichment	PSEN1	1.98
86	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.96
87	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.96
88	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	HELLS	1.96
89	Colorectal cancer	Enrichment	EP300, SMAD4	1.96
90	Gallbladder cancer	Enrichment	SMAD4	1.89
91	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.89
92	Alzheimer disease, familial, 1	Enrichment	PSEN1	1.86
93	Spastic paraplegia 4, autosomal dominant	Enrichment	TCF4	1.83
94	Neuroblastoma	Enrichment	MYCN	1.83
95	Charge syndrome	Enrichment	EP300	1.78
96	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	TNRC6B	1.78
97	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.78
98	2q23.1 microduplication syndrome	Enrichment	ACVR2A	1.77
99	Skin disease	Enrichment	NCSTN	1.75
100	Autosomal non-syndromic agammaglobulinemia	Enrichment	TCF3	1.74
101	Cystic fibrosis	Enrichment	TGFB1	1.73
102	Microcephaly	Enrichment	EP300, TCF4	1.67
103	Epicanthus	Enrichment	TCF4	1.66
104	Acute promyelocytic leukemia	Enrichment	RARA	1.63
105	Stereotypic movement disorder	Enrichment	TCF4	1.63
106	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.59
107	Polydactyly, postaxial, type a1	Enrichment	EP300	1.56
108	Rare genetic intellectual disability	Enrichment	EP300	1.56
109	Craniosynostosis	Enrichment	TCF12	1.44
110	Scoliosis	Enrichment	MYF5	1.36
111	Pancreatic cancer	Enrichment	SMAD4	1.35
112	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	1.34
113	Fetal akinesia deformation sequence 1	Enrichment	MYOD1	1.18
114	Distal arthrogryposis	Enrichment	MYOD1	1.13
115	Gastric cancer	Enrichment	SMAD4	1.12
116	Congenital nervous system abnormality	Enrichment	PSEN1	1.08
117	Nervous system disease	Enrichment	PSEN1	1.08
118	Thrombocytopenia	Enrichment	SMAD4	1.07
119	Autosomal dominant non-syndromic intellectual disability	Enrichment	TCF4	1.05
120	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by TGFBR3

Pathway Network for Signaling by TGFBR3

Pathway network for the Signaling by TGFBR3 SuperPath

Member Pathways for Signaling by TGFBR3

Pathways in the Signaling by TGFBR3 SuperPath

Gene overlap in member pathways for Signaling by TGFBR3 SuperPath

Associated Genes for Signaling by TGFBR3

Associated Disorders for Signaling by TGFBR3

Disorders associated with Signaling by TGFBR3 SuperPath

STRING Interaction Network for Signaling by TGFBR3

Sources for Signaling by TGFBR3