Signaling by VEGF

No Pathway Network information available for Signaling by VEGF

Pathways in the Signaling by VEGF SuperPath

#	Name	Source	Genes
1	Signaling by VEGF	Reactome	AAMP ABI1 ABI2 ACTB ACTG1 AHCYL1 AKT1 AKT2 AKT3 AXL BAIAP2 BCAR1 BRK1 CALM1 CALM2 CALM3 CAV1 CDC42 CDH5 CRK CTNNA1 CTNNB1 CTNND1 CYBA CYBB CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 FLT1 FLT4 FYN HRAS HSP90AA1 HSPB1 ITGAV ITGB3 ITPR1 ITPR2 ITPR3 JUP KDR KRAS MAPK11 MAPK12 MAPK13 MAPK14 MAPKAP1 MAPKAPK2 MAPKAPK3 MLST8 MTOR NCF1 NCF2 NCF4 NCK1 NCK2 NCKAP1 NCKAP1L NOS3 NRAS NRP1 NRP2 PAK1 PAK2 PAK3 PDPK1 PGF PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCD PRKCZ PRR5 PTK2 PTK2B PXN RAC1 RASA1 RHOA RICTOR ROCK1 ROCK2 SH2D2A SHB SHC2 SPHK1 SRC THEM4 TRIB3 VAV1 VAV2 VAV3 VEGFA VEGFB VEGFC VEGFD WASF1 WASF2 WASF3 (see all 108) (see less)
2	VEGFA-VEGFR2 Pathway	Reactome	ABI1 ABI2 ACTB ACTG1 AHCYL1 AKT1 AKT2 AKT3 AXL BAIAP2 BCAR1 BRK1 CALM1 CALM2 CALM3 CAV1 CDC42 CDH5 CRK CTNNA1 CTNNB1 CTNND1 CYBA CYBB CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 FYN HRAS HSP90AA1 HSPB1 ITGAV ITGB3 ITPR1 ITPR2 ITPR3 JUP KDR KRAS MAPK11 MAPK12 MAPK13 MAPK14 MAPKAP1 MAPKAPK2 MAPKAPK3 MLST8 MTOR NCF1 NCF2 NCF4 NCK1 NCK2 NCKAP1 NCKAP1L NOS3 NRAS PAK1 PAK2 PAK3 PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCD PRKCZ PRR5 PTK2 PTK2B PXN RAC1 RASA1 RHOA RICTOR ROCK1 ROCK2 SH2D2A SHB SHC2 SPHK1 SRC THEM4 TRIB3 VAV1 VAV2 VAV3 VEGFA WASF1 WASF2 WASF3 (see all 99) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
2	ABI1	Abl Interactor 1	Protein Coding	2
3	CDH5	Cadherin 5	Protein Coding	2
4	ABI2	Abl Interactor 2	Protein Coding	2
5	WASF2	WASP Family Member 2	Protein Coding	2
6	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	2
7	BAIAP2	BAR/IMD Domain Containing Adaptor Protein 2	Protein Coding	2
8	AHCYL1	Adenosylhomocysteinase Like 1	Protein Coding	2
9	NCKAP1	NCK Associated Protein 1	Protein Coding	2
10	WASF3	WASP Family Member 3	Protein Coding	2
11	THEM4	Thioesterase Superfamily Member 4	Protein Coding	2
12	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	2
13	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
14	CTNNA1	Catenin Alpha 1	Protein Coding	2
15	CTNNB1	Catenin Beta 1	Protein Coding	2
16	CTNND1	Catenin Delta 1	Protein Coding	2
17	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	2
18	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	2
19	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	2
20	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
21	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
22	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	2
23	CYFIP1	Cytoplasmic FMR1 Interacting Protein 1	Protein Coding	2
24	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	2
25	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	2
26	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
27	SHC2	SHC Adaptor Protein 2	Protein Coding	2
28	CYFIP2	Cytoplasmic FMR1 Interacting Protein 2	Protein Coding	2
29	NCKAP1L	NCK Associated Protein 1 Like	Protein Coding	2
30	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
31	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	2
32	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	2
33	ITGAV	Integrin Subunit Alpha V	Protein Coding	2
34	ITGB3	Integrin Subunit Beta 3	Protein Coding	2
35	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	2
36	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	2
37	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	2
38	JUP	Junction Plakoglobin	Protein Coding	2
39	KDR	Kinase Insert Domain Receptor	Protein Coding	2
40	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
41	RHOA	Ras Homolog Family Member A	Protein Coding	2
42	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	2
43	NCF4	Neutrophil Cytosolic Factor 4	Protein Coding	2
44	NCK1	NCK Adaptor Protein 1	Protein Coding	2
45	NOS3	Nitric Oxide Synthase 3	Protein Coding	2
46	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
47	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
48	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
49	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	2
50	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
51	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
52	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
53	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
54	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
55	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
56	PRR5	Proline Rich 5	Protein Coding	2
57	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	2
58	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	2
59	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	2
60	PRKCA	Protein Kinase C Alpha	Protein Coding	2
61	PRKCB	Protein Kinase C Beta	Protein Coding	2
62	AXL	AXL Receptor Tyrosine Kinase	Protein Coding	2
63	PRKCD	Protein Kinase C Delta	Protein Coding	2
64	BRK1	BRICK1 Subunit Of SCAR/WAVE Actin Nucleating Complex	Protein Coding	2
65	PRKCZ	Protein Kinase C Zeta	Protein Coding	2
66	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
67	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
68	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
69	TRIB3	Tribbles Pseudokinase 3	Protein Coding	2
70	PXN	Paxillin	Protein Coding	2
71	RAC1	Rac Family Small GTPase 1	Protein Coding	2
72	RASA1	RAS P21 Protein Activator 1	Protein Coding	2
73	ACTB	Actin Beta	Protein Coding	2
74	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	2
75	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
76	ELMO2	Engulfment And Cell Motility 2	Protein Coding	2
77	MLST8	MTOR Associated Protein MLST8	Protein Coding	2
78	SHB	SH2 Domain Containing Adaptor Protein B	Protein Coding	2
79	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	2
80	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
81	ACTG1	Actin Gamma 1	Protein Coding	2
82	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	2
83	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	2
84	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	2
85	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	2
86	MAPKAP1	MAPK Associated Protein 1	Protein Coding	2
87	CALM1	Calmodulin 1	Protein Coding	2
88	CALM2	Calmodulin 2	Protein Coding	2
89	CALM3	Calmodulin 3	Protein Coding	2
90	NCK2	NCK Adaptor Protein 2	Protein Coding	2
91	CAV1	Caveolin 1	Protein Coding	2
92	SPHK1	Sphingosine Kinase 1	Protein Coding	2
93	WASF1	WASP Family Member 1	Protein Coding	2
94	SH2D2A	SH2 Domain Containing 2A	Protein Coding	2
95	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	2
96	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	2
97	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	2
98	ELMO1	Engulfment And Cell Motility 1	Protein Coding	2
99	CDC42	Cell Division Cycle 42	Protein Coding	2
100	AAMP	Angio Associated Migratory Cell Protein	Protein Coding	1
101	VEGFD	Vascular Endothelial Growth Factor D	Protein Coding	1
102	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	1
103	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	1
104	PGF	Placental Growth Factor	Protein Coding	1
105	VEGFB	Vascular Endothelial Growth Factor B	Protein Coding	1
106	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	1
107	NRP2	Neuropilin 2	Protein Coding	1
108	NRP1	Neuropilin 1	Protein Coding	1

Disorders associated with Signaling by VEGF SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chronic granulomatous disease	Enrichment	CYBA, CYBB, NCF1, NCF2, NCF4	8.64
2	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	7.04
3	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS, PIK3CA	6.07
4	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.82
5	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	5.82
6	Colorectal cancer	Enrichment	AKT1, CTNNA1, CTNNB1, NRAS, PIK3CA, PIK3R1, SRC	5.49
7	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA	5.43
8	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	5.13
9	Hemangioma, capillary infantile	Enrichment	FLT4, KDR, RASA1	5.02
10	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA, RASA1	4.89
11	Gallbladder cancer	Enrichment	CTNNB1, KRAS, PIK3CA	4.89
12	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	4.69
13	Arteriovenous malformation	Enrichment	HRAS, PIK3CA, RASA1	4.51
14	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA, RASA1	4.36
15	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.28
16	Immunodeficiency 72 with autoinflammation and lymphoproliferation	Enrichment	NCKAP1, NCKAP1L	4.28
17	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.28
18	Immunodeficiency 72	Enrichment	NCKAP1, NCKAP1L	4.28
19	Bladder cancer	Enrichment	CTNNB1, HRAS, KRAS, PIK3CA	4.26
20	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	4.20
21	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1, NCF2	3.80
22	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.80
23	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.80
24	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS	3.79
25	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CTNNA1, KRAS	3.50
26	Granulomatous disease, chronic, x-linked	Enrichment	CYBB, NCF1	3.50
27	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.50
28	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.50
29	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	3.28
30	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS	3.22
31	Pre-eclampsia	Enrichment	FLT1, NOS3	3.21
32	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	3.11
33	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.11
34	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	3.11
35	Rasopathy	Enrichment	HRAS, KRAS, NRAS	3.06
36	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	2.97
37	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.97
38	Noonan syndrome 3	Enrichment	HRAS, KRAS	2.97
39	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	2.97
40	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	2.97
41	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	2.92
42	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	2.84
43	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.74
44	Adult hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	2.74
45	Cowden syndrome	Enrichment	AKT1, PIK3CA	2.74
46	Non-immune hydrops fetalis	Enrichment	FLT4, HRAS, KRAS	2.73
47	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	2.48
48	Meningioma	Enrichment	AKT1, PIK3CA	2.48
49	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	2.48
50	Nk-cell enteropathy	Enrichment	AXL, PIK3CB	2.41
51	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA	2.40
52	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.28
53	Ovarian cancer	Enrichment	AKT1, CTNNB1, KRAS, PIK3CA	2.20
54	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.14
55	Macrodactyly	Enrichment	PIK3CA	2.14
56	Proteus syndrome	Enrichment	AKT1	2.14
57	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.14
58	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.14
59	Granulomatous disease, chronic, autosomal recessive, 4	Enrichment	CYBA	2.14
60	Ramon syndrome	Enrichment	ELMO2	2.14
61	Baraitser-winter syndrome 1	Enrichment	ACTB	2.14
62	Oculoectodermal syndrome	Enrichment	KRAS	2.14
63	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.14
64	Immunodeficiency 34	Enrichment	CYBB	2.14
65	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.14
66	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.14
67	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.14
68	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.14
69	Cowden syndrome 5	Enrichment	PIK3CA	2.14
70	Melanosis, neurocutaneous	Enrichment	NRAS	2.14
71	Noonan syndrome 6	Enrichment	NRAS	2.14
72	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.14
73	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.14
74	Naxos disease	Enrichment	JUP	2.14
75	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.14
76	Neurodevelopmental disorder with absent language and variable seizures	Enrichment	WASF1	2.14
77	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.14
78	Knobloch syndrome 2	Enrichment	PAK2	2.14
79	Short syndrome	Enrichment	PIK3R1	2.14
80	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.14
81	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.14
82	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.14
83	Vascular malformation, primary intraosseous	Enrichment	ELMO2	2.14
84	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.14
85	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.14
86	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.14
87	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.14
88	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.14
89	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.14
90	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.14
91	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.14
92	Becker nevus syndrome	Enrichment	ACTB	2.14
93	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.14
94	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.14
95	Long qt syndrome 16	Enrichment	CALM3	2.14
96	Cowden syndrome 6	Enrichment	AKT1	2.14
97	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.14
98	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.14
99	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.14
100	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.14
101	Thrombocytopenia 6	Enrichment	SRC	2.14
102	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.14
103	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.14
104	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.14
105	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.14
106	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.14
107	Tufted angioma of skin	Enrichment	KDR	2.14
108	Primary intraosseous venous malformation	Enrichment	ELMO2	2.14
109	Adenoid ameloblastoma	Enrichment	CTNNB1	2.14
110	Long qt syndrome 15	Enrichment	CALM2	2.14
111	Baraitser-winter syndrome	Enrichment	ACTB	2.14
112	Hypospadias	Enrichment	PIK3CA	2.14
113	Capillary hemangioma	Enrichment	AKT3	2.14
114	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.14
115	Congenital pulmonary airway malformation	Enrichment	KRAS	2.14
116	Rare venous malformation	Enrichment	PIK3CA	2.14
117	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.14
118	Gorham's disease	Enrichment	RASA1	2.14
119	Diaphragmatic eventration	Enrichment	PIK3CA	2.14
120	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.14
121	Nocarh syndrome	Enrichment	CDC42	2.14
122	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.14
123	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.14
124	Rare combined vascular malformation	Enrichment	PIK3CA	2.14
125	Cavernous lymphangioma	Enrichment	PIK3CA	2.14
126	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.14
127	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.14
128	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.14
129	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.14
130	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.14
131	Macrodactyly of toe	Enrichment	PIK3CA	2.14
132	Neurocutaneous melanocytosis	Enrichment	NRAS	2.14
133	Microcystic stromal tumor	Enrichment	CTNNB1	2.14
134	Temporomandibular joint anomaly	Enrichment	DOCK1	2.14
135	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.14
136	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1, CTNNA1, KRAS	2.12
137	Hereditary lymphedema id	Enrichment	VEGFC	2.10
138	Lymphatic malformation 4	Enrichment	VEGFC	2.10
139	Congenital heart defects, multiple types, 7	Enrichment	FLT4	2.10
140	Congenital primary lymphedema of gordon	Enrichment	VEGFC	2.10
141	Primary ovarian insufficiency	Enrichment	KDR, NOS3, RICTOR	2.04
142	Hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	1.96
143	Microcephaly	Enrichment	ACTB, ACTG1, CTNNB1, PAK3	1.90
144	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.84
145	Blepharocheilodontic syndrome 1	Enrichment	CTNND1	1.84
146	Costello syndrome	Enrichment	HRAS	1.84
147	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	1.84
148	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.84
149	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.84
150	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.84
151	Keratosis, seborrheic	Enrichment	PIK3CA	1.84
152	Granulomatous disease, chronic, autosomal recessive, 3	Enrichment	NCF4	1.84
153	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.84
154	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	1.84
155	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.84
156	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.84
157	Angioma, tufted	Enrichment	KDR	1.84
158	Noonan syndrome 8	Enrichment	PIK3CA	1.84
159	Long qt syndrome 14	Enrichment	CALM1	1.84
160	Blepharocheilodontic syndrome 2	Enrichment	CTNND1	1.84
161	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.84
162	Cebalid syndrome	Enrichment	MTOR	1.84
163	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.84
164	Senior-loken syndrome 7	Enrichment	AKT3	1.84
165	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.84
166	Fibrolamellar carcinoma	Enrichment	PRKACA	1.84
167	Immune system disease	Enrichment	CDC42	1.84
168	Bardet-biedl syndrome 16	Enrichment	AKT3	1.84
169	Smith-kingsmore syndrome	Enrichment	MTOR	1.84
170	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.84
171	Teratoma	Enrichment	CTNNB1	1.84
172	Wooly hair nevus	Enrichment	HRAS	1.84
173	Lymphatic malformation 1	Enrichment	FLT4	1.80
174	Intracranial hypertension, idiopathic	Enrichment	FLT4	1.80
175	Hereditary lymphedema i	Enrichment	FLT4	1.80
176	Breast cancer	Enrichment	AKT1, KRAS, PIK3CA	1.76
177	Tetralogy of fallot	Enrichment	FLT4, KDR	1.74
178	Hydrops fetalis, nonimmune	Enrichment	FLT4, HRAS	1.74
179	Long qt syndrome	Enrichment	CALM1, CALM2	1.67
180	Desmoid disease, hereditary	Enrichment	CTNNB1	1.66
181	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.66
182	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	1.66
183	Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	Enrichment	CYBA	1.66
184	Gillespie syndrome	Enrichment	ITPR1	1.66
185	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.66
186	Langerhans cell histiocytosis	Enrichment	NRAS	1.66
187	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	1.66
188	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.66
189	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.66
190	Anus, imperforate	Enrichment	CTNNB1	1.66
191	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.66
192	Developmental and epileptic encephalopathy 65	Enrichment	CYFIP2	1.66
193	Bacteremia 2	Enrichment	MAPKAPK3	1.66
194	Desmoid tumor	Enrichment	CTNNB1	1.66
195	Wieacker-wolff syndrome	Enrichment	RASA1	1.66
196	Immunodeficiency 14	Enrichment	PIK3R1	1.66
197	Spermatocytoma	Enrichment	HRAS	1.66
198	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	1.66
199	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.66
200	Autoimmune polyendocrine syndrome type 1	Enrichment	CYBA	1.66
201	Keratoacanthoma	Enrichment	PIK3CA	1.66
202	Lung cancer	Enrichment	KRAS, PIK3CA	1.64
203	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.54
204	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	1.54
205	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.54
206	Pilomatrixoma	Enrichment	CTNNB1	1.54
207	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.54
208	Aminoacylase 1 deficiency	Enrichment	ACTB	1.54
209	Alazami syndrome	Enrichment	CTNNB1	1.54
210	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.54
211	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.54
212	Cerebrovascular disease	Enrichment	PIK3CA	1.54
213	Craniopharyngioma	Enrichment	CTNNB1	1.54
214	Tuberculosis	Enrichment	MAPKAPK3	1.54
215	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.54
216	Pilocytic astrocytoma	Enrichment	KRAS	1.54
217	Epidermolytic nevus	Enrichment	HRAS	1.54
218	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.54
219	Knobloch syndrome	Enrichment	PAK2	1.54
220	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.54
221	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.54
222	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.46
223	Alzheimer disease 2	Enrichment	NOS3	1.44
224	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.44
225	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.44
226	Knobloch syndrome 1	Enrichment	PAK2	1.44
227	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.44
228	Coloboma of choroid and retina	Enrichment	ACTG1	1.44
229	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.44
230	Gastric cancer	Enrichment	KRAS, PIK3CA	1.41
231	Cowden syndrome 1	Enrichment	PIK3CA	1.37
232	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.37
233	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.37
234	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.37
235	Basal cell carcinoma 1	Enrichment	RASA1	1.37
236	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.37
237	Adrenocortical carcinoma	Enrichment	CTNNB1	1.37
238	Limited scleroderma	Enrichment	CAV1	1.37
239	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.37
240	Cleft lip with or without cleft palate	Enrichment	CTNND1	1.37
241	Thrombocytopenia	Enrichment	ITGB3, SRC	1.32
242	Myelofibrosis	Enrichment	SRC	1.30
243	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.30
244	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.30
245	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.30
246	Pilomyxoid astrocytoma	Enrichment	KRAS	1.30
247	Megacolon	Enrichment	AKT3	1.30
248	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.24
249	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.24
250	Myeloma, multiple	Enrichment	KRAS, PIK3R2	1.20
251	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	1.20
252	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.20
253	Cat eye syndrome	Enrichment	ACTG1	1.15
254	Stroke, ischemic	Enrichment	NOS3	1.15
255	Polymicrogyria	Enrichment	AKT3	1.15
256	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.15
257	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.15
258	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.11
259	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP	1.07
260	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP	1.07
261	Congenital long qt syndrome	Enrichment	ITPR3	1.07
262	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.04
263	Protein-deficiency anemia	Enrichment	NRAS	1.04
264	Multiple sclerosis	Enrichment	ITPR1	1.01
265	Osteoporosis	Enrichment	SRC	1.01
266	Medulloblastoma	Enrichment	CTNNB1	1.01
267	Lung cancer susceptibility 3	Enrichment	KRAS	1.01
268	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP	1.01
269	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	0.98
270	Anterior segment dysgenesis	Enrichment	ITPR1	0.98
271	Rare genetic intellectual disability	Enrichment	MTOR	0.98
272	Wolff-parkinson-white syndrome	Enrichment	JUP	0.96
273	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	JUP	0.96
274	Rhabdomyosarcoma	Enrichment	HRAS	0.96
275	Alzheimer disease, familial, 1	Enrichment	NOS3	0.93
276	Hypertension, essential	Enrichment	NOS3	0.93
277	Sudden infant death syndrome	Enrichment	CALM2	0.93
278	Polycystic liver disease	Enrichment	CTNNB1	0.93
279	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	0.93
280	Arteriovenous malformations of the brain	Enrichment	KRAS	0.89
281	Williams-beuren syndrome	Enrichment	NCF1	0.87
282	Craniosynostosis	Enrichment	CTNNA1	0.87
283	Endometrial cancer	Enrichment	PIK3CA	0.85
284	Lissencephaly	Enrichment	ACTG1	0.85
285	Hepatoblastoma	Enrichment	CTNNB1	0.85
286	Myocardial infarction	Enrichment	ITGB3	0.83
287	Malaria	Enrichment	MAPKAPK3	0.81
288	Pancreatic cancer	Enrichment	KRAS	0.78
289	Prostate cancer	Enrichment	PIK3CA	0.72
290	Severe covid-19	Enrichment	ITGAV	0.72
291	Cakut	Enrichment	ACTG1	0.66
292	Complex neurodevelopmental disorder	Enrichment	PAK3, WASF1	0.64
293	Non-syndromic genetic deafness	Enrichment	ACTG1	0.63
294	Charcot-marie-tooth disease	Enrichment	HSPB1	0.59
295	Type 2 diabetes mellitus	Enrichment	AKT2	0.58
296	Nonsyndromic hearing loss	Enrichment	ACTG1	0.58
297	Hypertelorism	Enrichment	PIK3CA	0.50
298	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.50
299	Spastic ataxia	Enrichment	ITPR1	0.49
300	Undetermined early-onset epileptic encephalopathy	Enrichment	CYFIP2	0.47
301	Rare genetic deafness	Enrichment	ACTG1	0.36
302	Dilated cardiomyopathy	Enrichment	JUP	0.35
303	Congenital nervous system abnormality	Enrichment	CTNNB1	0.27
304	Nervous system disease	Enrichment	CTNNB1	0.27
305	Inherited cancer-predisposing syndrome	Enrichment	CTNNA1	0.21
306	Hereditary retinal dystrophy	Enrichment	CTNNA1	0.05
307	Fundus dystrophy	Enrichment	CTNNA1	0.05

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Signaling by VEGF

Pathway Network for Signaling by VEGF

Member Pathways for Signaling by VEGF

Pathways in the Signaling by VEGF SuperPath

Associated Genes for Signaling by VEGF

Associated Disorders for Signaling by VEGF

Disorders associated with Signaling by VEGF SuperPath

STRING Interaction Network for Signaling by VEGF

Sources for Signaling by VEGF